Outputs (2)

Introducing novel key genes and transcription factors associated with rectal cancer response to chemoradiation through co-expression network analysis. (2023)
Journal Article
Afshar, S., Leili, T., Amini, P., & Dinu, I. (2023). Introducing novel key genes and transcription factors associated with rectal cancer response to chemoradiation through co-expression network analysis. Heliyon, 9(8), Article e18869. https://doi.org/10.1016/j.heliyon.2023.e18869

Preoperative radiochemotherapy is a promising therapeutic method for locally advanced rectal cancer patients. However, the response of colorectal cancer (CRC) patients to preoperative radiotherapy varies widely. In this study, we aimed to identify no... Read More about Introducing novel key genes and transcription factors associated with rectal cancer response to chemoradiation through co-expression network analysis..

Geographically weighted linear combination test for gene-set analysis of a continuous spatial phenotype as applied to intratumor heterogeneity. (2023)
Journal Article
Amini, P., Hajihosseini, M., Pyne, S., & Dinu, I. (2023). Geographically weighted linear combination test for gene-set analysis of a continuous spatial phenotype as applied to intratumor heterogeneity. Frontiers in Cell and Developmental Biology, 11, Article 1065586. https://doi.org/10.3389/fcell.2023.1065586

Background: The impact of gene-sets on a spatial phenotype is not necessarily uniform across different locations of cancer tissue. This study introduces a computational platform, GWLCT, for combining gene set analysis with spatial data modeling to pr... Read More about Geographically weighted linear combination test for gene-set analysis of a continuous spatial phenotype as applied to intratumor heterogeneity..