Outputs (6)

Biocatalysis Using Immobilized Enzymes in Continuous Flow for the Synthesis of Fine Chemicals (2018)
Journal Article
Thompson, M. P., Peñafiel, I., Cosgrove, S. C., & Turner, N. J. (2019). Biocatalysis Using Immobilized Enzymes in Continuous Flow for the Synthesis of Fine Chemicals. Organic Process Research and Development, 23(1), 9-18. https://doi.org/10.1021/acs.oprd.8b00305

Biocatalysis has emerged as one of the most promising technologies to enable green synthesis of important chemicals, due to the ambient conditions generally applied for these reactions. Nonetheless, a general uptake of enzymatic transformations has b... Read More about Biocatalysis Using Immobilized Enzymes in Continuous Flow for the Synthesis of Fine Chemicals.

Continuous Flow for the Photochemical C‐H Amination of Arenes (2018)
Journal Article
Cosgrove, S. C., Douglas, G. E., Raw, S. A., & Marsden, S. P. (2018). Continuous Flow for the Photochemical C‐H Amination of Arenes. ChemPhotoChem, 2(10), 851-854. https://doi.org/10.1002/cptc.201800105

The direct C−H amination of arenes by aminium radicals generated by photolysis of N-chloroamines is demonstrated under continuous flow conditions. The reactions proceed with comparable efficiency to small scale batch processes but are superior to lar... Read More about Continuous Flow for the Photochemical C‐H Amination of Arenes.

Radical-mediated direct C–H amination of arenes with secondary amines (2018)
Journal Article
Cosgrove, S. C., Plane, J. M. C., & Marsden, S. P. (2018). Radical-mediated direct C–H amination of arenes with secondary amines. Chemical Science, 9(32), 6647-6652. https://doi.org/10.1039/c8sc01747f

Aryl dialkyl amines, valuable subunits of a wide range of effect chemicals, are accessed by intramolecular amination of aromatic C–H bonds employing UV photolysis of N-chloroamines. The reactions show good functional group tolerance and allow access... Read More about Radical-mediated direct C–H amination of arenes with secondary amines.

Imine Reductases, Reductive Aminases, and Amine Oxidases for the Synthesis of Chiral Amines: Discovery, Characterization, and Synthetic Applications (2018)
Book Chapter
Cosgrove, S. C., Brzezniak, A., France, S. P., Ramsden, J. I., Mangas-Sanchez, J., Montgomery, S. L., …Turner, N. J. (2018). Imine Reductases, Reductive Aminases, and Amine Oxidases for the Synthesis of Chiral Amines: Discovery, Characterization, and Synthetic Applications. In Enzymes in Synthetic Biology (131-149). Elsevier. https://doi.org/10.1016/bs.mie.2018.04.022

Synthesis of the chiral amine moiety is a key challenge for synthetic organic chemistry due to its prevalence in many biologically active molecules. Imine reductase and amine oxidase enzymes have enabled the biocatalytic synthesis of a host of chiral... Read More about Imine Reductases, Reductive Aminases, and Amine Oxidases for the Synthesis of Chiral Amines: Discovery, Characterization, and Synthetic Applications.

Synergistic Chemo/Biocatalytic Synthesis of Alkaloidal Tetrahydroquinolines (2018)
Journal Article
Cosgrove, S. C., Hussain, S., Turner, N. J., & Marsden, S. P. (2018). Synergistic Chemo/Biocatalytic Synthesis of Alkaloidal Tetrahydroquinolines. ACS catalysis, 8(6), 5570-5573. https://doi.org/10.1021/acscatal.8b01220

The power of complementary chemocatalytic and biocatalytic transformations is demonstrated in the asymmetric synthesis of 2-substituted tetrahydroquinolines. A series of racemic tetrahydroquinolines were synthesized through a convergent one-pot Rh(I)... Read More about Synergistic Chemo/Biocatalytic Synthesis of Alkaloidal Tetrahydroquinolines.

Highly Productive Oxidative Biocatalysis in Continuous Flow by Enhancing the Aqueous Equilibrium Solubility of Oxygen (2018)
Journal Article
Chapman, M. R., Cosgrove, S. C., Turner, N. J., Kapur, N., & Blacker, A. J. (2018). Highly Productive Oxidative Biocatalysis in Continuous Flow by Enhancing the Aqueous Equilibrium Solubility of Oxygen. Angewandte Chemie International Edition, 57(33), 10535-10539. https://doi.org/10.1002/anie.201803675

We report a simple, mild, and synthetically clean approach to accelerate the rate of enzymatic oxidation reactions by a factor of up to 100 when compared to conventional batch gas/liquid systems. Biocatalytic decomposition of H2O2 is used to produce... Read More about Highly Productive Oxidative Biocatalysis in Continuous Flow by Enhancing the Aqueous Equilibrium Solubility of Oxygen.