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Simon Trent's Outputs (13)

Fear conditioning: Insights into learning, memory and extinction and its relevance to clinical disorders (2025)
Journal Article
Trent, S., Abdullah, M. H., Parwana, K., Valdivieso, M. A., Hassan, Z., & Müller, C. P. (2025). Fear conditioning: Insights into learning, memory and extinction and its relevance to clinical disorders. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 138, Article 111310. https://doi.org/10.1016/j.pnpbp.2025.111310

Fear, whether innate or learned, is an essential emotion required for survival. The learning, and subsequent memory, of fearful events enhances our ability to recognise and respond to threats, aiding adaptation to new, ever-changing environments. Con... Read More about Fear conditioning: Insights into learning, memory and extinction and its relevance to clinical disorders.

Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility (2019)
Journal Article
Silva, A. I., Haddon, J. E., Ahmed Syed, Y., Trent, S., Lin, T.-C. E., Patel, Y., Carter, J., Haan, N., Honey, R. C., Humby, T., Assaf, Y., Owen, M. J., Linden, D. E., Hall, J., & Wilkinson, L. S. (2019). Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility. Nature communications, 10, Article 3455. https://doi.org/10.1038/s41467-019-11119-7

The biological basis of the increased risk for psychiatric disorders seen in 15q11.2 copy number deletion is unknown. Previous work has shown disturbances in white matter tracts in human carriers of the deletion. Here, in a novel rat model, we recapi... Read More about Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility.

Cyfip1 Haploinsufficiency Does Not Alter GABAA Receptor d-Subunit Expression and Tonic Inhibition in Dentate Gyrus PV+ Interneurons and Granule Cells (2019)
Journal Article
Trent, S., Hall, J., Connelly, W. M., & Errington, A. C. (2019). Cyfip1 Haploinsufficiency Does Not Alter GABAA Receptor d-Subunit Expression and Tonic Inhibition in Dentate Gyrus PV+ Interneurons and Granule Cells. eNeuro, 6(3), ENEURO.0364 - 18.2019. https://doi.org/10.1523/ENEURO.0364-18.2019

Copy number variation (CNV) at chromosomal region 15q11.2 is linked to increased risk of neurodevelopmental disorders including autism and schizophrenia. A significant gene at this locus is cytoplasmic fragile X mental retardation protein (FMRP) inte... Read More about Cyfip1 Haploinsufficiency Does Not Alter GABAA Receptor d-Subunit Expression and Tonic Inhibition in Dentate Gyrus PV+ Interneurons and Granule Cells.

Regulation and Function of Activity-Dependent Homer in Synaptic Plasticity (2019)
Journal Article
Clifton, N. E., Trent, S., Thomas, K. L., & Hall, J. (2019). Regulation and Function of Activity-Dependent Homer in Synaptic Plasticity. Molecular Neuropsychiatry, 5(3), 147 - 161. https://doi.org/10.1159/000500267

Alterations in synaptic signaling and plasticity occur during the refinement of neural circuits over the course of development and the adult processes of learning and memory. Synaptic plasticity requires the rearrangement of protein complexes in the... Read More about Regulation and Function of Activity-Dependent Homer in Synaptic Plasticity.

Hippocampal Regulation of Postsynaptic Density Homer1 by Associative Learning (2017)
Journal Article
Clifton, N. E., Cameron, D., Trent, S., Sykes, L. H., Thomas, K. L., & Hall, J. (2017). Hippocampal Regulation of Postsynaptic Density Homer1 by Associative Learning. Neural Plasticity, 2014, 1 - 11. https://doi.org/10.1155/2017/5959182

<jats:p>Genes involved in synaptic plasticity, particularly genes encoding postsynaptic density proteins, have been recurrently linked to psychiatric disorders including schizophrenia and autism. Postsynaptic density Homer1 proteins contribute to syn... Read More about Hippocampal Regulation of Postsynaptic Density Homer1 by Associative Learning.

AMPA receptors control fear extinction through an Arc-dependent mechanism (2017)
Journal Article
Trent, S., Barnes, P., Hall, J., & Thomas, K. L. (2017). AMPA receptors control fear extinction through an Arc-dependent mechanism. Learning & Memory, 24(8), 375 - 380. https://doi.org/10.1101/lm.045013.117

Activity-regulated cytoskeleton-associated protein (Arc) supports fear memory through synaptic plasticity events requiring actin cytoskeleton rearrangements. We have previously shown that reducing hippocampal Arc levels through antisense knockdown le... Read More about AMPA receptors control fear extinction through an Arc-dependent mechanism.

Rescue of long-term memory after reconsolidation blockade (2015)
Journal Article
Trent, S., Barnes, P., Hall, J., & Thomas, K. L. (2015). Rescue of long-term memory after reconsolidation blockade. Nature communications, 4, Article 7897. https://doi.org/10.1038/ncomms8897

Memory reconsolidation is considered to be the process whereby stored memories become labile on recall, allowing updating. Blocking the restabilization of a memory during reconsolidation is held to result in a permanent amnesia. The targeted knockdow... Read More about Rescue of long-term memory after reconsolidation blockade.

Altered brain gene expression but not steroid biochemistry in a genetic mouse model of neurodevelopmental disorder (2014)
Journal Article
Trent, S., Fry, J. P., Ojarikre, O. A., & Davies, W. (2014). Altered brain gene expression but not steroid biochemistry in a genetic mouse model of neurodevelopmental disorder. Molecular Autism, 5, Article 21. https://doi.org/10.1186/2040-2392-5-21

Background
The 39,XY*O mouse, which lacks the orthologues of the ADHD and autism candidate genes STS (steroid sulphatase) and ASMT (acetylserotonin O-methyltransferase), exhibits behavioural phenotypes relevant to developmental disorders. The neurob... Read More about Altered brain gene expression but not steroid biochemistry in a genetic mouse model of neurodevelopmental disorder.