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Johannes Reynisson's Outputs (122)

New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors. (2019)
Journal Article
Reynisson, J. (2019). New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors. Molecules, https://doi.org/10.3390/molecules24203711

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a promising therapeutic target in cancer therapy. Combination chemotherapy using Tdp1 inhibitors as a component can potentially improve therapeutic response to many chemotherapeutic regimes. A new set of usni... Read More about New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors..

Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2 (2019)
Journal Article
Reynisson. (2019). Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2. Nature communications, 4639 - ?. https://doi.org/10.1038/s41467-019-12614-7

Isocitrate lyase is important for lipid utilisation by Mycobacterium tuberculosis but its ICL2 isoform is poorly understood. Here we report that binding of the lipid metabolites acetyl-CoA or propionyl-CoA to ICL2 induces a striking structural rearra... Read More about Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2.

The Development of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors. Combination of Monoterpene and Adamantine Moieties via Amide or Thioamide Bridges (2019)
Journal Article
Reynisson. (2019). The Development of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors. Combination of Monoterpene and Adamantine Moieties via Amide or Thioamide Bridges. Applied Sciences, 2767 -2767. https://doi.org/10.3390/app9132767

Eleven amide and thioamide derivatives with monoterpene and adamantine substituents were synthesised. They were tested for their activity against the tyrosyl-DNA phosphodiesterase 1 DNA (Tdp1) repair enzyme with the most potent compound 47a, having a... Read More about The Development of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors. Combination of Monoterpene and Adamantine Moieties via Amide or Thioamide Bridges.

Antifungal screening and in silico mechanistic studies of an in-house azole library (2019)
Journal Article
Reynisson. (2019). Antifungal screening and in silico mechanistic studies of an in-house azole library. Chemical Biology & Drug Design, https://doi.org/10.1111/cbdd.13587

Systemic Candida infections pose a serious public health problem with high morbidity and mortality. C. albicans is the major pathogen identified in candidiasis, however non-albicans Candida spp. with antifungal resistance are now more prevalent. Azol... Read More about Antifungal screening and in silico mechanistic studies of an in-house azole library.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-5 (2019)
Journal Article
Reynisson. (2019). Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-5. Molecules, https://doi.org/10.3390/molecules24132415

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes is a series of Editorials which is published on a biannual basis by the Editorial Board of the Medicinal Chemistry section of the journal Molecules. In these Edito... Read More about Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-5.

Novel Inhibitors of DNA Repair Enzyme TDP1 Combining Monoterpenoid and Adamantane Fragments (2019)
Journal Article
Mozhaitsev, E. S., Zakharenko, A. L., Suslov, E. V., Korchagina, D. V., Zakharova, O. D., Vasil'eva, I. A., Chepanova, A. A., Black, E., Patel, J., Chand, R., Reynisson, J., Leung, I. K., Volcho, K. P., Salakhutdinov, N. F., & Lavrik, O. I. (2019). Novel Inhibitors of DNA Repair Enzyme TDP1 Combining Monoterpenoid and Adamantane Fragments. Anti-Cancer Agents in Medicinal Chemistry, 19(4), 463-472. https://doi.org/10.2174/1871520619666181207094243

Design, Synthesis, Antibacterial Potential, and Structural Characterization of N-Acylated Derivatives of the Human Autophagy 16 Polypeptide (2019)
Journal Article
Varnava, K. G., Mohid, S. A., Calligari, P., Stella, L., Reynison, J., Bhunia, A., & Sarojini, V. (2019). Design, Synthesis, Antibacterial Potential, and Structural Characterization of N-Acylated Derivatives of the Human Autophagy 16 Polypeptide. Bioconjugate Chemistry, 30(7), 1998-2010. https://doi.org/10.1021/acs.bioconjchem.9b00290

The Development of Tyrosyl-DNA Phosphodyesterase 1 (TDP1) Inhibitors Based on the Amines Combining Aromatic/Heteroaromatic and Monoterpenoid Moieties (2019)
Journal Article
Mozhaitsev, E., Suslov, E., Demidova, Y., Korchagina, D., Volcho, K., Zakharenko, A., Vasil'eva, I., Kupryushkin, M., Chepanova, A., Ayine-Tora, D. M., Reynisson, J., Salakhutdinov, N., & Lavrik, O. (2019). The Development of Tyrosyl-DNA Phosphodyesterase 1 (TDP1) Inhibitors Based on the Amines Combining Aromatic/Heteroaromatic and Monoterpenoid Moieties. Letters in Drug Design and Discovery, 16(5), 597-605. https://doi.org/10.2174/1570180816666181220121042

Novel tyrosyl-DNA phosphodiesterase 1 inhibitors enhance the therapeutic impact of topoteсan on in vivo tumor models (2019)
Journal Article
Zakharenko, A., Luzina, O., Sokolov, D., Kaledin, V., Nikolin, V., Popova, N., Patel, J., Zakharova, O., Chepanova, A., Zafar, A., Reynisson, J., Leung, E., Leung, I., Volcho, K., Salakhutdinov, N., & Lavrik, O. (2019). Novel tyrosyl-DNA phosphodiesterase 1 inhibitors enhance the therapeutic impact of topoteсan on in vivo tumor models. European Journal of Medicinal Chemistry, 161, 581-593. https://doi.org/10.1016/j.ejmech.2018.10.055

Structural Modifications of the Antiinflammatory Oxicam Scaffold and Preparation of Anticancer Organometallic Compounds (2019)
Journal Article
Ashraf, A., Aman, F., Movassaghi, S., Zafar, A., Kubanik, M., Siddiqui, W. A., Reynisson, J., Söhnel, T., Jamieson, S. M. F., Hanif, M., & Hartinger, C. G. (2019). Structural Modifications of the Antiinflammatory Oxicam Scaffold and Preparation of Anticancer Organometallic Compounds. Organometallics, 38(2), 361-374. https://doi.org/10.1021/acs.organomet.8b00751

New Water-Soluble Copper(II) Complexes with Morpholine-Thiosemicarbazone Hybrids: Insights into the Anticancer and Antibacterial Mode of Action. (2018)
Journal Article
Reynisson. (2018). New Water-Soluble Copper(II) Complexes with Morpholine-Thiosemicarbazone Hybrids: Insights into the Anticancer and Antibacterial Mode of Action. Journal of Medicinal Chemistry, https://doi.org/10.1021/acs.jmedchem.8b01031

Six morpholine-(iso)thiosemicarbazone hybrids HL1-HL6 and their Cu(II) complexes with good-to-moderate solubility and stability in water were synthesized and characterized. Cu(II) complexes [Cu(L1-6)Cl] (1-6) formed weak dimeric associates in the sol... Read More about New Water-Soluble Copper(II) Complexes with Morpholine-Thiosemicarbazone Hybrids: Insights into the Anticancer and Antibacterial Mode of Action..

From Catalysis to Cancer: Toward Structure–Activity Relationships for Benzimidazol-2-ylidene-Derived N-Heterocyclic-Carbene Complexes as Anticancer Agents (2018)
Journal Article
Lam, N. Y. S., Truong, D., Burmeister, H., Babak, M. V., Holtkamp, H. U., Movassaghi, S., Ayine-Tora, D. M., Zafar, A., Kubanik, M., Oehninger, L., Söhnel, T., Reynisson, J., Jamieson, S. M. F., Gaiddon, C., Ott, I., & Hartinger, C. G. (2018). From Catalysis to Cancer: Toward Structure–Activity Relationships for Benzimidazol-2-ylidene-Derived N-Heterocyclic-Carbene Complexes as Anticancer Agents. Inorganic Chemistry, 57(22), 14427-14434. https://doi.org/10.1021/acs.inorgchem.8b02634

A Novel Class of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Contains the Octahydro-2H-chromen-4-ol Scaffold. (2018)
Journal Article
Li-Zhulanov, N. S., Zakharenko, A. L., Chepanova, A. A., Patel, J., Zafar, A., Volcho, K. P., Salakhutdinov, N. F., Reynisson, J., Leung, I. K., & Lavrik, O. I. (2018). A Novel Class of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Contains the Octahydro-2H-chromen-4-ol Scaffold. Molecules, 23(10), Article 2468. https://doi.org/10.3390/molecules23102468

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a DNA repair enzyme that mends topoisomerase 1-mediated DNA damage. Tdp1 is a current inhibition target for the development of improved anticancer treatments, as its inhibition may enhance the therapeutic eff... Read More about A Novel Class of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Contains the Octahydro-2H-chromen-4-ol Scaffold..

Synthesis and evaluation of aryliden- and hetarylidenfuranone derivatives of usnic acid as highly potent Tdp1 inhibitors (2018)
Journal Article
Zakharova, O., Luzina, O., Zakharenko, A., Sokolov, D., Filimonov, A., Dyrkheeva, N., Chepanova, A., Ilina, E., Ilyina, A., Klabenkova, K., Chelobanov, B., Stetsenko, D., Zafar, A., Eurtivong, C., Reynisson, J., Volcho, K., Salakhutdinov, N., & Lavrik, O. (2018). Synthesis and evaluation of aryliden- and hetarylidenfuranone derivatives of usnic acid as highly potent Tdp1 inhibitors. Bioorganic and Medicinal Chemistry, 26(15), 4470-4480. https://doi.org/10.1016/j.bmc.2018.07.039

Organoruthenium and Organoosmium Complexes of 2-Pyridinecarbothioamides Functionalized with a Sulfonamide Motif: Synthesis, Cytotoxicity and Biomolecule Interactions (2018)
Journal Article
Arshad, J., Hanif, M., Zafar, A., Movassaghi, S., Tong, K. K. H., Reynisson, J., Kubanik, M., Waseem, A., Söhnel, T., Jamieson, S. M. F., & Hartinger, C. G. (2018). Organoruthenium and Organoosmium Complexes of 2-Pyridinecarbothioamides Functionalized with a Sulfonamide Motif: Synthesis, Cytotoxicity and Biomolecule Interactions. ChemPlusChem, 83(7), 612-619. https://doi.org/10.1002/cplu.201800194

Synthesis, antibacterial, and antibiofilm potential of human autophagy 16 polypeptide and analogues (2018)
Journal Article
Reynisson. (2018). Synthesis, antibacterial, and antibiofilm potential of human autophagy 16 polypeptide and analogues. Peptide Science, e24076. https://doi.org/10.1002/pep2.24076

This work demonstrates that the human autophagy 16 polypeptide (Atg16) has antibacterial and antibiofilm potential, perturbs both Gram positive and negative bacterial membranes and subsequently also produces ROS in compromised bacteria. Engineered At... Read More about Synthesis, antibacterial, and antibiofilm potential of human autophagy 16 polypeptide and analogues.