Are the metal identity and stoichiometry of metal complexes important for colchicine site binding and inhibition of tubulin polymerization? †
(2024)
Journal Article
Synthesis, antibacterial, and antibiofilm potential of human autophagy 16 polypeptide and analogues
Abstract
This work demonstrates that the human autophagy 16 polypeptide (Atg16) has antibacterial and antibiofilm potential, perturbs both Gram positive and negative bacterial membranes and subsequently also produces ROS in compromised bacteria. Engineered Atg 16 analogues containing 1- and 2-naphthyl alanines showed significant enhancement of antibacterial activity and eradicated biofilms while also possessing negligible hemolysis of mouse erythrocytes. This new family of antibacterial peptides are promising candidates in the fight against bacterial biofilms, responsible for several thousand deaths annually which are predicted to rise into the millions.
Citation
Reynisson. (2018). Synthesis, antibacterial, and antibiofilm potential of human autophagy 16 polypeptide and analogues. Peptide Science, e24076. https://doi.org/10.1002/pep2.24076
Acceptance Date | Apr 3, 2018 |
---|---|
Publication Date | May 14, 2018 |
Journal | Peptide Science |
Print ISSN | 2475-8817 |
Publisher | Wiley |
Pages | e24076 |
DOI | https://doi.org/10.1002/pep2.24076 |
Keywords | antimicrobial peptide, biofilm, membrane lysis, scanning electron microscopy, transmission electron microscopy |
Publisher URL | https://onlinelibrary.wiley.com/doi/full/10.1002/pep2.24076 |
You might also like
Accessing active fragments for drug discovery utilising nitroreductase biocatalysis.
(2024)
Journal Article
Downloadable Citations
About Keele Repository
Administrator e-mail: research.openaccess@keele.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search