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Addressing the Global Burden of Cardiovascular Disease in Women JACC State-of-the-Art Review (2024)
Journal Article
Vervoort, D., Wang, R., Li, G., Filbey, L., Maduka, O., Brewer, L. C., …Van Spall, H. G. (2024). Addressing the Global Burden of Cardiovascular Disease in Women JACC State-of-the-Art Review. Journal of the American College of Cardiology, 83(25), 2690-2707. https://doi.org/10.1016/j.jacc.2024.04.028

Cardiovascular diseases (CVDs) are responsible for approximately 35% of all deaths in women. In 2019, the global age-standardized CVD prevalence and mortality of women were 6,403 per 100,000 and 204 per 100,000, respectively. Althou... Read More about Addressing the Global Burden of Cardiovascular Disease in Women JACC State-of-the-Art Review.

Sex disparities in the use and outcomes of septal reduction therapies for obstructive hypertrophic cardiomyopathy (2024)
Journal Article
Diaz-Arocutipa, C., Moreno, G., Giráldez, M., Hernandez, A. V., Mamas, M. A., & Vicent, L. (2024). Sex disparities in the use and outcomes of septal reduction therapies for obstructive hypertrophic cardiomyopathy. CJC Open, https://doi.org/10.1016/j.cjco.2024.05.013

Background There is limited data examining potential sex-based disparities in the utilization and complications of septal reduction therapy (SRT) in patients with obstructive hypertrophic cardiomyopathy (HCM). Our aim was t... Read More about Sex disparities in the use and outcomes of septal reduction therapies for obstructive hypertrophic cardiomyopathy.

The prognostic value of metabolic dysfunction-associated steatotic liver disease in acute myocardial infarction: A propensity score-matched analysis. (2024)
Journal Article
Kong, G., Cao, G., Koh, J., Chan, S. P., Zhang, A., Wong, E., …Loh, P. (in press). The prognostic value of metabolic dysfunction-associated steatotic liver disease in acute myocardial infarction: A propensity score-matched analysis. Diabetes, Obesity and Metabolism, https://doi.org/10.1111/dom.15660

Patients with metabolic dysfunction-associated steatotic liver disease (MASLD) are at increased risk of incident cardiovascular disease. However, the clinical characteristics and prognostic importance of MASLD in patients presenting with acute myocar... Read More about The prognostic value of metabolic dysfunction-associated steatotic liver disease in acute myocardial infarction: A propensity score-matched analysis..

Sex differences in transcatheter aortic valve replacement outcomes among patients with bicuspid aortic stenosis. (2024)
Journal Article
Rivera, F. B., Cha, S. W., Redula, S. C., Liston, M. B. O., Ong, E. P., Bantayan, N. R. B., …Mamas, M. A. (2024). Sex differences in transcatheter aortic valve replacement outcomes among patients with bicuspid aortic stenosis. Heart and Lung, 67, 144-151. https://doi.org/10.1016/j.hrtlng.2024.05.003

Despite comprising almost half of all patients undergoing valvular repair, data on transcatheter aortic valve replacement (TAVR) in patients with bicuspid aortic stenosis (BAS) are limited. We aimed to evaluate whether there are any sex differences i... Read More about Sex differences in transcatheter aortic valve replacement outcomes among patients with bicuspid aortic stenosis..

Serum Albumin and Post-Stroke Outcomes: Analysis of UK Regional Registry Data, Systematic Review, and Meta-Analysis (2024)
Journal Article
Thuemmler, R. J., Pana, T. A., Carter, B., Mahmood, R., Bettencourt-Silva, J. H., Metcalf, A. K., …Myint, P. K. (in press). Serum Albumin and Post-Stroke Outcomes: Analysis of UK Regional Registry Data, Systematic Review, and Meta-Analysis. Nutrients, 16(10), Article 1486. https://doi.org/10.3390/nu16101486

Hypoalbuminemia associates with poor acute ischemic stroke (AIS) outcomes. We hypothesised a non-linear relationship and aimed to systematically assess this association using prospective stroke data from the Norfolk and Norwich Stroke and TIA Registe... Read More about Serum Albumin and Post-Stroke Outcomes: Analysis of UK Regional Registry Data, Systematic Review, and Meta-Analysis.

Calibration plots for multistate risk predictions models (2024)
Journal Article
Pate, A., Sperrin, M., Riley, R. D., Peek, N., Van Staa, T., Sergeant, J. C., …Martin, G. P. (in press). Calibration plots for multistate risk predictions models. Statistics in Medicine, https://doi.org/10.1002/sim.10094

Introduction There is currently no guidance on how to assess the calibration of multistate models used for risk prediction. We introduce several techniques that can be used to produce calibration plots for the transition probabilities of a multistat... Read More about Calibration plots for multistate risk predictions models.

Rural-Urban Stroke Mortality Gaps in the United States. (2024)
Journal Article
Chang, D., Ibrahim, R., Pham, H. N., Sainbayar, E., Shahid, M., Makkieh, M., …Lee, K. (in press). Rural-Urban Stroke Mortality Gaps in the United States. Journal of Stroke and Cerebrovascular Diseases, Article 107762. https://doi.org/10.1016/j.jstrokecerebrovasdis.2024.107762

Disparities in stroke outcomes, influenced by the use of systemic thrombolysis, endovascular therapies, and rehabilitation services, have been identified. Our study assesses these disparities in mortality after stroke between rural and urban areas ac... Read More about Rural-Urban Stroke Mortality Gaps in the United States..

Impact of Society Guidelines on Trends in Use of Newer P2Y (2024)
Journal Article
Mohamed, M. O., Kontopantelis, E., Alasnag, M., Abid, L., Banerjee, A., Sharp, A. S. P., …Mamas, M. A. (2024). Impact of Society Guidelines on Trends in Use of Newer P2Y. Journal of the American Heart Association, 13(9), Article e034414. https://doi.org/10.1161/JAHA.124.034414

Over the past decade, major society guidelines have recommended the use of newer P2Y inhibitors over clopidogrel for those undergoing percutaneous coronary intervention for acute coronary syndrome. It is unclear what impact these recommendations had... Read More about Impact of Society Guidelines on Trends in Use of Newer P2Y.

E-40 | Transcatheter Aortic Valve Replacement versus Surgical Aortic Valve Replacement in Patients with Bicuspid Aortic Stenosis: A Propensity Score Matching Analysis (2024)
Presentation / Conference
Rivera, F. B., Cha, S. W., Shiza, S., Redula, S., Liston, M., Carado, G., …Mamas, M. A. (2024, May). E-40 | Transcatheter Aortic Valve Replacement versus Surgical Aortic Valve Replacement in Patients with Bicuspid Aortic Stenosis: A Propensity Score Matching Analysis. Poster presented at Society for Cardiovascular Angiography & Interventions 47th Annual Scientific Sessions, Long Beach, California

Clinical Significance of Coronary Arterial Dominance: A Review of the Literature. (2024)
Journal Article
Wu, B., Kheiwa, A., Swamy, P., Mamas, M. A., Tedford, R. J., Alasnag, M., …Abramov, D. (in press). Clinical Significance of Coronary Arterial Dominance: A Review of the Literature. Journal of the American Heart Association, 13(9), Article e032851. https://doi.org/10.1161/JAHA.123.032851

Coronary dominance describes the anatomic variation of coronary arterial supply, notably as it relates to perfusion of the inferior cardiac territories. Differences in the development and outcome in select disease states between coronary dominance pa... Read More about Clinical Significance of Coronary Arterial Dominance: A Review of the Literature..

Intravascular Imaging-Guided Versus Coronary Angiography-Guided Complex PCI: A Meta-analysis of Randomized Controlled Trials. (2024)
Journal Article
Hamed, M., Mohamed, S., Mahmoud, M., Kahan, J., Mohsen, A., Rahman, F., …Elbadawi, A. (in press). Intravascular Imaging-Guided Versus Coronary Angiography-Guided Complex PCI: A Meta-analysis of Randomized Controlled Trials. Cardiology and Therapy, 13(2), 379-399. https://doi.org/10.1007/s40119-024-00364-7

Trials evaluating the role of intravascular imaging in percutaneous coronary intervention (PCI) for complex coronary artery disease have yielded mixed results. This study aimed to compare the outcomes of intravascular imaging specifically intravascul... Read More about Intravascular Imaging-Guided Versus Coronary Angiography-Guided Complex PCI: A Meta-analysis of Randomized Controlled Trials..

Influence of Social Vulnerability Index on Medicare Beneficiaries’ Expenditures upon Discharge (2024)
Journal Article
Ibrahim, R., Lin, L., Sainbayar, E., Pham, H. N., Shahid, M., Le Cam, E., …Mamas, M. A. (in press). Influence of Social Vulnerability Index on Medicare Beneficiaries’ Expenditures upon Discharge. Journal of Investigative Medicine, https://doi.org/10.1177/10815589241247791

Medicare beneficiaries’ healthcare spending varies across geographical regions, influenced by availability of medical resources and institutional efficiency. We aimed to evaluate whether social vulnerability influences healthcare costs among Medicare... Read More about Influence of Social Vulnerability Index on Medicare Beneficiaries’ Expenditures upon Discharge.

Socioeconomic and ethnic disparities in the process of care and outcomes among cancer patients with acute coronary syndrome (2024)
Journal Article
Mohamed, M., Ghosh, A. K., Banerjee, A., & Mamas, M. (in press). Socioeconomic and ethnic disparities in the process of care and outcomes among cancer patients with acute coronary syndrome. Canadian Journal of Cardiology, https://doi.org/10.1016/j.cjca.2024.03.012

Cancer and acute coronary syndrome (ACS) are the leading causes of morbidity and mortality globally, with many shared risk factors between both conditions. There are several challenges to the management of patients with cancer prese... Read More about Socioeconomic and ethnic disparities in the process of care and outcomes among cancer patients with acute coronary syndrome.

The Evolving Field of Acute Coronary Syndrome Management: A Critical Appraisal of the 2023 European Society of Cardiology Guidelines for the Management of Acute Coronary Syndrome (2024)
Journal Article
Licordari, R., Costa, F., Garcia-Ruiz, V., Mamas, M. A., Marquis-Gravel, G., de la Torre Hernandez, J. M., …Micari, A. (in press). The Evolving Field of Acute Coronary Syndrome Management: A Critical Appraisal of the 2023 European Society of Cardiology Guidelines for the Management of Acute Coronary Syndrome. Journal of Clinical Medicine, 13(7), Article 1885. https://doi.org/10.3390/jcm13071885

Acute coronary syndromes (ACS), encompassing conditions like ST-elevation myocardial infarction (STEMI) and non-ST-elevation acute coronary syndromes (NSTE-ACS), represent a significant challenge in cardiovascular care due to their complex pathophysi... Read More about The Evolving Field of Acute Coronary Syndrome Management: A Critical Appraisal of the 2023 European Society of Cardiology Guidelines for the Management of Acute Coronary Syndrome.

Association of myocardial injury with adverse long-term survival among cancer patients. (2024)
Journal Article
Bashar, H., Kobo, O., Curzen, N., & Mamas, M. A. (in press). Association of myocardial injury with adverse long-term survival among cancer patients. European Journal of Preventive Cardiology, Article zwae116. https://doi.org/10.1093/eurjpc/zwae116

Over time, cardiovascular disease (CVD) deaths increasingly exceed those from malignancy among cancer survivors. However, the association of myocardial injury with long-term survival (beyond three years) in cancer patients has not been previously des... Read More about Association of myocardial injury with adverse long-term survival among cancer patients..

Pregnancy-Associated Cancer: A Systematic Review and Meta-Analysis (2024)
Journal Article
Walters, B., Midwinter, I., A. Chew-Graham, C., P. Jordan, K., Sharma, G., C. Chappell, L., …Wu, P. (2024). Pregnancy-Associated Cancer: A Systematic Review and Meta-Analysis. Mayo Clinic Proceedings, 8(2), 188-199. https://doi.org/10.1016/j.mayocpiqo.2024.02.002

This study aimed to systematically evaluate and quantify the risk of adverse maternal and neonatal outcomes in patients with pregnancy-associated cancer (PAC). This study was conducted from February 13, 2021, through July 24, 2023.... Read More about Pregnancy-Associated Cancer: A Systematic Review and Meta-Analysis.

Has the first year of the COVID pandemic impacted the trends in obesity-related CVD mortality between 1999 and 2019 in the United States? (2024)
Journal Article
Qamar, A., Abramov, D., Bang, V., Chew, N. W., Kobo, O., & Mamas, M. A. (2024). Has the first year of the COVID pandemic impacted the trends in obesity-related CVD mortality between 1999 and 2019 in the United States?. International Journal of Cardiology Cardiovascular Risk and Prevention, 21, 1-5. https://doi.org/10.1016/j.ijcrp.2024.200248

Background During the covid-19 pandemic there was a marked rise in the number of cardiovascular deaths. Obesity is a well-known modifiable risk factor for cardiovascular disease and has been identified as a factor... Read More about Has the first year of the COVID pandemic impacted the trends in obesity-related CVD mortality between 1999 and 2019 in the United States?.

Sex differences in trends and in-hospital outcomes of acute myocardial infarction in patients with familial hypercholesterolemia: insights from a large national database. (2024)
Journal Article
Rivera, F. B., Cha, S. W., Liston, M. B., Redula, S., Bantayan, N. R. B., Shah, N., …Mamas, M. A. (in press). Sex differences in trends and in-hospital outcomes of acute myocardial infarction in patients with familial hypercholesterolemia: insights from a large national database. Expert Review of Cardiovascular Therapy, 1-8. https://doi.org/10.1080/14779072.2024.2329720

Sex differences in clinical outcomes following acute myocardial infarction (AMI) are well known. However, data on sex differences among patients with familial hypercholesterolemia (FH) are limited. We aimed to explore sex differences in outcomes of A... Read More about Sex differences in trends and in-hospital outcomes of acute myocardial infarction in patients with familial hypercholesterolemia: insights from a large national database..

Systematic Review of the Association of the Hospital Frailty Risk Score with Mortality in Patients with Cerebrovascular and Cardiovascular Disease. (2024)
Journal Article
Sokhal, B. S., Menon, S. P. K., Willes, C., Corp, N., Matetić, A., Mallen, C., & Mamas, M. (in press). Systematic Review of the Association of the Hospital Frailty Risk Score with Mortality in Patients with Cerebrovascular and Cardiovascular Disease. Current Cardiology Reviews, 20(3), Article e290224227533. https://doi.org/10.2174/011573403X276647240217112151

There is limited systematic data on the association between the Hospital Frailty Risk Score (HFRS) and characteristics and mortality in patients with cerebrovascular and cardiovascular disease (CVD). This systematic review aimed to summarise the use... Read More about Systematic Review of the Association of the Hospital Frailty Risk Score with Mortality in Patients with Cerebrovascular and Cardiovascular Disease..

Efficacy and safety of tirzepatide, GLP-1 receptor agonists, and other weight loss drugs in overweight and obesity: a network meta-analysis. (2024)
Journal Article
Pan, X., Tan, B., Chin, Y. H., Lee, E. C. Z., Kong, G., Chong, B., …Chan, M. Y. (in press). Efficacy and safety of tirzepatide, GLP-1 receptor agonists, and other weight loss drugs in overweight and obesity: a network meta-analysis. Obesity, 32(5), 840-856. https://doi.org/10.1002/oby.24002

This network meta-analysis evaluates the efficacy and safety of tirzepatide compared to glucagon-like peptide-1 receptor agonists (GLP-1 RA) and other weight loss drugs in the treatment of overweight and obesity. MEDLINE, Embase, and Cochrane CENTRAL... Read More about Efficacy and safety of tirzepatide, GLP-1 receptor agonists, and other weight loss drugs in overweight and obesity: a network meta-analysis..

Impact of the number of modifiable risk factors on clinical outcomes after percutaneous coronary intervention: An analysis from the e-Ultimaster registry. (2024)
Journal Article
Kobo, O., Levi, Y., Abu-Fanne, R., Von Birgelen, C., Guédès, A., Aminian, A., …Roguin, A. (in press). Impact of the number of modifiable risk factors on clinical outcomes after percutaneous coronary intervention: An analysis from the e-Ultimaster registry. IJC Heart & Vasculature, 51, Article 101370. https://doi.org/10.1016/j.ijcha.2024.101370

A substantial proportion of the patients undergoing percutaneous coronary intervention (PCI) have none of the of standard modifiable cardiovascular risk factors (SMuRFs): hypertension, diabetes, hypercholesterolaemia and smoking. The aim of this anal... Read More about Impact of the number of modifiable risk factors on clinical outcomes after percutaneous coronary intervention: An analysis from the e-Ultimaster registry..

Transcatheter Aortic Valve Implantation Wait-Time Management: Derivation and Validation of the Canadian TAVI Triage Tool (CAN3T). (2024)
Journal Article
Miranda, R. N., Qiu, F., Manoragavan, R., Austin, P. C., Naimark, D. M. J., Fremes, S. E., …Wijeysundera, H. C. (2024). Transcatheter Aortic Valve Implantation Wait-Time Management: Derivation and Validation of the Canadian TAVI Triage Tool (CAN3T). Journal of the American Heart Association, 13(5), e033768. https://doi.org/10.1161/JAHA.123.033768

Transcatheter aortic valve implantation (TAVI) has seen indication expansion and thus exponential growth in demand over the past decade. In many jurisdictions, the growing demand has outpaced capacity, increasing wait times and preprocedural adverse... Read More about Transcatheter Aortic Valve Implantation Wait-Time Management: Derivation and Validation of the Canadian TAVI Triage Tool (CAN3T)..

Association of Cardiovascular Health Metrics and Mortality Among Individuals With and Without Cancer. (2024)
Journal Article
Abramov, D., Kobo, O., & Mamas, M. A. (2024). Association of Cardiovascular Health Metrics and Mortality Among Individuals With and Without Cancer. Journal of the American Heart Association, 13(5), Article e032683. https://doi.org/10.1161/JAHA.123.032683

Although metrics of cardiovascular health have been associated with improved mortality, whether the association remains among individuals with a history of cancer has not been well characterized. The National Health and Nutrition Examination Survey d... Read More about Association of Cardiovascular Health Metrics and Mortality Among Individuals With and Without Cancer..

Cardiovascular Risk Profile Among Reproductive-Aged Women in the U.S.: The Behavioral Risk Factor Surveillance System, 2015–2020 (2024)
Journal Article
Boakye, E., Oyeka, C. P., Kwapong, Y. A., Metlock, F. E., Khan, S. S., Mamas, M. A., …Sharma, G. (2024). Cardiovascular Risk Profile Among Reproductive-Aged Women in the U.S.: The Behavioral Risk Factor Surveillance System, 2015–2020. AJPM Focus, 3(4), Article 100210. https://doi.org/10.1016/j.focus.2024.100210

Introduction Suboptimal cardiovascular health is associated with adverse pregnancy outcomes and long-term cardiovascular risk. The authors examined trends in cardiovascular risk factors and correlates of suboptima... Read More about Cardiovascular Risk Profile Among Reproductive-Aged Women in the U.S.: The Behavioral Risk Factor Surveillance System, 2015–2020.

A comparison of endothelial cell growth on commercial coronary stents with and without laser surface texturing. (2024)
Journal Article
Mirhosseini, N., Li, L., Liu, Z., Mamas, M., Fraser, D., & Wang, T. (2024). A comparison of endothelial cell growth on commercial coronary stents with and without laser surface texturing. Heliyon, 10(5), Article e26425. https://doi.org/10.1016/j.heliyon.2024.e26425

Complete endothelialisation of coronary stents is an important determinant of future thrombotic complications following coronary stenting. Stent surface texture is an important factor that influences endothelial cell growth. With the emergence of sec... Read More about A comparison of endothelial cell growth on commercial coronary stents with and without laser surface texturing..

Cardiovascular Disease and the Mediterranean Diet: Insights into Sex-Specific Responses (2024)
Journal Article
Pant, A., Chew, D. P., Mamas, M. A., & Zaman, S. (in press). Cardiovascular Disease and the Mediterranean Diet: Insights into Sex-Specific Responses. Nutrients, 16(4), Article 570. https://doi.org/10.3390/nu16040570

Cardiovascular disease (CVD) is a leading cause of mortality and disease burden in women globally. A healthy diet is important for the prevention of CVD. Research has consistently favoured the Mediterranean diet as a cardio-protective diet. Several s... Read More about Cardiovascular Disease and the Mediterranean Diet: Insights into Sex-Specific Responses.

The quality of care and long-term mortality of out of hospital cardiac arrest survivors after acute myocardial infarction: a nationwide cohort study. (2024)
Journal Article
Weight, N., Moledina, S., Hennessy, T., Jia, H., Banach, M., Rashid, M., …Mamas, M. A. (in press). The quality of care and long-term mortality of out of hospital cardiac arrest survivors after acute myocardial infarction: a nationwide cohort study. European Heart Journal - Quality of Care and Clinical Outcomes, Article qcae015. https://doi.org/10.1093/ehjqcco/qcae015

The long-terms outcomes of out of hospital cardiac arrest (OHCA) survivors are not well known. Using the Myocardial Ischaemia National Audit Project (MINAP) registry, linked to Office for National Statistics (ONS) mortality data, we analysed 661 326... Read More about The quality of care and long-term mortality of out of hospital cardiac arrest survivors after acute myocardial infarction: a nationwide cohort study..

Chronic total occlusion in non-ST elevation myocardial infarction - A multi-centre observational study. (2024)
Journal Article
Sharma, V., Choudhury, A., Basavarajaiah, S., Rashid, M., Yuan, M., Jefferey, D., …Mamas, M. A. (in press). Chronic total occlusion in non-ST elevation myocardial infarction - A multi-centre observational study. Cardiovascular Revascularization Medicine, S1553-8389(24)00049-6. https://doi.org/10.1016/j.carrev.2024.02.008

To evaluate the characteristics and outcomes of patients with a chronic total occlusion (CTO) in a Non-ST Elevation Myocardial Infarction (NSTEMI) cohort. There is limited data on the clinical characteristics, revascularisation strategies and outcome... Read More about Chronic total occlusion in non-ST elevation myocardial infarction - A multi-centre observational study..

Recommended and observed statin use among US adults with and without cancer. (2024)
Journal Article
Kobo, O., Michos, E. D., Roguin, A., Bagur, R., Gulati, M., & Mamas, M. A. (in press). Recommended and observed statin use among US adults with and without cancer. European Journal of Preventive Cardiology, Article zwae057. https://doi.org/10.1093/eurjpc/zwae057

Patients with cancer are at increased cardiovascular risk. We aimed to compare the recommended and observed statin use among individuals with and without cancer. Using three 2-year cycles from the National Health and Nutrition Examination Survey [NHA... Read More about Recommended and observed statin use among US adults with and without cancer..

Sex-based analysis of NSTEMI processes of care and outcomes by hospital: a nationwide cohort study (2024)
Journal Article
Weight, N., Moledina, S., Kontopantelis, E., Van Spall, H., Dafaalla, M., Chieffo, A., …Mamas, M. A. (in press). Sex-based analysis of NSTEMI processes of care and outcomes by hospital: a nationwide cohort study. European Heart Journal - Quality of Care and Clinical Outcomes, Article qcae011. https://doi.org/10.1093/ehjqcco/qcae011

Background Contemporary studies demonstrate that non-ST-segment elevation myocardial infarction (NSTEMI) processes of care vary according to sex. Little is known regarding variation in practice between geographical areas and centres. Methods We... Read More about Sex-based analysis of NSTEMI processes of care and outcomes by hospital: a nationwide cohort study.

The clinical characteristics, managements, and outcomes of acute myocardial infarction in osteoarthritis patients; a cross-sectional analysis of 6.5 million patients. (2024)
Journal Article
Parmar, S. S., Mohamed, M. O., Mamas, M. A., & Wilkie, R. (in press). The clinical characteristics, managements, and outcomes of acute myocardial infarction in osteoarthritis patients; a cross-sectional analysis of 6.5 million patients. Expert Review of Cardiovascular Therapy, 22(1-3), 1-9. https://doi.org/10.1080/14779072.2024.2311696

The prevalence of osteoarthritis (OA) and cardiovascular disease are increasing and both conditions share similar risk factors. We investigated the association between OA and receipt of invasive managements and clinical outcomes in patients with acut... Read More about The clinical characteristics, managements, and outcomes of acute myocardial infarction in osteoarthritis patients; a cross-sectional analysis of 6.5 million patients..

European Society of Cardiology Quality indicators for the care and outcomes of adults undergoing transcatheter aortic valve implantation (2024)
Journal Article
Ali, N., Aktaa, S., Younsi, T., Beska, B., Batra, G., Blackman, D. J., …Gale, C. P. (in press). European Society of Cardiology Quality indicators for the care and outcomes of adults undergoing transcatheter aortic valve implantation. European Heart Journal - Quality of Care and Clinical Outcomes, Article qcae006. https://doi.org/10.1093/ehjqcco/qcae006

Aims To develop a suite of quality indicators (QIs) for the evaluation of the care and outcomes for adults undergoing transcatheter aortic valve implantation (TAVI). Methods and results We followed the European Society of Cardiology (ESC) method... Read More about European Society of Cardiology Quality indicators for the care and outcomes of adults undergoing transcatheter aortic valve implantation.

The invasive investigation of INOCA in the coronary catheterization lab (2024)
Journal Article
Burgess, S. N., & Mamas, M. A. (2024). The invasive investigation of INOCA in the coronary catheterization lab. American Heart Journal Plus: Cardiology Research and Practice, 38, Article 100365. https://doi.org/10.1016/j.ahjo.2024.100365

Over half of all patients with angina have no angiographically demonstratable obstructive coronary disease, with a significant proportion of these patients having undiagnosed microvascular dysfunction and/or vasospastic angina. In chronic coronary sy... Read More about The invasive investigation of INOCA in the coronary catheterization lab.

Complex High-risk Percutaneous Coronary Intervention Types, Trends, and Outcomes in Non-surgical Centres (2024)
Journal Article
Shamkhani, W., Rashid, M., Moledina, S., Ludman, P., Curzen, N., Wijeysundera, H. C., …Mamas, M. A. (2024). Complex High-risk Percutaneous Coronary Intervention Types, Trends, and Outcomes in Non-surgical Centres. Canadian Journal of Cardiology, https://doi.org/10.1016/j.cjca.2024.01.003

Background Limited data are available on complex, high-risk percutaneous coronary intervention (CHiP) trends and outcomes in non-surgical centres (NSC), particularly in healthcare systems where most centers are NSCs. Methods Using data from a na... Read More about Complex High-risk Percutaneous Coronary Intervention Types, Trends, and Outcomes in Non-surgical Centres.

Heart Failure Readmission in Patients With ST-Segment Elevation Myocardial Infarction and Active Cancer (2024)
Journal Article
Dafaalla, M., Abramov, D., Van Spall, H. G., Ghosh, A. K., Gale, C. P., Zaman, S., …Mamas, M. A. (in press). Heart Failure Readmission in Patients With ST-Segment Elevation Myocardial Infarction and Active Cancer. JACC: CardioOncology, 6(1), 117-129. https://doi.org/10.1016/j.jaccao.2023.10.011

Background Although numerous studies have examined readmission with heart failure (HF) after acute myocardial infarction (AMI), limited data are available on HF readmission in cancer patients post-AMI. Objectives This study aimed... Read More about Heart Failure Readmission in Patients With ST-Segment Elevation Myocardial Infarction and Active Cancer.

Clinical Outcomes of Percutaneous Coronary Intervention in Amyloidosis, Sarcoidosis, and Hemochromatosis (2023)
Journal Article
Hussain, B., Malik, H., Mamas, M. A., Desai, R., Aggarwal, V., Kumar, G., …Paul, T. K. (2023). Clinical Outcomes of Percutaneous Coronary Intervention in Amyloidosis, Sarcoidosis, and Hemochromatosis. Journal of the Society for Cardiovascular Angiography & Interventions, Article 101267. https://doi.org/10.1016/j.jscai.2023.101267

Background Infiltrative diseases (ID), including amyloidosis, sarcoidosis, and hemochromatosis comprise a wide spectrum of disorders characterized by abnormal cellular infiltration in multiple organs, including th... Read More about Clinical Outcomes of Percutaneous Coronary Intervention in Amyloidosis, Sarcoidosis, and Hemochromatosis.

Efficacy and safety of colchicine for the prevention of postoperative atrial fibrillation among patients undergoing major cardiothoracic surgery: a meta-analysis and meta-regression of randomized controlled trials. (2023)
Journal Article
Rivera, F. B., Cha, S. W., Aparece, J. P., Jariyatamkitti, S., & Mamas, M. (in press). Efficacy and safety of colchicine for the prevention of postoperative atrial fibrillation among patients undergoing major cardiothoracic surgery: a meta-analysis and meta-regression of randomized controlled trials. Journal of Cardiovascular Pharmacology, 83(3), 265-270. https://doi.org/10.1097/FJC.0000000000001533

The role of colchicine for the prevention of postoperative atrial fibrillation (POAF) following cardiothoracic surgery is not well-established. We aimed to evaluate its potential in preventing POAF using data from randomized controlled trials (RCTs).... Read More about Efficacy and safety of colchicine for the prevention of postoperative atrial fibrillation among patients undergoing major cardiothoracic surgery: a meta-analysis and meta-regression of randomized controlled trials..

Oral anticoagulant prescribing among patients with cancer and atrial fibrillation in England, 2009–2019 (2023)
Journal Article
Ajabnoor, A. M., Parisi, R., Zghebi, S. S., Ashcroft, D. M., Faivre‐Finn, C., Morris, C., …Kontopantelis, E. (in press). Oral anticoagulant prescribing among patients with cancer and atrial fibrillation in England, 2009–2019. Cancer, https://doi.org/10.1002/cncr.35152

Background Anticoagulation of patients with atrial fibrillation (AF) and cancer is challenging because of their high risk for stroke and bleeding. Little is known of the variations of oral anticoagulant (OAC) prescribing in patients with AF with and... Read More about Oral anticoagulant prescribing among patients with cancer and atrial fibrillation in England, 2009–2019.

Cost-effectiveness of intravascular ultrasound-guided percutaneous intervention in patients with acute coronary syndromes: A UK perspective (2023)
Journal Article
Sharp, A. S. P., Kinnaird, T., Curzen, N., Ayyub, R., Alfonso, J. E., Mamas, M. A., & Bavière, H. V. (in press). Cost-effectiveness of intravascular ultrasound-guided percutaneous intervention in patients with acute coronary syndromes: A UK perspective. European Heart Journal - Quality of Care and Clinical Outcomes, https://doi.org/10.1093/ehjqcco/qcad073

Background Use of intravascular ultrasound (IVUS) during percutaneous coronary intervention (PCI) is associated with improved clinical outcomes over angiography alone. Despite this, the adoption of IVUS in clinical practice remains low. Aims To... Read More about Cost-effectiveness of intravascular ultrasound-guided percutaneous intervention in patients with acute coronary syndromes: A UK perspective.

European Society of Cardiology Core Curriculum for Cardio-Oncology. (2023)
Journal Article
López-Fernández, T., Farmakis, D., Ameri, P., Asteggiano, R., de Azambuja, E., Aznar, M., …Rosano, G. M. C. (in press). European Society of Cardiology Core Curriculum for Cardio-Oncology. European Journal of Heart Failure, 10.1002/ejhf.3102. https://doi.org/10.1002/ejhf.3102

Cardio-oncology is a rapidly growing field of cardiovascular (CV) medicine that has resulted from the continuously increasing clinical demand for specialized CV evaluation, prevention and management of patients suffering or surviving from malignant d... Read More about European Society of Cardiology Core Curriculum for Cardio-Oncology..

COVID-19 vaccine-associated myocarditis: Analysis of the suspected cases reported to the EudraVigilance and a systematic review of the published literature. (2023)
Journal Article
Jaiswal, V., Mukherjee, D., Peng Ang, S., Kainth, T., Naz, S., Babu Shrestha, A., …Siller-Matula, J. M. (2023). COVID-19 vaccine-associated myocarditis: Analysis of the suspected cases reported to the EudraVigilance and a systematic review of the published literature. IJC Heart & Vasculature, 49, 101280. https://doi.org/10.1016/j.ijcha.2023.101280

Background Myocarditis secondary to Coronavirus Disease 2019 (COVID-19) vaccination has been reported in the literature. Objective This study aimed to characterize the reported cases of myocarditis after COVID-19 vaccination based on age, gender... Read More about COVID-19 vaccine-associated myocarditis: Analysis of the suspected cases reported to the EudraVigilance and a systematic review of the published literature..

Cardiovascular Health Metrics Differ Between Individuals With and Without Cancer. (2023)
Journal Article
Kobo, O., Abramov, D., Fiuza, M., Chew, N. W. S., Ng, C. H., Parwani, P., …Mamas, M. A. (in press). Cardiovascular Health Metrics Differ Between Individuals With and Without Cancer. Journal of the American Heart Association, 12(23), Article e030942. https://doi.org/10.1161/JAHA.123.030942

Although individuals with cancer experience high rates of cardiovascular morbidity, there are limited data on the potential differences in cardiovascular health (CVH) metrics between individuals with and without cancer. The National Health and Nutrit... Read More about Cardiovascular Health Metrics Differ Between Individuals With and Without Cancer..

Sex-specific lifetime risk of cardiovascular events: the European Prospective Investigation into Cancer-Norfolk prospective population cohort study. (2023)
Journal Article
Pana, T. A., Mamas, M. A., Wareham, N. J., Khaw, K., Dawson, D. K., & Myint, P. K. (in press). Sex-specific lifetime risk of cardiovascular events: the European Prospective Investigation into Cancer-Norfolk prospective population cohort study. European Journal of Preventive Cardiology, Article zwad283. https://doi.org/10.1093/eurjpc/zwad283

Better understanding of sex differences in cardiovascular disease (CVD) is essential in tailoring appropriate preventative strategies. Using a large population-based study with follow-up >25 years, we aimed to determine sex-specific lifetime risks of... Read More about Sex-specific lifetime risk of cardiovascular events: the European Prospective Investigation into Cancer-Norfolk prospective population cohort study..

Cardiovascular Risk in Patients with Hematological Malignancies: A Systematic Review and Meta-Analysis (2023)
Journal Article
Yong, J. H., Mai, A. S., Matetić, A., Elbadawi, A., Elgendy, I. Y., Lopez-Fernandez, T., & Mamas, M. A. (2024). Cardiovascular Risk in Patients with Hematological Malignancies: A Systematic Review and Meta-Analysis. The American Journal of Cardiology, 212, 80-102. https://doi.org/10.1016/j.amjcard.2023.11.039

Patients with haematological malignancies (HM) are at risk of future cardiovascular (CV) events. We therefore conducted a systematic review and meta-analysis to quantify their risk of future CV events. We searched Medline and Embase databases from in... Read More about Cardiovascular Risk in Patients with Hematological Malignancies: A Systematic Review and Meta-Analysis.

Pre-existing musculoskeletal pain and its association with mortality in newly diagnosed co-morbid conditions: an electronic health record cohort study (2023)
Journal Article
Marshall, M., Mason, K. J., Edwards, J. J., Mamas, M. A., Bailey, J., Heron, N., …Jordan, K. P. (2023). Pre-existing musculoskeletal pain and its association with mortality in newly diagnosed co-morbid conditions: an electronic health record cohort study. Rheumatology Advances in Practice, 8(1), Article rkad104. https://doi.org/10.1093/rap/rkad104

Objective Musculoskeletal pain is a common risk factor for co-morbid conditions and might increase the risk of poor outcomes. The objective was to determine whether patients with pre-existing musculoskeletal pain have an increased risk for mortality... Read More about Pre-existing musculoskeletal pain and its association with mortality in newly diagnosed co-morbid conditions: an electronic health record cohort study.

Optical Coherence Tomography Predictors of SIde Branch REstenosis after unprotected Left Main bifurcation angioplasty using double kissing crush technique (OP-SIBRE LM Study). (2023)
Journal Article
Gupta, A., Shrivastava, A., Chhikara, S., Mamas, M. A., Vijayvergiya, R., Swamy, A., …Singh, C. (in press). Optical Coherence Tomography Predictors of SIde Branch REstenosis after unprotected Left Main bifurcation angioplasty using double kissing crush technique (OP-SIBRE LM Study). Catheterization and Cardiovascular Interventions, 103(1), 51-60. https://doi.org/10.1002/ccd.30915

Among the two stent strategies, contemporary evidence favors double kissing crush technique (DKC) for complex unprotected distal left main bifurcation (UdLMB) lesions. However one of the major challenges to these lesions is side branch (SB) restenosi... Read More about Optical Coherence Tomography Predictors of SIde Branch REstenosis after unprotected Left Main bifurcation angioplasty using double kissing crush technique (OP-SIBRE LM Study)..

Trends in Cardiovascular Mortality Among Individuals with Alzheimer's Disease in the United States, 1999-2020 (2023)
Journal Article
Ranganathan, S., Abramov, D., Chew, N. W., Mallen, C., Marshall, M., Kobo, O., & Mamas, M. A. (2024). Trends in Cardiovascular Mortality Among Individuals with Alzheimer's Disease in the United States, 1999-2020. The American Journal of Cardiology, 211, Article 326-333. https://doi.org/10.1016/j.amjcard.2023.11.044

This study aimed to compare the trends in cardiovascular diseases (CVD)-related mortality in patients with Alzheimer's Disease (AD) and in the general population aged 65 and above. Data from the CDC WONDER Multiple Cause of Death da... Read More about Trends in Cardiovascular Mortality Among Individuals with Alzheimer's Disease in the United States, 1999-2020.

Intravascular imaging guided versus coronary angiography guided percutaneous coronary intervention: systematic review and meta-analysis (2023)
Journal Article
Khan, S. U., Agarwal, S., Arshad, H. B., Akbar, U. A., Mamas, M. A., Arora, S., …Shah, A. R. (in press). Intravascular imaging guided versus coronary angiography guided percutaneous coronary intervention: systematic review and meta-analysis. BMJ, 383, e077848. https://doi.org/10.1136/bmj-2023-077848

Objective: To assess the absolute treatment effects of intravascular imaging guided versus angiography guided percutaneous coronary intervention in patients with coronary artery disease, considering their baseline risk. Design: Systematic review and... Read More about Intravascular imaging guided versus coronary angiography guided percutaneous coronary intervention: systematic review and meta-analysis.

Risk of myocardial infarction following capecitabine treatment in patients with gastrointestinal cancer - a nationwide registry-based study (2023)
Journal Article
Shanmuganathan, J., Kragholm, K. H., Schou, M., Torp-Pedersen, C., Ostergaard Poulsen, L., Pareek, M., …Freeman, P. (2023). Risk of myocardial infarction following capecitabine treatment in patients with gastrointestinal cancer - a nationwide registry-based study. European Heart Journal, 44(Supplement_2), https://doi.org/10.1093/eurheartj/ehad655.1208

Background Myocardial infarction is a cardiac adverse event associated with fluoropyrimidines such as 5-fluorouracil and its orally available prodrug capecitabine. There are limited data on the incidence, risk, and prognosis of capecitabine associate... Read More about Risk of myocardial infarction following capecitabine treatment in patients with gastrointestinal cancer - a nationwide registry-based study.

Cardiovascular events following vascular endothelial growth factor inhibitor therapy with sunitinib or pazopanib in patients with renal cell carcinoma - a nationwide registry-based follow-up study (2023)
Journal Article
Shanmuganathan, J., Schou, M., Haider Butt, J., Torp-Pedersen, C., Ostergaard Poulsen, L., Pareek, M., …Kragholm, K. H. (2023). Cardiovascular events following vascular endothelial growth factor inhibitor therapy with sunitinib or pazopanib in patients with renal cell carcinoma - a nationwide registry-based follow-up study. European Heart Journal, 44(Supplement_2), https://doi.org/10.1093/eurheartj/ehad655.2699

Background Use of oral vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors (TKIs) with focus on sunitinib and pazopanib approved for treatment of patients with renal cell carcinoma (RCC) may be associated with cardiovascula... Read More about Cardiovascular events following vascular endothelial growth factor inhibitor therapy with sunitinib or pazopanib in patients with renal cell carcinoma - a nationwide registry-based follow-up study.

Sex-based analysis of NSTEMI processes of care and outcomes by hospital: a nationwide cohort study (2023)
Journal Article
Moledina, S., Weight, N., Dafaalla, M., Chen, D., Rashid, M., Mohamed, M., …Mamas, M. (2023). Sex-based analysis of NSTEMI processes of care and outcomes by hospital: a nationwide cohort study. European Heart Journal, 44(Supplement_2), Article ehad655.3027. https://doi.org/10.1093/eurheartj/ehad655.3027

Background Contemporary studies have demonstrated that in non-ST-segment elevation myocardial infarction (NSTEMI), processes of care vary significantly according to biological sex. Little is known regarding variation in practice between geographical... Read More about Sex-based analysis of NSTEMI processes of care and outcomes by hospital: a nationwide cohort study.

Impact of intracoronary imaging-guided percutaneous coronary intervention on procedural outcomes among patients with cardiogenic shock (2023)
Journal Article
Mohamed, M., Kinnaird, T., Rab, T., Zaman, S., Banerjee, A., Sirker, A., …Mamas, M. (2023). Impact of intracoronary imaging-guided percutaneous coronary intervention on procedural outcomes among patients with cardiogenic shock. European Heart Journal, 44(Supplement_2), https://doi.org/10.1093/eurheartj/ehad655.2111

Background Intracoronary imaging (ICI), including intravascular ultrasound (IVUS) or optical coherence tomography (OCT), is known to correlate with a reduction in rates of cardiac death after percutaneous coronary intervention (PCI), driven by lower... Read More about Impact of intracoronary imaging-guided percutaneous coronary intervention on procedural outcomes among patients with cardiogenic shock.

Impact of intracoronary imaging-guided percutaneous coronary intervention on procedural outcomes among complex patient groups (2023)
Journal Article
Mohamed, M., Kinnaird, T., Wijeysundera, H. C., Johnson, T. W., Zaman, S., Moledina, S., & Mamas, M. (2023). Impact of intracoronary imaging-guided percutaneous coronary intervention on procedural outcomes among complex patient groups. European Heart Journal, 44(Supplement_2), https://doi.org/10.1093/eurheartj/ehad655.2112

Background Intracoronary imaging (ICI) has been previously shown to improve survival and clinical outcomes after percutaneous coronary intervention (PCI). However, whether this prognostic benefit is sustained across different indications/patient grou... Read More about Impact of intracoronary imaging-guided percutaneous coronary intervention on procedural outcomes among complex patient groups.

Sex specific lifetime risk of incident cardiovascular events. Results from a large British population-based cohort study (2023)
Journal Article
Pana, T. A., Mamas, M. A., Wareham, N. J., Khaw, K. T., Dawson, D. K., & Myint, P. K. (2023). Sex specific lifetime risk of incident cardiovascular events. Results from a large British population-based cohort study. European Heart Journal, 44(Supplement_2), https://doi.org/10.1093/eurheartj/ehad655.2375

Background There are marked sex differences in cardiovascular (CV) disease, most characteristically with men having a higher risk of coronary heart disease and myocardial infarction (MI). The sex differences in the absolute lifetime risk of CV diseas... Read More about Sex specific lifetime risk of incident cardiovascular events. Results from a large British population-based cohort study.

Abstract 14815: Sex Differences in Transcatheter Aortic Valve Replacement Outcomes Among Patients With Bicuspid Aortic Stenosis: Insights From the National In-Patient Sample (2023)
Journal Article
Rivera, F. B., Redula, S., Liston, M. B., Ong, E., Bantayan, N. R., Choi, S., …Mamas, M. (2023). Abstract 14815: Sex Differences in Transcatheter Aortic Valve Replacement Outcomes Among Patients With Bicuspid Aortic Stenosis: Insights From the National In-Patient Sample. Circulation, 148(Suppl_1), https://doi.org/10.1161/circ.148.suppl_1.14815

Alcoholic cardiomyopathy mortality and social vulnerability index: A nationwide cross-sectional analysis. (2023)
Journal Article
Shahid, M., Ibrahim, R., Arakelyan, A., Hassan, K., Sainbayar, E., Pham, H. N., & Mamas, M. A. (in press). Alcoholic cardiomyopathy mortality and social vulnerability index: A nationwide cross-sectional analysis. International Journal of Cardiology Cardiovascular Risk and Prevention, 19, Article 200224. https://doi.org/10.1016/j.ijcrp.2023.200224

Social vulnerability index (SVI) plays a pivotal role in the outcomes of cardiovascular diseases and prevalence of alcohol use. We evaluated the impact of the SVI on alcoholic cardiomyopathy (ACM) mortality. Mortality data from 1999 to 2020 and the S... Read More about Alcoholic cardiomyopathy mortality and social vulnerability index: A nationwide cross-sectional analysis..

Sex Differences in the Clinical Outcomes of Patients with Takotsubo Stress Cardiomyopathy: A Meta-analysis of Observational Studies. (2023)
Journal Article
Abusnina, W., Elhouderi, E., Walters, R. W., Al-Abdouh, A., Mostafa, M. R., Ben-Dor, I., …Mamas, M. A. (in press). Sex Differences in the Clinical Outcomes of Patients with Takotsubo Stress Cardiomyopathy: A Meta-analysis of Observational Studies. The American Journal of Cardiology, 211, 316-325. https://doi.org/10.1016/j.amjcard.2023.10.066

The incidence of takotsubo stress cardiomyopathy (TSCM) in males is low compared to females. Sex-based differences in clinical outcomes of TSCM are not well characterized. The aim of this meta-analysis was to analyze whether sex-based differences are... Read More about Sex Differences in the Clinical Outcomes of Patients with Takotsubo Stress Cardiomyopathy: A Meta-analysis of Observational Studies..

Comorbidity clusters and in-hospital outcomes in patients admitted with acute myocardial infarction in the USA: A national population-based study (2023)
Journal Article
Zghebi, S. S., Rutter, M. K., Sun, L. Y., Ullah, W., Rashid, M., Ashcroft, D. M., …Mamas, M. A. (in press). Comorbidity clusters and in-hospital outcomes in patients admitted with acute myocardial infarction in the USA: A national population-based study. PloS one, 18(10), e0293314. https://doi.org/10.1371/journal.pone.0293314

Background: The prevalence of multimorbidity in patients with acute myocardial infarction (AMI) is increasing. It is unclear whether comorbidities cluster into distinct phenogroups and whether are associated with clinical trajectories. Methods: Surve... Read More about Comorbidity clusters and in-hospital outcomes in patients admitted with acute myocardial infarction in the USA: A national population-based study.

Intracoronary imaging guided percutaneous coronary intervention outcomes among individuals with cardiogenic shock (2023)
Journal Article
Mohamed, M. O., Kinnaird, T., Rab, S. T., Zaman, S., Banerjee, A., Sirker, A., …Mamas, M. A. (in press). Intracoronary imaging guided percutaneous coronary intervention outcomes among individuals with cardiogenic shock. Catheterization and Cardiovascular Interventions, 102(6), 1004-1011. https://doi.org/10.1002/ccd.30859

Background: Limited data exist around the utility of intracoronary imaging (ICI) during percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS) and cardiogenic shock (CS), who are inherently at a high risk of stent thr... Read More about Intracoronary imaging guided percutaneous coronary intervention outcomes among individuals with cardiogenic shock.

Do two operators improve outcomes in left main percutaneous coronary intervention? Insights from the ORPKI Registry. (2023)
Journal Article
Doolub, G., Mamas, M. A., Dziewierz, A., Malinowski, K. P., Oleś, I., Kuleta, M., …Siudak, Z. (in press). Do two operators improve outcomes in left main percutaneous coronary intervention? Insights from the ORPKI Registry. Minerva Cardiology and Angiology, 72(1), 79-86. https://doi.org/10.23736/S2724-5683.23.06364-0

Significant left main coronary artery (LMCA) disease is prevalent in 7% of patients undergoing angiography. Limited data exists on the impact of double scrubbing in LMCA PCI. We sought to assess periprocedural outcomes in two-operator LMCA percutaneo... Read More about Do two operators improve outcomes in left main percutaneous coronary intervention? Insights from the ORPKI Registry..

Social Vulnerability and Cardiovascular-related Mortality Among Older Adults In the United States. (2023)
Journal Article
Khan Minhas, A. M., Kobo, O., Mamas, M. A., Al-Kindi, S. G., Abushamat, L. A., Nambi, V., …Abramov, D. (in press). Social Vulnerability and Cardiovascular-related Mortality Among Older Adults In the United States. American Journal of Medicine, 137(2), 122-127. https://doi.org/10.1016/j.amjmed.2023.10.012

The association of social vulnerability and cardiovascular disease- related mortality in older adults has not been well characterized. The Centers for Disease Control and Prevention database was evaluated to examine the relationship between county-le... Read More about Social Vulnerability and Cardiovascular-related Mortality Among Older Adults In the United States..

Estimating the direct healthcare utilization and cost of musculoskeletal pain among people with comorbidity: a retrospective electronic health record study (2023)
Journal Article
Png, M. E., Mason, K. J., Marshall, M., Jordan, K. P., Bailey, J., Frisher, M., …Achana, F. (2023). Estimating the direct healthcare utilization and cost of musculoskeletal pain among people with comorbidity: a retrospective electronic health record study. Current Medical Research and Opinion, 1-8. https://doi.org/10.1080/03007995.2023.2271862

Objective To investigate the impact of pre-existing painful musculoskeletal conditions on healthcare utilization and costs among patients with five common conditions: acute coronary syndrome (ACS), stroke, cancer, dementia and pneumonia. Methods... Read More about Estimating the direct healthcare utilization and cost of musculoskeletal pain among people with comorbidity: a retrospective electronic health record study.

Impact of Social Vulnerability on Diabetes‐Related Cardiovascular Mortality in the United States (2023)
Journal Article
Bashar, H., Kobo, O., Khunti, K., Banerjee, A., Bullock‐Palmer, R. P., Curzen, N., & Mamas, M. A. (in press). Impact of Social Vulnerability on Diabetes‐Related Cardiovascular Mortality in the United States. Journal of the American Heart Association, 12(21), Article e029649. https://doi.org/10.1161/jaha.123.029649

Background Social vulnerability impacts the natural history of diabetes as well as cardiovascular disease (CVD). However, there are little data regarding the social vulnerability association with diabetes‐related CVD mortality. Methods and Result... Read More about Impact of Social Vulnerability on Diabetes‐Related Cardiovascular Mortality in the United States.

TCT-401 Sex-Related Differences in Baseline Characteristic and Outcomes in Patients With Myocardial Infarction With Nonobstructive Coronary Arteries: Insight From Large-Scale Polish Registry (2023)
Journal Article
Milewski, M., Desperak, A., Bujak, M., Gierlotka, M., Milewski, K., Wita, K., …Gasior, P. (2023). TCT-401 Sex-Related Differences in Baseline Characteristic and Outcomes in Patients With Myocardial Infarction With Nonobstructive Coronary Arteries: Insight From Large-Scale Polish Registry. Journal of the American College of Cardiology, 82(17), B161. https://doi.org/10.1016/j.jacc.2023.09.410

Efficacy and safety of the new generation Watchman FLX device compared to the Watchman 2.5: a systematic review and meta-analysis. (2023)
Journal Article
Najim, M., Reda Mostafa, M., Eid, M. M., Alabdouh, A., Awad, A. K., Elbanna, M., …Mamas, M. A. (in press). Efficacy and safety of the new generation Watchman FLX device compared to the Watchman 2.5: a systematic review and meta-analysis. American Journal of Cardiovascular Disease, 13(5), 291-299

The first-generation Watchman 2.5 (W 2.5) presented several limitations, such as challenges in implantation within complex left atrial appendage (LAA) anatomies, higher incidence of peri-device leak, device recapture, and device-related thrombus (DR... Read More about Efficacy and safety of the new generation Watchman FLX device compared to the Watchman 2.5: a systematic review and meta-analysis..

Association between Surgeon/anesthesiologist Sex Discordance and One-year Mortality Among Adults Undergoing Noncardiac Surgery (2023)
Journal Article
Etherington, C., Boet, S., Chen, I., Duffy, M., Mamas, M. A., Eddeen, A. B., …Sun, L. Y. (in press). Association between Surgeon/anesthesiologist Sex Discordance and One-year Mortality Among Adults Undergoing Noncardiac Surgery. Annals of Surgery, https://doi.org/10.1097/sla.0000000000006111

Objective: To investigate the association between surgeon-anesthesiologist sex discordance and patient mortality after noncardiac surgery. Summary Background Data: Evidence suggests different practice patterns exist amongst female and male physicians... Read More about Association between Surgeon/anesthesiologist Sex Discordance and One-year Mortality Among Adults Undergoing Noncardiac Surgery.

Social disparities in cardiovascular mortality of patients with cancer in the USA between 1999 and 2019 (2023)
Journal Article
Raisi-Estabragh, Z., Kobo, O., López-Fernández, T., Qadir, H. A., Chew, N. W., Wojakowski, W., …Mamas, M. A. (2023). Social disparities in cardiovascular mortality of patients with cancer in the USA between 1999 and 2019. International Journal of Cardiology Cardiovascular Risk and Prevention, 19, Article 200218. https://doi.org/10.1016/j.ijcrp.2023.200218

Background Temporal trends of the impact of social determinants on cardiovascular outcomes of cancer patients has not been previously studied. Objectives This study examined social disparities in cardiovascular mortality of people... Read More about Social disparities in cardiovascular mortality of patients with cancer in the USA between 1999 and 2019.

Detecting transthyretin amyloid cardiomyopathy (ATTR-CM) using machine learning: an evaluation of the performance of an algorithm in a UK setting (2023)
Journal Article
Tsang, C., Huda, A., Norman, M., Dickerson, C., Leo, V., Brownrigg, J., …Elliott, P. (2023). Detecting transthyretin amyloid cardiomyopathy (ATTR-CM) using machine learning: an evaluation of the performance of an algorithm in a UK setting. BMJ Open, 13(10), Article e070028. https://doi.org/10.1136/bmjopen-2022-070028

Objective: The aim of this study was to evaluate the potential real-world application of a machine learning (ML) algorithm, developed and trained on heart failure (HF) cohorts in the USA, to detect patients with undiagnosed wild type cardiac amyloido... Read More about Detecting transthyretin amyloid cardiomyopathy (ATTR-CM) using machine learning: an evaluation of the performance of an algorithm in a UK setting.

Common Cancer Types and Risk of Stroke and Bleeding in Patients With Nonvalvular Atrial Fibrillation: A Population-Based Study in England. (2023)
Journal Article
Ajabnoor, A. M., Parisi, R., Zghebi, S. S., Ashcroft, D. M., Faivre-Finn, C., Morris, C., …Kontopantelis, E. (2023). Common Cancer Types and Risk of Stroke and Bleeding in Patients With Nonvalvular Atrial Fibrillation: A Population-Based Study in England. Journal of the American Heart Association, 12(19), Article e029423. https://doi.org/10.1161/JAHA.123.029423

Background The association between cancer and stroke or bleeding outcomes in atrial fibrillation is unclear. We sought to examine how certain types of cancer influence the balance between stroke and bleeding risk in patients with nonvalvular atrial... Read More about Common Cancer Types and Risk of Stroke and Bleeding in Patients With Nonvalvular Atrial Fibrillation: A Population-Based Study in England..

Complex high‐risk percutaneous coronary intervention types, trends, and outcomes according to vascular access site (2023)
Journal Article
Shamkhani, W., Moledina, S., Rashid, M., & Mamas, M. A. (in press). Complex high‐risk percutaneous coronary intervention types, trends, and outcomes according to vascular access site. Catheterization and Cardiovascular Interventions, 102(5), 803-813. https://doi.org/10.1002/ccd.30846

Background Radial access is associated with improved outcomes following percutaneous coronary intervention (PCI); however, its role in complex, high-risk percutaneous coronary intervention (CHiP) remains poorly studied. Methods We studied retros... Read More about Complex high‐risk percutaneous coronary intervention types, trends, and outcomes according to vascular access site.

NATIONWIDE ASSESSMENT OF MORTALITY DISPARITIES LINKED TO ACUTE MYOCARDIAL INFARCTION AND COVID-19 IN THE US (2023)
Journal Article
Muhyieddeen, A., Ranasinghe, S., Cheng, S., Mamas, M. A., Beasley, D., Weins, G. C., & Gulati, M. (2023). NATIONWIDE ASSESSMENT OF MORTALITY DISPARITIES LINKED TO ACUTE MYOCARDIAL INFARCTION AND COVID-19 IN THE US. American Journal of Preventive Cardiology, 15, Article 100546. https://doi.org/10.1016/j.ajpc.2023.100546

Therapeutic Area ASCVD/CVD in Special Populations Background The influence of the COVID-19 pandemic on possible racial disparities in the management and outcomes of acute myocardial infarction (AMI) remains uncertain. We investiga... Read More about NATIONWIDE ASSESSMENT OF MORTALITY DISPARITIES LINKED TO ACUTE MYOCARDIAL INFARCTION AND COVID-19 IN THE US.

NATIONWIDE EVALUATION OF REVASCULARIZATION INEQUALITIES ASSOCIATED WITH STEMI AND COVID-19 IN THE UNITED STATES (2023)
Journal Article
Muhyieddeen, A., Ranasinghe, S., Cheng, S., Mamas, M. A., Beasley, D., Weins, G. C., & Gulati, M. (2023). NATIONWIDE EVALUATION OF REVASCULARIZATION INEQUALITIES ASSOCIATED WITH STEMI AND COVID-19 IN THE UNITED STATES. American Journal of Preventive Cardiology, 15, 100547. https://doi.org/10.1016/j.ajpc.2023.100547

Therapeutic Area ASCVD/CVD in Special Populations Background The impact of the COVID-19 pandemic on potential racial disparities in ST-segment elevation myocardial infarction (STEMI) treatment is still unclear. We investigated var... Read More about NATIONWIDE EVALUATION OF REVASCULARIZATION INEQUALITIES ASSOCIATED WITH STEMI AND COVID-19 IN THE UNITED STATES.

Sex-Specific Differences in Potent P2Y12 Inhibitor Use in British Cardiovascular Intervention Society Registry STEMI Patients (2023)
Journal Article
Burgess, S. N., Shoaib, A., Sharp, A. S., Ludman, P., Graham, M. M., Figtree, G. A., …Mamas, M. A. (2023). Sex-Specific Differences in Potent P2Y12 Inhibitor Use in British Cardiovascular Intervention Society Registry STEMI Patients. Circulation: Cardiovascular Interventions, 16(9), https://doi.org/10.1161/circinterventions.122.012447

BACKGROUND: Sex-based outcome differences for women with ST-segment–elevation myocardial infarction (STEMI) have not been adequately addressed, and the role played by differences in prescription of potent P2Y12 inhibitors (P-P2Y12) is not well defin... Read More about Sex-Specific Differences in Potent P2Y12 Inhibitor Use in British Cardiovascular Intervention Society Registry STEMI Patients.

Clinical Pathway for Coronary Atherosclerosis in Patients Without Conventional Modifiable Risk Factors JACC State-of-the-Art Review (2023)
Journal Article
Figtree, G. A., Vernon, S. T., Harmer, J. A., Gray, M. P., Arnott, C., Bachour, E., …Nicholls, S. J. (in press). Clinical Pathway for Coronary Atherosclerosis in Patients Without Conventional Modifiable Risk Factors JACC State-of-the-Art Review. Journal of the American College of Cardiology, 82(13), 1343-1359. https://doi.org/10.1016/j.jacc.2023.06.045

Reducing the incidence and prevalence of standard modifiable cardiovascular risk factors (SMuRFs) is critical to tackling the global burden of coronary artery disease (CAD). However, a substantial number of individuals develop coro... Read More about Clinical Pathway for Coronary Atherosclerosis in Patients Without Conventional Modifiable Risk Factors JACC State-of-the-Art Review.

Readmissions After Left Atrial Appendage Closure in Patients with Previous Ischemic Stroke or Transient Ischemic Attack (2023)
Journal Article
Sparrow, R. T., Sposato, L. A., Alkhouli, M. A., García, S., Elgendy, I. Y., Kuchtaruk, A. A., …Bagur, R. (2023). Readmissions After Left Atrial Appendage Closure in Patients with Previous Ischemic Stroke or Transient Ischemic Attack. CJC Open, 5(12), 950-964. https://doi.org/10.1016/j.cjco.2023.09.009

Background We examined the frequency and risk factors associated with readmissions after left atrial appendage closure (LAAC) in patients with and without previous ischemic stroke/transient ischemic attack (TIA). Methods Hospitali... Read More about Readmissions After Left Atrial Appendage Closure in Patients with Previous Ischemic Stroke or Transient Ischemic Attack.

Outcomes and Discriminatory Accuracy of the CHA2DS2VASc Score in Atrial Fibrillation and Cancer (2023)
Journal Article
Ullah, W., DiMeglio, M., Frisch, D. R., Bagur, R., Sun, L. Y., Fischman, D. L., …Mamas, M. A. (2023). Outcomes and Discriminatory Accuracy of the CHA2DS2VASc Score in Atrial Fibrillation and Cancer. JACC: Advances, 2(8), 100609. https://doi.org/10.1016/j.jacadv.2023.100609

Background Atrial fibrillation (AF) is highly prevalent among cancer patients. The role of traditional risk stratification scores in the context of different cancer types in these patients remains unknown.... Read More about Outcomes and Discriminatory Accuracy of the CHA2DS2VASc Score in Atrial Fibrillation and Cancer.

Substance Use in Pregnancy and its Association With Cardiovascular Events (2023)
Journal Article
Evans, K., Wu, P., Mamas, M. A., Irwin, C., Kang, P., Perlow, J. H., …Gulati, M. (2023). Substance Use in Pregnancy and its Association With Cardiovascular Events. JACC: Advances, 2(8), 100619. https://doi.org/10.1016/j.jacadv.2023.100619

Background Substance use and cardiovascular (CV) events are increasing among pregnant women in the United States, but association between substance use in pregnancy and CV events remains unknown. Objectives The purpose of this stu... Read More about Substance Use in Pregnancy and its Association With Cardiovascular Events.

Impact of Frailty on Emergency Department Encounters for Cardiovascular Disease: A Retrospective Cohort Study (2023)
Journal Article
Sokhal, B. S., Matetić, A., Abhishek, A., Banerjee, A., Partington, R., Roddy, E., …Mamas, M. A. (2023). Impact of Frailty on Emergency Department Encounters for Cardiovascular Disease: A Retrospective Cohort Study. American Journal of Cardiology, 206, 210-218. https://doi.org/10.1016/j.amjcard.2023.08.138

Data are limited on whether the causes of emergency department (ED) encounters for cardiovascular diseases (CVDs) and associated clinical outcomes vary by frailty status. Using the United States Nationwide ED Sample, selected CVD encounters (acute my... Read More about Impact of Frailty on Emergency Department Encounters for Cardiovascular Disease: A Retrospective Cohort Study.

Prediction of clinical outcomes after percutaneous coronary intervention: Machine-learning analysis of the National Inpatient Sample (2023)
Journal Article
Galimzhanov, A., Matetic, A., Tenekecioglu, E., & Mamas, M. A. (2023). Prediction of clinical outcomes after percutaneous coronary intervention: Machine-learning analysis of the National Inpatient Sample. International Journal of Cardiology, 392, Article 131339. https://doi.org/10.1016/j.ijcard.2023.131339

Background This study aimed to develop a multiclass machine-learning (ML) model to predict all-cause mortality, ischemic and hemorrhagic events in unselected hospitalized patients undergoing percutaneous coronary intervention (PCI). Methods This... Read More about Prediction of clinical outcomes after percutaneous coronary intervention: Machine-learning analysis of the National Inpatient Sample.

Racial Disparities in Obesity‐Related Cardiovascular Mortality in the United States: Temporal Trends From 1999 to 2020 (2023)
Journal Article
Raisi‐Estabragh, Z., Kobo, O., Mieres, J. H., Bullock‐Palmer, R. P., Van Spall, H. G., Breathett, K., & Mamas, M. A. (in press). Racial Disparities in Obesity‐Related Cardiovascular Mortality in the United States: Temporal Trends From 1999 to 2020. Journal of the American Heart Association, 12(18), Article e028409. https://doi.org/10.1161/jaha.122.028409

Background Obesity is a major risk factor for cardiovascular disease, with differential impact across populations. This descriptive epidemiologic study outlines trends and disparities in obesity‐related cardiovascular mortality in the US population... Read More about Racial Disparities in Obesity‐Related Cardiovascular Mortality in the United States: Temporal Trends From 1999 to 2020.

The Effect of Daylight-Saving Time on Percutaneous Coronary Intervention Outcomes in Acute Coronary Syndrome Patients—Data from the Polish National Registry of Percutaneous Coronary Interventions (ORPKI) in the Years 2014–2022 (2023)
Journal Article
Kaziród-Wolski, K., Piotrowska, A., Sielski, J., Zając, P., Malinowski, K. P., Zabojszcz, M., …Siudak, Z. (2023). The Effect of Daylight-Saving Time on Percutaneous Coronary Intervention Outcomes in Acute Coronary Syndrome Patients—Data from the Polish National Registry of Percutaneous Coronary Interventions (ORPKI) in the Years 2014–2022. Journal of Cardiovascular Development and Disease, 10(9), Article 375. https://doi.org/10.3390/jcdd10090375

Introduction: Many factors related to the switch to summer/winter time interfere with biological rhythms. Objectives: This study aimed to analyze the impact of time change on clinical outcomes of patients with acute coronary syndromes (ACS) undergoin... Read More about The Effect of Daylight-Saving Time on Percutaneous Coronary Intervention Outcomes in Acute Coronary Syndrome Patients—Data from the Polish National Registry of Percutaneous Coronary Interventions (ORPKI) in the Years 2014–2022.

Predicting Target Lesion Failure following Percutaneous Coronary Intervention through Machine Learning Risk Assessment Models. (2023)
Journal Article
Mamas, M. A., Roffi, M., Fröbert, O., Chieffo, A., Beneduce, A., Matetic, A., …Kontopantelis, E. (in press). Predicting Target Lesion Failure following Percutaneous Coronary Intervention through Machine Learning Risk Assessment Models. European Heart Journal – Digital Health, 4(6), 433–443. https://doi.org/10.1093/ehjdh/ztad051

Aims Central to the practice of precision medicine in percutaneous coronary intervention (PCI) is a risk-stratification tool to predict outcomes following the procedure. This study is intended to assess machine learning (ML)-based risk models to pre... Read More about Predicting Target Lesion Failure following Percutaneous Coronary Intervention through Machine Learning Risk Assessment Models..

Persistent high prevalence of modifiable cardiovascular risk factors among patients with osteoarthritis in the UK in 1992–2017 (2023)
Journal Article
Yu, D., Huang, X., Mamas, M., & Wilkie, R. (2023). Persistent high prevalence of modifiable cardiovascular risk factors among patients with osteoarthritis in the UK in 1992–2017. RMD Open, 9(3), Article e003298. https://doi.org/10.1136/rmdopen-2023-003298

Objectives: To compare the annual and period prevalence of modifiable cardiovascular risk factors (MCVRFs) between populations with and without osteoarthritis (OA) in the UK over 25 years. Methods: 215 190 patients aged 35 years and over from the... Read More about Persistent high prevalence of modifiable cardiovascular risk factors among patients with osteoarthritis in the UK in 1992–2017.

Rural and urban disparities in cardiovascular disease-related mortality in the USA over 20 years; have the trends been reversed by COVID-19? (2023)
Journal Article
Chaganty, S. S., Abramov, D., Van Spall, H. G. C., Bullock-Palmer, R. P., Vassiliou, V., Myint, P. K., …Mamas, M. A. (in press). Rural and urban disparities in cardiovascular disease-related mortality in the USA over 20 years; have the trends been reversed by COVID-19?. International Journal of Cardiology Cardiovascular Risk and Prevention, 19, Article 200202. https://doi.org/10.1016/j.ijcrp.2023.200202

Causes of Death Among Health Care Professionals in the United States (2023)
Journal Article
Kobo, O., Abramov, D., Volgman, A. S., Mieres, J. H., Wijeysundera, H. C., Van Spall, H. G., & Mamas, M. A. (2023). Causes of Death Among Health Care Professionals in the United States. Population Health Management, 26(5), 294-302. https://doi.org/10.1089/pop.2023.0070

Specific causes of mortality among various types of health care professionals (HCPs), including those characterized by age, gender, and race, have not been well described. The National Occupational Mortality Surveillance data for deaths in 26 US stat... Read More about Causes of Death Among Health Care Professionals in the United States.

Temporal analysis of non-ST segment elevation-acute coronary syndrome (NSTEACS) outcomes in 'young' patients under the age of fifty: A nationwide cohort study. (2023)
Journal Article
Weight, N., Moledina, S., Rashid, M., Chew, N., Castelletti, S., Buchanan, G. L., …Mamas, M. A. (in press). Temporal analysis of non-ST segment elevation-acute coronary syndrome (NSTEACS) outcomes in 'young' patients under the age of fifty: A nationwide cohort study. International Journal of Cardiology, 391, Article 131294. https://doi.org/10.1016/j.ijcard.2023.131294

The characteristics and risk factor profile of young patients presenting with non-ST segment elevation acute coronary syndrome (NSTEACS) and how they may have changed over time is not well reported. We identified 26,708 NSTEACS patients aged under 50... Read More about Temporal analysis of non-ST segment elevation-acute coronary syndrome (NSTEACS) outcomes in 'young' patients under the age of fifty: A nationwide cohort study..

Association between troponin level and medium-term mortality in 20 000 hospital patients. (2023)
Journal Article
Hinton, J., Mariathas, M. N., Gabara, L., Allan, R., Nicholas, Z., Kwok, C. S., …Curzen, N. (in press). Association between troponin level and medium-term mortality in 20 000 hospital patients. Heart, heartjnl-2023-322463. https://doi.org/10.1136/heartjnl-2023-322463

Cardiac troponin (cTn) concentrations above the manufacturer recommended upper limit of normal (ULN) are frequently seen in hospital patients without a clinical presentation consistent with type 1 myocardial infarction, and the significance of this i... Read More about Association between troponin level and medium-term mortality in 20 000 hospital patients..

In-Hospital Outcomes of Combined Coronary Revascularization and Transcatheter Aortic Valve Implantation in Inpatient Nationwide Analysis. (2023)
Journal Article
Zghouzi, M., Osman, H., Erdem, S., Ullah, W., Patel, N., Sattar, Y., …Alraies, M. C. (in press). In-Hospital Outcomes of Combined Coronary Revascularization and Transcatheter Aortic Valve Implantation in Inpatient Nationwide Analysis. Current Problems in Cardiology, 49(1), Article 101913. https://doi.org/10.1016/j.cpcardiol.2023.101913

Transcatheter aortic valve implantation (TAVI) is accepted as an alternative to surgery, but data on combined percutaneous coronary interventions (PCI) and TAVI during the same in-hospital stay are still lacking. Using the national inpatient sample (... Read More about In-Hospital Outcomes of Combined Coronary Revascularization and Transcatheter Aortic Valve Implantation in Inpatient Nationwide Analysis..

Characteristics and Outcomes of Patients Who Underwent Coronary Atherectomy in Centers With and Without On-Site Cardiac Surgery (2023)
Journal Article
Dafaalla, M., Rashid, M., Moledina, S., Kinnaird, T., Ludman, P., Curzen, N., …Mamas, M. A. (in press). Characteristics and Outcomes of Patients Who Underwent Coronary Atherectomy in Centers With and Without On-Site Cardiac Surgery. American Journal of Cardiology, 204, 242-248. https://doi.org/10.1016/j.amjcard.2023.07.073

We aimed to describe the clinical characteristics and outcomes of patients who underwent atherectomy at the time of percutaneous coronary intervention in centers with on-site surgical centers (SCs) versus nonsurgical centers (NSCs)... Read More about Characteristics and Outcomes of Patients Who Underwent Coronary Atherectomy in Centers With and Without On-Site Cardiac Surgery.

Antipsychotic drug prescribing and mortality in people with dementia before and during the COVID-19 pandemic: a retrospective cohort study in Wales, UK. (2023)
Journal Article
Schnier, C., McCarthy, A., Morales, D. R., Akbari, A., Sofat, R., Dale, C., …Wilkinson, T. (2023). Antipsychotic drug prescribing and mortality in people with dementia before and during the COVID-19 pandemic: a retrospective cohort study in Wales, UK. The Lancet Healthy Longevity, 4(8), e421-e430. https://doi.org/10.1016/S2666-7568%2823%2900105-8

Background Concerns have been raised that antipsychotic drug prescribing, which has been associated with increased mortality in people with dementia, might have increased during the COVID-19 pandemic due to social restrictions imposed to limit the s... Read More about Antipsychotic drug prescribing and mortality in people with dementia before and during the COVID-19 pandemic: a retrospective cohort study in Wales, UK..

Socioeconomic disparities in the management and outcomes of acute myocardial infarction (2023)
Journal Article
Weight, N., Moledina, S., Volgman, A. S., Bagur, R., Wijeysundera, H. C., Sun, L. Y., …Mamas, M. A. (2023). Socioeconomic disparities in the management and outcomes of acute myocardial infarction. Heart, heartjnl-2023-322601. https://doi.org/10.1136/heartjnl-2023-322601

Background: Patients from lower socioeconomic status areas have poorer outcomes following acute myocardial infarction (AMI); however, how ethnicity modifies such socioeconomic disparities is unclear. Methods: Using the UK Myocardial Ischaemia Nat... Read More about Socioeconomic disparities in the management and outcomes of acute myocardial infarction.

Clinical Frailty Scale as a predictor of adverse outcomes following aortic valve replacement: a systematic review and meta-analysis (2023)
Journal Article
Prendiville, T., Leahy, A., Gabr, A., Ahmad, F., Afilalo, J., Martin, G. P., …Galvin, R. (2023). Clinical Frailty Scale as a predictor of adverse outcomes following aortic valve replacement: a systematic review and meta-analysis. Open Heart, 10(2), Article e002354. https://doi.org/10.1136/openhrt-2023-002354

Objectives: Assessment of frailty prior to aortic valve intervention is recommended in European and North American valvular heart disease guidelines. However, there is a lack of consensus on how it is best measured. The Clinical Frailty Scale (CFS) i... Read More about Clinical Frailty Scale as a predictor of adverse outcomes following aortic valve replacement: a systematic review and meta-analysis.

Reply (2023)
Journal Article
Cipolletta, E., Tata, L. J., Nakafero, G., Avery, A. J., Mamas, M. A., & Abhishek, A. (in press). Reply. Arthritis & Rheumatology, 75(10), 1868-1869. https://doi.org/10.1002/art.42553

Cardiovascular outcomes in breast cancer survivors: a systematic review and meta-analysis (2023)
Journal Article
Galimzhanov, A., Istanbuly, S., Tun, H. N., Ozbay, B., Alasnag, M., Ky, B., …Mamas, M. A. (in press). Cardiovascular outcomes in breast cancer survivors: a systematic review and meta-analysis. European Journal of Preventive Cardiology, Article zwad243. https://doi.org/10.1093/eurjpc/zwad243

Aims It is unclear whether the future risk of cardiovascular events in breast cancer (bc) survivors is greater than in the general population. This meta-analysis quantifies the risk of cardiovascular disease development in bc patients, compared to th... Read More about Cardiovascular outcomes in breast cancer survivors: a systematic review and meta-analysis.

Impact of Frailty on Clinical Outcomes in Patients With Atrial Fibrillation Who Underwent Cardiac Ablation Using a Nationwide Database (2023)
Journal Article
Diaz-Arocutipa, C., Carvallo-Castañeda, D., Chumbiauca, M., Mamas, M. A., & Hernandez, A. V. (2023). Impact of Frailty on Clinical Outcomes in Patients With Atrial Fibrillation Who Underwent Cardiac Ablation Using a Nationwide Database. American Journal of Cardiology, 203, 98-104. https://doi.org/10.1016/j.amjcard.2023.07.020

This study aimed to assess the association between frailty and clinical outcomes in patients with atrial fibrillation (AF) who undergo catheter ablation. We conducted a retrospective cohort study using the National Inpatient Sample database from 2017... Read More about Impact of Frailty on Clinical Outcomes in Patients With Atrial Fibrillation Who Underwent Cardiac Ablation Using a Nationwide Database.

Sex‐based treatment and outcomes for coronary bifurcation stenting: A report from the e‐ULTIMASTER registry (2023)
Journal Article
Doolub, G., Iannaccone, M., Rab, T., Routledge, H., Aminian, A., Chevalier, B., …Mamas, M. A. (in press). Sex‐based treatment and outcomes for coronary bifurcation stenting: A report from the e‐ULTIMASTER registry. Catheterization and Cardiovascular Interventions, 102(3), 430-439. https://doi.org/10.1002/ccd.30770

Background Percutaneous coronary intervention (PCI) for bifurcation lesions can be technically challenging and is associated with higher risk. There is little data on sex-based differences in strategy and outcomes in bifurcation PCI. Aims We sou... Read More about Sex‐based treatment and outcomes for coronary bifurcation stenting: A report from the e‐ULTIMASTER registry.

Prognostic role of CA‐125 in patients undergoing transcatheter aortic valve replacement: A systematic review and meta‐analysis (2023)
Journal Article
Diaz‐Arocutipa, C., Saucedo‐Chinchay, J., & Mamas, M. A. (in press). Prognostic role of CA‐125 in patients undergoing transcatheter aortic valve replacement: A systematic review and meta‐analysis. Clinical Cardiology, 46(10), 1129-1136. https://doi.org/10.1002/clc.24064

Transcatheter aortic valve replacement (TAVR) has become a widely used therapy for patients with severe aortic stenosis. Carbohydrate antigen 125 (CA‐125) is a promising biomarker in some cardiovascular diseases. This systematic review aims to assess... Read More about Prognostic role of CA‐125 in patients undergoing transcatheter aortic valve replacement: A systematic review and meta‐analysis.

Prevalence and outcomes of type 2 myocardial infarction in patients with cancer: A retrospective analysis from the National Inpatient Sample dataset. (2023)
Journal Article
Castaldi, G., Bharadwaj, A. S., Bagur, R., Van Spall, H. G. C., Kobo, O., & Mamas, M. A. (in press). Prevalence and outcomes of type 2 myocardial infarction in patients with cancer: A retrospective analysis from the National Inpatient Sample dataset. International Journal of Cardiology, 389, Article 131154. https://doi.org/10.1016/j.ijcard.2023.131154

This study aimed to investigate the prevalence, clinical characteristics and outcomes of type 2 myocardial infarction (T2AMI) in patients with versus without cancer. All hospitalizations with a primary discharge diagnosis of T2AMI were stratified acc... Read More about Prevalence and outcomes of type 2 myocardial infarction in patients with cancer: A retrospective analysis from the National Inpatient Sample dataset..

Impact of Neighborhood Social Deprivation on Health Care Costs Associated With TAVR. (2023)
Journal Article
Sidhu, H., Qiu, F., Manoragavan, R., Ko, D. T., Mamas, M. A., Sud, M., …Wijeysundera, H. C. (2023). Impact of Neighborhood Social Deprivation on Health Care Costs Associated With TAVR. Circulation: Cardiovascular Quality and Outcomes, 16(7), Article e009761. https://doi.org/10.1161/CIRCOUTCOMES.122.009761

Cumulative costs of transcatheter aortic valve replacement (TAVR) differ in the referral, procedural and postprocedural phases depending on patient comorbidities, type of procedure, and procedural complications. Our goal was to determine the associat... Read More about Impact of Neighborhood Social Deprivation on Health Care Costs Associated With TAVR..

Impact of the COVID-19 Pandemic on Diabetes-Related Cardiovascular Mortality in the United States. (2023)
Journal Article
Bashar, H., Kobo, O., Khunti, K., Sun, L. Y., Rutter, M. K., Chew, N. W. S., …Mamas, M. A. (in press). Impact of the COVID-19 Pandemic on Diabetes-Related Cardiovascular Mortality in the United States. Journal of the American Heart Association, 12(13), e028896. https://doi.org/10.1161/JAHA.122.028896

Background In the past few decades, diabetes-related cardiovascular mortality has been steadily declining. However, the impact of the COVID19 pandemic on this trend has not been previously defined. Methods and Results Diabetes-related cardiovascular... Read More about Impact of the COVID-19 Pandemic on Diabetes-Related Cardiovascular Mortality in the United States..

Meta-Analysis on the Clinical Outcomes With Polypills for Cardiovascular Disease Prevention (2023)
Journal Article
Sedhom, R., Hamed, M., Tan, W., Mansoor, H., Stoletniy, L., Mamas, M., …Elbadawi, A. (in press). Meta-Analysis on the Clinical Outcomes With Polypills for Cardiovascular Disease Prevention. American Journal of Cardiology, 201, 211-218. https://doi.org/10.1016/j.amjcard.2023.06.001

Randomized controlled trials (RCTs) examining the outcomes of “polypill” therapy in cardiovascular disease prevention have yielded mixed results. We performed an electronic search through January 2023 for RCTs that examined the use... Read More about Meta-Analysis on the Clinical Outcomes With Polypills for Cardiovascular Disease Prevention.

In-hospital outcomes of acute ischaemic stroke patients with atrial septal defect. A national inpatient sample study. (2023)
Journal Article
Pana, T. A., Craigen, F., Mohamed, M. O., Mamas, M. A., & Myint, P. K. (in press). In-hospital outcomes of acute ischaemic stroke patients with atrial septal defect. A national inpatient sample study. American Journal of Cardiovascular Research, 13(3), 183-191

Atrial septal defects (ASD) are a well-recognised risk factor for acute ischaemic stroke (AIS). We aimed to delineate the relationship between ASD and in-hospital AIS outcomes (mortality, severe stroke (National Institutes of Health Stroke Scale (NIH... Read More about In-hospital outcomes of acute ischaemic stroke patients with atrial septal defect. A national inpatient sample study..

Regional variations in heart failure: a global perspective. (2023)
Journal Article
Yogeswaran, V., Hidano, D., Diaz, A. E., Van Spall, H. G. C., Mamas, M. A., Roth, G. A., & Cheng, R. K. (in press). Regional variations in heart failure: a global perspective. Heart, heartjnl-2022-321295. https://doi.org/10.1136/heartjnl-2022-321295

Heart failure (HF) is a global public health concern that affects millions of people worldwide. While there have been significant therapeutic advancements in HF over the last few decades, there remain major disparities in risk factors, treatment patt... Read More about Regional variations in heart failure: a global perspective..

Mortality across treatment strategies in intermediate-to-high risk pulmonary embolism in the modern era: A meta-analysis of observational studies and RCTs. (2023)
Journal Article
Iannaccone, M., Franchin, L., Russo, F., Botti, G., Castellano, D., Montorfano, M., …Chieffo, A. (2023). Mortality across treatment strategies in intermediate-to-high risk pulmonary embolism in the modern era: A meta-analysis of observational studies and RCTs. International Journal of Cardiology, 387, Article 131127. https://doi.org/10.1016/j.ijcard.2023.131127

Pulmonary embolism (PE) represents one of the leading causes of death worldwide and mainly treated with medical management, although the utility of more invasive approaches has emerged more recently. This meta-analysis aims to evaluate the 30-day mor... Read More about Mortality across treatment strategies in intermediate-to-high risk pulmonary embolism in the modern era: A meta-analysis of observational studies and RCTs..

Outcomes of Prediabetes Compared with Normoglycaemia and Diabetes Mellitus in Patients Undergoing Percutaneous Coronary Intervention: A Systematic Review and Meta-analysis. (2023)
Journal Article
Ahsan, M. J., Latif, A., Ahmad, S., Willman, C., Lateef, N., Shabbir, M. A., …Velagapudi, P. (in press). Outcomes of Prediabetes Compared with Normoglycaemia and Diabetes Mellitus in Patients Undergoing Percutaneous Coronary Intervention: A Systematic Review and Meta-analysis. Heart International, 17(1), 45-53. https://doi.org/10.17925/HI.2023.17.1.45

: Patients with prediabetes are at increased risk of coronary artery disease (CAD). However, the association between prediabetes and adverse clinical outcomes following percutaneous coronary intervention (PCI) is inconsistent, in contrast to outcomes... Read More about Outcomes of Prediabetes Compared with Normoglycaemia and Diabetes Mellitus in Patients Undergoing Percutaneous Coronary Intervention: A Systematic Review and Meta-analysis..

The added value of hypertonic saline solution to furosemide monotherapy in patients with acute decompensated heart failure: A meta‐analysis and trial sequential analysis (2023)
Journal Article
Diaz‐Arocutipa, C., Denegri‐Galvan, J., Vicent, L., Pariona, M., Mamas, M. A., & Hernandez, A. V. (in press). The added value of hypertonic saline solution to furosemide monotherapy in patients with acute decompensated heart failure: A meta‐analysis and trial sequential analysis. Clinical Cardiology, https://doi.org/10.1002/clc.24033

We assessed the effects of hypertonic saline solution (HSS) plus furosemide versus furosemide alone in patients with acute decompensated heart failure (ADHF). We searched four electronic databases for randomized controlled trials (RCTs) until June 30... Read More about The added value of hypertonic saline solution to furosemide monotherapy in patients with acute decompensated heart failure: A meta‐analysis and trial sequential analysis.

Risk of Venous Thromboembolism With Gout Flares (2023)
Journal Article
Cipolletta, E., Tata, L. J., Nakafero, G., Avery, A. J., Mamas, M. A., & Abhishek, A. (2023). Risk of Venous Thromboembolism With Gout Flares. Arthritis and Rheumatology, 75(9), 1638-1647. https://doi.org/10.1002/art.42480

ObjectivePrevious studies demonstrated that the risk of venous thromboembolism (VTE) is increased in patients with gout, but not whether there was a temporal association between gout flare and VTE. This study was undertaken to evaluate potential temp... Read More about Risk of Venous Thromboembolism With Gout Flares.

Trends In ST-elevation Myocardial Infarction Hospitalisation Among Young Adults: A Binational Analysis (2023)
Journal Article
Moledina, S. M., Matetic, A., Weight, N., Rashid, M., Sun, L., Fischman, D. L., …Mamas, M. A. (in press). Trends In ST-elevation Myocardial Infarction Hospitalisation Among Young Adults: A Binational Analysis. European Heart Journal - Quality of Care and Clinical Outcomes, https://doi.org/10.1093/ehjqcco/qcad035

Background ST-segment myocardial infarction (STEMI) is typically associated with increased age, but there is an important group of patients that suffer STEMI under the age of fifty, that are not well characterized in studies. Methods & Results We... Read More about Trends In ST-elevation Myocardial Infarction Hospitalisation Among Young Adults: A Binational Analysis.

Ethnic Disparities in ST-Segment Elevation Myocardial Infarction Outcomes and Processes of Care in Patients With and Without Standard Modifiable Cardiovascular Risk Factors: A Nationwide Cohort Study (2023)
Journal Article
Weight, N., Moledina, S., Sun, L., Kragholm, K., Freeman, P., Diaz-Arocutipa, C., …Mamas, M. A. (in press). Ethnic Disparities in ST-Segment Elevation Myocardial Infarction Outcomes and Processes of Care in Patients With and Without Standard Modifiable Cardiovascular Risk Factors: A Nationwide Cohort Study. Angiology, https://doi.org/10.1177/00033197231182555

Trials suggest patients with ST-elevation myocardial infarction (STEMI) without ‘standard modifiable cardiovascular risk factors’ (SMuRFs) have poorer outcomes, but the role of ethnicity has not been investigated. We analyzed 118,177 STEMI patients u... Read More about Ethnic Disparities in ST-Segment Elevation Myocardial Infarction Outcomes and Processes of Care in Patients With and Without Standard Modifiable Cardiovascular Risk Factors: A Nationwide Cohort Study.

Effects of Valvular Heart Disease on Clinical Outcomes in Sarcoidosis. (2023)
Journal Article
Hussain, B., Markson, F., Mamas, M. A., Alraies, C., Aggarwal, V., Kumar, G., …Paul, T. K. (2023). Effects of Valvular Heart Disease on Clinical Outcomes in Sarcoidosis. Current Problems in Cardiology, 48(10), Article 101866. https://doi.org/10.1016/j.cpcardiol.2023.101866

Systemic sarcoidosis can lead to heart failure, conduction abnormalities and ventricular arrhythmias although data on concomitant valvular heart disease (VHD) is limited. We reported the prevalence and outcomes of VHD in systemic sarcoidosis. A retro... Read More about Effects of Valvular Heart Disease on Clinical Outcomes in Sarcoidosis..

Predicted clinical and economic burden associated with reduction in access to acute coronary interventional care during the COVID-19 lockdown in two European countries. (2023)
Journal Article
Lunardi, M., Mamas, M. A., Mauri, J., Molina, C. M., Rodriguez-Leor, O., Eggington, S., …Solé, A. R. (in press). Predicted clinical and economic burden associated with reduction in access to acute coronary interventional care during the COVID-19 lockdown in two European countries. European Heart Journal, Article qcad025. https://doi.org/10.1093/ehjqcco/qcad025

Aims As a consequence of untimely or missed revascularization of ST-elevation myocardial infarction (STEMI) patients during the COVID-19 pandemic, many patients died at home or survived with serious sequelae, resulting in potential long-term worse p... Read More about Predicted clinical and economic burden associated with reduction in access to acute coronary interventional care during the COVID-19 lockdown in two European countries..

Intravenous iron therapy among patients with heart failure and iron deficiency: An updated meta-analysis of randomized controlled trials. (2023)
Journal Article
Hamed, M., Elseidy, S. A., Ahmed, A., Thakker, R., Mansoor, H., Khalili, H., …Elbadawi, A. (2023). Intravenous iron therapy among patients with heart failure and iron deficiency: An updated meta-analysis of randomized controlled trials. Heliyon, 9(6), Article e17245. https://doi.org/10.1016/j.heliyon.2023.e17245

Background: Randomized clinical trials (RCTs) evaluating the role of intravenous (IV) iron administration in patients with heart failure (HF) and iron deficiency (ID) have yielded inconsistent results. Methods: Electronic search of MEDLINE, EMBASE... Read More about Intravenous iron therapy among patients with heart failure and iron deficiency: An updated meta-analysis of randomized controlled trials..

Trends and predictions of metabolic risk factors for acute myocardial infarction: findings from a multiethnic nationwide cohort. (2023)
Journal Article
Chew, N. W. S., Chong, B., Kuo, S. M., Jayabaskaran, J., Cai, M., Zheng, H., …Chan, M. Y. (2023). Trends and predictions of metabolic risk factors for acute myocardial infarction: findings from a multiethnic nationwide cohort. The Lancet Regional Health - Western Pacific, 37, Article 100803. https://doi.org/10.1016/j.lanwpc.2023.100803

Understanding the trajectories of metabolic risk factors for acute myocardial infarction (AMI) is necessary for healthcare policymaking. We estimated future projections of the incidence of metabolic diseases in a multi-ethnic population with AMI. The... Read More about Trends and predictions of metabolic risk factors for acute myocardial infarction: findings from a multiethnic nationwide cohort..

Intracoronary imaging in PCI for acute coronary syndrome: Insights from British Cardiovascular Intervention Society registry. (2023)
Journal Article
Zaman, M., Stevens, C., Ludman, P., Wijeysundera, H. C., Siudak, Z., Sharp, A. S. P., …Mamas, M. A. (2023). Intracoronary imaging in PCI for acute coronary syndrome: Insights from British Cardiovascular Intervention Society registry. Cardiovascular Revascularization Medicine, 56, 50-56. https://doi.org/10.1016/j.carrev.2023.05.020

While previous studies have demonstrated the superiority of ICI-guided PCI over an angiography-based approach, there are limited data on all-comer ACS patients. This study aimed to identify the characteristics and in-hospital outcomes of patients und... Read More about Intracoronary imaging in PCI for acute coronary syndrome: Insights from British Cardiovascular Intervention Society registry..

Developing prediction models to estimate the risk of two survival outcomes both occurring: A comparison of techniques (2023)
Journal Article
Pate, A., Sperrin, M., Riley, R. D., Sergeant, J. C., Van Staa, T., Peek, N., …Martin, G. P. (2023). Developing prediction models to estimate the risk of two survival outcomes both occurring: A comparison of techniques. Statistics in Medicine, 42(18), 3184-3207. https://doi.org/10.1002/sim.9771

Introduction This study considers the prediction of the time until two survival outcomes have both occurred. We compared a variety of analytical methods motivated by a typical clinical problem of multimorbidity prognosis. Methods We considered f... Read More about Developing prediction models to estimate the risk of two survival outcomes both occurring: A comparison of techniques.

Sex-based differences in risk factors for incident myocardial infarction and stroke in the UK Biobank (2023)
Journal Article
Remfry, E., Ardissino, M., McCracken, C., Szabo, L., Neubauer, S., Harvey, N. C., …Raisi-Estabragh, Z. (in press). Sex-based differences in risk factors for incident myocardial infarction and stroke in the UK Biobank. European Heart Journal - Quality of Care and Clinical Outcomes, https://doi.org/10.1093/ehjqcco/qcad029

Aim This study examined sex-based differences in associations of vascular risk factors with incident cardiovascular events in the UK Biobank. Methods Baseline participant demographic, clinical, laboratory, anthropometric, and imaging characteris... Read More about Sex-based differences in risk factors for incident myocardial infarction and stroke in the UK Biobank.

What do we mean by complex percutaneous coronary intervention? An assessment of agreement amongst interventional cardiologists for defining complexity (2023)
Journal Article
Rjoob, K., McGilligan, V., McAllister, R., Bond, R., Doolub, G., Leslie, S. J., …Peace, A. (2023). What do we mean by complex percutaneous coronary intervention? An assessment of agreement amongst interventional cardiologists for defining complexity. Catheterization and Cardiovascular Interventions, 102(1), 1-10. https://doi.org/10.1002/ccd.30684

Epicardial Adipose Tissue Assessed by Computed Tomography and Echocardiography Are Associated With Adverse Cardiovascular Outcomes: A Systematic Review and Meta-Analysis (2023)
Journal Article
Chong, B., Jayabaskaran, J., Ruban, J., Goh, R., Chin, Y. H., Kong, G., …Chew, N. W. (2023). Epicardial Adipose Tissue Assessed by Computed Tomography and Echocardiography Are Associated With Adverse Cardiovascular Outcomes: A Systematic Review and Meta-Analysis. Circulation: Cardiovascular Imaging, 16(5), https://doi.org/10.1161/circimaging.122.015159

Epicardial adipose tissue (EAT) has garnered attention as a prognostic and risk stratification factor for cardiovascular disease. This study, via meta-analyses, evaluates the associations between EAT and cardiovascular outcomes stratified across imag... Read More about Epicardial Adipose Tissue Assessed by Computed Tomography and Echocardiography Are Associated With Adverse Cardiovascular Outcomes: A Systematic Review and Meta-Analysis.

Racial Disparities in Mortality Associated With Acute Myocardial Infarction and COVID-19 in the United States: A Nationwide Analysis (2023)
Journal Article
Muhyieddeen, A., Cheng, S., Mamas, M. A., Beasley, D., Weins, G. C., & Gulati, M. (2023). Racial Disparities in Mortality Associated With Acute Myocardial Infarction and COVID-19 in the United States: A Nationwide Analysis. Current Problems in Cardiology, 48(9), Article 101798. https://doi.org/10.1016/j.cpcardiol.2023.101798

This study assessed the COVID-19 pan-demic's impact on racial disparities in acute myocar-dial infarction (AMI) management and outcomes. We reviewed AMI patient management and outcomes in the pandemic's initial nine months, comparing COVID-19 and non... Read More about Racial Disparities in Mortality Associated With Acute Myocardial Infarction and COVID-19 in the United States: A Nationwide Analysis.

Long-term Outcomes of Acute Myocardial Infarction in Pre-existing Coronary Artery Ectasia: A Systematic Review and Meta-Analysis (2023)
Journal Article
Mamas. (2023). Long-term Outcomes of Acute Myocardial Infarction in Pre-existing Coronary Artery Ectasia: A Systematic Review and Meta-Analysis. Current Problems in Cardiology, 101626 - 101626. https://doi.org/10.1016/j.cpcardiol.2023.101626

Coronary artery ectasia is associated with an increased risk of acute myocardial infarction. This meta-analysis evaluates outcomes following acute myocardial infarction in patients with pre-existing coronary artery ectasia. A search strategy was desi... Read More about Long-term Outcomes of Acute Myocardial Infarction in Pre-existing Coronary Artery Ectasia: A Systematic Review and Meta-Analysis.

In-hospital Outcomes of Patients With and Without Previous Coronary Artery Bypass Graft Surgery Who Present With a Non-ST-Segment Elevation Myocardial Infarction (2023)
Journal Article
Dhaduk, N., Xia, Y., Feit, F., Mamas, M., Alviar, C., Keller, N., …Bangalore, S. (2023). In-hospital Outcomes of Patients With and Without Previous Coronary Artery Bypass Graft Surgery Who Present With a Non-ST-Segment Elevation Myocardial Infarction. American Journal of Cardiology, 194, 78-85. https://doi.org/10.1016/j.amjcard.2023.02.013

The clinical course of patients with a previous coronary artery bypass graft surgery (CABG) presenting with non-ST-elevation myocardial infarction (NSTEMI) is not well defined. We aimed to compare the management and outcomes of patients with and with... Read More about In-hospital Outcomes of Patients With and Without Previous Coronary Artery Bypass Graft Surgery Who Present With a Non-ST-Segment Elevation Myocardial Infarction.

Higher risk of adverse cardiovascular outcomes in females with type 2 diabetes Mellitus: an Umbrella review of systematic reviews (2023)
Journal Article
Yaow, C. Y. L., Chong, B., Chin, Y. H., Kueh, M. T. W., Ng, C. H., Chan, K. E., …Chew, N. W. S. (2023). Higher risk of adverse cardiovascular outcomes in females with type 2 diabetes Mellitus: an Umbrella review of systematic reviews. European Journal of Preventive Cardiology, 30(12), 1227–1235. https://doi.org/10.1093/eurjpc/zwad133

Background Previous studies have shown that females with type 2 diabetes mellitus (T2DM) may have excess mortality risk compared to their male counterparts. An important next step to address the high global burden of T2DM and cardiovascular disease... Read More about Higher risk of adverse cardiovascular outcomes in females with type 2 diabetes Mellitus: an Umbrella review of systematic reviews.

Socioeconomic deprivation and prognostic outcomes in acute coronary syndrome: A meta-analysis using multidimensional socioeconomic status indices (2023)
Journal Article
Anand, V. V., Zhe, E. L. C., Chin, Y. H., Goh, R. S. J., Lin, C., Kueh, M. T. W., …Chew, N. W. S. (2023). Socioeconomic deprivation and prognostic outcomes in acute coronary syndrome: A meta-analysis using multidimensional socioeconomic status indices. International Journal of Cardiology, 383, 140-150. https://doi.org/10.1016/j.ijcard.2023.04.042

Early experience of intravascular lithotripsy in unprotected calcified left main coronary artery disease (2023)
Journal Article
Hesse, K., Shahid, F., Ahmed, R., Ahmed, F., Cartlidge, T. R., Rashid, M., …Ahmed, J. M. (2023). Early experience of intravascular lithotripsy in unprotected calcified left main coronary artery disease. Cardiovascular Revascularization Medicine, 55, 33-41. https://doi.org/10.1016/j.carrev.2023.04.019

Background Treatment of unprotected severely calcified left main coronary artery (LMCA) disease is a complex interventional procedure. Intravascular lithotripsy (IVL) and rotational atherectomy (RA) are safe and effective methods of treating coronar... Read More about Early experience of intravascular lithotripsy in unprotected calcified left main coronary artery disease.

Race and sex disparities in acute outcomes of patients with acute ischemic stroke and diabetes mellitus. A national inpatient sample study (2023)
Journal Article
Thuemmler, R. J., Pana, T. A., Mohamed, M. O., Poobalan, A., Mamas, M. A., & Myint, P. K. (2023). Race and sex disparities in acute outcomes of patients with acute ischemic stroke and diabetes mellitus. A national inpatient sample study. Clinical Neurology and Neurosurgery, 229, Article 107747. https://doi.org/10.1016/j.clineuro.2023.107747

Background: Diabetes Mellitus (DM) disproportionately affects racial minority groups and is a well-established risk factor for ischemic stroke and worse stroke outcomes. Whether racial disparities exist in acute outcomes of patients presenting with... Read More about Race and sex disparities in acute outcomes of patients with acute ischemic stroke and diabetes mellitus. A national inpatient sample study.

Assessment of Paclitaxel Drug-Coated Balloon Only Angioplasty in STEMI. (2023)
Journal Article
Mamas. (2023). Assessment of Paclitaxel Drug-Coated Balloon Only Angioplasty in STEMI. JACC. Cardiovascular interventions, 16(7), 771 - 779. https://doi.org/10.1016/j.jcin.2023.01.380

BACKGROUND: Primary percutaneous coronary intervention (pPCI) with drug-eluting stents (DES) has emerged as the standard of care, but stent-related events have persisted. Drug-coated balloon (DCB)-only angioplasty is an emerging technology, although... Read More about Assessment of Paclitaxel Drug-Coated Balloon Only Angioplasty in STEMI..

Role of oesophageal cooling in the prevention of oesophageal injury in atrial fibrillation catheter ablation: a systematic review and meta-analysis of randomized controlled trials. (2023)
Journal Article
Hamed, M., Elseidy, S. A., Abdelazeem, M., Morcos, R., Abdallah, A., Sammour, Y., …Elbadawi, A. (2023). Role of oesophageal cooling in the prevention of oesophageal injury in atrial fibrillation catheter ablation: a systematic review and meta-analysis of randomized controlled trials. EP-Europace, https://doi.org/10.1093/europace/euad080

AIMS: To evaluate the efficacy of oesophageal cooling in the prevention of oesophageal injury in patients undergoing atrial fibrillation (AF) catheter ablation. METHODS AND RESULTS: Comprehensive search of MEDLINE, EMBASE, and Cochrane databases thro... Read More about Role of oesophageal cooling in the prevention of oesophageal injury in atrial fibrillation catheter ablation: a systematic review and meta-analysis of randomized controlled trials..

Short-term risk of periprocedural stroke relative to radial vs. femoral access: systematic review, meta-analysis, study sequential analysis and meta-regression of 2,188,047 real-world cardiac catheterizations. (2023)
Journal Article
Tužil, J., Matějka, J., Mamas, M. A., & Doležal, T. (2023). Short-term risk of periprocedural stroke relative to radial vs. femoral access: systematic review, meta-analysis, study sequential analysis and meta-regression of 2,188,047 real-world cardiac catheterizations. Expert Review of Cardiovascular Therapy, 293 - 304. https://doi.org/10.1080/14779072.2023.2187378

OBJECTIVES: To verify whether transradial (TRA) compared to transfemoral (TFA) cardiac catheterization reduces the risk of periprocedural stroke (PS). METHODS: We reviewed (CRD42021277918) published real-world cohorts reporting the incidence of PS wi... Read More about Short-term risk of periprocedural stroke relative to radial vs. femoral access: systematic review, meta-analysis, study sequential analysis and meta-regression of 2,188,047 real-world cardiac catheterizations..

Association of Frailty Status on the Causes and Outcomes of Patients Admitted With Cardiovascular Disease. (2023)
Journal Article
Sokhal, B., Matetić, A., Rashid, M., Protheroe, J., Partington, R., Mallen, C., & Mamas, M. (2023). Association of Frailty Status on the Causes and Outcomes of Patients Admitted With Cardiovascular Disease. American Journal of Cardiology, 7 - 15. https://doi.org/10.1016/j.amjcard.2022.12.029

Data are limited about the contemporary association between frailty and the causes and outcomes of patients admitted with cardiovascular diseases (CVD). Using the US National Inpatient Sample, CVD admissions of interest (acute myocardial infarction,... Read More about Association of Frailty Status on the Causes and Outcomes of Patients Admitted With Cardiovascular Disease..

Is high sensitivity troponin, taken regardless of a clinical indication, associated with 1 year mortality in critical care patients? (2023)
Journal Article
Hinton, J., Augustine, M., Gabara, L., Mariathas, M., Allan, R., Borca, F., …Curzen, N. (2023). Is high sensitivity troponin, taken regardless of a clinical indication, associated with 1 year mortality in critical care patients?. Journal of the Intensive Care Society, 24(4), 392-398. https://doi.org/10.1177/17511437231160078

The aim of this study was to assess whether high sensitivity troponin (hs-cTnI) is associated with 1 year mortality in critical care (CC). One year mortality data were obtained from NHS Digital for a consecutive cohort of patients admitted to general... Read More about Is high sensitivity troponin, taken regardless of a clinical indication, associated with 1 year mortality in critical care patients?.

Outcomes of ST elevation myocardial infarction in patients with cancer: a nationwide study (2023)
Journal Article
Dafaalla, M., Abdel-Qadir, H., Gale, C. P., Sun, L., López-Fernández, T., Miller, R. J. H., …Mamas, M. A. (2023). Outcomes of ST elevation myocardial infarction in patients with cancer: a nationwide study. European Heart Journal - Quality of Care and Clinical Outcomes, 9(8), 806-817. https://doi.org/10.1093/ehjqcco/qcad012

AIMS: To assess processes of care and clinical outcomes in cancer patients with ST elevation myocardial infarction (STEMI) according to cancer type. METHODS: This is a national population-based study of patients admitted with STEMI in England and Wal... Read More about Outcomes of ST elevation myocardial infarction in patients with cancer: a nationwide study.

Primary prevention of cardiovascular disease in women with a Mediterranean diet: systematic review and meta-analysis. (2023)
Journal Article
Mamas. (2023). Primary prevention of cardiovascular disease in women with a Mediterranean diet: systematic review and meta-analysis. Heart, https://doi.org/10.1136/heartjnl-2022-321930

BACKGROUND: Dietary modification is a cornerstone of cardiovascular disease (CVD) prevention. A Mediterranean diet has been associated with a lower risk of CVD but no systematic reviews have evaluated this relationship specifically in women. OBJECTIV... Read More about Primary prevention of cardiovascular disease in women with a Mediterranean diet: systematic review and meta-analysis..

Determining cardiovascular risk in patients with unattributed chest pain in UK primary care: an electronic health record study (2023)
Journal Article
Jordan, K. P., Rathod-Mistry, T., van der Windt, D. A., Bailey, J., Chen, Y., Clarson, L., …Mamas, M. A. (2023). Determining cardiovascular risk in patients with unattributed chest pain in UK primary care: an electronic health record study. European Journal of Preventive Cardiology, 30(11), 1151-1161. https://doi.org/10.1093/eurjpc/zwad055

BACKGROUND: Most adults presenting in primary care with chest pain symptoms will not receive a diagnosis ("unattributed" chest pain) but are at increased risk of cardiovascular events. AIM: To assess within patients with unattributed chest pain, risk... Read More about Determining cardiovascular risk in patients with unattributed chest pain in UK primary care: an electronic health record study.

Overcoming professional barriers encountered by women in interventional cardiology: an EAPCI statement (2023)
Journal Article
Buchanan, G. L., Paradies, V., Karam, N., Holmvang, L., Mamas, M. A., Mehilli, J., …Chieffo, A. (2023). Overcoming professional barriers encountered by women in interventional cardiology: an EAPCI statement. European Heart Journal, 44(15), 1301 - 1312. https://doi.org/10.1093/eurheartj/ehad053

Abstract Despite the increasing proportion of female medical and nursing students, there is still a significant under-representation of women working as healthcare providers in interventional cardiology, with very few of them reaching senior leadersh... Read More about Overcoming professional barriers encountered by women in interventional cardiology: an EAPCI statement.

Unplanned readmissions after Impella mechanical circulatory support (2023)
Journal Article
Kuchtaruk, A. A., Sparrow, R. T., Azzalini, L., García, S., Villablanca, P. A., Jneid, H., …Bagur, R. (2023). Unplanned readmissions after Impella mechanical circulatory support. International Journal of Cardiology, 379, 48-59. https://doi.org/10.1016/j.ijcard.2023.03.013

Background Early readmissions significantly impact on patient-wellbeing, burden the health-care system, and are important quality metrics. Data on 30-day readmission following Impella mechanical circulatory support (MCS) are unknown. We aimed to ass... Read More about Unplanned readmissions after Impella mechanical circulatory support.

Role of Cardiac Magnetic Resonance Imaging in the Evaluation of MINOCA (2023)
Journal Article
Mamas. (2023). Role of Cardiac Magnetic Resonance Imaging in the Evaluation of MINOCA. Journal of Clinical Medicine, 2017 - 2017. https://doi.org/10.3390/jcm12052017

Myocardial infarction with Non Obstructive Coronary Arteries (MINOCA) is defined by patients presenting with signs and symptoms similar to acute myocardial infarction, but are found to have non-obstructive coronary arteries angiography. What was once... Read More about Role of Cardiac Magnetic Resonance Imaging in the Evaluation of MINOCA.

Incident cardiovascular events and imaging phenotypes in UK Biobank participants with past cancer (2023)
Journal Article
Mamas, M. A., Raisi-Estabragh, Z., Cooper, J., McCracken, C., Crosbie, E. J., Walter, F. M., …Petersen, S. E. (2023). Incident cardiovascular events and imaging phenotypes in UK Biobank participants with past cancer. Heart, heartjnl-2022-321888. https://doi.org/10.1136/heartjnl-2022-321888

Objectives: To evaluate incident cardiovascular outcomes and imaging phenotypes in UK Biobank participants with previous cancer. Methods: Cancer and cardiovascular disease (CVD) diagnoses were ascertained using health record linkage. Participants wit... Read More about Incident cardiovascular events and imaging phenotypes in UK Biobank participants with past cancer.

CKD-Associated Cardiovascular Mortality in the United States: Temporal Trends From 1999 to 2020. (2023)
Journal Article
Kobo, O., Abramov, D., Davies, S., Ahmed, S. B., Sun, L. Y., Mieres, J. H., …Mamas, M. A. (2023). CKD-Associated Cardiovascular Mortality in the United States: Temporal Trends From 1999 to 2020. KIDNEY MEDICINE, 5(3), Article 100597. https://doi.org/10.1016/j.xkme.2022.100597

RATIONALE & OBJECTIVE: Chronic kidney disease (CKD) is associated with an increased risk of cardiovascular (CV) mortality, but there are limited data on temporal trends disaggregated by sex, race, and urban/rural status in this population. STUDY DESI... Read More about CKD-Associated Cardiovascular Mortality in the United States: Temporal Trends From 1999 to 2020..

Musculoskeletal pain and its impact on prognosis following acute coronary syndrome or stroke: A linked electronic health record cohort study (2023)
Journal Article
Mason, K. J., Jordan, K. P., Heron, N., Edwards, J. J., Bailey, J., Achana, F. A., …Marshall, M. (2023). Musculoskeletal pain and its impact on prognosis following acute coronary syndrome or stroke: A linked electronic health record cohort study. Musculoskeletal Care, 21(3), 749-762. https://doi.org/10.1002/msc.1748

OBJECTIVE: Musculoskeletal painful conditions are a risk factor for cardiovascular disease (CVD), but less is known about whether musculoskeletal pain also worsens prognosis from CVD. The objective was to determine whether patients with musculoskelet... Read More about Musculoskeletal pain and its impact on prognosis following acute coronary syndrome or stroke: A linked electronic health record cohort study.

Association of Diabetes Mellitus and Its Types with In-Hospital Management and Outcomes of Patients with Acute Myocardial Infarction (2023)
Journal Article
Sethupathi, P., Matetic, A., Bang, V., Myint, P. K., Rendon, I., Bagur, R., …Mamas, M. A. (2023). Association of Diabetes Mellitus and Its Types with In-Hospital Management and Outcomes of Patients with Acute Myocardial Infarction. Cardiovascular Revascularization Medicine, 52, 16-22. https://doi.org/10.1016/j.carrev.2023.02.008

Background: Diabetes mellitus (DM) is an important risk factor for adverse outcomes following acute myocardial infarction (AMI), but large-scale studies investigating the differential impact of Type 1 DM (T1DM) and Type 2 DM (T2DM) on AMI outcomes ar... Read More about Association of Diabetes Mellitus and Its Types with In-Hospital Management and Outcomes of Patients with Acute Myocardial Infarction.

Predicting Risk of Cardiotoxic Effects in Breast Cancer: Are We There Yet? (2023)
Journal Article
Averbuch, T., Mamas, M. A., & Van Spall, H. G. C. (in press). Predicting Risk of Cardiotoxic Effects in Breast Cancer: Are We There Yet?. Jama Network Open, 6(2), e230577. https://doi.org/10.1001/jamanetworkopen.2023.0577

People with breast cancer are at increased risk of cardiovascular disease, myocardial injury, and heart failure (HF) due to underlying risk factors, a proinflammatory milieu, and cancer therapy–related cardiovascular toxic effects (CTR-CVT).1 Of the... Read More about Predicting Risk of Cardiotoxic Effects in Breast Cancer: Are We There Yet?.

Outcomes with plug-based versus suture-based vascular closure device after transfemoral transcatheter aortic valve replacement: A systematic review and meta-analysis (2023)
Journal Article
Sedhom, R., Dang, A. T., Elwagdy, A., Megaly, M., Elgendy, I. Y., Zahr, F., …Mamas, M. (2023). Outcomes with plug-based versus suture-based vascular closure device after transfemoral transcatheter aortic valve replacement: A systematic review and meta-analysis. Catheterization and Cardiovascular Interventions, 101(4), 817-827. https://doi.org/10.1002/ccd.30597

AbstractBackgroundStudies comparing plug‐based (i.e., MANTA) with suture‐based (i.e., ProStar XL and ProGlide) vascular closure devices (VCDs) for large‐bore access closure after transcatheter aortic valve replacement (TAVR) have yielded mixed result... Read More about Outcomes with plug-based versus suture-based vascular closure device after transfemoral transcatheter aortic valve replacement: A systematic review and meta-analysis.

Trends and Predictions of Malnutrition and Obesity in 204 Countries and Territories: an analysis of the Global Burden of Disease Study 2019 (2023)
Journal Article
Chong, B., Jayabaskaran, J., Kong, G., Huak Chan, Y., Han Chin, Y., Goh, R., …Chew, N. W. (2023). Trends and Predictions of Malnutrition and Obesity in 204 Countries and Territories: an analysis of the Global Burden of Disease Study 2019. EClinicalMedicine, 57, 3164-3178. https://doi.org/10.1016/j.eclinm.2023.101850

Aims The effect of the COVID-19 pandemic on care and outcomes across non-COVID-19 cardiovascular (CV) diseases is unknown. A systematic review and meta-analysis was performed to quantify the effect and investigate for variation by CV disease, geogra... Read More about Trends and Predictions of Malnutrition and Obesity in 204 Countries and Territories: an analysis of the Global Burden of Disease Study 2019.

Coronary Physiologic Assessment Based on Angiography and Intracoronary Imaging (2023)
Journal Article
Reddy, M. S. H., Maddury, J., Mamas, M. A., Assa, H. V., & Kornowski, R. (2023). Coronary Physiologic Assessment Based on Angiography and Intracoronary Imaging. Indian Journal of Cardiovascular Disease in Women, 8(3), 200-210. https://doi.org/10.25259/ijcdw_15_2022

Intracoronary physiology testing has evolved as a promising diagnostic approach in the management of patients with coronary artery disease. The value of hyperemic translesional pressure ratios to estimate the functional relevance of coronary stenoses... Read More about Coronary Physiologic Assessment Based on Angiography and Intracoronary Imaging.

Meta-analysis of the effect of colchicine on C-reactive protein in patients with acute and chronic coronary syndromes (2023)
Journal Article
Alam, M., Kontopantelis, E., Mamas, M. A., Savinova, O. V., Jhaveri, A., Siddiqui, E., & Jhamnani, S. (2023). Meta-analysis of the effect of colchicine on C-reactive protein in patients with acute and chronic coronary syndromes. Coronary Artery Disease, 34(3), 210-215. https://doi.org/10.1097/mca.0000000000001220

Objective The anti-inflammatory drug colchicine has recently shown benefits in the prevention of major adverse cardiovascular events (MACE) in patients with the acute coronary syndrome (ACS) and chronic coronary syndromes (CCS). This meta-analysis... Read More about Meta-analysis of the effect of colchicine on C-reactive protein in patients with acute and chronic coronary syndromes.

Artificial intelligence-augmented analysis of contemporary procedural, mortality, and cost trends in carcinoid heart disease in a large national cohort with a focus on the “forgotten pulmonic valve” (2023)
Journal Article
Mamas. (2023). Artificial intelligence-augmented analysis of contemporary procedural, mortality, and cost trends in carcinoid heart disease in a large national cohort with a focus on the “forgotten pulmonic valve”. Frontiers in Cardiovascular Medicine, https://doi.org/10.3389/fcvm.2022.1071138

BackgroundCarcinoid heart disease is increasingly recognized and challenging to manage due to limited outcomes data. This is the largest known cohort study of valvular pathology, treatment (including pulmonary and tricuspid valve replacements [PVR an... Read More about Artificial intelligence-augmented analysis of contemporary procedural, mortality, and cost trends in carcinoid heart disease in a large national cohort with a focus on the “forgotten pulmonic valve”.

Association of Depression and Poor Mental Health With Cardiovascular Disease and Suboptimal Cardiovascular Health Among Young Adults in the United States. (2023)
Journal Article
Mamas, M. A., Kwapong, Y. A., Boakye, E., Khan, S. S., Honigberg, M. C., Martin, S. S., …Sharma, G. (2023). Association of Depression and Poor Mental Health With Cardiovascular Disease and Suboptimal Cardiovascular Health Among Young Adults in the United States. Journal of the American Heart Association, 12(3), Article e028332. https://doi.org/10.1161/jaha.122.028332

Background Depression is a nontraditional risk factor for cardiovascular disease (CVD). Data on the association of depression and poor mental health with CVD and suboptimal cardiovascular health (CVH) among young adults are limited. Methods and Resul... Read More about Association of Depression and Poor Mental Health With Cardiovascular Disease and Suboptimal Cardiovascular Health Among Young Adults in the United States..

Outcomes with catheter-directed thrombolysis vs. catheter-directed embolectomy among patients with high-risk pulmonary embolism: a nationwide analysis (2023)
Journal Article
Sedhom, R., Elbadawi, A., Megaly, M., Athar, A., Bharadwaj, A. S., Prasad, V., …Elgendy, I. Y. (2023). Outcomes with catheter-directed thrombolysis vs. catheter-directed embolectomy among patients with high-risk pulmonary embolism: a nationwide analysis. European Heart Journal: Acute Cardiovascular Care, 12(4), 224-231. https://doi.org/10.1093/ehjacc/zuad004

Aims To examine the shot-term outcomes with catheter-directed thrombolysis (CDT) vs. catheter-directed embolectomy (CDE) for high-risk pulmonary embolism (PE). Methods and results The Nationwide Readmissions Database was utilized to identify hospital... Read More about Outcomes with catheter-directed thrombolysis vs. catheter-directed embolectomy among patients with high-risk pulmonary embolism: a nationwide analysis.

Comparison of care and outcomes for myocardial infarction by heart failure status between United Kingdom and Japan. (2023)
Journal Article
Rashid, Mamas, & Dafaalla. (2023). Comparison of care and outcomes for myocardial infarction by heart failure status between United Kingdom and Japan. ESC Heart Failure, https://doi.org/10.1002/ehf2.14290

AIMS: Prognosis for ST-segment elevation myocardial infarction (STEMI) is worse when heart failure is present on admission. Understanding clinical practice in different health systems can identify areas for quality improvement initiatives to improve... Read More about Comparison of care and outcomes for myocardial infarction by heart failure status between United Kingdom and Japan..

Comparative analysis of percutaneous revascularization practice in the United States and the United Kingdom: Insights from the BMC2 and BCIS databases (2023)
Journal Article
Wanamaker, B. L., Shoaib, A., Seth, M., Sukul, D., Mamas, M. A., & Gurm, H. S. (2023). Comparative analysis of percutaneous revascularization practice in the United States and the United Kingdom: Insights from the BMC2 and BCIS databases. Catheterization and Cardiovascular Interventions, 101(3), 495-504. https://doi.org/10.1002/ccd.30567

BACKGROUND: International registry comparisons provide insight into regional differences in clinical practice patterns, procedural outcomes, and general trends in population health and resource utilization in percutaneous coronary intervention (PCI).... Read More about Comparative analysis of percutaneous revascularization practice in the United States and the United Kingdom: Insights from the BMC2 and BCIS databases.

The prognostic value of including non‐alcoholic fatty liver disease in the definition of metabolic syndrome (2023)
Journal Article
Fu, C. E., Yong, J. N., Ng, C. H., Nah, B., Chew, N. W. S., Chin, Y. H., …Muthiah, M. (2023). The prognostic value of including non‐alcoholic fatty liver disease in the definition of metabolic syndrome. Alimentary pharmacology & therapeutics, 57(9), 979-987. https://doi.org/10.1111/apt.17397

Background/Aims Metabolic syndrome (MetS) affects over one third of the US adult population. Despite its close association with non-alcoholic fatty liver disease (NAFLD), the traditional definition of MetS does not account for the presence of NAFLD.... Read More about The prognostic value of including non‐alcoholic fatty liver disease in the definition of metabolic syndrome.

The global syndemic of metabolic diseases in the young adult population: A consortium of trends and projections from the Global Burden of Disease 2000–2019 (2023)
Journal Article
Mamas. (2023). The global syndemic of metabolic diseases in the young adult population: A consortium of trends and projections from the Global Burden of Disease 2000–2019. Metabolism, 141, Article 155402. https://doi.org/10.1016/j.metabol.2023.155402

Background: A significant proportion of premature deaths globally are related to metabolic diseases in young adults. We examined the global trends and mortality of metabolic diseases in individuals aged below 40 years using data from the Global Burde... Read More about The global syndemic of metabolic diseases in the young adult population: A consortium of trends and projections from the Global Burden of Disease 2000–2019.

The impact of the COVID-19 pandemic on cardiovascular disease prevention and management. (2023)
Journal Article
Mamas, M., Scourfield, A., Dale, C., Takhar, R., Carragher, R., Katsoulis, M., …Thygesen, J. (2023). The impact of the COVID-19 pandemic on cardiovascular disease prevention and management. Nature Medicine, 219 - 225. https://doi.org/10.1038/s41591-022-02158-7

How the Coronavirus Disease 2019 (COVID-19) pandemic has affected prevention and management of cardiovascular disease (CVD) is not fully understood. In this study, we used medication data as a proxy for CVD management using routinely collected, de-id... Read More about The impact of the COVID-19 pandemic on cardiovascular disease prevention and management..

Temporal Trends in In-Hospital Outcomes Following Unprotected Left-Main Percutaneous Coronary Intervention: An Analysis of 14 522 Cases From British Cardiovascular Intervention Society Database 2009 to 2017 (2023)
Journal Article
Kinnaird, T., Gallagher, S., Farooq, V., Protty, M., Back, L., Devlin, P., …Curzen, N. (2023). Temporal Trends in In-Hospital Outcomes Following Unprotected Left-Main Percutaneous Coronary Intervention: An Analysis of 14 522 Cases From British Cardiovascular Intervention Society Database 2009 to 2017. Circulation: Cardiovascular Interventions, 16(1), Article e012350. https://doi.org/10.1161/CIRCINTERVENTIONS.122.012350

Background: Percutaneous coronary intervention (PCI) is increasingly used as a treatment option for unprotected left main stem artery (unprotected left main stem percutaneous intervention) disease. However, whether patient outcomes have improved over... Read More about Temporal Trends in In-Hospital Outcomes Following Unprotected Left-Main Percutaneous Coronary Intervention: An Analysis of 14 522 Cases From British Cardiovascular Intervention Society Database 2009 to 2017.

Sex-Specific Outcomes of Acute Stroke in Patients with Systemic Lupus Erythematosus: A National Inpatient Sample Study. (2023)
Journal Article
Carter, B., Jesenakova, S., Pana, T., Mohamed, M., Mamas, M., Myint, P., & Hollick, R. (2023). Sex-Specific Outcomes of Acute Stroke in Patients with Systemic Lupus Erythematosus: A National Inpatient Sample Study. Journal of Clinical Medicine, https://doi.org/10.3390/jcm12020462

Background: Systemic lupus erythematosus (SLE) is an autoimmune disorder associated with increased stroke risk. Its association with stroke outcomes remains poorly understood. In this study, we aimed to compare the sex-specific SLE-associated acute s... Read More about Sex-Specific Outcomes of Acute Stroke in Patients with Systemic Lupus Erythematosus: A National Inpatient Sample Study..

Association between cancer, CHA2DS2VASc risk, and in-hospital ischaemic stroke in patients hospitalized for atrial fibrillation (2023)
Journal Article
Matetic, A., Mohamed, M. O., Essien, U. R., Guha, A., Elkaryoni, A., Elbadawi, A., …Mamas, M. A. (2023). Association between cancer, CHA2DS2VASc risk, and in-hospital ischaemic stroke in patients hospitalized for atrial fibrillation. European Heart Journal - Quality of Care and Clinical Outcomes, 9(8), 749-757. https://doi.org/10.1093/ehjqcco/qcac090

Background Atrial fibrillation (AF) is commonly encountered in cancer patients. We investigated the CHA2DS2VASc score, and its association with in-hospital ischaemic stroke in patients with cancer who were hospitalized for AF. Methods and results Usi... Read More about Association between cancer, CHA2DS2VASc risk, and in-hospital ischaemic stroke in patients hospitalized for atrial fibrillation.

Sex differences in the etiology and burden of heart failure across country income level: analysis of 204 countries and territories 1990–2019 (2022)
Journal Article
Wei, S., Miranda, J. J., Mamas, M. A., Zühlke, L. J., Kontopantelis, E., Thabane, L., & Van Spall, H. G. C. (2023). Sex differences in the etiology and burden of heart failure across country income level: analysis of 204 countries and territories 1990–2019. European Heart Journal - Quality of Care and Clinical Outcomes, 9(7), 662-672. https://doi.org/10.1093/ehjqcco/qcac088

Background Heart failure (HF) is a global epidemic. Objective To assess global sex differences in HF epidemiology across country income levels. Methods and results Using Global Burden of Disease (GBD) data from 204 countries and territories 1990–2019... Read More about Sex differences in the etiology and burden of heart failure across country income level: analysis of 204 countries and territories 1990–2019.

Phenotyping for percutaneous coronary intervention and long-term recurrent weighted outcomes (2022)
Journal Article
Mamas. (2022). Phenotyping for percutaneous coronary intervention and long-term recurrent weighted outcomes. International Journal of Cardiology, 374, 12 - 19. https://doi.org/10.1016/j.ijcard.2022.12.035

Introduction Percutaneous coronary interventions (PCI) are often performed in multimorbid patients with heterogeneous characteristics and variable clinical outcomes. We aimed to identify distinct clinical phenotypes utilizing machine learning and exp... Read More about Phenotyping for percutaneous coronary intervention and long-term recurrent weighted outcomes.

Social Deprivation and Post-TAVR Outcomes in Ontario, Canada: A Population-Based Study. (2022)
Journal Article
Patel, R. V., Ravindran, M., Qiu, F., Manoragavan, R., Sud, M., Tam, D. Y., …Wijeysundera, H. C. (2023). Social Deprivation and Post-TAVR Outcomes in Ontario, Canada: A Population-Based Study. Journal of the American Heart Association, 12(1), Article e028144. https://doi.org/10.1161/JAHA.122.028144

Background Transcatheter aortic valve replacement (TAVR)/intervention has become the standard of care for treatment of severe aortic stenosis across the spectrum of risk. There are socioeconomic disparities in access to TAVR. The impact of these disp... Read More about Social Deprivation and Post-TAVR Outcomes in Ontario, Canada: A Population-Based Study..

Post-infarction ventricular septal defect: percutaneous or surgical management in the UK national registry (2022)
Journal Article
Mamas. (2022). Post-infarction ventricular septal defect: percutaneous or surgical management in the UK national registry. European Heart Journal, 5020-5032. https://doi.org/10.1093/eurheartj/ehac511

Background and Aims Postinfarction ventricular septal defect (PIVSD) is a mechanical complication of myocardial infarction (MI) with a poor prognosis. Surgical repair is the mainstay of treatment, although percutaneous closure is increasingly underta... Read More about Post-infarction ventricular septal defect: percutaneous or surgical management in the UK national registry.

Sex differences in clinical profile and outcome after percutaneous coronary intervention for chronic total occlusion. (2022)
Journal Article
Mamas, & Rashid. (2022). Sex differences in clinical profile and outcome after percutaneous coronary intervention for chronic total occlusion. Cardiovascular Revascularization Medicine, 49, 34-41. https://doi.org/10.1016/j.carrev.2022.12.005

BACKGROUND: There are limited data around sex differences in the risk profile, treatments and outcomes of percutaneous coronary intervention (PCI) in chronic total occlusion (CTO) lesions in contemporary interventional practice. We investigated the i... Read More about Sex differences in clinical profile and outcome after percutaneous coronary intervention for chronic total occlusion..

Temporal trends of hospitalizations, comorbidity burden and in-hospital outcomes in patients admitted with asthma in the United States: Population-based study. (2022)
Journal Article
Mamas. (2022). Temporal trends of hospitalizations, comorbidity burden and in-hospital outcomes in patients admitted with asthma in the United States: Population-based study. PloS one, e0276731 - ?. https://doi.org/10.1371/journal.pone.0276731

BACKGROUND: Asthma is a prevalent chronic respiratory condition and remains a common cause for hospitalization. However, contemporary data on asthma hospitalization rates, comorbidity burden, and in-hospital outcomes are lacking. METHODS: Survey-... Read More about Temporal trends of hospitalizations, comorbidity burden and in-hospital outcomes in patients admitted with asthma in the United States: Population-based study..

Aortic valve treatment: from the first aortic valve replacement to the last decade of revolution (2022)
Journal Article
Paradies, V., & Mamas, M. A. (2022). Aortic valve treatment: from the first aortic valve replacement to the last decade of revolution. Heart, heartjnl-2022-321933. https://doi.org/10.1136/heartjnl-2022-321933

The first aortic valve replacement (AVR) from a human patient performed in 1962 marked the beginning of an evidence-based journey of open-heart surgery for aortic valve stenosis (AVS). Surgical aortic valve replacement (SAVR) has long been the standa... Read More about Aortic valve treatment: from the first aortic valve replacement to the last decade of revolution.

Comparison of Transfemoral versus Transsubclavian/Transaxillary access for transcatheter aortic valve replacement: A systematic review and meta-analysis (2022)
Journal Article
Mamas. (2022). Comparison of Transfemoral versus Transsubclavian/Transaxillary access for transcatheter aortic valve replacement: A systematic review and meta-analysis. https://doi.org/10.1016/j.ijcha.2022.101156

Femoral access is the gold standard for transcatheter aortic valve replacement (TAVR). Safe alternative access, that represents about 15 % of TAVR cases, remains important for patients without adequate transfemoral access. We aimed to perform a syste... Read More about Comparison of Transfemoral versus Transsubclavian/Transaxillary access for transcatheter aortic valve replacement: A systematic review and meta-analysis.

Mortality in ST-segment elevation myocardial infarction patients without standard modifiable risk factors: A race disaggregated analysis. (2022)
Journal Article
Mamas, & Rashid. (2022). Mortality in ST-segment elevation myocardial infarction patients without standard modifiable risk factors: A race disaggregated analysis. https://doi.org/10.1016/j.ijcha.2022.101135

Background: Individuals who present with STEMI without the standard cardiovascular risk factors (SMuRFs) of diabetes, hypercholesterolemia, hypertension, and smoking, coined SMuRF-less are not uncommon. Little is known about their outcomes as a cohor... Read More about Mortality in ST-segment elevation myocardial infarction patients without standard modifiable risk factors: A race disaggregated analysis..

Differential remodelling of mitochondrial subpopulations and mitochondrial dysfunction are a feature of early stage diabetes (2022)
Journal Article
Mamas. (2022). Differential remodelling of mitochondrial subpopulations and mitochondrial dysfunction are a feature of early stage diabetes. Scientific reports, https://doi.org/10.1038/s41598-022-04929-1

AbstractMitochondrial dysfunction is a feature of type I and type II diabetes, but there is a lack of consistency between reports and links to disease development. We aimed to investigate if mitochondrial structure–function remodelling occurs in the... Read More about Differential remodelling of mitochondrial subpopulations and mitochondrial dysfunction are a feature of early stage diabetes.

Has the first year of the COVID-19 pandemic reversed the trends in CV mortality between 1999-2019 in the United States? (2022)
Journal Article
Mamas. (2022). Has the first year of the COVID-19 pandemic reversed the trends in CV mortality between 1999-2019 in the United States?. European Heart Journal - Quality of Care and Clinical Outcomes, https://doi.org/10.1093/ehjqcco/qcac080

Aims Although cardiovascular (CV) mortality increased during the COVID-19 pandemic, little is known about how these patterns varied across key subgroups, include age, sex, and race and ethnicity, as well as by specific cause of CV death. Methods... Read More about Has the first year of the COVID-19 pandemic reversed the trends in CV mortality between 1999-2019 in the United States?.

Invasive Management and In-Hospital Outcomes of Myocardial Infarction Patients in United States Safety-Net Hospitals. (2022)
Journal Article
Mamas. (2022). Invasive Management and In-Hospital Outcomes of Myocardial Infarction Patients in United States Safety-Net Hospitals. Cardiovascular Revascularization Medicine, 49, 7 - 12. https://doi.org/10.1016/j.carrev.2022.11.006

AIM: Safety-net hospitals (SNHs) look after a higher proportion of uninsured patients and are often located in deprived areas. This study aimed to determine whether there are differences in the clinical characteristics, treatments and outcomes of pat... Read More about Invasive Management and In-Hospital Outcomes of Myocardial Infarction Patients in United States Safety-Net Hospitals..

Effects of the COVID-19 pandemic on secondary care for cardiovascular disease in the UK: an electronic health record analysis across three countries. (2022)
Journal Article
Wright, F. L., Cheema, K., Goldacre, R., Hall, N., Herz, N., Islam, N., …Banerjee, A. (2023). Effects of the COVID-19 pandemic on secondary care for cardiovascular disease in the UK: an electronic health record analysis across three countries. European Heart Journal - Quality of Care and Clinical Outcomes, 9(4), 377-388. https://doi.org/10.1093/ehjqcco/qcac077

Background Although morbidity and mortality from COVID-19 have been widely reported, the indirect effects of the pandemic beyond 2020 on other major diseases and health service activity have not been well described. Methods and results Analyses... Read More about Effects of the COVID-19 pandemic on secondary care for cardiovascular disease in the UK: an electronic health record analysis across three countries..

Palliative Care Utilization Among Hospitalized Patients With Common Chronic Conditions in the United States. (2022)
Journal Article
Rashid, & Mamas. (2022). Palliative Care Utilization Among Hospitalized Patients With Common Chronic Conditions in the United States. Journal of Palliative Care, 8258597221136733 - ?. https://doi.org/10.1177/08258597221136733

Objective: Limited data exist around the receipt of palliative care (PC) in patients hospitalized with common chronic conditions. We studied the independent predictors, temporal trends in rates of PC utilization in patients hospitalized with acute ex... Read More about Palliative Care Utilization Among Hospitalized Patients With Common Chronic Conditions in the United States..

Palliative Care Use in Patients With Acute Myocardial Infarction and Do-Not-Resuscitate Status From a Nationwide Inpatient Cohort. (2022)
Journal Article
Mamas. (2022). Palliative Care Use in Patients With Acute Myocardial Infarction and Do-Not-Resuscitate Status From a Nationwide Inpatient Cohort. Mayo Clinic Proceedings, 98(4), 569-578. https://doi.org/10.1016/j.mayocp.2022.08.018

OBJECTIVE: To examine the predictors, treatments, and outcomes of the use of palliative care in patients hospitalized with acute myocardial infarction (AMI) who had a do-not-resuscitate (DNR) order. PATIENTS AND METHODS: Using the National (Natio... Read More about Palliative Care Use in Patients With Acute Myocardial Infarction and Do-Not-Resuscitate Status From a Nationwide Inpatient Cohort..

Impact of Sex on Clinical Outcomes in Patients undergoing Complex Percutaneous Coronary Angioplasty (from the e-ULTIMASTER Study) (2022)
Journal Article
Mamas. (2022). Impact of Sex on Clinical Outcomes in Patients undergoing Complex Percutaneous Coronary Angioplasty (from the e-ULTIMASTER Study). American Journal of Cardiology, 186, 71 - 79. https://doi.org/10.1016/j.amjcard.2022.10.023

Female gender has been shown to be associated with worse clinical outcomes after percutaneous coronary intervention (PCI). However, the impact of gender on the clinical outcomes of complex PCI is still poorly understood. This study examined the diffe... Read More about Impact of Sex on Clinical Outcomes in Patients undergoing Complex Percutaneous Coronary Angioplasty (from the e-ULTIMASTER Study).

The relationship between nutritional status at the time of stroke on adverse outcomes: a systematic review and meta-analysis of prospective cohort studies. (2022)
Journal Article
Mamas, M. (2022). The relationship between nutritional status at the time of stroke on adverse outcomes: a systematic review and meta-analysis of prospective cohort studies. Nutrition Reviews, 2275 - 2287. https://doi.org/10.1093/nutrit/nuac034

CONTEXT AND OBJECTIVE: The impact of existing malnutrition on stroke outcomes is poorly recognised and treated. Evidence was systematically reviewed and quantified by meta-analysis. METHODS: MEDLINE, EMBASE and Web of Science were searched from incep... Read More about The relationship between nutritional status at the time of stroke on adverse outcomes: a systematic review and meta-analysis of prospective cohort studies..

Screening for atrial fibrillation in the elderly: A network meta-analysis of randomized trials. (2022)
Journal Article
Elbadawi, A., Sedhom, R., Gad, M., Hamed, M., Elwagdy, A., Barakat, A. F., …Jneid, H. (2022). Screening for atrial fibrillation in the elderly: A network meta-analysis of randomized trials. European Journal of Internal Medicine, 105, 38 - 45. https://doi.org/10.1016/j.ejim.2022.07.015

BACKGROUND: Randomized controlled trials (RCTs) investigating the optimal screening strategy for atrial fibrillation (AF) have yielded conflicting results. OBJECTIVE: To examine the comparative efficacy of different AF screening strategies in old... Read More about Screening for atrial fibrillation in the elderly: A network meta-analysis of randomized trials..

Impact of QRS Duration on Non–ST-Segment Elevation Myocardial Infarction (from a National Registry) (2022)
Journal Article
Mamas. (2022). Impact of QRS Duration on Non–ST-Segment Elevation Myocardial Infarction (from a National Registry). American Journal of Cardiology, 1 - 7. https://doi.org/10.1016/j.amjcard.2022.07.039

QRS duration (QRSd) is ill-defined and under-researched as a prognosticator in patients with non–ST-segment myocardial infarction (NSTEMI). We analyzed 240,866 adult (=18 years) hospitalizations with non–ST-segment elevation myocardial infarction usi... Read More about Impact of QRS Duration on Non–ST-Segment Elevation Myocardial Infarction (from a National Registry).

Derivation and External Validation of a Clinical Model to Predict Heart Failure Onset in Patients with Incident Diabetes (2022)
Journal Article
Mamas. (2022). Derivation and External Validation of a Clinical Model to Predict Heart Failure Onset in Patients with Incident Diabetes. Diabetes Care, 2737-2745. https://doi.org/10.2337/dc22-0894

OBJECTIVE Heart failure (HF) often develops in patients with diabetes and is recognized for its role in increased cardiovascular morbidity and mortality in this population. Most existing models predict risk in patients with prevalent rather than i... Read More about Derivation and External Validation of a Clinical Model to Predict Heart Failure Onset in Patients with Incident Diabetes.

Outcomes of acute myocardial infarction in patients with preexisting physical disability: a report in the United States. (2022)
Journal Article
Mamas. (2022). Outcomes of acute myocardial infarction in patients with preexisting physical disability: a report in the United States. https://doi.org/10.1080/14779072.2022.2138858

BACKGROUND: A significant proportion of the world's population lives with physical disability (PD) requiring healthcare services. Risk factors for cardiovascular disease (CVD) such as hypertension and diabetes are more prevalent among patients with P... Read More about Outcomes of acute myocardial infarction in patients with preexisting physical disability: a report in the United States..

Socioeconomic Factors and their Impact on Access and Use of Coronary and Structural Interventions (2022)
Journal Article
Bullock-Palmer, R. P., Bravo-Jaimes, K., Mamas, M. A., & Grines, C. L. (2022). Socioeconomic Factors and their Impact on Access and Use of Coronary and Structural Interventions. European Cardiology Review, 17, https://doi.org/10.15420/ecr.2022.23

In the past few decades, the accelerated improvement in technology has allowed the development of new and effective coronary and structural heart disease interventions. There has been inequitable patient access to these advanced therapies and signifi... Read More about Socioeconomic Factors and their Impact on Access and Use of Coronary and Structural Interventions.

Phenotypical differences in the characteristics of a population affects both the mortality and the performance of a risk-scoring model. (2022)
Journal Article
Moledina, S. M., Kontopantelis, E., & Mamas, M. (2022). Phenotypical differences in the characteristics of a population affects both the mortality and the performance of a risk-scoring model. European Heart Journal, 4212 - ?. https://doi.org/10.1093/eurheartj/ehac477

This commentary refers to ‘Ethnicity-dependent performance of the Global Registry of Acute Coronary Events risk score for prediction of non-ST-segment elevation myocardial infarction in-hospital mortality: nationwide cohort study’, by S.M. Moledina e... Read More about Phenotypical differences in the characteristics of a population affects both the mortality and the performance of a risk-scoring model..

Prevalence, characteristics and mortality of cancer patients undergoing pericardiocentesis in the United States between 2004 and 2017. (2022)
Journal Article
Mamas, & Rashid. (2022). Prevalence, characteristics and mortality of cancer patients undergoing pericardiocentesis in the United States between 2004 and 2017. Cancer Medicine, https://doi.org/10.1002/cam4.5373

BACKGROUND: Pericardiocentesis is undertaken in patients with cancer for diagnostic and therapeutic purposes. However, there are limited data on the frequency, characteristics and mortality of patients with different cancers undergoing pericardiocent... Read More about Prevalence, characteristics and mortality of cancer patients undergoing pericardiocentesis in the United States between 2004 and 2017..

Left Main Stem Percutaneous Coronary Intervention: Does On-Site Surgical Cover Make a Difference? (2022)
Journal Article
Mamas, M. A., Rashid, M., Zaman, M., Ludman, P., Wijeysundera, H. C., Curzen, N., …Grines, C. L. (2022). Left Main Stem Percutaneous Coronary Intervention: Does On-Site Surgical Cover Make a Difference?. Circulation: Cardiovascular Interventions, 15(10), Article e012037. https://doi.org/10.1161/circinterventions.122.012037

Background: Nonsurgical centers (NSC) contribute significantly to the capacity of overall percutaneous coronary intervention (PCI) in the United Kingdom. Although previous studies have demonstrated similar PCI outcomes in surgical centers (SC) versus... Read More about Left Main Stem Percutaneous Coronary Intervention: Does On-Site Surgical Cover Make a Difference?.

Indirect effects of the first two years of the COVID-19 pandemic on secondary care for cardiovascular disease in the UK: an electronic health record analysis across three countries (2022)
Journal Article
Mamas. (2022). Indirect effects of the first two years of the COVID-19 pandemic on secondary care for cardiovascular disease in the UK: an electronic health record analysis across three countries. https://doi.org/10.1101/2022.10.13.22281031

Background Although morbidity and mortality from COVID-19 have been widely reported, the indirect effects of the pandemic beyond 2020 on other major diseases and health service activity have not been well described. Methods Analyses used national adm... Read More about Indirect effects of the first two years of the COVID-19 pandemic on secondary care for cardiovascular disease in the UK: an electronic health record analysis across three countries.

Current status of perioperative temporary mechanical circulatory support during cardiac surgery. (2022)
Journal Article
Mamas. (2022). Current status of perioperative temporary mechanical circulatory support during cardiac surgery. Journal of Cardiac Surgery, https://doi.org/10.1111/jocs.17020

OBJECTIVES: We sought to determine utilization and outcomes of perioperative temporary mechanical circulatory support (tMCS) in the current practice of cardiac surgery. BACKGROUND: tMCS is an evolving adjunct to cardiac surgery not fully characterize... Read More about Current status of perioperative temporary mechanical circulatory support during cardiac surgery..

Relationship of Neighbourhood Social Deprivation and Ethnicity on Access to Transcatheter and Surgical Aortic Valve Replacement: A Population-Level Study. (2022)
Journal Article
Marcus, G., Dahir, M., Qiu, F., Manoragavan, R., Austin, P. C., Roifman, I., …Wijeysundera, H. C. (2022). Relationship of Neighbourhood Social Deprivation and Ethnicity on Access to Transcatheter and Surgical Aortic Valve Replacement: A Population-Level Study. https://doi.org/10.1016/j.cjca.2022.10.002

BACKGROUND: Wide geographic variation in access to transcatheter (TAVR) and surgical (SAVR) aortic valve replacement exists, but the impact of socioethnic factors on the geographic variation of AS management in Ontario, Canada, is unknown. METHODS: N... Read More about Relationship of Neighbourhood Social Deprivation and Ethnicity on Access to Transcatheter and Surgical Aortic Valve Replacement: A Population-Level Study..

Relationship of Neighbourhood Social Deprivation and Ethnicity on Access to Transcatheter and Surgical Aortic Valve A (2022)
Journal Article
Marcus, G., Dahir, M., Qiu, F., Manoragavan, R., Austin, P. C., Roifman, I., …Wijeysundera, H. C. (2023). Relationship of Neighbourhood Social Deprivation and Ethnicity on Access to Transcatheter and Surgical Aortic Valve A. Canadian Journal of Cardiology, 39(1), 22-31. https://doi.org/10.1016/j.cjca.2022.10.0020828-282X

Background Wide geographic variation in access to transcatheter (TAVR) and surgical (SAVR) aortic valve replacement exists, but the impact of socioethnic factors on the geographic variation of AS management in Ontario, Canada, is unknown. Methods... Read More about Relationship of Neighbourhood Social Deprivation and Ethnicity on Access to Transcatheter and Surgical Aortic Valve A.

Impact of Left Ventricular End-Diastolic Pressure on the Outcomes of Patients Undergoing Percutaneous Coronary Intervention. (2022)
Journal Article
Mamas. (2022). Impact of Left Ventricular End-Diastolic Pressure on the Outcomes of Patients Undergoing Percutaneous Coronary Intervention. The American Journal of Cardiology, 107 - 114. https://doi.org/10.1016/j.amjcard.2022.09.007

Left ventricular end-diastolic pressure (LVEDP) is an important hemodynamic marker of left ventricular performance and affects coronary perfusion. We evaluated the association of LVEDP with patient outcomes after elective or urgent percutaneous coron... Read More about Impact of Left Ventricular End-Diastolic Pressure on the Outcomes of Patients Undergoing Percutaneous Coronary Intervention..

Data standards for transcatheter aortic valve implantation: the European Unified Registries for Heart Care Evaluation and Randomised Trials (EuroHeart) (2022)
Journal Article
Aktaa, S., Batra, G., James, S. K., Blackman, D. J., Ludman, P. F., Mamas, M., …Gale, C. P. (2023). Data standards for transcatheter aortic valve implantation: the European Unified Registries for Heart Care Evaluation and Randomised Trials (EuroHeart). European Heart Journal - Quality of Care and Clinical Outcomes, 9(5), 529-536. https://doi.org/10.1093/ehjqcco/qcac063

Aims Standardized data definitions are necessary for the quantification of quality of care and patient outcomes in observational studies and randomised controlled trials (RCTs). The European Unified Registries for Heart Care Evaluation and Randomised... Read More about Data standards for transcatheter aortic valve implantation: the European Unified Registries for Heart Care Evaluation and Randomised Trials (EuroHeart).

Temporal trends and patterns in atrial fibrillation incidence: a population-based study of 3.4 million individuals (2022)
Journal Article
Mamas. (2022). Temporal trends and patterns in atrial fibrillation incidence: a population-based study of 3.4 million individuals. European Heart Journal, https://doi.org/10.1093/eurheartj/ehac544.528

Background Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia worldwide; confers an increased risk of adverse outcomes and once diagnosed most patients will require lifelong-treatment. Population-based studies of AF incidence ar... Read More about Temporal trends and patterns in atrial fibrillation incidence: a population-based study of 3.4 million individuals.

Ethnic disparities in ST-segment myocardial infarction outcomes and processes of care in patients with and without standard modifiable cardiovascular risk factors: a nationwide cohort study (2022)
Journal Article
Mamas. (2022). Ethnic disparities in ST-segment myocardial infarction outcomes and processes of care in patients with and without standard modifiable cardiovascular risk factors: a nationwide cohort study. European Heart Journal, https://doi.org/10.1093/eurheartj/ehac544.1179

Background There is growing interest in patients presenting with ST-elevation myocardial infarction (STEMI) in the absence of `standard modifiable cardiovascular risk factors' (SMuRFs), which include current smoking, hypertension, diabetes and hyperc... Read More about Ethnic disparities in ST-segment myocardial infarction outcomes and processes of care in patients with and without standard modifiable cardiovascular risk factors: a nationwide cohort study.

To compare efficacy and safety of direct oral anticoagulants in patients with concurrent atrial fibrillation and bioprosthetic heart valve repair or replacement: a systematic review and meta-analysis (2022)
Journal Article
Mamas. (2022). To compare efficacy and safety of direct oral anticoagulants in patients with concurrent atrial fibrillation and bioprosthetic heart valve repair or replacement: a systematic review and meta-analysis. European Heart Journal, https://doi.org/10.1093/eurheartj/ehac544.1630

Abstract Background Use of direct oral anticoagulants (DOACs) is contraindicated in patients with mechanical valves. However data on their use in patients with atrial fibrillation (AF) and bioprosthetic valves (BV) is still limited. Purpose To ass... Read More about To compare efficacy and safety of direct oral anticoagulants in patients with concurrent atrial fibrillation and bioprosthetic heart valve repair or replacement: a systematic review and meta-analysis.

Comparing direct oral anticoagulants versus vitamin K antagonist in patients with atrial fibrillation after transcatheter aortic valve replacement: an updated meta-analysis (2022)
Journal Article
Mamas. (2022). Comparing direct oral anticoagulants versus vitamin K antagonist in patients with atrial fibrillation after transcatheter aortic valve replacement: an updated meta-analysis. European Heart Journal, https://doi.org/10.1093/eurheartj/ehac544.1631

Abstract Background Oral anticoagulation therapy is indicated for patients undergoing transcatheter aortic valve replacement (TAVR) with concomitant or new onset atrial fibrillation (AF). However the data on optimal anticoagulation regimen in this p... Read More about Comparing direct oral anticoagulants versus vitamin K antagonist in patients with atrial fibrillation after transcatheter aortic valve replacement: an updated meta-analysis.

Sex-based differences of the impact of aortic valve calcium score on mortality and post-procedural outcomes after trans-catheter aortic valve replacement (2022)
Journal Article
Mamas. (2022). Sex-based differences of the impact of aortic valve calcium score on mortality and post-procedural outcomes after trans-catheter aortic valve replacement. European Heart Journal, https://doi.org/10.1093/eurheartj/ehac544.134

Abstract Introduction Sex based differences exist in the presentation, outcomes, and management of cardiovascular diseases. Although aortic valve calcium (AVC) score has been postulated to be associated with post-procedural outcomes after transcathe... Read More about Sex-based differences of the impact of aortic valve calcium score on mortality and post-procedural outcomes after trans-catheter aortic valve replacement.

Saphenous Vein Graft Intervention. (2022)
Journal Article
Bharadwaj, A. S., & Mamas, M. (2022). Saphenous Vein Graft Intervention. Interventional Cardiology Clinics, 383 - 391. https://doi.org/10.1016/j.iccl.2022.05.001

Even though saphenous vein grafts (SVGs) are the most commonly used surgical conduits, their long-term patency is limited by accelerated atherosclerosis often resulting in acute coronary syndrome or asymptomatic occlusion. SVG intervention is associa... Read More about Saphenous Vein Graft Intervention..

Cardiovascular outcomes and trends of Transcatheter vs. Surgical aortic valve replacement among octogenarians with heart failure: A Propensity Matched national cohort analysis. (2022)
Journal Article
Mamas, & Rashid. (2022). Cardiovascular outcomes and trends of Transcatheter vs. Surgical aortic valve replacement among octogenarians with heart failure: A Propensity Matched national cohort analysis

Background: Heart failure (HF) is a complex clinical syndrome with symptoms and signs that result from any structural or functional impairment of ventricular filling or ejection of blood. Limited data is available regarding the in-hospital outcomes o... Read More about Cardiovascular outcomes and trends of Transcatheter vs. Surgical aortic valve replacement among octogenarians with heart failure: A Propensity Matched national cohort analysis..

Sex-Specific Considerations in Degenerative Aortic Stenosis for Female-Tailored Transfemoral Aortic Valve Implantation Management (2022)
Journal Article
Masiero, G., Paradies, V., Franzone, A., Bellini, B., De Biase, C., Karam, N., …Chieffo, A. (2022). Sex-Specific Considerations in Degenerative Aortic Stenosis for Female-Tailored Transfemoral Aortic Valve Implantation Management. Journal of the American Heart Association, 11(19), 1-15. https://doi.org/10.1161/jaha.121.025944

The impact of sex on pathophysiological processes, clinical presentation, treatment options, as well as outcomes of degenerative aortic stenosis remain poorly understood. Female patients are well represented in transfemoral aortic valve implantation... Read More about Sex-Specific Considerations in Degenerative Aortic Stenosis for Female-Tailored Transfemoral Aortic Valve Implantation Management.

Impact of Intracoronary Imaging‐Guided Percutaneous Coronary Intervention on Procedural Outcomes Among Complex Patient Groups (2022)
Journal Article
Mohamed, M. O., Kinnaird, T., Wijeysundera, H. C., Johnson, T. W., Zaman, S., Rashid, M., …Mamas, M. A. (2022). Impact of Intracoronary Imaging‐Guided Percutaneous Coronary Intervention on Procedural Outcomes Among Complex Patient Groups. Journal of the American Heart Association, 11(19), 1-17. https://doi.org/10.1161/jaha.122.026500

Background Intracoronary imaging (ICI) has been shown to improve survival after percutaneous coronary intervention (PCI). Whether this prognostic benefit is sustained across different indications remains unclear. Methods and Results All PCI procedure... Read More about Impact of Intracoronary Imaging‐Guided Percutaneous Coronary Intervention on Procedural Outcomes Among Complex Patient Groups.

Randomized comparison of chest pain evaluation with FFRCT or standard care: Factors determining US costs. (2022)
Journal Article
Mamas. (2022). Randomized comparison of chest pain evaluation with FFRCT or standard care: Factors determining US costs. Journal of Cardiovascular Computed Tomography, https://doi.org/10.1016/j.jcct.2022.09.005

BACKGROUND: FFRCT assesses the functional significance of lesions seen on CTCA, and may be a more efficient approach to chest pain evaluation. The FORECAST randomized trial found no significant difference in costs within the UK National Health Servic... Read More about Randomized comparison of chest pain evaluation with FFRCT or standard care: Factors determining US costs..

The Association Between Cancer Diagnosis, Care, and Outcomes in 1 Million Patients Hospitalized for Acute Pulmonary Embolism. (2022)
Journal Article
Mamas. (2022). The Association Between Cancer Diagnosis, Care, and Outcomes in 1 Million Patients Hospitalized for Acute Pulmonary Embolism. International Journal of Cardiology, 354-362. https://doi.org/10.1016/j.ijcard.2022.09.049

OBJECTIVES: To evaluate the clinical care provided to cancer patients hospitalized for acute pulmonary embolism (PE), as well as the association between type of cancer, in-hospital care, and clinical outcomes. METHODS: This study examined the in-... Read More about The Association Between Cancer Diagnosis, Care, and Outcomes in 1 Million Patients Hospitalized for Acute Pulmonary Embolism..

Impact of extracardiac vascular disease on outcomes of 1.4 million patients undergoing percutaneous coronary intervention. (2022)
Journal Article
Bashar, H., Matetić, A., Curzen, N., & Mamas, M. A. (2022). Impact of extracardiac vascular disease on outcomes of 1.4 million patients undergoing percutaneous coronary intervention. Catheterization and Cardiovascular Interventions, 100(5), 737-746. https://doi.org/10.1002/ccd.30404

OBJECTIVES: Extracardiac vascular disease (ECVD) is increasingly recognized as a cardiovascular risk factor, but its association with outcomes after percutaneous coronary intervention (PCI) has not been well characterized. METHODS: Using the National... Read More about Impact of extracardiac vascular disease on outcomes of 1.4 million patients undergoing percutaneous coronary intervention..

Quantitative Flow Ratio and Virtual Percutaneous Coronary Intervention for Serial Coronary Stenoses: Attractive Technology, But Still Crawling (2022)
Journal Article
Sumaya, W., Mamas, M. A., & Bagur, R. (2022). Quantitative Flow Ratio and Virtual Percutaneous Coronary Intervention for Serial Coronary Stenoses: Attractive Technology, But Still Crawling. Journal of the American Heart Association, 11(19), https://doi.org/10.1161/JAHA.122.027165

Objectives To evaluate the clinical care provided to cancer patients hospitalized for acute pulmonary embolism (PE), as well as the association between type of cancer, in-hospital care, and clinical outcomes. Methods This study examined the in-hos... Read More about Quantitative Flow Ratio and Virtual Percutaneous Coronary Intervention for Serial Coronary Stenoses: Attractive Technology, But Still Crawling.

TCT-146 Left Main Stem Percutaneous Coronary Intervention: Does Onsite Surgical Cover Make a Difference? (2022)
Journal Article
Mamas, & Rashid. (2022). TCT-146 Left Main Stem Percutaneous Coronary Intervention: Does Onsite Surgical Cover Make a Difference?. Journal of the American College of Cardiology, B59 - B59. https://doi.org/10.1016/j.jacc.2022.08.171

Background Nonsurgical centres (NSCs) contribute to the significant capacity of overall PCI in the UK. Whilst previous studies have demonstrated similar PCI outcomes in surgical centres (SCs) vs NSCs, it is unknown whether this applies to more comple... Read More about TCT-146 Left Main Stem Percutaneous Coronary Intervention: Does Onsite Surgical Cover Make a Difference?.

Management and outcomes of patients admitted with type 2 myocardial infarction with and without standard modifiable risk factors. (2022)
Journal Article
Rashid, M., Matetić, A., Lambrinou, E., Sokhal, B., Figtree, G., Moledina, S., …Velagapudi, P. (2022). Management and outcomes of patients admitted with type 2 myocardial infarction with and without standard modifiable risk factors. International Journal of Cardiology, 391-396. https://doi.org/10.1016/j.ijcard.2022.09.037

BACKGROUND: Whilst it is known patients without standard modifiable cardiovascular risk factors (SMuRF; hypertension, diabetes, hypercholesterolaemia, smoking) have worse outcomes in Type 1 acute myocardial infarction (AMI), the relationship between... Read More about Management and outcomes of patients admitted with type 2 myocardial infarction with and without standard modifiable risk factors..

Logistic regression frequently outperformed propensity score methods, especially for large datasets: a simulation study. (2022)
Journal Article
Mamas. (2022). Logistic regression frequently outperformed propensity score methods, especially for large datasets: a simulation study. Journal of Clinical Epidemiology, 176 - 184. https://doi.org/10.1016/j.jclinepi.2022.09.009

OBJECTIVES: In observational studies, researchers must select a method to control for confounding. Options include propensity score (PS) methods and regression. It remains unclear how dataset characteristics (size, overlap in PSs, and exposure preval... Read More about Logistic regression frequently outperformed propensity score methods, especially for large datasets: a simulation study..

Cardiac computed tomographic imaging in cardio-oncology: An expert consensus document of the Society of Cardiovascular Computed Tomography (SCCT). Endorsed by the International Cardio-Oncology Society (ICOS). (2022)
Journal Article
Mamas. (2022). Cardiac computed tomographic imaging in cardio-oncology: An expert consensus document of the Society of Cardiovascular Computed Tomography (SCCT). Endorsed by the International Cardio-Oncology Society (ICOS). Journal of Cardiovascular Computed Tomography, 17(1), 66 - 83. https://doi.org/10.1016/j.jcct.2022.09.002

Cardio-Oncology is a rapidly growing sub-specialty of medicine, however, there is very limited guidance on the use of cardiac CT (CCT) in the care of Cardio-Oncology patients. In order to fill in the existing gaps, this Expert Consensus statement com... Read More about Cardiac computed tomographic imaging in cardio-oncology: An expert consensus document of the Society of Cardiovascular Computed Tomography (SCCT). Endorsed by the International Cardio-Oncology Society (ICOS)..

Emergency department cardiovascular disease encounters and associated mortality in patients with cancer: A study of 20.6 million records from the USA. (2022)
Journal Article
Mamas. (2022). Emergency department cardiovascular disease encounters and associated mortality in patients with cancer: A study of 20.6 million records from the USA. International Journal of Cardiology, 210 - 217. https://doi.org/10.1016/j.ijcard.2022.06.053

BACKGROUND: there is limited data on Emergency department (ED) cardiovascular disease (CVD) presentations and outcomes amongst cancer patients. OBJECTIVES: The present study aimed to describe the clinical characteristics, prevalence, and clinical out... Read More about Emergency department cardiovascular disease encounters and associated mortality in patients with cancer: A study of 20.6 million records from the USA..

Paclitaxel drug-coated balloon-only angioplasty for de novo coronary artery disease in elective clinical practice (2022)
Journal Article
Merinopoulos, I., Gunawardena, T., Corballis, N., Bhalraam, U., Gilbert, T., Maart, C., …Eccleshall, S. C. (2023). Paclitaxel drug-coated balloon-only angioplasty for de novo coronary artery disease in elective clinical practice. Clinical Research in Cardiology, 112(9), 1186-1193. https://doi.org/10.1007/s00392-022-02106-y

Objective: We aimed to investigate the safety of drug-coated balloon (DCB)-only angioplasty compared to drug-eluting stent (DES), as part of routine clinical practice. Background: The recent BASKETSMALL2 trial demonstrated the safety and efficacy of... Read More about Paclitaxel drug-coated balloon-only angioplasty for de novo coronary artery disease in elective clinical practice.

Rates of Elective Percutaneous Coronary Intervention in England and Wales: Impact of COURAGE and ORBITA Trials (2022)
Journal Article
Rashid, M., Stevens, C., Wijeysundera, H. C., Curzen, N., Wah Khoo, C., Osama Mohamed, M., …Mamas, M. A. (2022). Rates of Elective Percutaneous Coronary Intervention in England and Wales: Impact of COURAGE and ORBITA Trials. Journal of the American Heart Association, 11(18), Article e025426. https://doi.org/10.1161/jaha.122.025426

Background There are limited data about how COURAGE (Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation) and ORBITA (Objective Randomized Blinded Investigation With Optimal Medical Therapy of Angioplasty in Stable Angina) tr... Read More about Rates of Elective Percutaneous Coronary Intervention in England and Wales: Impact of COURAGE and ORBITA Trials.

Urban-rural disparities in diabetes-related mortality in the USA 1999-2019. (2022)
Journal Article
Mamas. (2022). Urban-rural disparities in diabetes-related mortality in the USA 1999-2019. Diabetologia, https://doi.org/10.1007/s00125-022-05785-4

AIMS/HYPOTHESIS: Our study aimed to examine the trends in diabetes-related mortality in urban and rural areas in the USA over the past two decades. METHODS: We examined the trends in diabetes-related mortality (as the underlying or a contributing cau... Read More about Urban-rural disparities in diabetes-related mortality in the USA 1999-2019..

Differential Patterns and Outcomes of 20.6 Million Cardiovascular Emergency Department Encounters for Men and Women in the United States (2022)
Journal Article
Raisi‐Estabragh, Z., Kobo, O., Elbadawi, A., Velagapudi, P., Sharma, G., Bullock‐Palmer, R. P., …Mamas, M. A. (2022). Differential Patterns and Outcomes of 20.6 Million Cardiovascular Emergency Department Encounters for Men and Women in the United States. Journal of the American Heart Association, 11(19), 1-19. https://doi.org/10.1161/JAHA.122.026432

Background We describe sex‐differential disease patterns and outcomes of >20.6 million cardiovascular emergency department encounters in the United States. Methods and Results We analyzed primary cardiovascular encounters from the Nationwide Emerg... Read More about Differential Patterns and Outcomes of 20.6 Million Cardiovascular Emergency Department Encounters for Men and Women in the United States.

Ischemic Heart Disease in Young Women (2022)
Journal Article
Mamas. (2022). Ischemic Heart Disease in Young Women. Journal of the American College of Cardiology, 1014 - 1022. https://doi.org/10.1016/j.jacc.2022.01.057

The Cardiovascular Disease in Women Committee of the American College of Cardiology convened a working group to develop a consensus regarding the continuing rise of mortality rates in young women aged 35 to 54 years. Heart disease mortality rates in... Read More about Ischemic Heart Disease in Young Women.

Complex, high-risk percutaneous coronary intervention types, trends, and in-hospital outcomes among different age groups: An insight from a national registry. (2022)
Journal Article
Rashid, M., Shamkhani, W., & Mamas, M. (2022). Complex, high-risk percutaneous coronary intervention types, trends, and in-hospital outcomes among different age groups: An insight from a national registry. Catheterization & Cardiovascular Interventions, 100(5), 711-720. https://doi.org/10.1002/ccd.30366

BACKGROUND: Complex, high-risk percutaneous coronary intervention (PCI) (CHiP) is increasingly being undertaken in octogenarians. However, limited data exist on CHiP types, trends, and outcomes in the octogenarian. METHODS: This is a retrospective co... Read More about Complex, high-risk percutaneous coronary intervention types, trends, and in-hospital outcomes among different age groups: An insight from a national registry..

The Prognostic Utility of Mean Platelet Volume in Patients With Acute Coronary Syndrome: A Systematic Review With Meta-Analyses. (2022)
Journal Article
Galimzhanov, A., Tenekecioglu, E., Rustamova, F., Naung Tun, H., & Mamas, M. (2022). The Prognostic Utility of Mean Platelet Volume in Patients With Acute Coronary Syndrome: A Systematic Review With Meta-Analyses. Angiology, 734 - 743. https://doi.org/10.1177/00033197211070908

Mean platelet volume (MPV) is a hematological index that is routinely measured in clinical settings. Although many studies have been conducted to investigate the prognostic significance of MPV in acute coronary syndromes (ACS), the findings have been... Read More about The Prognostic Utility of Mean Platelet Volume in Patients With Acute Coronary Syndrome: A Systematic Review With Meta-Analyses..

Gender differences in mortality of hospitalised stroke patients. Systematic review and meta-analysis. (2022)
Journal Article
Mamas. (2022). Gender differences in mortality of hospitalised stroke patients. Systematic review and meta-analysis. Clinical Neurology and Neurosurgery, -. https://doi.org/10.1016/j.clineuro.2022.107359

OBJECTIVE: Gender differences in mortality after stroke remains unclear in the current literature. We therefore aimed to systematically review the gender differences in mortality up to five years after ischaemic (IS) or haemorrhagic stroke (HS) to ad... Read More about Gender differences in mortality of hospitalised stroke patients. Systematic review and meta-analysis..

Women Are Less Likely to Survive AMI Presenting With Out-of-Hospital Cardiac Arrest: A Nationwide Study. (2022)
Journal Article
Dafaalla, M., Rashid, M., Van Spall, H. G., Mehta, L., Parwani, P., Sharma, G., …Mamas, M. (2022). Women Are Less Likely to Survive AMI Presenting With Out-of-Hospital Cardiac Arrest: A Nationwide Study. Mayo Clinic Proceedings, 97(9), 1608 - 1618. https://doi.org/10.1016/j.mayocp.2022.06.011

OBJECTIVE: To assess the impact of patient's sex on outcomes and management of acute myocardial infarction (AMI) patients presenting with out-of-hospital cardiac arrest (OHCA). PATIENTS AND METHODS: We conducted a population-based retrospective cohor... Read More about Women Are Less Likely to Survive AMI Presenting With Out-of-Hospital Cardiac Arrest: A Nationwide Study..

Direct Oral Anticoagulants Versus Antiplatelet Therapy After Transcatheter Aortic Valve Replacement: A Meta-Analysis of Randomized Trials (2022)
Journal Article
Mamas, M. A., Elbadawi, A., Dang, A. T., Sedhom, R., Hamed, M., Eid, M., …Elgendy, I. Y. (2022). Direct Oral Anticoagulants Versus Antiplatelet Therapy After Transcatheter Aortic Valve Replacement: A Meta-Analysis of Randomized Trials. Circulation: Cardiovascular Interventions, 15(9), Article e012194. https://doi.org/10.1161/circinterventions.122.012194

Inequalities in the incidence and management of non-valvular atrial fibrillation in England, 2009 to 2019: Cohort study using electronic health records from general practices (2022)
Presentation / Conference
Ajabnoor, A., Zghebi, S., Parisi, R., Ashcroft, D., Rutter, M., Doran, T., …Kontopantelis, E. (2022, August). Inequalities in the incidence and management of non-valvular atrial fibrillation in England, 2009 to 2019: Cohort study using electronic health records from general practices

Background Atrial fibrillation is an important risk factor for ischaemic stroke and AF incidence is expected to increase. Guidelines recommend using oral anticoagulants (OACs) to prevent the development of stroke. However, studies have reported the f... Read More about Inequalities in the incidence and management of non-valvular atrial fibrillation in England, 2009 to 2019: Cohort study using electronic health records from general practices.

Percutaneous Coronary Angioplasty in Patients with Cancer: Clinical Challenges and Management Strategies (2022)
Journal Article
Mamas. (2022). Percutaneous Coronary Angioplasty in Patients with Cancer: Clinical Challenges and Management Strategies. Journal of Personalized Medicine, 1372 - 1372. https://doi.org/10.3390/jpm12091372

The number of cancer survivors in the United States is projected to increase by 31% by 2030. With advances in early screening, diagnosis and therapeutic strategies, a steadily increasing number of patients are surviving cancer. Coronary artery diseas... Read More about Percutaneous Coronary Angioplasty in Patients with Cancer: Clinical Challenges and Management Strategies.

Invasive management and in-hospital outcomes of myocardial infarction patients in rural versus urban hospitals in the United States. (2022)
Journal Article
Mamas. (2022). Invasive management and in-hospital outcomes of myocardial infarction patients in rural versus urban hospitals in the United States. Cardiovascular Revascularization Medicine, 3 -9. https://doi.org/10.1016/j.carrev.2022.08.023

OBJECTIVES: The variation in the management and outcome of acute myocardial infarction (AMI) between rural and urban settings has been previously recognized, but there has previously been no nationwide data reported that is inclusive of the whole adu... Read More about Invasive management and in-hospital outcomes of myocardial infarction patients in rural versus urban hospitals in the United States..

Clinical Outcomes of Percutaneous Coronary Intervention for Bifurcation Lesions According to Medina Classification (2022)
Journal Article
Mamas, M. A., Mohamed, M. O., Lamellas, P., Roguin, A., Oemrawsingh, R. M., Ijsselmuiden, A. J. J., …Roffi, M. (2022). Clinical Outcomes of Percutaneous Coronary Intervention for Bifurcation Lesions According to Medina Classification. Journal of the American Heart Association, 11(17), Article e025459. https://doi.org/10.1161/JAHA.122.025459

Background Coronary bifurcation lesions (CBLs) are frequently encountered in clinical practice and are associated with worse outcomes after percutaneous coronary intervention. However, there are limited data around the prognostic impact of different... Read More about Clinical Outcomes of Percutaneous Coronary Intervention for Bifurcation Lesions According to Medina Classification.

330 Gender Differences in Mortality After Stroke in Thai Patients. a National Cohort Study (2022)
Journal Article
Abdel-Fattah, A., Pana, T., Tiamkao, S., Sawanyawisuth, K., Kasemsap, N., Mamas, M., & Myint, P. (2022). 330 Gender Differences in Mortality After Stroke in Thai Patients. a National Cohort Study. British Journal of Surgery, 109(Supplement_6), https://doi.org/10.1093/bjs/znac269.226

Aim Gender differences in patients hospitalised with stroke is a major public health concern carrying important implications to service provision. There has not yet been a study specifically focussing on patients in Thailand. We aimed to assess the g... Read More about 330 Gender Differences in Mortality After Stroke in Thai Patients. a National Cohort Study.

Routine Pressure Wire Assessment Versus Conventional Angiography in the Management of Patients With Coronary Artery Disease: The RIPCORD 2 Trial (2022)
Journal Article
Stables, R. H., Mullen, L. J., Elguindy, M., Nicholas, Z., Aboul-Enien, Y. H., Kemp, I., …Curzen, N. (2022). Routine Pressure Wire Assessment Versus Conventional Angiography in the Management of Patients With Coronary Artery Disease: The RIPCORD 2 Trial. Circulation, 146(9), 687-698. https://doi.org/10.1161/CIRCULATIONAHA.121.057793

Background: Measurement of fractional flow reserve (FFR) has an established role in guiding percutaneous coronary intervention. We tested the hypothesis that, at the stage of diagnostic invasive coronary angiography, systematic FFR-guided assessment... Read More about Routine Pressure Wire Assessment Versus Conventional Angiography in the Management of Patients With Coronary Artery Disease: The RIPCORD 2 Trial.

Meta-Analysis of Efficacy of Vasopressin During Cardiopulmonary Resuscitation. (2022)
Journal Article
Mamas. (2022). Meta-Analysis of Efficacy of Vasopressin During Cardiopulmonary Resuscitation. https://doi.org/10.1016/j.amjcard.2022.06.042

Randomized controlled trials evaluating the efficacy of vasopressin versus standard of care during cardiopulmonary resuscitation (CPR) have yielded conflicting results. An electronic search of MEDLINE, Cochrane, and Embase databases was conducted thr... Read More about Meta-Analysis of Efficacy of Vasopressin During Cardiopulmonary Resuscitation..

Echocardiographic predictors of presence of cardiac amyloidosis in aortic stenosis. (2022)
Journal Article
Mamas. (2022). Echocardiographic predictors of presence of cardiac amyloidosis in aortic stenosis. https://doi.org/10.1093/ehjci/jeac146

AIMS: Aortic stenosis (AS) and cardiac amyloidosis (CA) frequently coexist but the diagnosis of CA in AS patients remains a diagnostic challenge. We aim to evaluate the echocardiographic parameters that may aid in the detection of the presence of CA... Read More about Echocardiographic predictors of presence of cardiac amyloidosis in aortic stenosis..

Association Between Gout Flare and Subsequent Cardiovascular Events Among Patients with Gout (2022)
Journal Article
Mamas. (2022). Association Between Gout Flare and Subsequent Cardiovascular Events Among Patients with Gout. Journal of the American Medical Association, https://doi.org/10.1001/jama.2022.11390

Importance Gout is associated with cardiovascular diseases. The temporal association between gout flares and cardiovascular events has not been investigated. Objective To investigate whether there is a transient increase in risk of cardiovascular eve... Read More about Association Between Gout Flare and Subsequent Cardiovascular Events Among Patients with Gout.

Cardiovascular Health Care Implications of the COVID-19 pandemic. (2022)
Journal Article
Mamas. (2022). Cardiovascular Health Care Implications of the COVID-19 pandemic. Cardiology Clinics, 389 - 396. https://doi.org/10.1016/j.ccl.2022.03.010

The coronavirus disease 2019 (COVID-19) pandemic has challenged the capacity of health care systems around the world, including substantial disruptions to cardiovascular care across key areas of health care delivery. In this narrative review, we exam... Read More about Cardiovascular Health Care Implications of the COVID-19 pandemic..

Five-Year Outcomes After Coronary Computed Tomography Angiography (From 110,599 Patients in a Danish Nationwide Register-Based Follow-Up Study). (2022)
Journal Article
Mamas. (2022). Five-Year Outcomes After Coronary Computed Tomography Angiography (From 110,599 Patients in a Danish Nationwide Register-Based Follow-Up Study). American Journal of Cardiology, 1 - 7. https://doi.org/10.1016/j.amjcard.2022.04.035

The long-term cardiovascular risk for patients examined with coronary computed tomography angiography (CCTA) to rule out coronary heart disease compared with population controls remains unexplored. A nationwide register-based study including first-ti... Read More about Five-Year Outcomes After Coronary Computed Tomography Angiography (From 110,599 Patients in a Danish Nationwide Register-Based Follow-Up Study)..

Impact of cancer diagnosis on distribution and trends of cardiovascular hospitalizations in the USA between 2004 to 2017 (2022)
Journal Article
Mamas. (2022). Impact of cancer diagnosis on distribution and trends of cardiovascular hospitalizations in the USA between 2004 to 2017. European Heart Journal, 787-797. https://doi.org/10.1093/ehjqcco/qcac045

Background and aims There is limited data on temporal trends of cardiovascular hospitalizations and outcomes amongst cancer patients. We describe the distribution, trends of admissions, and in-hospital mortality associated with key cardiovascular di... Read More about Impact of cancer diagnosis on distribution and trends of cardiovascular hospitalizations in the USA between 2004 to 2017.

Health Care Professional's Knowledge of Pregnancy Complications and Women's Cardiovascular Health: An International Study Utilizing Social Media (2022)
Journal Article
Wu, P., Mamas, M. A., & Gulati, M. (2022). Health Care Professional's Knowledge of Pregnancy Complications and Women's Cardiovascular Health: An International Study Utilizing Social Media. Journal of Women's Health, https://doi.org/10.1089/jwh.2021.0298

Background Despite guidelines recommending the evaluation of adverse pregnancy outcomes (APOs) as a part of the atherosclerotic cardiovascular disease (ASCVD) risk assessment in women, there is limited awareness of this issue in healthcare professio... Read More about Health Care Professional's Knowledge of Pregnancy Complications and Women's Cardiovascular Health: An International Study Utilizing Social Media.

Impact of Multisite artery disease on Clinical Outcomes After Percutaneous Coronary Intervention: An Analysis from the e-Ultimaster Registry. (2022)
Journal Article
Mamas. (2022). Impact of Multisite artery disease on Clinical Outcomes After Percutaneous Coronary Intervention: An Analysis from the e-Ultimaster Registry. European Heart Journal - Quality of Care and Clinical Outcomes, https://doi.org/10.1093/ehjqcco/qcac043

BACKGROUND: multisite artery disease is considered a 'malignant' type of atherosclerotic disease associated with an increased cardiovascular risk, but the impact of multisite artery disease on clinical outcomes after percutaneous coronary interventio... Read More about Impact of Multisite artery disease on Clinical Outcomes After Percutaneous Coronary Intervention: An Analysis from the e-Ultimaster Registry..

Hospital procedural volume and outcomes with catheter-directed intervention for pulmonary embolism: a nationwide analysis. (2022)
Journal Article
Mamas. (2022). Hospital procedural volume and outcomes with catheter-directed intervention for pulmonary embolism: a nationwide analysis. https://doi.org/10.1093/ehjacc/zuac082

AIMS: There is limited data on the association between hospital catheter-directed intervention (CDI) volume and outcomes among patients with acute pulmonary embolism (PE). METHODS AND RESULTS: The Nationwide Readmissions Database years 2016-2019 was... Read More about Hospital procedural volume and outcomes with catheter-directed intervention for pulmonary embolism: a nationwide analysis..

Influence of the Danish Co-morbidity Index Score on the Treatment and Outcomes of 2.5 Million Patients Admitted With Acute Myocardial Infarction in the United States. (2022)
Journal Article
Mamas, M., & Mallen, C. (2022). Influence of the Danish Co-morbidity Index Score on the Treatment and Outcomes of 2.5 Million Patients Admitted With Acute Myocardial Infarction in the United States. American Journal of Cardiology, https://doi.org/10.1016/j.amjcard.2022.06.008

This study aimed to determine the association between the Danish Co-morbidity Index for Acute Myocardial Infarction (DANCAMI) and restricted DANCAMI (rDANCAMI) scores and clinical outcomes in patients hospitalized with AMI. Using the National Inpatie... Read More about Influence of the Danish Co-morbidity Index Score on the Treatment and Outcomes of 2.5 Million Patients Admitted With Acute Myocardial Infarction in the United States..

Digital health in older adults for the prevention and management of cardiovascular diseases and frailty. A clinical consensus statement from the ESC Council for Cardiology Practice/Taskforce on Geriatric Cardiology, the ESC Digital Health Committee and the ESC Working Group on e-Cardiology (2022)
Journal Article
Mamas, M., Guasti, L., Dilaveris, P., Richter, D., Christodorescu, R., Lumens, J., …Cowie, M. R. (2022). Digital health in older adults for the prevention and management of cardiovascular diseases and frailty. A clinical consensus statement from the ESC Council for Cardiology Practice/Taskforce on Geriatric Cardiology, the ESC Digital Health Committee and the ESC Working Group on e-Cardiology. ESC Heart Failure, 9(5), 2808-2822. https://doi.org/10.1002/ehf2.14022

Digital health technology is receiving increasing attention in cardiology. The rise of accessibility of digital health tools including wearable technologies and smart phone applications used in medical practice has created a new era in healthcare. Th... Read More about Digital health in older adults for the prevention and management of cardiovascular diseases and frailty. A clinical consensus statement from the ESC Council for Cardiology Practice/Taskforce on Geriatric Cardiology, the ESC Digital Health Committee and the ESC Working Group on e-Cardiology.

Incidence and 1-year outcome of periprocedural myocardial infarction following cardiac surgery: are the Universal Definition and Society for Cardiovascular Angiography and Intervention criteria fit for purpose? (2022)
Journal Article
Mamas. (2022). Incidence and 1-year outcome of periprocedural myocardial infarction following cardiac surgery: are the Universal Definition and Society for Cardiovascular Angiography and Intervention criteria fit for purpose?. European Journal of Cardio-Thoracic Surgery, https://doi.org/10.1093/ejcts/ezac019

OBJECTIVES: The diagnosis and clinical implications of periprocedural myocardial infarction (PPMI) following coronary artery bypass grafting (CABG) are contentious, especially the importance of PPMI in the interpretation of trial data. METHODS: Conse... Read More about Incidence and 1-year outcome of periprocedural myocardial infarction following cardiac surgery: are the Universal Definition and Society for Cardiovascular Angiography and Intervention criteria fit for purpose?.

Safety and efficacy of transcatheter aortic valve implantation in stenotic bicuspid aortic valve compared to tricuspid aortic valve: a systematic review and meta-analysis. (2022)
Journal Article
Zghouzi, M., Osman, H., Ullah, W., Suleiman, A., Razvi, P., Abdalrazzak, M., …Chadi Alraies, M. (2022). Safety and efficacy of transcatheter aortic valve implantation in stenotic bicuspid aortic valve compared to tricuspid aortic valve: a systematic review and meta-analysis. Expert Review of Cardiovascular Therapy, 581 - 588. https://doi.org/10.1080/14779072.2022.2094368

BACKGROUND: Transcatheter aortic valve implantation (TAVI) has emerged as a safe and effective alternative to surgical replacement for tricuspid aortic valve (TAV) stenosis. However, utilization of TAVI for aortic stenosis in bicuspid aortic valve (B... Read More about Safety and efficacy of transcatheter aortic valve implantation in stenotic bicuspid aortic valve compared to tricuspid aortic valve: a systematic review and meta-analysis..

Musculoskeletal pain and its impact on rates of hospitalisation and mortality in cancer: a linked electronic health record cohort study (MSKCOM) (2022)
Presentation / Conference
Mason, K., Bailey, J., Heron, N., Marshall, M., Achana, F., Chen, Y., …Jordan, K. (2022, July). Musculoskeletal pain and its impact on rates of hospitalisation and mortality in cancer: a linked electronic health record cohort study (MSKCOM). Paper presented at SAPC ASM 2022 - UCLan 50th Annual Scientific Meeting, University of Central Lancashire, UK

Background: Patients with painful musculoskeletal conditions have an increased risk of developing cancer, but less is known about whether this impacts on the longer-term cancer prognosis. This study aims to determine whether patients with painful mus... Read More about Musculoskeletal pain and its impact on rates of hospitalisation and mortality in cancer: a linked electronic health record cohort study (MSKCOM).

COVID-19 trajectories among 57 million adults in England: a cohort study using electronic health records. (2022)
Journal Article
Mamas. (2022). COVID-19 trajectories among 57 million adults in England: a cohort study using electronic health records. The Lancet Digital Health, e542 - e557. https://doi.org/10.1016/S2589-7500%2822%2900091-7

BACKGROUND: Updatable estimates of COVID-19 onset, progression, and trajectories underpin pandemic mitigation efforts. To identify and characterise disease trajectories, we aimed to define and validate ten COVID-19 phenotypes from nationwide linked e... Read More about COVID-19 trajectories among 57 million adults in England: a cohort study using electronic health records..

Serum urate outcomes of treat-to-target urate lowering treatment: results of a nationwide cohort study from 1997 to the COVID-19 pandemic using data from the Clinical Practice Research Datalink. (2022)
Journal Article
Abhishek, A., Cipolletta, E., Nakafero, G., Avery, A. J., Mamas, M., & Tata, L. J. (2022). Serum urate outcomes of treat-to-target urate lowering treatment: results of a nationwide cohort study from 1997 to the COVID-19 pandemic using data from the Clinical Practice Research Datalink. https://doi.org/10.1136/ard-2022-222668

Effect of Pneumococcal Vaccine on Mortality and Cardiovascular Outcomes: A Systematic Review and Meta-Analysis (2022)
Journal Article
Mamas. (2022). Effect of Pneumococcal Vaccine on Mortality and Cardiovascular Outcomes: A Systematic Review and Meta-Analysis. Journal of Clinical Medicine, 3799 - 3799. https://doi.org/10.3390/jcm11133799

Various studies have suggested the possible cardiovascular (CV) protective effects of the pneumococcal vaccine (PV). Therefore, we conducted a meta-analysis to assess the association between recipients of PV with mortality and CV outcomes among patie... Read More about Effect of Pneumococcal Vaccine on Mortality and Cardiovascular Outcomes: A Systematic Review and Meta-Analysis.

Variation in practice for out-of-hospital cardiac arrest treated with percutaneous coronary intervention in England and Wales. (2022)
Journal Article
Rashid, M., Kinnaird, T., Ludman, P., Keeble, T. R., Mamas, M., & Curzen, N. (2022). Variation in practice for out-of-hospital cardiac arrest treated with percutaneous coronary intervention in England and Wales. Catheterization and Cardiovascular Interventions, 100(3), 306-316. https://doi.org/10.1002/ccd.30316

Objectives We assessed the association between total center volume, operator volume, and out-of-hospital cardiac arrest (OHCA) percutaneous coronary intervention (PCI) volume. Background Variations between OHCA PCI volume, hospital total PCI, an... Read More about Variation in practice for out-of-hospital cardiac arrest treated with percutaneous coronary intervention in England and Wales..

IGFBP7 as a preoperative predictor of congestive acute kidney injury after cardiac surgery. (2022)
Journal Article
Mamas. (2022). IGFBP7 as a preoperative predictor of congestive acute kidney injury after cardiac surgery. Open Heart, https://doi.org/10.1136/openhrt-2022-002027

OBJECTIVE: Congestive acute kidney injury (c-AKI) refers to AKI in the presence of right ventricular failure (RVF) and is a highly morbid complication of cardiac surgery. However, treatment has traditionally been reactive rather than proactive due to... Read More about IGFBP7 as a preoperative predictor of congestive acute kidney injury after cardiac surgery..

A retrospective cohort study predicting and validating impact of the COVID-19 pandemic in individuals with chronic kidney disease (2022)
Journal Article
Dashtban, A., Mizani, M. A., Denaxas, S., Nitsch, D., Quint, J., Corbett, R., …Banerjee, A. (2022). A retrospective cohort study predicting and validating impact of the COVID-19 pandemic in individuals with chronic kidney disease. Kidney International, 102(3), 652-660. https://doi.org/10.1016/j.kint.2022.05.015

Chronic kidney disease (CKD) is associated with increased risk of baseline mortality and severe COVID-19, but analyses across CKD stages, and comorbidities are lacking. In prevalent and incident CKD, we investigated comorbidities, baseline risk, COVI... Read More about A retrospective cohort study predicting and validating impact of the COVID-19 pandemic in individuals with chronic kidney disease.

Biomarker Determinants of Early Anthracycline-Induced Left Ventricular Dysfunction in Breast Cancer: A Systematic Review and Meta-Analysis (2022)
Journal Article
Mamas, M., Kastora, S. L., Pana, T. A., Sarwar, Y., & Myint, P. K. (2022). Biomarker Determinants of Early Anthracycline-Induced Left Ventricular Dysfunction in Breast Cancer: A Systematic Review and Meta-Analysis. Molecular Diagnosis and Therapy, 26, 369-382. https://doi.org/10.1007/s40291-022-00597-z

BACKGROUND AND OBJECTIVE: Breast cancer is the leading cause of cancer-related mortality amongst women. One of the most common chemotherapeutic agents used to treat breast cancer, anthracyclines, are associated with anthracycline-induced cardiotoxici... Read More about Biomarker Determinants of Early Anthracycline-Induced Left Ventricular Dysfunction in Breast Cancer: A Systematic Review and Meta-Analysis.

Aortic stenosis post-COVID-19: a mathematical model on waiting lists and mortality (2022)
Journal Article
Mamas, Stickels, C. P., Nadarajah, R., Gale, C. P., Jiang, H., Sharkey, K. J., …Erhun, F. (2022). Aortic stenosis post-COVID-19: a mathematical model on waiting lists and mortality. BMJ Open, 12(6), Article ARTN e059309. https://doi.org/10.1136/bmjopen-2021-059309

OBJECTIVES: To provide estimates for how different treatment pathways for the management of severe aortic stenosis (AS) may affect National Health Service (NHS) England waiting list duration and associated mortality. DESIGN: We constructed a mathemat... Read More about Aortic stenosis post-COVID-19: a mathematical model on waiting lists and mortality.

Transcatheter Aortic Valve Implantation With and Without Resheathing and Repositioning: A Systematic Review and Meta-analysis (2022)
Journal Article
Moroni, F., Azzalini, L., Sondergaard, L., Attizzani, G. F., Garcia, S., Jneid, H., …Bagur, R. (2022). Transcatheter Aortic Valve Implantation With and Without Resheathing and Repositioning: A Systematic Review and Meta-analysis. Journal of the American Heart Association, 11(12), e024707 - ?. https://doi.org/10.1161/JAHA.121.024707

Background There is a concern that resheathing/repositioning of transcatheter heart valves during transcatheter aortic valve implantation (TAVI) may lead to an increased risk of periprocedural complications. We aimed to evaluate the short- and long-t... Read More about Transcatheter Aortic Valve Implantation With and Without Resheathing and Repositioning: A Systematic Review and Meta-analysis.

Real-world management and outcomes of 7 million patients with acute coronary syndrome according to clinical research trial enrolment status: a propensity matched analysis. (2022)
Journal Article
Matetic, A., Mohamed, M. O., Roberts, D. J., Rana, J. S., Chadi Alraies, M., Patel, B., …Mamas, M. A. (2022). Real-world management and outcomes of 7 million patients with acute coronary syndrome according to clinical research trial enrolment status: a propensity matched analysis. European Heart Journal - Quality of Care and Clinical Outcomes, 409 - 419. https://doi.org/10.1093/ehjqcco/qcab098

AIMS: We aimed to determine whether clinical outcomes and invasive care of acute coronary syndrome (ACS) patients participating in trials differed from those of non-participants, particularly including those who were trial eligible. METHODS AND RESUL... Read More about Real-world management and outcomes of 7 million patients with acute coronary syndrome according to clinical research trial enrolment status: a propensity matched analysis..

Turnpike Catheter failure, causes and mechanisms: Insights from the MAUDE database. (2022)
Journal Article
Mamas, Alhusain, R., Dayco, J., Awadelkarim, A., Almas, T., Halboni, A., …Alraies, M. C. (2022). Turnpike Catheter failure, causes and mechanisms: Insights from the MAUDE database. https://doi.org/10.1016/j.amsu.2022.103923

Background: The Turnpike catheters (Teleflex, Wayne, PA, USA) is a microcatheter that was approved by the Food and Drug Administration in November 2014 to be used to access discrete regions of the coronary and peripheral vasculature. Methods: The Man... Read More about Turnpike Catheter failure, causes and mechanisms: Insights from the MAUDE database..

Maternal Glycemic Spectrum and Adverse Pregnancy and Perinatal Outcomes in a Multiracial US Cohort (2022)
Journal Article
Wu, Mamas, Kwapong, Y. A., Boakye, E., Wang, G., Hong, X., …Sharma, G. (2022). Maternal Glycemic Spectrum and Adverse Pregnancy and Perinatal Outcomes in a Multiracial US Cohort. Journal of Cardiovascular Development and Disease, 9(6), Article ARTN 179. https://doi.org/10.3390/jcdd9060179

Diabetes mellitus (pregestational (PDM) and gestational (GDM)) is associated with adverse pregnancy outcomes (APOs). However, studies exploring the association of APOs with maternal glycemia among women without PDM/GDM are limited. We utilized data f... Read More about Maternal Glycemic Spectrum and Adverse Pregnancy and Perinatal Outcomes in a Multiracial US Cohort.

Design and evaluation of an interactive quality dashboard for national clinical audit data: a realist evaluation (2022)
Journal Article
Randell, R., Alvarado, N., Elshehaly, M., McVey, L., West, R. M., Doherty, P., …Ruddle, R. A. (2022). Design and evaluation of an interactive quality dashboard for national clinical audit data: a realist evaluation. Health and Social Care Delivery Research, 10(12), 1-156. https://doi.org/10.3310/WBKW4927

Background National audits aim to reduce variations in quality by stimulating quality improvement. However, varying provider engagement with audit data means that this is not being realised. Aim The aim of the study was to develop and evaluate a qual... Read More about Design and evaluation of an interactive quality dashboard for national clinical audit data: a realist evaluation.

A systematic review and meta-analysis of the impact of the left atrial appendage closure on left atrial function. (2022)
Journal Article
Mamas. (2022). A systematic review and meta-analysis of the impact of the left atrial appendage closure on left atrial function. Clinical Cardiology, 614 - 621. https://doi.org/10.1002/clc.23824

BACKGROUND: Left atrial (LA) appendage closure (LAAC) is effective in patients with atrial fibrillation who are not candidates for long-term anticoagulation. However, the impact of LAAC on LA function is unknown. The aim of this study is to evaluate... Read More about A systematic review and meta-analysis of the impact of the left atrial appendage closure on left atrial function..

Incidence of nonvalvular atrial fibrillation and oral anticoagulant prescribing in England, 2009 to 2019: A cohort study. (2022)
Journal Article
Mamas. (2022). Incidence of nonvalvular atrial fibrillation and oral anticoagulant prescribing in England, 2009 to 2019: A cohort study. PLoS Medicine, e1004003 - ?. https://doi.org/10.1371/journal.pmed.1004003

BACKGROUND: Atrial fibrillation (AF) is an important risk factor for ischaemic stroke, and AF incidence is expected to increase. Guidelines recommend using oral anticoagulants (OACs) to prevent the development of stroke. However, studies have reporte... Read More about Incidence of nonvalvular atrial fibrillation and oral anticoagulant prescribing in England, 2009 to 2019: A cohort study..

RISK OF VENOUS THROMBOEMBOLISM AFTER GOUT FLARES (2022)
Presentation / Conference
Cipolletta, E., Nakafero, G., Mamas, M., Avery, A., Tata, L., & Abhishek, A. (2022, June). RISK OF VENOUS THROMBOEMBOLISM AFTER GOUT FLARES. Poster presented at EULAR 2022 European Congress of Rheumatology, Copenhagen, Denmark

Background Several population-based cohort studies have reported an increased risk of venous thromboembolism (VTE) in gout patients. However, none of these studies has investigated the temporal relationship between gout flares and VTE. Objectives... Read More about RISK OF VENOUS THROMBOEMBOLISM AFTER GOUT FLARES.

The collateral damage of COVID-19 on cardiovascular services: a meta-analysis (2022)
Journal Article
Mamas. (2022). The collateral damage of COVID-19 on cardiovascular services: a meta-analysis. European Heart Journal, https://doi.org/10.1093/eurheartj/ehac227

Aims The effect of the COVID-19 pandemic on care and outcomes across non-COVID-19 cardiovascular (CV) diseases is unknown. A systematic review and meta-analysis was performed to quantify the effect and investigate for variation by CV disease, geograp... Read More about The collateral damage of COVID-19 on cardiovascular services: a meta-analysis.

Baseline platelet count in percutaneous coronary intervention: a dose-response meta-analysis. (2022)
Journal Article
Mamas. (2022). Baseline platelet count in percutaneous coronary intervention: a dose-response meta-analysis. Heart, https://doi.org/10.1136/heartjnl-2022-320910

OBJECTIVES: The nature of the relationship between baseline platelet count and clinical outcomes following percutaneous coronary intervention (PCI) is unclear. We undertook dose-response and pairwise meta-analyses to better describe the prognostic va... Read More about Baseline platelet count in percutaneous coronary intervention: a dose-response meta-analysis..

Temporal patterns, characteristics, and predictors of clinical outcomes in patients undergoing percutaneous coronary intervention for stent thrombosis. (2022)
Journal Article
Mohamed, M. O., Sirker, A., Chieffo, A., Avanzas, P., Nolan, J., Rashid, M., …Mamas, M. (2022). Temporal patterns, characteristics, and predictors of clinical outcomes in patients undergoing percutaneous coronary intervention for stent thrombosis. EuroIntervention, 18(9), https://doi.org/10.4244/EIJ-D-22-00049

BACKGROUND: There are limited data on the outcomes of percutaneous coronary intervention (PCI) following stent thrombosis (ST) and differences exist based on timing. AIMS: Our aim was to study the rates of PCI procedures for an ST indication among al... Read More about Temporal patterns, characteristics, and predictors of clinical outcomes in patients undergoing percutaneous coronary intervention for stent thrombosis..

Treatment Effect of Percutaneous Coronary Intervention in Dialysis Patients With ST-Elevation Myocardial Infarction. (2022)
Journal Article
Mamas, M. (2022). Treatment Effect of Percutaneous Coronary Intervention in Dialysis Patients With ST-Elevation Myocardial Infarction. American Journal of Kidney Diseases, 832 - 840. https://doi.org/10.1053/j.ajkd.2021.08.023

RATIONALE & OBJECTIVE: Patients receiving maintenance dialysis have higher mortality after primary percutaneous coronary intervention (pPCI) than patients not receiving dialysis. Whether pPCI confers a benefit to patients receiving dialysis that is s... Read More about Treatment Effect of Percutaneous Coronary Intervention in Dialysis Patients With ST-Elevation Myocardial Infarction..

Impact of pre-existing vascular disease on clinical outcomes (2022)
Journal Article
Weight, N., Moledina, S., Zoccai, G. B., Zaman, S., Smith, T., Siller-Matula, J., …Mamas, M. A. (2022). Impact of pre-existing vascular disease on clinical outcomes. European Heart Journal - Quality of Care and Clinical Outcomes, https://doi.org/10.1093/ehjqcco/qcac026

AIMS: Little is known about the outcomes and processes of care of patients with non ST-segment myocardial infarction (NSTEMI) who present with 'polyvascular' disease. METHODS AND RESULTS: We analysed 287,279 NSTEMI patients using the Myocardial Infar... Read More about Impact of pre-existing vascular disease on clinical outcomes.

Ethnicity in Complex High-Risk but Indicated Percutaneous Coronary Intervention Types and Outcomes. (2022)
Journal Article
Rashid, & Mamas. (2022). Ethnicity in Complex High-Risk but Indicated Percutaneous Coronary Intervention Types and Outcomes. American Journal of Cardiology, 26-37. https://doi.org/10.1016/j.amjcard.2022.03.056

Complex High-risk but indicated Percutaneous coronary interventions (CHiPs) is increasingly common in contemporary practice. However, data on ethnic differences in CHiP types, outcomes, and trends in patients with stable angina are limited; this is p... Read More about Ethnicity in Complex High-Risk but Indicated Percutaneous Coronary Intervention Types and Outcomes..

Mortality after transcatheter aortic valve replacement for aortic stenosis among patients with malignancy: a systematic review and meta-analysis (2022)
Journal Article
Mamas. (2022). Mortality after transcatheter aortic valve replacement for aortic stenosis among patients with malignancy: a systematic review and meta-analysis. BMC Cardiovascular Disorders, https://doi.org/10.1186/s12872-022-02651-4

Background: With advancements in cancer treatment, the life expectancy of oncology patients has improved. Thus, transcatheter aortic valve replacement (TAVR) may be considered as a feasible option for oncology patients with severe symptomatic aortic... Read More about Mortality after transcatheter aortic valve replacement for aortic stenosis among patients with malignancy: a systematic review and meta-analysis.

Bempedoic acid and its role in contemporary management of hyperlipidemia in atherosclerosis. (2022)
Journal Article
Mamas. (2022). Bempedoic acid and its role in contemporary management of hyperlipidemia in atherosclerosis. https://doi.org/10.1080/07853890.2022.2059559

Atherosclerotic heart disease is the leading cause of mortality and morbidity in the USA. Low density lipoprotein (LDL) has been the target for many hypolipidemic agents to modify atherosclerotic risk. Bempedoic acid is a novel hypolipidemic drug tha... Read More about Bempedoic acid and its role in contemporary management of hyperlipidemia in atherosclerosis..

Relation of Extracardiac Vascular Disease and Outcomes in Patients With Diabetes (1.1 Million) Hospitalized for Acute Myocardial Infarction (2022)
Journal Article
Mamas. (2022). Relation of Extracardiac Vascular Disease and Outcomes in Patients With Diabetes (1.1 Million) Hospitalized for Acute Myocardial Infarction. American Journal of Cardiology, 8-18. https://doi.org/10.1016/j.amjcard.2022.04.005

The association between vascular disease and outcomes of patients with acute myocardial infarction (AMI) has not been well-defined in the diabetes mellitus (DM) population. All patients with DM presenting with AMI between October 2015 and December 20... Read More about Relation of Extracardiac Vascular Disease and Outcomes in Patients With Diabetes (1.1 Million) Hospitalized for Acute Myocardial Infarction.

Body Mass Index and Mortality, Recurrence and Readmission after Myocardial Infarction: Systematic Review and Meta-Analysis (2022)
Journal Article
Mamas. (2022). Body Mass Index and Mortality, Recurrence and Readmission after Myocardial Infarction: Systematic Review and Meta-Analysis. Journal of Clinical Medicine, 2581 - 2581. https://doi.org/10.3390/jcm11092581

The following study aimed to systematically review and meta-analyse the literature on the relations between markers of nutritional status and long-term mortality, recurrence and all-cause hospital readmission following myocardial infarction (MI). Med... Read More about Body Mass Index and Mortality, Recurrence and Readmission after Myocardial Infarction: Systematic Review and Meta-Analysis.

Differential Impact of Type 1 and Type 2 Diabetes Mellitus on Outcomes Among 1.4 Million US Patients Undergoing Percutaneous Coronary Intervention. (2022)
Journal Article
Mamas. (2022). Differential Impact of Type 1 and Type 2 Diabetes Mellitus on Outcomes Among 1.4 Million US Patients Undergoing Percutaneous Coronary Intervention. https://doi.org/10.1016/j.carrev.2021.08.018

BACKGROUND: The aim was to determine the impact of diabetes mellitus (DM) on outcomes after percutaneous coronary intervention (PCI). There is limited data on the impact of DM and its subtypes among patients who underwent PCI during hospitalization.... Read More about Differential Impact of Type 1 and Type 2 Diabetes Mellitus on Outcomes Among 1.4 Million US Patients Undergoing Percutaneous Coronary Intervention..

Temporal trends and patterns in atrial fibrillation incidence: a population-based study of 3·4 million individuals (2022)
Journal Article
Mamas. (2022). Temporal trends and patterns in atrial fibrillation incidence: a population-based study of 3·4 million individuals. The Lancet Regional Health Europe, https://doi.org/10.1016/j.lanepe.2022.100386

Background Population-based studies of atrial fibrillation (AF) incidence are needed to inform health-service planning, but evidence is conflicting. We assessed trends of AF incidence in a large general population cohort from England. Methods We used... Read More about Temporal trends and patterns in atrial fibrillation incidence: a population-based study of 3·4 million individuals.

Treatment and Outcomes of Acute Myocardial Infarction in Patients With Polymyalgia Rheumatica With and Without Giant Cell Arteritis. (2022)
Journal Article
Sokhal, B., Matetić, A., Bharadwaj, A., Helliwell, T., Abhishek, A., Mallen, C., …Mamas, M. (2022). Treatment and Outcomes of Acute Myocardial Infarction in Patients With Polymyalgia Rheumatica With and Without Giant Cell Arteritis. American Journal of Cardiology, 12-19. https://doi.org/10.1016/j.amjcard.2022.03.034

This study analyzed the characteristics, management, and outcomes of patients with polymyalgia rheumatica (PMR) hospitalized with acute myocardial infarction (AMI), including sensitivity analysis for presence of giant cell arteritis (GCA). Using the... Read More about Treatment and Outcomes of Acute Myocardial Infarction in Patients With Polymyalgia Rheumatica With and Without Giant Cell Arteritis..

P181 Musculoskeletal pain and prognosis of acute coronary syndrome and cerebrovascular accident: a linked electronic health record cohort study (2022)
Journal Article
Mason, K. J., Jordan, K. P., Achana, F. A., Bailey, J., Chen, Y., Frisher, M., …Edwards, J. J. (2022). P181 Musculoskeletal pain and prognosis of acute coronary syndrome and cerebrovascular accident: a linked electronic health record cohort study. Rheumatology, 61(S1), https://doi.org/10.1093/rheumatology/keac133.180

Abstract Background/Aims There is some evidence of an increased risk of cardiovascular disease in patients with painful musculoskeletal conditions, but it is unclear if musculoskeletal pain also worsens its prognosis. The aim was to determine whethe... Read More about P181 Musculoskeletal pain and prognosis of acute coronary syndrome and cerebrovascular accident: a linked electronic health record cohort study.

Temporal trends in disease-specific causes of cardiovascular mortality amongst patients with cancer in the USA between 1999 and 2019 (2022)
Journal Article
Mamas. (2022). Temporal trends in disease-specific causes of cardiovascular mortality amongst patients with cancer in the USA between 1999 and 2019. European Heart Journal - Quality of Care and Clinical Outcomes, https://doi.org/10.1093/ehjqcco/qcac016

Aims: We report disease-specific cardiovascular causes of mortality among cancer patients in the USA between 1999 and 2019, considering temporal trends by age, sex, and cancer site. Methods and results: We used the Multiple Cause of Death databas... Read More about Temporal trends in disease-specific causes of cardiovascular mortality amongst patients with cancer in the USA between 1999 and 2019.

Financial Incentives for Transcatheter Aortic Valve Implantation in Ontario, Canada: A Cost-Utility Analysis (2022)
Journal Article
Peel, J. K., Miranda, R. N., Naimark, D., Woodward, G., Mamas, M. A., Madan, M., & Wijeysundera, H. C. (2022). Financial Incentives for Transcatheter Aortic Valve Implantation in Ontario, Canada: A Cost-Utility Analysis. Journal of the American Heart Association, 11(8), Article ARTN e025085. https://doi.org/10.1161/jaha.121.025085

Background Transcatheter aortic valve implantation (TAVI) is a minimally invasive therapy for patients with severe aortic stenosis, which has become standard of care. The objective of this study was to determine the maximum cost-effective investment... Read More about Financial Incentives for Transcatheter Aortic Valve Implantation in Ontario, Canada: A Cost-Utility Analysis.

Age stratified sex‐related differences in incidence, management, and outcomes of cardiogenic shock (2022)
Journal Article
Mamas, M. A., Osman, M., Syed, M., Kheiri, B., Bianco, C., Kalra, A., …Balla, S. (2022). Age stratified sex‐related differences in incidence, management, and outcomes of cardiogenic shock. Catheterization and Cardiovascular Interventions, 99(7), 1984-1995. https://doi.org/10.1002/ccd.30177

BACKGROUND: There is a lack of data on age-stratified sex differences in the incidence, treatment, and outcomes of cardiogenic shock (CS). We sought to study these differences from a contemporary database. METHODS: Patients admitted with CS (2004-201... Read More about Age stratified sex‐related differences in incidence, management, and outcomes of cardiogenic shock.

Evidence for overuse of cardiovascular healthcare services in high-income countries: protocol for a systematic review and meta-analysis. (2022)
Journal Article
Mamas. (2022). Evidence for overuse of cardiovascular healthcare services in high-income countries: protocol for a systematic review and meta-analysis. BMJ Open, e053920 - ?. https://doi.org/10.1136/bmjopen-2021-053920

INTRODUCTION: Overuse of cardiovascular healthcare services, defined as the provision of low-value (ineffective, harmful, cost-ineffective) tests, medications and procedures, may be common and associated with increased patient harm and health system... Read More about Evidence for overuse of cardiovascular healthcare services in high-income countries: protocol for a systematic review and meta-analysis..

Outcomes of rotational atherectomy followed by cutting balloon versus plain balloon before drug‐eluting stent implantation for calcified coronary lesions: A meta‐analysis (2022)
Journal Article
Mamas, M. A., Patel, N., Bandyopadhyay, D., Agarwal, G., Chakraborty, S., Kumar, A., …Naidu, S. S. (2022). Outcomes of rotational atherectomy followed by cutting balloon versus plain balloon before drug‐eluting stent implantation for calcified coronary lesions: A meta‐analysis. Catheterization and Cardiovascular Interventions, 99(6), 1741-1749. https://doi.org/10.1002/ccd.30159

AbstractObjectiveThe aim of this study is to compare outcomes of rotational atherectomy and cutting balloon (RACB) versus rotational atherectomy and plain balloon (RAPB) before drug‐eluting stent (DES) implantation in calcified coronary lesions.Metho... Read More about Outcomes of rotational atherectomy followed by cutting balloon versus plain balloon before drug‐eluting stent implantation for calcified coronary lesions: A meta‐analysis.

COMPARATIVE ANALYSIS OF PERCUTANEOUS REVASCULARIZATION PRACTICE IN THE UNITED STATES AND THE UNITED KINGDOM: INSIGHTS FROM THE BMC2 AND BCIS DATABASES (2022)
Presentation / Conference
Mamas. (2022, April). COMPARATIVE ANALYSIS OF PERCUTANEOUS REVASCULARIZATION PRACTICE IN THE UNITED STATES AND THE UNITED KINGDOM: INSIGHTS FROM THE BMC2 AND BCIS DATABASES. Presented at ACC 22, Washington DC, USA

Background: We compared clinical practice patterns, procedural outcomes, and trends in percutaneous coronary intervention (PCI) utilization using a state-wide PCI registry in the United States and a national registry from the United Kingdom (UK).... Read More about COMPARATIVE ANALYSIS OF PERCUTANEOUS REVASCULARIZATION PRACTICE IN THE UNITED STATES AND THE UNITED KINGDOM: INSIGHTS FROM THE BMC2 AND BCIS DATABASES.

Clinical and angiographic success and safety comparison of coronary intravascular lithotripsy: An updated meta-analysis (2022)
Journal Article
Mamas, M. (2022). Clinical and angiographic success and safety comparison of coronary intravascular lithotripsy: An updated meta-analysis. https://doi.org/10.1016/j.ijcha.2022.100975

Background Intravascular lithotripsy (IVL) can be used to assist stent deployment in severe coronary artery calcifications (CAC). Methods Studies employing IVL for CAC lesions were included. The primary outcomes included clinical and angiographi... Read More about Clinical and angiographic success and safety comparison of coronary intravascular lithotripsy: An updated meta-analysis.

Management and outcomes of acute myocardial infarction in patients with preexisting heart failure: an analysis of 2 million patients from the national inpatient sample. (2022)
Journal Article
Mamas. (2022). Management and outcomes of acute myocardial infarction in patients with preexisting heart failure: an analysis of 2 million patients from the national inpatient sample. Expert Review of Cardiovascular Therapy, 233 - 240. https://doi.org/10.1080/14779072.2022.2058931

BACKGROUND: Inpatient management and outcomes of patients presenting with acute myocardial infarction (AMI) with a history of heart failure (HF) have not been well characterized. METHODS: Hospitalizations for AMI from the Nationwide Inpatient Sample... Read More about Management and outcomes of acute myocardial infarction in patients with preexisting heart failure: an analysis of 2 million patients from the national inpatient sample..

Influenza vaccine improves cardiovascular outcomes in patients with coronary artery disease: A systematic review and meta-analysis. (2022)
Journal Article
Mamas. (2022). Influenza vaccine improves cardiovascular outcomes in patients with coronary artery disease: A systematic review and meta-analysis. Travel Medicine and Infectious Disease, 102311 - ?. https://doi.org/10.1016/j.tmaid.2022.102311

BACKGROUND: There are inconsistent data on the clinical benefit of the influenza vaccine on cardiovascular outcomes in patients with coronary artery disease (CAD). Therefore, the aim of our study was to evaluate the effect of the influenza vaccine on... Read More about Influenza vaccine improves cardiovascular outcomes in patients with coronary artery disease: A systematic review and meta-analysis..

Comparative Effectiveness of Statins on Non-HDL Cholesterol by Type and Intensity in People with Diabetes and at Risk of Cardiovascular Disease: Systematic Review and Network Meta-Analysis (2022)
Journal Article
Hodkinson, A., Tsimpida, D., Kontopantelis, E., Rutter, M. K., Mamas, M., & Panagioti, M. (2022). Comparative Effectiveness of Statins on Non-HDL Cholesterol by Type and Intensity in People with Diabetes and at Risk of Cardiovascular Disease: Systematic Review and Network Meta-Analysis. BMJ, 376, Article e067731. https://doi.org/10.1136/bmj-2021-067731

Objective: To compare the efficacy of different statin treatments by intensity on levels of non-high density lipoprotein cholesterol (non-HDL-C) for the prevention of cardiovascular disease in people with diabetes. Design: Systematic review and ne... Read More about Comparative Effectiveness of Statins on Non-HDL Cholesterol by Type and Intensity in People with Diabetes and at Risk of Cardiovascular Disease: Systematic Review and Network Meta-Analysis.

FFR- Versus Angiography-Guided Revascularization for Nonculprit Stenosis in STEMI and Multivessel Disease: A Network Meta-Analysis. (2022)
Journal Article
Mamas. (2022). FFR- Versus Angiography-Guided Revascularization for Nonculprit Stenosis in STEMI and Multivessel Disease: A Network Meta-Analysis. JACC. Cardiovascular interventions, 656 - 666. https://doi.org/10.1016/j.jcin.2022.01.002

OBJECTIVES: The aim of this study was to examine the efficacy and safety of fractional flow reserve (FFR)-guided versus angiography-guided approaches for nonculprit stenosis among patients with acute ST-segment elevation myocardial infarction (STEMI)... Read More about FFR- Versus Angiography-Guided Revascularization for Nonculprit Stenosis in STEMI and Multivessel Disease: A Network Meta-Analysis..

Long‐Term Cardiovascular Risk and Management of Patients Recorded in Primary Care With Unattributed Chest Pain: An Electronic Health Record Study (2022)
Journal Article
Jordan, K. P., Rathod‐Mistry, T., Bailey, J., Chen, Y., Clarson, L., Denaxas, S., …Mamas, M. A. (2022). Long‐Term Cardiovascular Risk and Management of Patients Recorded in Primary Care With Unattributed Chest Pain: An Electronic Health Record Study. Journal of the American Heart Association, 11(7), Article e023146. https://doi.org/10.1161/JAHA.121.023146

Background Most adults presenting with chest pain will not receive a diagnosis and be recorded with unattributed chest pain. The objective was to assess if they have increased risk of cardiovascular disease compared with those with noncoronary chest... Read More about Long‐Term Cardiovascular Risk and Management of Patients Recorded in Primary Care With Unattributed Chest Pain: An Electronic Health Record Study.

The Impact of Intracoronary Imaging on PCI Outcomes in Cases Utilising Rotational Atherectomy: An Analysis of 8,417 Rotational Atherectomy Cases from the British Cardiovascular Intervention Society Database. (2022)
Journal Article
Protty, M. B., Gallagher, S., Sharp, A. S., Farooq, V., Egred, M., O’Kane, P., …Kinnaird, T. (2022). The Impact of Intracoronary Imaging on PCI Outcomes in Cases Utilising Rotational Atherectomy: An Analysis of 8,417 Rotational Atherectomy Cases from the British Cardiovascular Intervention Society Database. Journal of Interventional Cardiology, 5879187 - ?. https://doi.org/10.1155/2022/5879187

INTRODUCTION: There is increasing evidence supporting the use of intracoronary imaging to optimize the outcomes of percutaneous coronary intervention (PCI). However, there are no studies examining the impact of imaging on PCI outcomes in cases utilis... Read More about The Impact of Intracoronary Imaging on PCI Outcomes in Cases Utilising Rotational Atherectomy: An Analysis of 8,417 Rotational Atherectomy Cases from the British Cardiovascular Intervention Society Database..

Outcomes of Percutaneous Coronary Intervention in Patients With Acquired Immunosuppression (2022)
Journal Article
Mamas. (2022). Outcomes of Percutaneous Coronary Intervention in Patients With Acquired Immunosuppression. American Journal of Cardiology, https://doi.org/10.1016/j.amjcard.2022.01.045

There are limited data on the clinical outcomes of percutaneous coronary intervention (PCI) in patients with acquired immunosuppression who are frequently underrepresented in clinical trials. All PCI procedures between October 2015 and December 2018... Read More about Outcomes of Percutaneous Coronary Intervention in Patients With Acquired Immunosuppression.

Spironolactone effect on the blood pressure of patients at risk of developing heart failure: an analysis from the HOMAGE trial (2022)
Journal Article
Mamas. (2022). Spironolactone effect on the blood pressure of patients at risk of developing heart failure: an analysis from the HOMAGE trial. European Heart Journal - Cardiovascular Pharmacotherapy, 149 - 156. https://doi.org/10.1093/ehjcvp/pvab031

Aims Uncontrolled blood pressure (BP) increases the risk of developing heart failure (HF). The effect of spironolactone on BP of patients at risk of developing HF is yet to be determined. To evaluate the effect of spironolactone on the BP of patients... Read More about Spironolactone effect on the blood pressure of patients at risk of developing heart failure: an analysis from the HOMAGE trial.

COMPLEX, HIGH-RISK BUT INDICATED PERCUTANEOUS CORONARY INTERVENTIONS (CHIP) TYPES AND OUTCOMES AMONG DIFFERENT AGE GROUPS. AN INSIGHT FROM A NATIONAL REGISTRY (2022)
Journal Article
Rashid, & Mamas. (2022). COMPLEX, HIGH-RISK BUT INDICATED PERCUTANEOUS CORONARY INTERVENTIONS (CHIP) TYPES AND OUTCOMES AMONG DIFFERENT AGE GROUPS. AN INSIGHT FROM A NATIONAL REGISTRY. Journal of the American College of Cardiology, 855 - 855. https://doi.org/10.1016/s0735-1097%2822%2901846-0

Background: Studies looking at Complex, High-risk but Indicated Percutaneous coronary intervention (CHiP) type and outcomes among the octogenarian are limited. Methods: Data on PCI for stable angina from 1st January 2006 to 31st December 2017 was obt... Read More about COMPLEX, HIGH-RISK BUT INDICATED PERCUTANEOUS CORONARY INTERVENTIONS (CHIP) TYPES AND OUTCOMES AMONG DIFFERENT AGE GROUPS. AN INSIGHT FROM A NATIONAL REGISTRY.

THE IMPACT OF COMORBIDITY BURDEN ON DE NOVO CIED PROCEDURAL OUTCOMES: INSIGHTS FROM THE NATIONAL INPATIENT SAMPLE (2022)
Journal Article
Mamas. (2022). THE IMPACT OF COMORBIDITY BURDEN ON DE NOVO CIED PROCEDURAL OUTCOMES: INSIGHTS FROM THE NATIONAL INPATIENT SAMPLE. Journal of the American College of Cardiology, 185 - 185. https://doi.org/10.1016/S0735-1097%2822%2901176-7

Background: Limited data exist on the impact of comorbidity burden on procedural outcomes after de novo cardiac implantable electronic device (CIED) implantation. Methods: De novo CIED implantations in the National Inpatient Sample between 2015... Read More about THE IMPACT OF COMORBIDITY BURDEN ON DE NOVO CIED PROCEDURAL OUTCOMES: INSIGHTS FROM THE NATIONAL INPATIENT SAMPLE.

Same-Day Discharge After Elective Percutaneous Coronary Intervention for Chronic Total Occlusion in the UK. (2022)
Journal Article
Mamas. (2022). Same-Day Discharge After Elective Percutaneous Coronary Intervention for Chronic Total Occlusion in the UK

OBJECTIVES: This study examines the safety and feasibility of same-day discharge (SDD) in patients undergoing percutaneous coronary intervention (PCI) to coronary chronic total occlusions (CTOs) and explores independent associations of clinical and p... Read More about Same-Day Discharge After Elective Percutaneous Coronary Intervention for Chronic Total Occlusion in the UK..

Ethnicity-dependent performance of the GRACE risk score for prediction of non-ST-segment elevation myocardial infarction in-hospital mortality: Nationwide cohort study (2022)
Journal Article
Mamas. (2022). Ethnicity-dependent performance of the GRACE risk score for prediction of non-ST-segment elevation myocardial infarction in-hospital mortality: Nationwide cohort study. European Heart Journal, https://doi.org/10.1093/eurheartj/ehac052

Background: The Global Registry of Acute Coronary Events (GRACE) score was developed to evaluate risk in patients with acute coronary syndrome with or without ST-segment elevation. Little is known about its performance at predicting in-hospital morta... Read More about Ethnicity-dependent performance of the GRACE risk score for prediction of non-ST-segment elevation myocardial infarction in-hospital mortality: Nationwide cohort study.

In‐Hospital Complications in Pregnancies Conceived by Assisted Reproductive Technology (2022)
Journal Article
Wu, P., V. Sharma, G., S. Mehta, L., Chew-Graham, C., P. Lundberg, G., A. Nerenberg, K., …A. Mamas, M. (2022). In‐Hospital Complications in Pregnancies Conceived by Assisted Reproductive Technology. Journal of the American Heart Association, 11(5), Article ARTN e022658. https://doi.org/10.1161/JAHA.121.022658

Background Assisted reproductive technology (ART) has emerged as a common treatment option for infertility, a problem that affects an estimated 48 million couples worldwide. Advancing maternal age with increasing prepregnancy cardiovascular risk fact... Read More about In‐Hospital Complications in Pregnancies Conceived by Assisted Reproductive Technology.

Index Admission and Thirty-Day Readmission Outcomes of Patients With Cancer Presenting With STEMI. (2022)
Journal Article
Mamas. (2022). Index Admission and Thirty-Day Readmission Outcomes of Patients With Cancer Presenting With STEMI. Cardiovascular Revascularization Medicine, 121 - 128. https://doi.org/10.1016/j.carrev.2021.04.015

BACKGROUND: National-level data of cancer patients' readmissions after ST-segment elevation myocardial infarction (STEMI) are lacking. OBJECTIVES: The primary aim of this study was to compare the rates and causes of 30-day readmissions in patients wi... Read More about Index Admission and Thirty-Day Readmission Outcomes of Patients With Cancer Presenting With STEMI..

Excess years of life lost to COVID-19 and other causes of death by sex, neighbourhood deprivation, and region in England and Wales during 2020: A registry-based study (2022)
Journal Article
Mamas. (2022). Excess years of life lost to COVID-19 and other causes of death by sex, neighbourhood deprivation, and region in England and Wales during 2020: A registry-based study. PLoS Medicine, e1003904 - e1003904. https://doi.org/10.1371/journal.pmed.1003904

Background Deaths in the first year of the Coronavirus Disease 2019 (COVID-19) pandemic in England and Wales were unevenly distributed socioeconomically and geographically. However, the full scale of inequalities may have been underestimated to da... Read More about Excess years of life lost to COVID-19 and other causes of death by sex, neighbourhood deprivation, and region in England and Wales during 2020: A registry-based study.

Association Between Handover of Anesthesiology Care and 1-Year Mortality Among Adults Undergoing Cardiac Surgery (2022)
Journal Article
Mamas, M., Sun, L. Y., Jones, P. M., Wijeysundera, D. N., Mamas, M. A., Bader Eddeen, A., …O’Connor, J. (2022). Association Between Handover of Anesthesiology Care and 1-Year Mortality Among Adults Undergoing Cardiac Surgery. Jama Network Open, 5(2), Article ARTN e2148161. https://doi.org/10.1001/jamanetworkopen.2021.48161

Importance Handovers of anesthesia care from one anesthesiologist to another is an important intraoperative event. Despite its association with adverse events after noncardiac surgery, its impact in the context of cardiac surgery remains unclear.... Read More about Association Between Handover of Anesthesiology Care and 1-Year Mortality Among Adults Undergoing Cardiac Surgery.

Palliative Care Penetration Among Hospitalizations with Acute Pulmonary Embolism: A Nationwide Analysis (2022)
Journal Article
Elkaryoni, A., Darki, A., Bunte, M., Mamas, M. A., Weinberg, I., & Elgendy, I. Y. (2022). Palliative Care Penetration Among Hospitalizations with Acute Pulmonary Embolism: A Nationwide Analysis. Journal of Palliative Care, 39(2), 129-137. https://doi.org/10.1177/08258597221078389

Background: Integration of palliative care in the management of critical illnesses has been linked with a better quality of life for patients and their families. Yet, there is a paucity of data regarding the role of palliative care for acute pulmonar... Read More about Palliative Care Penetration Among Hospitalizations with Acute Pulmonary Embolism: A Nationwide Analysis.

Higher anticholinergic burden from medications is associated with significant increase in markers of inflammation in the EPIC-Norfolk prospective population-based cohort study (2022)
Journal Article
Mamas, M. A., Sanghavi, R., Pana, T. A., Mamayusupova, H., Maidment, I., Fox, C., …Myint, P. K. (2022). Higher anticholinergic burden from medications is associated with significant increase in markers of inflammation in the EPIC-Norfolk prospective population-based cohort study. British Journal of Clinical Pharmacology, 88(7), 3297-3306. https://doi.org/10.1111/bcp.15261

Background Higher medication anticholinergic burden is associated with increased risk of cardiovascular disease and cognitive decline. A mechanistic pathway has not been established. We aimed to determine whether inflammation may mediate these assoc... Read More about Higher anticholinergic burden from medications is associated with significant increase in markers of inflammation in the EPIC-Norfolk prospective population-based cohort study.

Is There a Role for Triple Therapy After ACS? (2022)
Journal Article
Mamas. (2022). Is There a Role for Triple Therapy After ACS?. Current Cardiology Reports, 191 - 200. https://doi.org/10.1007/s11886-022-01634-3

PURPOSE OF REVIEW: The optimal antithrombotic strategy in patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI) remains the subject of controversy. In this article, we review the current evidence for the use of tr... Read More about Is There a Role for Triple Therapy After ACS?.

Transcatheter Aortic Valve Implantation With or Without Predilation: A Meta-Analysis. (2022)
Journal Article
Mamas. (2022). Transcatheter Aortic Valve Implantation With or Without Predilation: A Meta-Analysis

AIMS: To evaluate the impact of systematic predilation with balloon aortic valvuloplasty (BAV) on transcatheter aortic valve implantation (TAVI). METHODS AND RESULTS: We performed a systematic meta-analysis investigating patients undergoing TAVI with... Read More about Transcatheter Aortic Valve Implantation With or Without Predilation: A Meta-Analysis..

Quality of acute myocardial infarction care in England and Wales during the COVID-19 pandemic: linked nationwide cohort study. (2022)
Journal Article
Aktaa, S., Yadegarfar, M. E., Wu, J., Rashid, M., de Belder, M., Deanfield, J., …Gale, C. P. (2022). Quality of acute myocardial infarction care in England and Wales during the COVID-19 pandemic: linked nationwide cohort study. https://doi.org/10.1136/bmjqs-2021-013040

BACKGROUND AND OBJECTIVE: The impact of the COVID-19 pandemic on the quality of care for patients with acute myocardial infarction (AMI) is uncertain. We aimed to compare quality of AMI care in England and Wales during and before the COVID-19 pandemi... Read More about Quality of acute myocardial infarction care in England and Wales during the COVID-19 pandemic: linked nationwide cohort study..

Drivers and outcomes of variation in surgical versus transcatheter aortic valve replacement in Ontario, Canada: a population-based study. (2022)
Journal Article
Mamas. (2022). Drivers and outcomes of variation in surgical versus transcatheter aortic valve replacement in Ontario, Canada: a population-based study. Open Heart, https://doi.org/10.1136/openhrt-2021-001881

OBJECTIVES: To understand the patient and hospital level drivers of the variation in surgical versus trascatheter aortic valve replacement (SAVR vs TAVR) for patients with aortic stenosis (AS) and to explore whether this variation translates into dif... Read More about Drivers and outcomes of variation in surgical versus transcatheter aortic valve replacement in Ontario, Canada: a population-based study..

Primary Prevention of Cardiovascular and Heart Failure Events With SGLT2 Inhibitors, GLP-1 Receptor Agonists, and Their Combination in Type 2 Diabetes (2022)
Journal Article
Mamas. (2022). Primary Prevention of Cardiovascular and Heart Failure Events With SGLT2 Inhibitors, GLP-1 Receptor Agonists, and Their Combination in Type 2 Diabetes. Diabetes Care, 909-918. https://doi.org/10.2337/dc21-1113

OBJECTIVE To assess associations between current use of sodium–glucose cotransporter 2 inhibitors (SGLT2is), glucagon-like peptide 1 receptor agonists (GLP-1RAs), and their combination and risk for major adverse cardiac and cerebrovascular events (M... Read More about Primary Prevention of Cardiovascular and Heart Failure Events With SGLT2 Inhibitors, GLP-1 Receptor Agonists, and Their Combination in Type 2 Diabetes.

Frailty Among Patients With Acute ST-Elevation Myocardial Infarction in the United States: The Impact of the Primary Percutaneous Coronary Intervention on In-Hospital Outcomes (2022)
Journal Article
Borovac, J. A., Mohamed, M. O., Kontopantelis, E., Alkhouli, M., Alraies, M. C., Cheng, R. K., …Mamas, M. A. (2022). Frailty Among Patients With Acute ST-Elevation Myocardial Infarction in the United States: The Impact of the Primary Percutaneous Coronary Intervention on In-Hospital Outcomes. Journal of Invasive Cardiology,

Objectives. To determine the average treatment effect (ATE) of primary percutaneous coronary intervention (pPCI) versus medical treatment (MT) on in-hospital outcomes across the spectrum of frailty in patients with ST-elevation myocardial infarction... Read More about Frailty Among Patients With Acute ST-Elevation Myocardial Infarction in the United States: The Impact of the Primary Percutaneous Coronary Intervention on In-Hospital Outcomes.

Same-Day Discharge After Elective Percutaneous Coronary Intervention for Chronic Total Occlusion in the UK (2022)
Journal Article
Taxiarchi, P., Kontopantelis, E., Kinnaird, T., Curzen, N., Ahmed, J., Zaman, A., …Mamas, M. A. (2022). Same-Day Discharge After Elective Percutaneous Coronary Intervention for Chronic Total Occlusion in the UK. Journal of Invasive Cardiology,

Objectives. This study examines the safety and feasibility of same-day discharge (SDD) in patients undergoing percutaneous coronary intervention (PCI) to coronary chronic total occlusions (CTOs) and explores independent associations of clinical and p... Read More about Same-Day Discharge After Elective Percutaneous Coronary Intervention for Chronic Total Occlusion in the UK.

Impact of peripheral artery disease on prognosis after percutaneous coronary intervention: Outcomes from the multicenter prospective e-ULTIMASTER registry (2022)
Journal Article
Mamas. (2022). Impact of peripheral artery disease on prognosis after percutaneous coronary intervention: Outcomes from the multicenter prospective e-ULTIMASTER registry. Atherosclerosis, 71 - 77. https://doi.org/10.1016/j.atherosclerosis.2022.01.007

Background and aims Patients with peripheral artery disease (PAD) represent a high risk group, and have an increased risk of cardiovascular events and worse cardiovascular outcomes. Our aim was to study the impact of PAD among patients undergoing per... Read More about Impact of peripheral artery disease on prognosis after percutaneous coronary intervention: Outcomes from the multicenter prospective e-ULTIMASTER registry.

Beyond the revised cardiac risk index: Validation of the hospital frailty risk score in non-cardiac surgery (2022)
Journal Article
Mamas. (2022). Beyond the revised cardiac risk index: Validation of the hospital frailty risk score in non-cardiac surgery. PloS one, e0262322 - e0262322. https://doi.org/10.1371/journal.pone.0262322

Frailty is an established risk factor for adverse outcomes following non-cardiac surgery. The Hospital Frailty Risk Score (HFRS) is a recently described frailty assessment tool that harnesses administrative data and is composed of 109 International C... Read More about Beyond the revised cardiac risk index: Validation of the hospital frailty risk score in non-cardiac surgery.

Sex differences in high-risk but indicated coronary interventions (CHiP): National report from British Cardiovascular Intervention Society Registry. (2022)
Journal Article
Shamkhani, W., Kinnaird, T., Ludman, P., Rashid, M., & Mamas, M. A. (2022). Sex differences in high-risk but indicated coronary interventions (CHiP): National report from British Cardiovascular Intervention Society Registry. Catheterization and Cardiovascular Interventions, 99(2), 447-456. https://doi.org/10.1002/ccd.30081

OBJECTIVE: To assess sex-based differences in clinical outcomes following complex and high-risk but indicated percutaneous coronary intervention (CHiP). BACKGROUND: CHiP is increasingly common in contemporary percutaneous coronary intervention (PCI)... Read More about Sex differences in high-risk but indicated coronary interventions (CHiP): National report from British Cardiovascular Intervention Society Registry..

Trend, predictors, and outcomes of combined mitral valve replacement and coronary artery bypass graft in patients with concomitant mitral valve and coronary artery disease: a National Inpatient Sample database analysis (2022)
Journal Article
Ullah, W., Gul, S., Saleem, S., Syed, M. A., Khan, M. Z., Zahid, S., …Fischman, D. L. (2022). Trend, predictors, and outcomes of combined mitral valve replacement and coronary artery bypass graft in patients with concomitant mitral valve and coronary artery disease: a National Inpatient Sample database analysis. European Heart Journal Open, 2(1), Article oeac002. https://doi.org/10.1093/ehjopen/oeac002

Aims: Combined mitral valve replacement (MVR) and coronary artery bypass graft (CABG) procedures have been the norm for patients with concomitant mitral valve disease (MVD) and coronary artery disease (CAD) with no large-scale data on their safety an... Read More about Trend, predictors, and outcomes of combined mitral valve replacement and coronary artery bypass graft in patients with concomitant mitral valve and coronary artery disease: a National Inpatient Sample database analysis.

Defining Percutaneous Coronary Intervention Complexity and Risk: An Analysis of the United Kingdom BCIS Database 2006-2016. (2022)
Journal Article
Mamas. (2022). Defining Percutaneous Coronary Intervention Complexity and Risk: An Analysis of the United Kingdom BCIS Database 2006-2016. JACC: Cardiovascular Interventions, 39 - 49. https://doi.org/10.1016/j.jcin.2021.09.039

OBJECTIVES: The authors used the BCIS (British Cardiovascular Intervention Society) database to define the factors associated with percutaneous coronary intervention (PCI) procedural complexity. BACKGROUND: Complex high-risk indicated percutaneous co... Read More about Defining Percutaneous Coronary Intervention Complexity and Risk: An Analysis of the United Kingdom BCIS Database 2006-2016..

Outcomes and regional differences in practice in a worldwide coronary stent registry (2022)
Journal Article
Mamas. (2022). Outcomes and regional differences in practice in a worldwide coronary stent registry. Heart, https://doi.org/10.1136/heartjnl-2021-320116

Objective: The primary objective was to assess the performance of a new generation thin-strut sirolimus-eluting coronary stent with abluminal biodegradable polymer in an all comer population. The secondary objective was to detail differences in conte... Read More about Outcomes and regional differences in practice in a worldwide coronary stent registry.

Transcatheter Aortic Valve Implantation With or Without Predilation: A Meta-Analysis (2022)
Journal Article
Conrotto, F., D’Ascenzo, F., Franchin, L., Bruno, F., Mamas, M. A., Toutouzas, K., …De Ferrari, G. M. (2022). Transcatheter Aortic Valve Implantation With or Without Predilation: A Meta-Analysis. Journal of Invasive Cardiology, 34(2),

Aims. To evaluate the impact of systematic predilation with balloon aortic valvuloplasty (BAV) on transcatheter aortic valve implantation (TAVI). Methods and Results. We performed a systematic meta-analysis investigating patients undergoing TAVI with... Read More about Transcatheter Aortic Valve Implantation With or Without Predilation: A Meta-Analysis.

The adverse impact of COVID-19 pandemic on cardiovascular disease prevention and management in England, Scotland and Wales: A population-scale analysis of trends in medication data (2022)
Journal Article
Mamas. (2022). The adverse impact of COVID-19 pandemic on cardiovascular disease prevention and management in England, Scotland and Wales: A population-scale analysis of trends in medication data. MedRxiv, https://doi.org/10.1101/2021.12.31.21268587

Objectives To estimate the impact of the COVID-19 pandemic on cardiovascular disease (CVD) and CVD management using routinely collected medication data as a proxy. Design Descriptive and interrupted time series analysis using anonymised individual-le... Read More about The adverse impact of COVID-19 pandemic on cardiovascular disease prevention and management in England, Scotland and Wales: A population-scale analysis of trends in medication data.

Frailty Among Patients With Acute ST-Elevation Myocardial Infarction in the United States: The Impact of the Primary Percutaneous Coronary Intervention on In-Hospital Outcomes. (2022)
Journal Article
Mamas. (2022). Frailty Among Patients With Acute ST-Elevation Myocardial Infarction in the United States: The Impact of the Primary Percutaneous Coronary Intervention on In-Hospital Outcomes

OBJECTIVES: To determine the average treatment effect (ATE) of primary percutaneous coronary intervention (pPCI) versus medical treatment (MT) on in-hospital outcomes across the spectrum of frailty in patients with ST-elevation myocardial infarction... Read More about Frailty Among Patients With Acute ST-Elevation Myocardial Infarction in the United States: The Impact of the Primary Percutaneous Coronary Intervention on In-Hospital Outcomes..

The impact of Charlson Comorbidity Index on de novo CIED procedural outcomes in the United States (2022)
Journal Article
Rashid, Mamas, & Wu. (2022). The impact of Charlson Comorbidity Index on de novo CIED procedural outcomes in the United States. Mayo Clinic Proceedings, 88-100. https://doi.org/10.1016/j.mayocp.2021.06.029

Objective To investigate the utility of Charlson comorbidity index (CCI) as a measure of comorbidity burden to predict procedural outcomes after de novo cardiac implantable electronic device (CIED) implantation. Methods All de novo CIED implantati... Read More about The impact of Charlson Comorbidity Index on de novo CIED procedural outcomes in the United States.

Risk for Myocardial Infarction Following 5-Fluorouracil Treatment in Patients With Gastrointestinal Cancer: A Nationwide Registry-Based Study. (2021)
Journal Article
Mamas. (2021). Risk for Myocardial Infarction Following 5-Fluorouracil Treatment in Patients With Gastrointestinal Cancer: A Nationwide Registry-Based Study. https://doi.org/10.1016/j.jaccao.2021.11.001

Background: Myocardial infarction is a cardiac adverse event associated with 5-fluorouracil (5-FU). There are limited data on the incidence, risk, and prognosis of 5-FU-associated myocardial infarction. Objectives: The aim of this study was to examin... Read More about Risk for Myocardial Infarction Following 5-Fluorouracil Treatment in Patients With Gastrointestinal Cancer: A Nationwide Registry-Based Study..

Meta-Analysis Comparing Apixaban Versus Rivaroxaban for Management of Patients With Nonvalvular Atrial Fibrillation. (2021)
Journal Article
Mamas. (2021). Meta-Analysis Comparing Apixaban Versus Rivaroxaban for Management of Patients With Nonvalvular Atrial Fibrillation. The American Journal of Cardiology, 58 - 64. https://doi.org/10.1016/j.amjcard.2021.11.021

To compare the efficacy and safety of apixaban and rivaroxaban for the prevention of stroke in patients with nonvalvular atrial fibrillation (NVAF) by way of a meta-analysis informed by real-world evidence. Systematic review and meta-analysis of obse... Read More about Meta-Analysis Comparing Apixaban Versus Rivaroxaban for Management of Patients With Nonvalvular Atrial Fibrillation..

In-Hospital Characteristics and 30-Day Readmissions for Acute Myocardial Infarction and Major Bleeding in Patients With Active Cancer. (2021)
Journal Article
Mamas. (2021). In-Hospital Characteristics and 30-Day Readmissions for Acute Myocardial Infarction and Major Bleeding in Patients With Active Cancer. The American Journal of Cardiology, 25 - 37. https://doi.org/10.1016/j.amjcard.2021.11.015

There are limited data on readmission with ischemic and major bleeding events in patients with acute myocardial infarction (AMI) with active cancer. The purpose of our study was to evaluate in-hospital characteristics and 30-day readmission rates for... Read More about In-Hospital Characteristics and 30-Day Readmissions for Acute Myocardial Infarction and Major Bleeding in Patients With Active Cancer..

Factors Associated With Racial and Ethnic Diversity Among Heart Failure Trial Participants: A Systematic Bibliometric Review. (2021)
Journal Article
Mamas. (2021). Factors Associated With Racial and Ethnic Diversity Among Heart Failure Trial Participants: A Systematic Bibliometric Review. Circulation: Heart Failure, e008685 - ?. https://doi.org/10.1161/CIRCHEARTFAILURE.121.008685

BACKGROUND: Heart failure has a disproportionate burden on patients who are Black, Indigenous, and people of color (BIPOC), but not much is known about representation of these groups in randomized controlled trials (RCTs). We explored temporal trends... Read More about Factors Associated With Racial and Ethnic Diversity Among Heart Failure Trial Participants: A Systematic Bibliometric Review..

Addressing disparities of care in non-ST-segment elevation myocardial infarction (NSTEMI) patients without standard modifiable risk factors: insights from a nationwide cohort study (2021)
Journal Article
Rashid, Mamas, & Nolan. (2021). Addressing disparities of care in non-ST-segment elevation myocardial infarction (NSTEMI) patients without standard modifiable risk factors: insights from a nationwide cohort study. European Journal of Preventive Cardiology, 1084-1092. https://doi.org/10.1093/eurjpc/zwab200

Background: The importance of standard modifiable cardiovascular risk factors (SMuRFs) in preventing non-ST segment myocardial infarction (NSTEMI) is established. However, NSTEMI may present in the absence of SMuRFs, and little is known about their o... Read More about Addressing disparities of care in non-ST-segment elevation myocardial infarction (NSTEMI) patients without standard modifiable risk factors: insights from a nationwide cohort study.

Corrigendum to: Effect of primary percutaneous coronary intervention on in-hospital outcomes among active cancer patients presenting with ST-elevation myocardial infarction: a propensity score matching analysis. (2021)
Journal Article
Mamas. (2021). Corrigendum to: Effect of primary percutaneous coronary intervention on in-hospital outcomes among active cancer patients presenting with ST-elevation myocardial infarction: a propensity score matching analysis. European Heart Journal: Acute Cardiovascular Care, 1101 - ?. https://doi.org/10.1093/ehjacc/zuab013

The Impact of Charlson Comorbidity Index on De Novo Cardiac Implantable Electronic Device Procedural Outcomes in the United States (2021)
Journal Article
Mohamed, M. O., Van Spall, H. G., Morillo, C., Wilton, S. B., Kontopantelis, E., Rashid, M., …Mamas, M. (2022). The Impact of Charlson Comorbidity Index on De Novo Cardiac Implantable Electronic Device Procedural Outcomes in the United States. Mayo Clinic Proceedings, 97(1), 88 - 100. https://doi.org/10.1016/j.mayocp.2021.06.029

OBJECTIVE: To investigate the utility of Charlson comorbidity index (CCI) as a measure of comorbidity burden to predict procedural outcomes after de novo cardiac implantable electronic device (CIED) implantation. METHODS: All de novo CIED implantatio... Read More about The Impact of Charlson Comorbidity Index on De Novo Cardiac Implantable Electronic Device Procedural Outcomes in the United States.

Trends of Sex Differences in Clinical Outcomes After Myocardial Infarction in the United States. (2021)
Journal Article
Rashid, & Mamas. (2021). Trends of Sex Differences in Clinical Outcomes After Myocardial Infarction in the United States. https://doi.org/10.1016/j.cjco.2021.06.012

Background: Female patients have been shown to experience worse clinical outcomes after acute myocardial infarction (AMI) compared with male patients. However, it is unclear what trend these differences followed over time. Methods: Data from patients... Read More about Trends of Sex Differences in Clinical Outcomes After Myocardial Infarction in the United States..

Analysis of a Web-Based Dashboard to Support the Use of National Audit Data in Quality Improvement: Realist Evaluation. (2021)
Journal Article
Mamas. (2021). Analysis of a Web-Based Dashboard to Support the Use of National Audit Data in Quality Improvement: Realist Evaluation. Journal of Medical Internet Research, e28854 - ?. https://doi.org/10.2196/28854

BACKGROUND: Dashboards can support data-driven quality improvements in health care. They visualize data in ways intended to ease cognitive load and support data comprehension, but how they are best integrated into working practices needs further inve... Read More about Analysis of a Web-Based Dashboard to Support the Use of National Audit Data in Quality Improvement: Realist Evaluation..

Clinical outcomes of percutaneous coronary intervention for chronic total occlusion by treated segment length (2021)
Journal Article
Shoaib, A., Mamas, M. A., Spratt, J. C., Curzen, N., Wilson, S., Rashid, M., …Kinnaird, T. (2021). Clinical outcomes of percutaneous coronary intervention for chronic total occlusion by treated segment length. Catheterization and Cardiovascular Interventions, 99(2), 234-244. https://doi.org/10.1002/ccd.30015

AbstractBackgroundLong lesions are known to have worse outcomes following percutaneous coronary intervention (PCI), but there are limited data assessing the association between lesion length and clinical outcomes in PCI procedures undertaken in chron... Read More about Clinical outcomes of percutaneous coronary intervention for chronic total occlusion by treated segment length.

Predictors, Treatments, and Outcomes of Do-Not-Resuscitate Status in Acute Myocardial Infarction Patients (from a Nationwide Inpatient Cohort Study). (2021)
Journal Article
Mamas. (2021). Predictors, Treatments, and Outcomes of Do-Not-Resuscitate Status in Acute Myocardial Infarction Patients (from a Nationwide Inpatient Cohort Study). American Journal of Cardiology, 8 - 18. https://doi.org/10.1016/j.amjcard.2021.07.054

Little is known about how frequently do-not-resuscitate (DNR) orders are placed in patients with acute myocardial infarction (AMI), the types of patients in which they are placed, treatment strategies or clinical outcomes of such patients. Using the... Read More about Predictors, Treatments, and Outcomes of Do-Not-Resuscitate Status in Acute Myocardial Infarction Patients (from a Nationwide Inpatient Cohort Study)..

Aortic stenosis post-COVID-19: A mathematical model on waiting lists and mortality (2021)
Journal Article
Mamas. (2021). Aortic stenosis post-COVID-19: A mathematical model on waiting lists and mortality. MedRxiv, https://doi.org/10.1101/2021.11.11.21266212

Objectives To provide estimates for how different treatment pathways for the management of severe aortic stenosis (AS) may affect NHS England waiting list duration and associated mortality. Design We constructed a mathematical model of the excess wai... Read More about Aortic stenosis post-COVID-19: A mathematical model on waiting lists and mortality.

Impact of sex on outcomes of percutaneous coronary intervention for chronic total occlusion: A meta-analysis. (2021)
Journal Article
Mamas, M., Latif, A., Ahsan, M. J., Lateef, N., Aurit, S., Mirza, M. M., …Velagapudi, P. (2022). Impact of sex on outcomes of percutaneous coronary intervention for chronic total occlusion: A meta-analysis. Catheterization and Cardiovascular Interventions, 99(2), 254-262. https://doi.org/10.1002/ccd.30017

AbstractBackgroundWomen are underrepresented in chronic total occlusion (CTO) trials and little is known about sex differences in the outcomes of CTO percutaneous coronary intervention (PCI). This meta‐analysis aims to compare the outcomes of CTO PCI... Read More about Impact of sex on outcomes of percutaneous coronary intervention for chronic total occlusion: A meta-analysis..

Musculoskeletal pain and its impact on prognosis following hospitalisation for acute coronary syndrome or cerebrovascular accident: a linked electronic health record cohort study (MSKCOM) (2021)
Presentation / Conference
Mallen, Mason, Frisher, Mamas, Jordan, Marshall, …White. (2021, November). Musculoskeletal pain and its impact on prognosis following hospitalisation for acute coronary syndrome or cerebrovascular accident: a linked electronic health record cohort study (MSKCOM). Presented at SAPC North 2021, Virtual

Background: There is evidence that painful musculoskeletal conditions are associated with increased risk of cardiovascular disease, but less is known about whether this impacts on prognosis of cardiovascular disease. The aim was to determine whether... Read More about Musculoskeletal pain and its impact on prognosis following hospitalisation for acute coronary syndrome or cerebrovascular accident: a linked electronic health record cohort study (MSKCOM).

Musculoskeletal pain and its impact on prognosis following hospitalisation for acute coronary syndrome or cerebrovascular accident: a linked electronic health record cohort study (MSKCOM) (2021)
Presentation / Conference
Mason, K., Jordan, K. P., Achana, F., Bailey, J., Chen, Y., Frisher, M., …Edwards, J. J. (2021, November). Musculoskeletal pain and its impact on prognosis following hospitalisation for acute coronary syndrome or cerebrovascular accident: a linked electronic health record cohort study (MSKCOM). Paper presented at 2021 SAPC North, Virtual

Background: There is evidence that painful musculoskeletal conditions are associated with increased risk of cardiovascular disease, but less is known about whether this impacts on prognosis of cardiovascular disease. The aim was to determine whether... Read More about Musculoskeletal pain and its impact on prognosis following hospitalisation for acute coronary syndrome or cerebrovascular accident: a linked electronic health record cohort study (MSKCOM).

Musculoskeletal pain and its impact on prognosis following hospitalisation for acute coronary syndrome or cerebrovascular accident: a linked electronic health record cohort study (MSKCOM) (2021)
Presentation / Conference
Mason, K., Jordan, K., Achana, F., Bailey, J., Chen, Y., Frisher, M., …Edwards, J. (2021, November). Musculoskeletal pain and its impact on prognosis following hospitalisation for acute coronary syndrome or cerebrovascular accident: a linked electronic health record cohort study (MSKCOM). Poster presented at 2021 SAPC North, Virtual

Musculoskeletal pain and its impact on prognosis following hospitalisation for acute coronary syndrome or cerebrovascular accident: a linked electronic health record cohort study (MSKCOM) (2021)
Presentation / Conference
Mason, K., Jordan, K., Achana, F., Bailey, J., Chen, Y., Frisher, M., …Edwards, J. (2021, November). Musculoskeletal pain and its impact on prognosis following hospitalisation for acute coronary syndrome or cerebrovascular accident: a linked electronic health record cohort study (MSKCOM). Poster presented at 2021 SAPC North, Virtual

Dual pathway inhibition in atherothrombosis prevention: yes, now we can! (2021)
Journal Article
SUMMARIA, F., BIONDI-ZOCCAI, G., ROMAGNOLI, E., MAMAS, M. A., FRANCHI, F., SEVERINO, P., …BHATT, D. L. (2023). Dual pathway inhibition in atherothrombosis prevention: yes, now we can!. Minerva Cardiology and Angiology, 71(4), 363-373. https://doi.org/10.23736/S2724-5683.21.05867-1

Despite ongoing developments, prevention and treatment of atherothrombotic cardiovascular disease remains a common challenge. Antithrombotic options for cardiocerebrovascular disease prevention involves a choice between dual antiplatelet therapy (DAP... Read More about Dual pathway inhibition in atherothrombosis prevention: yes, now we can!.

Is There a Difference in the Types of Complex High-Risk but Indicated Percutaneous Coronary Interventions (CHIP) Undertaken and Their Outcomes Among Different Racial Groups? Insights From a National Cohort (2021)
Journal Article
Rashid, & Mamas. (2021). Is There a Difference in the Types of Complex High-Risk but Indicated Percutaneous Coronary Interventions (CHIP) Undertaken and Their Outcomes Among Different Racial Groups? Insights From a National Cohort. Journal of the American College of Cardiology, B131 - B132. https://doi.org/10.1016/j.jacc.2021.09.1176

'Meeting Abstract'

Choice and Outcomes of Left Main Coronary Disease Revascularization Strategies in England Before and After the COVID-19 Era (2021)
Journal Article
Mamas, & Rashid. (2021). Choice and Outcomes of Left Main Coronary Disease Revascularization Strategies in England Before and After the COVID-19 Era. Journal of the American College of Cardiology, B27 - B27. https://doi.org/10.1016/j.jacc.2021.09.916

Methods All patients with LM disease (= 50% stenosis) undergoing coronary revascularization in England between January 1, 2017 and August 19, 2020 were included (n = 22,235), stratified by time period (pre-COVID: January 1, 2017 to February 29, 2020;... Read More about Choice and Outcomes of Left Main Coronary Disease Revascularization Strategies in England Before and After the COVID-19 Era.

TCT-66 Choice and Outcomes of Left Main Coronary Disease Revascularization Strategies in England Before and After the COVID-19 Era (2021)
Journal Article
Mohamed, M., Curzen, N., de Belder, M., Spratt, J., Rashid, M., Shoaib, A., …Mamas, M. (2021). TCT-66 Choice and Outcomes of Left Main Coronary Disease Revascularization Strategies in England Before and After the COVID-19 Era. Journal of the American College of Cardiology, B27 - B27. https://doi.org/10.1016/j.jacc.2021.09.916

Background There are limited data on the impact of the COVID-19 pandemic on left main (LM) coronary revascularization activity, choice of strategy, and post-procedural outcomes. Methods All patients with LM disease (= 50% stenosis) undergoing coronar... Read More about TCT-66 Choice and Outcomes of Left Main Coronary Disease Revascularization Strategies in England Before and After the COVID-19 Era.

TCT-359 Treatment Effect of Primary Percutaneous Coronary Intervention on In-Hospital Outcomes of Active Cancer Patients Presenting With ST-Elevation Myocardial Infarction (2021)
Journal Article
Mohamed, M., Van Spall, H., Alkhouli, M., Khan, S., Barac, A., Shoaib, A., …Mamas, M. (2021). TCT-359 Treatment Effect of Primary Percutaneous Coronary Intervention on In-Hospital Outcomes of Active Cancer Patients Presenting With ST-Elevation Myocardial Infarction. Journal of the American College of Cardiology, B148 - B148

TCT-323 Is There a Difference in the Types of Complex High-Risk but Indicated Percutaneous Coronary Interventions (CHIP) Undertaken and Their Outcomes Among Different Racial Groups? Insights From a National Cohort (2021)
Journal Article
Shamkhani, W., Kinnaird, T., Wijeysundera, H., Ludman, P., Rashid, M., & Mamas, M. (2021). TCT-323 Is There a Difference in the Types of Complex High-Risk but Indicated Percutaneous Coronary Interventions (CHIP) Undertaken and Their Outcomes Among Different Racial Groups? Insights From a National Cohort. Journal of the American College of Cardiology, B131 - B132. https://doi.org/10.1016/j.jacc.2021.09.1176

Background In contemporary practice, complex high-risk but indicated percutaneous coronary intervention (CHIP) is increasingly common. Data on race-based differences in the nature of CHIP and their clinical outcomes in patients with stable coronary a... Read More about TCT-323 Is There a Difference in the Types of Complex High-Risk but Indicated Percutaneous Coronary Interventions (CHIP) Undertaken and Their Outcomes Among Different Racial Groups? Insights From a National Cohort.

TCT-110 Fifteen-Year Trends in the Rates of Elective Percutaneous Coronary Intervention and Impact of COURAGE and ORBITA Trials: Insights From British Cardiovascular Intervention Society Dataset (2021)
Journal Article
Rashid, & Mamas. (2021). TCT-110 Fifteen-Year Trends in the Rates of Elective Percutaneous Coronary Intervention and Impact of COURAGE and ORBITA Trials: Insights From British Cardiovascular Intervention Society Dataset. Journal of the American College of Cardiology, B46 - B47. https://doi.org/10.1016/j.jacc.2021.09.960

Background This study was designed to evaluate temporal trends in elective rates of percutaneous coronary intervention (PCI) for stable angina and, specifically, to study the impact of the COURAGE and ORBITA trials on real-life practice. Methods We a... Read More about TCT-110 Fifteen-Year Trends in the Rates of Elective Percutaneous Coronary Intervention and Impact of COURAGE and ORBITA Trials: Insights From British Cardiovascular Intervention Society Dataset.

Treatment Effect of Primary Percutaneous Coronary Intervention on In-Hospital Outcomes of Active Cancer Patients Presenting With ST-Elevation Myocardial Infarction (2021)
Journal Article
Mamas. (2021). Treatment Effect of Primary Percutaneous Coronary Intervention on In-Hospital Outcomes of Active Cancer Patients Presenting With ST-Elevation Myocardial Infarction. Journal of the American College of Cardiology, B148 - B148

Background Primary percutaneous coronary intervention (pPCI) is the optimal strategy for coronary revascularization in patients presenting with ST-segment elevation myocardial infarction (STEMI). However, there are limited data on the utility of pPCI... Read More about Treatment Effect of Primary Percutaneous Coronary Intervention on In-Hospital Outcomes of Active Cancer Patients Presenting With ST-Elevation Myocardial Infarction.

Temporal Trends and Factors Associated With the Inclusion of Patient-Reported Outcomes in Heart Failure Randomized Controlled Trials: A Systematic Review. (2021)
Journal Article
Eliya, Y., Averbuch, T., Le, N., Xie, F., Thabane, L., Mamas, M. A., & Van Spall, H. G. (2021). Temporal Trends and Factors Associated With the Inclusion of Patient-Reported Outcomes in Heart Failure Randomized Controlled Trials: A Systematic Review. Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, e022353 - ?. https://doi.org/10.1161/JAHA.121.022353

Background Patient-reported outcomes (PROs) are important measures of treatment response in heart failure. We assessed temporal trends in and factors associated with inclusion of PROs in heart failure randomized controlled trials (RCTs). Methods and... Read More about Temporal Trends and Factors Associated With the Inclusion of Patient-Reported Outcomes in Heart Failure Randomized Controlled Trials: A Systematic Review..

Relation of High-Sensitivity Troponin to 1 Year Mortality in 20,000 Consecutive Hospital Patients Undergoing a Blood Test for Any Reason. (2021)
Journal Article
Hinton, J., Mariathas, M., Gabara, L., Allan, R., Nicholas, Z., Shing Kwok, C., …Curzen, N. (2021). Relation of High-Sensitivity Troponin to 1 Year Mortality in 20,000 Consecutive Hospital Patients Undergoing a Blood Test for Any Reason. American Journal of Cardiology, 124 - 131. https://doi.org/10.1016/j.amjcard.2021.07.050

This was an observational study of the 1-year outcomes of the 20,000 patients included in the original CHARIOT study. The aim of the study was to assess the association between high sensitivity troponin I (hs-cTnI) concentration and 1 year mortality... Read More about Relation of High-Sensitivity Troponin to 1 Year Mortality in 20,000 Consecutive Hospital Patients Undergoing a Blood Test for Any Reason..

Shock index predicts up to 90-day mortality risk after intracerebral haemorrhage. (2021)
Journal Article
Pana, T. A., Quinn, T. J., Perdomo-Lampignano, J. A., Szlachetka, W. A., Knoery, C., Mamas, M. A., …Collaborators, V. (2021). Shock index predicts up to 90-day mortality risk after intracerebral haemorrhage. Clinical Neurology and Neurosurgery, 106994 - ?. https://doi.org/10.1016/j.clineuro.2021.106994

BACKGROUND: Shock index (SI - heart rate/systolic blood pressure) has been studied as a measure of haemodynamic status. We aimed to determine whether SI measures within 72 h of admission were associated with adverse outcomes in intracerebral haemorrh... Read More about Shock index predicts up to 90-day mortality risk after intracerebral haemorrhage..

Trends in cardiovascular mortality of cancer patients in the US over two decades 1999-2019. (2021)
Journal Article
Mamas, M. (2021). Trends in cardiovascular mortality of cancer patients in the US over two decades 1999-2019. International Journal of Clinical Practice, e14841 - ?. https://doi.org/10.1111/ijcp.14841

BACKGROUND: Cancer is the second most common cause of death globally after cardiovascular disease, and cancer patients are at an increased risk of CV death. This recognition has led to publication of cardio-oncological guidelines and to the widesprea... Read More about Trends in cardiovascular mortality of cancer patients in the US over two decades 1999-2019..

Impact of malignancy on In-hospital mortality, stratified by the cause of admission: An analysis of 67 million patients from the National Inpatient Sample. (2021)
Journal Article
Mamas. (2021). Impact of malignancy on In-hospital mortality, stratified by the cause of admission: An analysis of 67 million patients from the National Inpatient Sample. International Journal of Clinical Practice, e14758 - ?. https://doi.org/10.1111/ijcp.14758

OBJECTIVE: To describe the patient characteristics and the reason for admission of patients with malignancy by malignancy, and to study mortality rates for the different causes of admissions among the different types of cancer. PATIENTS AND METHODS:... Read More about Impact of malignancy on In-hospital mortality, stratified by the cause of admission: An analysis of 67 million patients from the National Inpatient Sample..

Outcomes of rotational atherectomy versus orbital atherectomy for the treatment of heavily calcified coronary stenosis: A systematic review and meta-analysis. (2021)
Journal Article
Mamas. (2021). Outcomes of rotational atherectomy versus orbital atherectomy for the treatment of heavily calcified coronary stenosis: A systematic review and meta-analysis. Catheterization and Cardiovascular Interventions, 884 - 892. https://doi.org/10.1002/ccd.29430

INTRODUCTION: The optimal approach to deal with severe coronary artery calcification (CAC) during percutaneous coronary intervention (PCI) remains ill-defined. METHODS: We conducted an electronic database search of all published studies comparing Orb... Read More about Outcomes of rotational atherectomy versus orbital atherectomy for the treatment of heavily calcified coronary stenosis: A systematic review and meta-analysis..

Substantial decline in hospital admissions for heart failure accompanied by increased community mortality during COVID-19 pandemic (2021)
Journal Article
Shoaib, A., Van Spall, H. G. C., Wu, J., Cleland, J. G. F., McDonagh, T. A., Rashid, M., …Mamas, M. A. (2021). Substantial decline in hospital admissions for heart failure accompanied by increased community mortality during COVID-19 pandemic. European Heart Journal - Quality of Care and Clinical Outcomes, 7(4), 378-387. https://doi.org/10.1093/ehjqcco/qcab040

Aims We hypothesized that a decline in admissions with heart failure during COVID-19 pandemic would lead to a reciprocal rise in mortality for patients with heart failure in the community. Methods and results We used National Heart Failure Audit d... Read More about Substantial decline in hospital admissions for heart failure accompanied by increased community mortality during COVID-19 pandemic.

Dual Antiplatelet Therapy after PCI in Patients at High Bleeding Risk. (2021)
Journal Article
Mamas, M. (2021). Dual Antiplatelet Therapy after PCI in Patients at High Bleeding Risk. https://doi.org/10.1056/NEJMoa2108749

BACKGROUND: The appropriate duration of dual antiplatelet therapy in patients at high risk for bleeding after the implantation of a drug-eluting coronary stent remains unclear. METHODS: One month after they had undergone implantation of a biodegradab... Read More about Dual Antiplatelet Therapy after PCI in Patients at High Bleeding Risk..

Impact of availability of catheter laboratory facilities on management and outcomes of acute myocardial infarction presenting with out of hospital cardiac arrest. (2021)
Journal Article
Mamas, M., & Rashid, M. (2021). Impact of availability of catheter laboratory facilities on management and outcomes of acute myocardial infarction presenting with out of hospital cardiac arrest. Resuscitation, 327-334. https://doi.org/10.1016/j.resuscitation.2021.10.031

OBJECTIVES: We aimed to identify whether the availability of catheter laboratory affects clinical outcomes of out-of-hospital cardiac arrest (OHCA) complicating myocardial infarction (AMI). METHODS: Patients admitted with a diagnosis of AMI and OHCA... Read More about Impact of availability of catheter laboratory facilities on management and outcomes of acute myocardial infarction presenting with out of hospital cardiac arrest..

Outcomes of intravascular ultrasound versus optical coherence tomography guided percutaneous coronary angiography: A meta regression-based analysis. (2021)
Journal Article
Mamas, M. A., Sattar, Y., Abdul Razzack, A., Kompella, R., Alhajri, N., Arshad, J., …Alraies, M. C. (2022). Outcomes of intravascular ultrasound versus optical coherence tomography guided percutaneous coronary angiography: A meta regression-based analysis. Catheterization and Cardiovascular Interventions, 99(1), E1 - E11. https://doi.org/10.1002/ccd.29976

BACKGROUND: Studies comparing clinical outcomes with intravascular ultrasound (IVUS) versus optical coherence tomography (OCT) guidance for percutaneous coronary intervention (PCI) in patients presenting with coronary artery disease, including stable... Read More about Outcomes of intravascular ultrasound versus optical coherence tomography guided percutaneous coronary angiography: A meta regression-based analysis..

Meta-Analysis of Transradial Versus Transfemoral Access for Percutaneous Coronary Intervention in Patients With Chronic Kidney Disease. (2021)
Journal Article
Mamas. (2021). Meta-Analysis of Transradial Versus Transfemoral Access for Percutaneous Coronary Intervention in Patients With Chronic Kidney Disease. American Journal of Cardiology, 8 - 14. https://doi.org/10.1016/j.amjcard.2021.07.018

Data comparing outcomes of transradial (TR) versus transfemoral (TF) access for percutaneous coronary intervention (PCI) in chronic kidney disease (CKD) including patients with eGFR< 30 ml/min/1.73m2 and patients with end-stage renal disease on dialy... Read More about Meta-Analysis of Transradial Versus Transfemoral Access for Percutaneous Coronary Intervention in Patients With Chronic Kidney Disease..

Impact of cancer diagnosis on causes and outcomes of 5.9 million US patients with cardiovascular admissions. (2021)
Journal Article
Mamas. (2021). Impact of cancer diagnosis on causes and outcomes of 5.9 million US patients with cardiovascular admissions. International Journal of Cardiology, 76 - 83. https://doi.org/10.1016/j.ijcard.2021.07.054

INTRODUCTION: There are limited data on causes of cardiovascular (CV) admissions and associated outcomes among patients with different cancers. METHODS: All CV admissions from the US National Inpatient Sample between October 2015 to December 2017 wer... Read More about Impact of cancer diagnosis on causes and outcomes of 5.9 million US patients with cardiovascular admissions..

Association of quality indicators for acute myocardial infarction and mortality: feasibility and validation study using linked nationwide registry data (2021)
Journal Article
Mamas, & Rashid. (2021). Association of quality indicators for acute myocardial infarction and mortality: feasibility and validation study using linked nationwide registry data. European Heart Journal, https://doi.org/10.1093/eurheartj/ehab724.1328

Abstract Background Quality indicators (QIs) have been increasingly used as tools to assess and improve the quality of care for acute myocardial infarction (AMI). However, it is not known if it is feasible to use the 2020 iteration of international A... Read More about Association of quality indicators for acute myocardial infarction and mortality: feasibility and validation study using linked nationwide registry data.

Comparison of risk factors for coronary event in people with unattributed and non-coronary chest pain: an electronic health record cohort study (2021)
Journal Article
Rathod-Mistry, T., Mamas, M., Bailey, J., Chen, Y., Clarson, L., Denaxas, S., …Jordan, K. (2021). Comparison of risk factors for coronary event in people with unattributed and non-coronary chest pain: an electronic health record cohort study. European Heart Journal, 42(S1), https://doi.org/10.1093/eurheartj/ehab724.1350

Background Patients presenting to primary care with chest pain are often not given a cause. Patients with such unattributed chest pain have an increased risk of future cardiovascular disease (CVD) compared to patients with diagnosed non-coronary che... Read More about Comparison of risk factors for coronary event in people with unattributed and non-coronary chest pain: an electronic health record cohort study.

Temporal trends in the inclusion of patient-reported outcomes in heart failure randomized trials published in high-impact medical journals: a systematic bibliometric review (2021)
Journal Article
Eliya, Y., Averbuch, T., Le, N., Xie, F., Thabane, L., Mamas, M., & Van Spall, H. (2021). Temporal trends in the inclusion of patient-reported outcomes in heart failure randomized trials published in high-impact medical journals: a systematic bibliometric review. European Heart Journal, https://doi.org/10.1093/eurheartj/ehab724.3171

Background Patient reported outcomes (PROs) are important measures of health, particularly in symptomatic conditions such as heart failure (HF), and regulatory agencies have encouraged their collection in randomized controlled trials (RCTs). Purpose... Read More about Temporal trends in the inclusion of patient-reported outcomes in heart failure randomized trials published in high-impact medical journals: a systematic bibliometric review.

Incidence and one year outcome of periprocedural myocardial infarction following cardiac surgery: are the universal definition and SCAI criteria fit for purpose? (2021)
Journal Article
Hinton, J., Augustine, M., Gabara, L., Mariathas, M., Allan, R., Borca, F., …Curzen, N. (2021). Incidence and one year outcome of periprocedural myocardial infarction following cardiac surgery: are the universal definition and SCAI criteria fit for purpose?. European Heart Journal, 42(Supplement_1), https://doi.org/10.1093/eurheartj/ehab724.1442

Introduction The diagnosis and clinical implication of periprocedural myocardial infarction (PPMI) following coronary artery bypass grafting (CABG) is contentious, especially given its importance in the interpretation of trial data. Two accepted def... Read More about Incidence and one year outcome of periprocedural myocardial infarction following cardiac surgery: are the universal definition and SCAI criteria fit for purpose?.

The relationship between high-sensitivity troponin taken on admission to critical care, regardless of whether there was a clinical indication for testing, and one year mortality (2021)
Journal Article
Hinton, J., Augustine, M., Gabara, L., Mariathas, M., Allan, R., Borca, F., …Curzen, N. (2021). The relationship between high-sensitivity troponin taken on admission to critical care, regardless of whether there was a clinical indication for testing, and one year mortality. European Heart Journal, 42(Supplement_1), https://doi.org/10.1093/eurheartj/ehab724.1381

Introduction High-sensitivity troponin (hs-cTn) assays now form a key component of the diagnostic pathways for patients presenting to emergency medical services with chest pain. However, hs-cTn concentrations above the manufacturer-provided upper li... Read More about The relationship between high-sensitivity troponin taken on admission to critical care, regardless of whether there was a clinical indication for testing, and one year mortality.

The association between socioeconomic status, sex, race/ethnicity and in-hospital mortality among patients hospitalized for heart failure (2021)
Journal Article
Mamas. (2021). The association between socioeconomic status, sex, race/ethnicity and in-hospital mortality among patients hospitalized for heart failure. Journal of Cardiac Failure, https://doi.org/10.1016/j.cardfail.2021.09.012

Background The association between socioeconomic status (SES), sex, race/ethnicity and outcomes during hospitalization for heart failure (HF) has not previously been investigated. Methods We analyzed HF hospitalizations in the United States National... Read More about The association between socioeconomic status, sex, race/ethnicity and in-hospital mortality among patients hospitalized for heart failure.

Clinical Characteristics, Management Strategies, and Outcomes of Non-ST-Segment-Elevation Myocardial Infarction Patients With and Without Prior Coronary Artery Bypass Grafting. (2021)
Journal Article
Mamas, M., & Rashid, M. (2021). Clinical Characteristics, Management Strategies, and Outcomes of Non-ST-Segment-Elevation Myocardial Infarction Patients With and Without Prior Coronary Artery Bypass Grafting. https://doi.org/10.1161/JAHA.120.018823

Background There are limited data on the management strategies, temporal trends and clinical outcomes of patients who present with non-ST-segment-elevation myocardial infarction and have a prior history of CABG. Methods and Results We identified 287 ... Read More about Clinical Characteristics, Management Strategies, and Outcomes of Non-ST-Segment-Elevation Myocardial Infarction Patients With and Without Prior Coronary Artery Bypass Grafting..

Racial disparities in management and outcomes of out-of-hospital cardiac arrest complicating myocardial infarction; a national study from England and Wales (2021)
Journal Article
Mamas, & Rashid. (2021). Racial disparities in management and outcomes of out-of-hospital cardiac arrest complicating myocardial infarction; a national study from England and Wales. https://doi.org/10.1016/j.cjco.2021.09.026

Background Studies of racial disparities in patients admitted with an OHCA in the setting of AMI have shown inconsistent results. Whether these differences in care exist in a universal healthcare system in England is unknown. Methods Patients admitte... Read More about Racial disparities in management and outcomes of out-of-hospital cardiac arrest complicating myocardial infarction; a national study from England and Wales.

Comparison of Outcomes of Patients With Versus Without Chronic Liver Disease Undergoing Percutaneous Coronary Intervention. (2021)
Journal Article
Mamas. (2021). Comparison of Outcomes of Patients With Versus Without Chronic Liver Disease Undergoing Percutaneous Coronary Intervention. American Journal of Cardiology, 32 - 38. https://doi.org/10.1016/j.amjcard.2021.06.044

There are limited data on the outcomes of chronic liver disease (CLD) patients admitted for percutaneous coronary intervention (PCI). All PCI hospitalizations from the Nationwide Inpatient Sample (2004 to 2015) were analyzed and stratified by the pre... Read More about Comparison of Outcomes of Patients With Versus Without Chronic Liver Disease Undergoing Percutaneous Coronary Intervention..

Fractional flow reserve derived from computed tomography coronary angiography in the assessment and management of stable chest pain: the FORECAST randomized trial. (2021)
Journal Article
Mamas. (2021). Fractional flow reserve derived from computed tomography coronary angiography in the assessment and management of stable chest pain: the FORECAST randomized trial. European Heart Journal, 3844 - 3852. https://doi.org/10.1093/eurheartj/ehab444

AIMS: Fractional flow reserve (FFRCT) using computed tomography coronary angiography (CTCA) determines both the presence of coronary artery disease and vessel-specific ischaemia. We tested whether an evaluation strategy based on FFRCT would improve e... Read More about Fractional flow reserve derived from computed tomography coronary angiography in the assessment and management of stable chest pain: the FORECAST randomized trial..

Distribution, management and outcomes of AMI according to principal diagnosis priority during inpatient admission. (2021)
Journal Article
Mamas. (2021). Distribution, management and outcomes of AMI according to principal diagnosis priority during inpatient admission. https://doi.org/10.1111/ijcp.14554

BACKGROUND: In recent years, there has been a growing interest in outcomes of patients with acute myocardial infarction (AMI) using large administrative datasets. The present study was designed to compare the characteristics, management strategies an... Read More about Distribution, management and outcomes of AMI according to principal diagnosis priority during inpatient admission..

In-hospital outcomes of endovascular versus surgical revascularization for chronic total occlusion in peripheral artery disease. (2021)
Journal Article
Mamas. (2021). In-hospital outcomes of endovascular versus surgical revascularization for chronic total occlusion in peripheral artery disease. Catheterization and Cardiovascular Interventions, E586 - E593. https://doi.org/10.1161/circinterventions.119.008150

BACKGROUND: The outcome of endovascular intervention (EVI) compared vs. surgical revascularization in patients with peripheral artery disease (PAD) due to chronic total occlusion (CTO) is unknown. METHODS: Using the National Inpatient Sample database... Read More about In-hospital outcomes of endovascular versus surgical revascularization for chronic total occlusion in peripheral artery disease..

Prevalence of Cardiovascular Risk Factors in Osteoarthritis Patients Derived from Primary Care Records: A Systematic Review of Observational Studies. (2021)
Journal Article
Huang, X., Wilkie, R., Mamas, M., & Yu, D. (2021). Prevalence of Cardiovascular Risk Factors in Osteoarthritis Patients Derived from Primary Care Records: A Systematic Review of Observational Studies. Journal of Diabetes and Clinical Research, 3(3), https://doi.org/10.33696/diabetes.3.042

Background: People with osteoarthritis are at a high risk of cardiovascular disease (CVD). Detecting CVD risk factors in this high-risk population will help to improve CVD outcomes. Primary care electronic health records (EHRs) provide opportunities... Read More about Prevalence of Cardiovascular Risk Factors in Osteoarthritis Patients Derived from Primary Care Records: A Systematic Review of Observational Studies..

Outcomes of Elderly Patients Undergoing Left Atrial Appendage Closure. (2021)
Journal Article
Mamas. (2021). Outcomes of Elderly Patients Undergoing Left Atrial Appendage Closure. Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, e021973 - ?. https://doi.org/10.1161/JAHA.121.021973

Background Elderly patients have a higher burden of comorbidities that influence clinical outcomes. We aimed to compare in-hospital outcomes in patients =80 years old to younger patients, and to determine the factors associated with increased risk of... Read More about Outcomes of Elderly Patients Undergoing Left Atrial Appendage Closure..

Treatment Effect of Percutaneous Coronary Intervention in Men Versus Women With ST-Segment-Elevation Myocardial Infarction. (2021)
Journal Article
Mamas. (2021). Treatment Effect of Percutaneous Coronary Intervention in Men Versus Women With ST-Segment-Elevation Myocardial Infarction

Background Women are less likely to receive primary percutaneous coronary intervention (pPCI) than men. A potential reason is risk aversion because of the worse outcomes with pPCI among women. However, whether pPCI is associated with a comparable mo... Read More about Treatment Effect of Percutaneous Coronary Intervention in Men Versus Women With ST-Segment-Elevation Myocardial Infarction..

Methodological Rigor and Temporal Trends of Cardiovascular Medicine Meta-Analyses in Highest-Impact Journals. (2021)
Journal Article
Mamas. (2021). Methodological Rigor and Temporal Trends of Cardiovascular Medicine Meta-Analyses in Highest-Impact Journals

Background Well-conducted meta-analyses are considered to be at the top of the evidence-based hierarchy pyramid, with an expansion of these publications within the cardiovascular research arena. There are limited data evaluating the trends and qual... Read More about Methodological Rigor and Temporal Trends of Cardiovascular Medicine Meta-Analyses in Highest-Impact Journals..

Racial, ethnic and socioeconomic disparities in patients undergoing transcatheter mitral edge-to-edge repair. (2021)
Journal Article
Sparrow, R. T., Sanjoy, S. S., Lindman, B. R., Tang, G. H., Kaneko, T., Wasfy, J. H., …Bagur, R. (2021). Racial, ethnic and socioeconomic disparities in patients undergoing transcatheter mitral edge-to-edge repair. International Journal of Cardiology, 73 - 81. https://doi.org/10.1016/j.ijcard.2021.09.037

BACKGROUND: Transcatheter mitral edge-to-edge repair (TEER) is an increasingly common procedure performed on patients with severe mitral regurgitation. This study assessed the impact of race/ethnicity and socioeconomic status on in-hospital complicat... Read More about Racial, ethnic and socioeconomic disparities in patients undergoing transcatheter mitral edge-to-edge repair..

Ultrasound- Versus Fluoroscopy-Guided Strategy for Transfemoral Transcatheter Aortic Valve Replacement Access: A Systematic Review and Meta-Analysis. (2021)
Journal Article
Mamas. (2021). Ultrasound- Versus Fluoroscopy-Guided Strategy for Transfemoral Transcatheter Aortic Valve Replacement Access: A Systematic Review and Meta-Analysis. https://doi.org/10.1161/CIRCINTERVENTIONS.121.010742

BACKGROUND: Access site vascular and bleeding complications remain problematic for patients undergoing transcatheter aortic valve replacement (TAVR). Ultrasound-guided transfemoral access approach has been suggested as a technique to reduce access si... Read More about Ultrasound- Versus Fluoroscopy-Guided Strategy for Transfemoral Transcatheter Aortic Valve Replacement Access: A Systematic Review and Meta-Analysis..

Invasive Hemodynamic Monitoring in Cardiogenic Shock Is Associated With Lower In‐Hospital Mortality (2021)
Journal Article
Osman, M., Syed, M., Patel, B., Munir, M. B., Kheiri, B., Caccamo, M., …Bianco, C. M. (2021). Invasive Hemodynamic Monitoring in Cardiogenic Shock Is Associated With Lower In‐Hospital Mortality. Journal of the American Heart Association, 10(18), https://doi.org/10.1161/jaha.121.021808

BackgroundThere is increasing utilization of cardiogenic shock treatment algorithms. The cornerstone of these algorithms is the use of invasive hemodynamic monitoring (IHM). We sought to compare the in‐hospital outcomes in patients who received IHM v... Read More about Invasive Hemodynamic Monitoring in Cardiogenic Shock Is Associated With Lower In‐Hospital Mortality.

Safety and efficacy of the polymer-free and polymer-coated drug-eluting stents in patients undergoing percutaneous coronary intervention. (2021)
Journal Article
Ullah, W., Zghouzi, M., Ahmad, B., Suleiman, A. M., Zahid, S., Faisaluddin, M., …Alraies, M. C. (2021). Safety and efficacy of the polymer-free and polymer-coated drug-eluting stents in patients undergoing percutaneous coronary intervention. Catheterization and Cardiovascular Interventions, 98(6), E802 - E813. https://doi.org/10.1002/ccd.29953

INTRODUCTION: The relative safety and efficacy of polymer-free (PF) versus polymer-coated (PC) drug-eluting stents (DES) in patients with angina or acute coronary syndrome (ACS) undergoing percutaneous coronary intervention has received limited study... Read More about Safety and efficacy of the polymer-free and polymer-coated drug-eluting stents in patients undergoing percutaneous coronary intervention..

Impact of the admitting ward on care quality and outcomes in non-ST-segment elevation myocardial infarction (NSTEMI): insights from a national registry. (2021)
Journal Article
Mamas. (2021). Impact of the admitting ward on care quality and outcomes in non-ST-segment elevation myocardial infarction (NSTEMI): insights from a national registry. European Heart Journal - Quality of Care and Clinical Outcomes, https://doi.org/10.1093/ehjqcco/qcab062

BACKGROUND: Little is known about the association between the type of admission ward and quality of care and outcomes for non-ST-segment elevation myocardial infarction (NSTEMI). METHODS & RESULTS: We analysed data from 337,155 NSTEMI admissions betw... Read More about Impact of the admitting ward on care quality and outcomes in non-ST-segment elevation myocardial infarction (NSTEMI): insights from a national registry..

496Higher predicted 10-year risk for cardiovascular disease in primary care consulters for osteoarthritis (2021)
Journal Article
Huang, M., Yu, D., Wilkie, R., & Mamas, M. (2021). 496Higher predicted 10-year risk for cardiovascular disease in primary care consulters for osteoarthritis. International Journal of Epidemiology, i105 - i105. https://doi.org/10.1093/ije/dyab168.295

Abstract Background Osteoarthritis (OA) has a major impact on the global burden of disease and is associated with poorer cardiovascular disease (CVD) outcomes. However it’s unclear whether people with OA have higher long-term (10-year) CVD risk comp... Read More about 496Higher predicted 10-year risk for cardiovascular disease in primary care consulters for osteoarthritis.

A snapshot global survey on side effects of COVID-19 vaccines among healthcare professionals and armed forces with a focus on headache. (2021)
Journal Article
Mamas. (2021). A snapshot global survey on side effects of COVID-19 vaccines among healthcare professionals and armed forces with a focus on headache. https://doi.org/10.23736/S0031-0808.21.04435-9

BACKGROUND: New messenger RNA (mRNA) and adenovirus-based vaccines (AdV) against Coronavirus disease 2019 (COVID-19) have entered large scale clinical trials. Since healthcare professionals (HCPs) and armed forces personnel (AFP) represent a high-ris... Read More about A snapshot global survey on side effects of COVID-19 vaccines among healthcare professionals and armed forces with a focus on headache..

Characteristics and hospital outcomes of coronary atherectomy within the United States: a multivariate and propensity-score matched analysis. (2021)
Journal Article
Mamas. (2021). Characteristics and hospital outcomes of coronary atherectomy within the United States: a multivariate and propensity-score matched analysis. Expert Review of Cardiovascular Therapy, 865 - 870. https://doi.org/10.1080/14779072.2021.1963233

BACKGROUND: Suboptimal stent delivery and deployment in calcified coronary lesions are associated with a poor clinical outcome. METHODS: Using the National Inpatient Sample database, we identified patients undergoing percutaneous coronary interventio... Read More about Characteristics and hospital outcomes of coronary atherectomy within the United States: a multivariate and propensity-score matched analysis..

Linked electronic health records for research on a nationwide cohort of more than 54 million people in England: data resource. (2021)
Journal Article
Mamas. (2021). Linked electronic health records for research on a nationwide cohort of more than 54 million people in England: data resource. https://doi.org/10.1136/bmj.n826

OBJECTIVE: To describe a novel England-wide electronic health record (EHR) resource enabling whole population research on covid-19 and cardiovascular disease while ensuring data security and privacy and maintaining public trust. DESIGN: Data resource... Read More about Linked electronic health records for research on a nationwide cohort of more than 54 million people in England: data resource..

Derivation and validation of a clinical model to predict death or cardiac hospitalizations while on the cardiac surgery waitlist (2021)
Journal Article
Mamas. (2021). Derivation and validation of a clinical model to predict death or cardiac hospitalizations while on the cardiac surgery waitlist. Canadian Medical Association Journal, E1333 - E1340

Background: Waitlist management is a global challenge. For patients with severe cardiovascular diseases awaiting cardiac surgery, prolonged wait times are associated with unplanned hospitalizations. To facilitate evidence-based resource allocation, w... Read More about Derivation and validation of a clinical model to predict death or cardiac hospitalizations while on the cardiac surgery waitlist.

Elixhauser outperformed Charlson comorbidity index in prognostic value after ACS: insights from a national registry. (2021)
Journal Article
Mamas. (2021). Elixhauser outperformed Charlson comorbidity index in prognostic value after ACS: insights from a national registry. Journal of Clinical Epidemiology, 26-35. https://doi.org/10.1016/j.jclinepi.2021.08.025

OBJECTIVE: To compare the performance of risk adjustment models using the Elixhauser and Charlson comorbidity scores in predicting in-hospital outcomes of ACS patients from a nationwide administrative database. STUDY DESIGN AND SETTING: All hospitali... Read More about Elixhauser outperformed Charlson comorbidity index in prognostic value after ACS: insights from a national registry..

Perturbations in cardiac metabolism in a human model of acute myocardial ischaemia (2021)
Journal Article
Mamas. (2021). Perturbations in cardiac metabolism in a human model of acute myocardial ischaemia. Metabolomics, https://doi.org/10.1007/s11306-021-01827-x

Introduction Acute myocardial ischaemia and the transition from reversible to irreversible myocardial injury are associated with abnormal metabolic patterns. Advances in metabolomics have extended our capabilities to define these metabolic perturbati... Read More about Perturbations in cardiac metabolism in a human model of acute myocardial ischaemia.

Predicting 10-year stroke mortality: development and validation of a nomogram (2021)
Journal Article
Mamas. (2021). Predicting 10-year stroke mortality: development and validation of a nomogram. Acta neurologica Belgica, https://doi.org/10.1007/s13760-021-01752-9

Predicting long-term stroke mortality is a clinically important and unmet need. We aimed to develop and internally validate a 10-year ischaemic stroke mortality prediction score. In this UK cohort study, 10,366 patients with first-ever ischaemic stro... Read More about Predicting 10-year stroke mortality: development and validation of a nomogram.

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock. (2021)
Journal Article
Mamas, M. (2021). Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock. https://doi.org/10.3791/62140

The left atrial to femoral artery bypass (LAFAB) system is a mechanical circulatory support (MCS) device used in cardiogenic shock (CS) that bypasses the left ventricle by draining blood from the left atrium (LA) and returning it to the systemic arte... Read More about Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock..

Results of an international crowdsourcing survey on the treatment of non-ST segment elevation ACS patients at high-bleeding risk undergoing percutaneous intervention. (2021)
Journal Article
Bhatt, D. L., Carlos Kaski, J., Delaney, S., Alasnag, M., Andreotti, F., Angiolillo, D. J., …Valgimigli, M. (2021). Results of an international crowdsourcing survey on the treatment of non-ST segment elevation ACS patients at high-bleeding risk undergoing percutaneous intervention. International Journal of Cardiology, 1 - 8. https://doi.org/10.1016/j.ijcard.2021.05.012

AIMS: Choosing an antiplatelet strategy in patients with non-ST segment elevation acute coronary syndrome (NSTE-ACS) at high bleeding risk (HBR), undergoing post-percutaneous coronary intervention (PCI), is complex. We used a unique open-source appro... Read More about Results of an international crowdsourcing survey on the treatment of non-ST segment elevation ACS patients at high-bleeding risk undergoing percutaneous intervention..

Ambulatory intravenous furosemide for decompensated heart failure: safe, feasible, and effective (2021)
Journal Article
Ahmed, F. Z., Taylor, J. K., John, A. V., Khan, M. A., Zaidi, A. M., Mamas, M. A., …Cunnington, C. (2021). Ambulatory intravenous furosemide for decompensated heart failure: safe, feasible, and effective. ESC Heart Failure, 8(5), 3906-3916. https://doi.org/10.1002/ehf2.13368

AIMS: This study aims to establish the feasibility, safety, and efficacy of outpatient intravenous (IV) diuretic treatment for the management of decompensated heart failure (HF) for patients enrolled in the HeartFailure@Home service. METHODS AND RESU... Read More about Ambulatory intravenous furosemide for decompensated heart failure: safe, feasible, and effective.

Intravascular imaging-guided intracoronary lithotripsy: First real-world experience (2021)
Journal Article
Sinclair, H., Fan, L., Fahy, E., Shahid, F., Ratib, K., Nolan, J., …Ahmed, J. (2021). Intravascular imaging-guided intracoronary lithotripsy: First real-world experience. Health Science Reports, 4(3), Article e307. https://doi.org/10.1002/hsr2.307

Background and Aims: Coronary calcification remains a significant challenge for the contemporary interventional cardiologist. We aim to describe the use of intravascular lithotripsy (IVL) in a range of real-world settings. Methods: A retrospective tw... Read More about Intravascular imaging-guided intracoronary lithotripsy: First real-world experience.

Acute Pulmonary Embolism During Pregnancy and Puerperium: National Trends and In-Hospital Outcomes. (2021)
Journal Article
Mamas. (2021). Acute Pulmonary Embolism During Pregnancy and Puerperium: National Trends and In-Hospital Outcomes. Mayo Clinic Proceedings, 2102 - 2113. https://doi.org/10.1016/j.mayocp.2021.01.015

OBJECTIVE: To investigate the trend and outcomes of acute pulmonary embolism (PE) during pregnancy and puerperium using a large national database. PATIENTS AND METHODS: The National Inpatient Sample was queried to identify pregnancy-related hospitali... Read More about Acute Pulmonary Embolism During Pregnancy and Puerperium: National Trends and In-Hospital Outcomes..

Excess deaths from COVID-19 and other causes by region, neighbourhood deprivation level and place of death during the first 30 weeks of the pandemic in England and Wales: A retrospective registry study. (2021)
Journal Article
Mamas. (2021). Excess deaths from COVID-19 and other causes by region, neighbourhood deprivation level and place of death during the first 30 weeks of the pandemic in England and Wales: A retrospective registry study. The Lancet Regional Health Europe, 100144 - ?. https://doi.org/10.1016/j.lanepe.2021.100144

BACKGROUND: Excess deaths during the COVID-19 pandemic compared with those expected from historical trends have been unequally distributed, both geographically and socioeconomically. Not all excess deaths have been directly related to COVID-19 infect... Read More about Excess deaths from COVID-19 and other causes by region, neighbourhood deprivation level and place of death during the first 30 weeks of the pandemic in England and Wales: A retrospective registry study..

Thrombolysis in acute ischaemic stroke patients with chronic kidney disease. (2021)
Journal Article
Mamas, M. (2021). Thrombolysis in acute ischaemic stroke patients with chronic kidney disease. https://doi.org/10.1111/ane.13513

OBJECTIVE: We aimed to determine whether chronic kidney disease (CKD) is associated with adverse in-hospital outcomes after acute ischaemic stroke (AIS) and whether this association is dependent on thrombolysis administration. METHODS: 885,537 record... Read More about Thrombolysis in acute ischaemic stroke patients with chronic kidney disease..

Hidden labour: the skilful work of clinical audit data collection and its implications for secondary use of data via integrated health IT (2021)
Journal Article
Mamas. (2021). Hidden labour: the skilful work of clinical audit data collection and its implications for secondary use of data via integrated health IT. BMC Health Services Research, 1-11. https://doi.org/10.1186/s12913-021-06657-0

Background Secondary use of data via integrated health information technology is fundamental to many healthcare policies and processes worldwide. However, repurposing data can be problematic and little research has been undertaken into the everyday... Read More about Hidden labour: the skilful work of clinical audit data collection and its implications for secondary use of data via integrated health IT.

In-Hospital Complications in Pregnant Women With Current or Historical Cancer Diagnoses (2021)
Journal Article
Wu, P., P. Jordan, K., A. Chew-Graham, C., O. Mohamed, M., Barac, A., P. Lundberg, G., …A. Mamas, M. (2021). In-Hospital Complications in Pregnant Women With Current or Historical Cancer Diagnoses. Mayo Clinic Proceedings, 96(11), 2779-2792. https://doi.org/10.1016/j.mayocp.2021.03.038

Objective To assess the temporal trends, patient characteristics and comorbidities, and in-hospital cardiovascular and obstetric complications and outcomes of pregnant women with current or historical cancer diagnosis at the time of admission for de... Read More about In-Hospital Complications in Pregnant Women With Current or Historical Cancer Diagnoses.

Operator Volumes and In-Hospital Outcomes: An Analysis of 7,740 Rotational Atherectomy Procedures From the BCIS National Database. (2021)
Journal Article
Mamas. (2021). Operator Volumes and In-Hospital Outcomes: An Analysis of 7,740 Rotational Atherectomy Procedures From the BCIS National Database. JACC. Cardiovascular interventions, 1423 - 1430. https://doi.org/10.1016/j.jcin.2021.04.034

OBJECTIVES: The aims of this study were to use a national percutaneous coronary intervention (PCI) registry to study temporal changes in procedure volumes of PCI using rotational atherectomy (ROTA-PCI), the patient and procedural factors associated w... Read More about Operator Volumes and In-Hospital Outcomes: An Analysis of 7,740 Rotational Atherectomy Procedures From the BCIS National Database..

Excess years of life lost to COVID-19 and other causes of death by sex, neighbourhood deprivation and region in England & Wales during 2020 (2021)
Journal Article
Mamas. (2021). Excess years of life lost to COVID-19 and other causes of death by sex, neighbourhood deprivation and region in England & Wales during 2020

Background Deaths in the first year of the COVID-19 pandemic in England & Wales have been shown to be unevenly distributed socioeconomically and geographically. However, the full scale of inequalities may have been underestimated as most measures of... Read More about Excess years of life lost to COVID-19 and other causes of death by sex, neighbourhood deprivation and region in England & Wales during 2020.

Propranolol Reduces Risk of Knee or Hip Replacement Due to Osteoarthritis: a Propensity Score Matched Cohort Study-using Data From the Clinical Practice Research Datalink. (2021)
Journal Article
Mamas, M., & Mallen, C. (2021). Propranolol Reduces Risk of Knee or Hip Replacement Due to Osteoarthritis: a Propensity Score Matched Cohort Study-using Data From the Clinical Practice Research Datalink. Research Square, https://doi.org/10.21203/rs.3.rs-670522/v1

Objectives: To examine the association between ß -blocker prescription and knee or hip total joint replacement (TJR) in a UK primary-care population with incident knee or hip osteoarthritis (OA). Methods: Cohort study using data from the Clinical P... Read More about Propranolol Reduces Risk of Knee or Hip Replacement Due to Osteoarthritis: a Propensity Score Matched Cohort Study-using Data From the Clinical Practice Research Datalink..

Long Term Prognostic Impact of Sex-specific Longitudinal Changes in Blood Pressure. The EPIC-Norfolk Prospective Population Cohort Study. (2021)
Journal Article
Mamas. (2021). Long Term Prognostic Impact of Sex-specific Longitudinal Changes in Blood Pressure. The EPIC-Norfolk Prospective Population Cohort Study. European Journal of Preventive Cardiology, https://doi.org/10.1093/eurjpc/zwab104

AIMS: We aimed to determine the sex differences in longitudinal systolic and diastolic blood pressure (SBP and DBP) trajectories in mid-life and delineate the associations between these and mortality (all-cause, cardiovascular, and non-cardiovascular... Read More about Long Term Prognostic Impact of Sex-specific Longitudinal Changes in Blood Pressure. The EPIC-Norfolk Prospective Population Cohort Study..

Association between serum secretory phospholipase A2 and risk of ischemic stroke. (2021)
Journal Article
Mamas. (2021). Association between serum secretory phospholipase A2 and risk of ischemic stroke. European Journal of Neurology, https://doi.org/10.1111/ene.15004

BACKGROUND AND PURPOSE: Previous literature has demonstrated an association between high serum levels of type-II secretory phospholipase A2 (sPLA2) concentration and an increased risk of coronary artery disease. However, such association has not been... Read More about Association between serum secretory phospholipase A2 and risk of ischemic stroke..

Sex Differences in Outcomes Following Left Atrial Appendage Closure. (2021)
Journal Article
Sanjoy, S. S., Choi, Y., Sparrow, R. T., Baron, S. J., Abbott, J. D., Azzalini, L., …Bagur, R. (2021). Sex Differences in Outcomes Following Left Atrial Appendage Closure. https://doi.org/10.1016/j.mayocp.2020.11.031

OBJECTIVE: To evaluate the effects of female sex on in-hospital outcomes and to provide estimates for sex-specific prediction models of adverse outcomes following left atrial appendage closure (LAAC). PATIENTS AND METHODS: Cohort-based observational... Read More about Sex Differences in Outcomes Following Left Atrial Appendage Closure..

Safety and Efficacy of Renin-Angiotensin-Aldosterone System Inhibitors in COVID-19 Population. (2021)
Journal Article
Sattar, Y., Mukuntharaj, P., Zghouzi, M., Suleiman, A. M., Attique, H., Ullah, W., …Alraies, M. C. (2021). Safety and Efficacy of Renin-Angiotensin-Aldosterone System Inhibitors in COVID-19 Population. High Blood Pressure and Cardiovascular Prevention, 405 - 416. https://doi.org/10.1007/s40292-021-00462-w

INTRODUCTION: The safety of renin-angiotensin-aldosterone system inhibitors (RAASi) among COVID-19 patients has been controversial since the onset of the pandemic. METHODS: Digital databases were queried to study the safety of RAASi in COVID-19. The... Read More about Safety and Efficacy of Renin-Angiotensin-Aldosterone System Inhibitors in COVID-19 Population..

Impact of Chronic Kidney Disease on Revascularization and Outcomes in Patients with ST-Elevation Myocardial Infarction. (2021)
Journal Article
Mamas. (2021). Impact of Chronic Kidney Disease on Revascularization and Outcomes in Patients with ST-Elevation Myocardial Infarction. https://doi.org/10.1016/j.amjcard.2021.03.057

Chronic kidney disease (CKD) in patients with ST-elevation myocardial infarction (STEMI) is associated with worse outcomes. We assessed the impact of CKD on guideline directed coronary revascularization and outcomes among STEMI patients. The Nationwi... Read More about Impact of Chronic Kidney Disease on Revascularization and Outcomes in Patients with ST-Elevation Myocardial Infarction..

46 The relationship between high-sensitivity troponin taken on admission to critical care, regardless of whether there was a clinical indication for testing, and one year mortality: a novel biomarker for outcome? (2021)
Presentation / Conference
Hinton, J., Augustine, M., Gabara, L., Mariathas, M., Allan, R., Borca, F., …Curzen, N. (2021, June). 46 The relationship between high-sensitivity troponin taken on admission to critical care, regardless of whether there was a clinical indication for testing, and one year mortality: a novel biomarker for outcome?. Paper presented at British Cardiovascular Society Virtual Annual Conference, ‘Cardiology and the Environment’, 7–10 June 2021

In‐hospital outcomes of endovascular versus surgical revascularization for chronic total occlusion in peripheral artery disease (2021)
Journal Article
Zghouzi, M., Moussa Pacha, H., Ullah, W., Sattar, Y., Ahmad, B., Osman, H., …Alraies, M. C. (in press). In‐hospital outcomes of endovascular versus surgical revascularization for chronic total occlusion in peripheral artery disease. Catheterization and Cardiovascular Interventions, 98(4), https://doi.org/10.1002/ccd.29827

Background The outcome of endovascular intervention (EVI) compared vs. surgical revascularization in patients with peripheral artery disease (PAD) due to chronic total occlusion (CTO) is unknown. Methods Using the National Inpatient Sample datab... Read More about In‐hospital outcomes of endovascular versus surgical revascularization for chronic total occlusion in peripheral artery disease.

Coronary revascularisation outcomes in patients with cancer. (2021)
Journal Article
Mamas. (2021). Coronary revascularisation outcomes in patients with cancer. Heart, 507 - 516. https://doi.org/10.1136/heartjnl-2020-318531

Cancer and coronary artery disease (CAD) overlap in traditional risk factors as well as molecular mechanisms underpinning the development of these two disease states. Patients with cancer are at increased risk of developing CAD, representing a high-r... Read More about Coronary revascularisation outcomes in patients with cancer..

Effect of Location on Treatment and Outcomes of Cardiac Arrest Complicating Acute Myocardial Infarction in England & Wales. (2021)
Journal Article
Dafaalla, M., Rashid, M., Weston, C., Kinnaird, T., Gurm, H., Appleby, C., …Mamas, M. (2021). Effect of Location on Treatment and Outcomes of Cardiac Arrest Complicating Acute Myocardial Infarction in England & Wales. American Journal of Cardiology, 152, 1 - 10. https://doi.org/10.1016/j.amjcard.2021.04.032

We investigated the incidence, management, and outcomes of acute myocardial infarction (AMI) patients according to cardiac arrest location. Patients admitted with a diagnosis of AMI between January 1, 2010 to March 31, 2017 from the Myocardial Ischae... Read More about Effect of Location on Treatment and Outcomes of Cardiac Arrest Complicating Acute Myocardial Infarction in England & Wales..

37 Incidence and one year outcome of periprocedural myocardial infarction following cardiac surgery: are the universal definition and scai criteria fit for purpose? (2021)
Presentation / Conference
Hinton, J., Augustine, M., Gabara, L., Mariathas, M., Allan, R., Borca, F., …Curzen, N. (2021, June). 37 Incidence and one year outcome of periprocedural myocardial infarction following cardiac surgery: are the universal definition and scai criteria fit for purpose?. Paper presented at British Cardiovascular Society Virtual Annual Conference, ‘Cardiology and the Environment’, 7–10 June 2021

Introduction The diagnosis and clinical implication of periprocedural myocardial infarction (PPMI) following coronary artery bypass grafting (CABG) is contentious, especially given its importance in the interpretation of trial data. Two accepted defi... Read More about 37 Incidence and one year outcome of periprocedural myocardial infarction following cardiac surgery: are the universal definition and scai criteria fit for purpose?.

184 Association between high-sensitivity troponin and one year mortality in 20,000 consecutive hospital patients undergoing a blood test for any reason (2021)
Presentation / Conference
Hinton, J., Mariathas, M., Gabara, L., Allan, R., Nicholas, Z., Kwok, C. S., …Curzen, N. (2021, June). 184 Association between high-sensitivity troponin and one year mortality in 20,000 consecutive hospital patients undergoing a blood test for any reason. Paper presented at British Cardiovascular Society Virtual Annual Conference, ‘Cardiology and the Environment’, 7–10 June 2021

Introduction High sensitivity troponin (hs-cTn) concentrations above the manufacturer recommended upper limit of normal (ULN) are seen frequently in patients without a clinical presentation consistent with an acute coronary syndrome. There is increas... Read More about 184 Association between high-sensitivity troponin and one year mortality in 20,000 consecutive hospital patients undergoing a blood test for any reason.

Higher anticholinergic burden from medications is associated with significant increase in markers of inflammation in the EPIC-Norfolk prospective population-based cohort study (2021)
Journal Article
Mamas. (2021). Higher anticholinergic burden from medications is associated with significant increase in markers of inflammation in the EPIC-Norfolk prospective population-based cohort study. https://doi.org/10.22541/au.162273979.95865645/v1

Background: Higher anticholinergic burden from medications is associated with increased risk of cardiovascular disease and cognitive function decline. A mechanistic pathway has never been established. We aimed to determine whether chronic inflammati... Read More about Higher anticholinergic burden from medications is associated with significant increase in markers of inflammation in the EPIC-Norfolk prospective population-based cohort study.

Incidence and mortality due to thromboembolic events during the COVID-19 pandemic: Multi-sourced population-based health records cohort study. (2021)
Journal Article
Mamas, & Rashid. (2021). Incidence and mortality due to thromboembolic events during the COVID-19 pandemic: Multi-sourced population-based health records cohort study. Thrombosis Research, 17 - 23. https://doi.org/10.1016/j.thromres.2021.03.006

BACKGROUND: Evidence supports an excess of deaths during the COVID-19 pandemic. We report the incidence and mortality of thrombo-embolic events (TE) during the COVID-19 pandemic. METHODS: Multi-sourced nationwide cohort study of adults (age =18 years... Read More about Incidence and mortality due to thromboembolic events during the COVID-19 pandemic: Multi-sourced population-based health records cohort study..

Indirect Impact of the COVID-19 Pandemic on Activity and Outcomes of Transcatheter and Surgical Treatment of Aortic Stenosis in England. (2021)
Journal Article
Mamas, & Nolan. (2021). Indirect Impact of the COVID-19 Pandemic on Activity and Outcomes of Transcatheter and Surgical Treatment of Aortic Stenosis in England. Circulation: Cardiovascular Interventions, 532-543. https://doi.org/10.1161/CIRCINTERVENTIONS.120.010413

Background: Aortic stenosis requires timely treatment with either surgical aortic valve replacement (SAVR) or transcatheter aortic valve replacement (TAVR). This study aimed to investigate the indirect impact of coronavirus disease 2019 (COVID-19) o... Read More about Indirect Impact of the COVID-19 Pandemic on Activity and Outcomes of Transcatheter and Surgical Treatment of Aortic Stenosis in England..

Sex-Based Differences in Prevalence and Outcomes of Common Acute Conditions Associated With Type 2 Myocardial Infarction. (2021)
Journal Article
Mohamed, M. O., Contractor, T., Abramov, D., Parwani, P., Michos, E. D., Fischman, D., …Mamas, M. (2021). Sex-Based Differences in Prevalence and Outcomes of Common Acute Conditions Associated With Type 2 Myocardial Infarction. https://doi.org/10.1016/j.amjcard.2021.02.011

Little is known about the association between acute prevalent conditions in patients with type 2 Myocardial Infarction (T2MI) and clinical outcomes, particularly between genders. Using the Nationwide Inpatient Sample (2017), we examined outcomes of T... Read More about Sex-Based Differences in Prevalence and Outcomes of Common Acute Conditions Associated With Type 2 Myocardial Infarction..

TRENDS OF IN-HOSPITAL AND 30-DAY MORTALITY AFTER PERCUTANEOUS CORONARY INTERVENTION IN ENGLAND BEFORE AND AFTER THE COVID-19 ERA (2021)
Presentation / Conference
Mohamed, M., Curzen, N., Ludman, P., Rashid, M., Shoaib, A., de Belder, M., …Mamas, M. (2021, May). TRENDS OF IN-HOSPITAL AND 30-DAY MORTALITY AFTER PERCUTANEOUS CORONARY INTERVENTION IN ENGLAND BEFORE AND AFTER THE COVID-19 ERA. Poster presented at ACC.21, Virtual

Background Public reporting of percutaneous coronary intervention (PCI) outcomes is a performance metric and a requirement in many healthcare systems. There are inconsistent data on the causes of death after PCI, and what proportion of these are att... Read More about TRENDS OF IN-HOSPITAL AND 30-DAY MORTALITY AFTER PERCUTANEOUS CORONARY INTERVENTION IN ENGLAND BEFORE AND AFTER THE COVID-19 ERA.

Association of admitting physician specialty and care quality and outcomes in non-ST-segment elevation myocardial infarction (NSTEMI): insights from a national registry. (2021)
Journal Article
Moledina, S. M., Shoaib, A., Graham, M. M., Biondi-Zoccai, G., Van Spall, H. G. C., Kontopantelis, E., …Mamas, M. A. (2022). Association of admitting physician specialty and care quality and outcomes in non-ST-segment elevation myocardial infarction (NSTEMI): insights from a national registry. European Heart Journal - Quality of Care and Clinical Outcomes, 8(5), 557–567. https://doi.org/10.1093/ehjqcco/qcab038

BACKGROUND: Little is known about the association between admitting physician specialty and care quality and outcomes for non-ST-segment elevation myocardial infarction (NSTEMI). METHODS & RESULTS: We identified 288,420 patients hospitalised with NST... Read More about Association of admitting physician specialty and care quality and outcomes in non-ST-segment elevation myocardial infarction (NSTEMI): insights from a national registry..

Prognostic impact of comorbidity measures on outcomes following acute coronary syndrome: a systematic review. (2021)
Journal Article
Mamas. (2021). Prognostic impact of comorbidity measures on outcomes following acute coronary syndrome: a systematic review. International Journal of Clinical Practice, e14345 - ?. https://doi.org/10.1111/ijcp.14345

AIM: To identify existing comorbidity measures and summarise their association with acute coronary syndrome (ACS) outcomes. METHODS: We searched published studies from MEDLINE (OVIDSP) and EMBASE from inception to March 2021, studies of the pre-speci... Read More about Prognostic impact of comorbidity measures on outcomes following acute coronary syndrome: a systematic review..

SEX DIFFERENCES IN DISTRIBUTION, MANAGEMENT AND OUTCOMES OF COMBINED ISCHEMIC-BLEEDING RISK FOLLOWING ACUTE CORONARY SYNDROME (2021)
Journal Article
Rashid, & Mamas. (2021). SEX DIFFERENCES IN DISTRIBUTION, MANAGEMENT AND OUTCOMES OF COMBINED ISCHEMIC-BLEEDING RISK FOLLOWING ACUTE CORONARY SYNDROME. Journal of the American College of Cardiology, 39 - 39. https://doi.org/10.1016/S0735-1097%2821%2901398-X

Background: Risk factors of bleeding and recurrent ischemic events after acute coronary syndrome (ACS) often overlap. Whether the distribution and management of these complications vary by sex remains unknown. Methods: ACS hospitalizations in the Uni... Read More about SEX DIFFERENCES IN DISTRIBUTION, MANAGEMENT AND OUTCOMES OF COMBINED ISCHEMIC-BLEEDING RISK FOLLOWING ACUTE CORONARY SYNDROME.

Clinical Outcomes of Proximal Optimization Technique (POT) in Bifurcation Stenting Short title: Impact of proximal optimization technique (2021)
Journal Article
Mamas, Rashid, & Rashid. (2021). Clinical Outcomes of Proximal Optimization Technique (POT) in Bifurcation Stenting Short title: Impact of proximal optimization technique. EuroIntervention, https://doi.org/10.4244/EIJ-D-20-01393

Background: Optimal deployment of coronary stents in a bifurcation lesion remains a matter of debate. Aims: We sought to capture the daily practice of bifurcation stenting by means of a worldwide registry and to investigate how the post-implantati... Read More about Clinical Outcomes of Proximal Optimization Technique (POT) in Bifurcation Stenting Short title: Impact of proximal optimization technique.

Clinical outcomes of percutaneous coronary intervention for chronic total occlusion in prior coronary artery bypass grafting patients (2021)
Journal Article
Rashid, M., Shoaib, A., Mohamed, M., Curzen, N., Ludman, P., Zaman, A., …Mamas, M. A. (2021). Clinical outcomes of percutaneous coronary intervention for chronic total occlusion in prior coronary artery bypass grafting patients. Catheterization and Cardiovascular Interventions, 99(1), 74-84. https://doi.org/10.1002/ccd.29691

OBJECTIVE: To compare the clinical characteristics and outcomes in patients with stable angina who have undergone chronic total occlusion (CTO) percutaneous coronary intervention (PCI) in native arteries with or without prior coronary artery bypass g... Read More about Clinical outcomes of percutaneous coronary intervention for chronic total occlusion in prior coronary artery bypass grafting patients.

Prognosis of Acute Ischaemic Stroke Patients with Cancer: A National Inpatient Sample Study (2021)
Journal Article
Mamas. (2021). Prognosis of Acute Ischaemic Stroke Patients with Cancer: A National Inpatient Sample Study. Cancers, 2193 - 2193. https://doi.org/10.3390/cancers13092193

Whilst cancer is a risk factor for acute ischaemic stroke (AIS), its impact on AIS prognosis between metastatic and non-metastatic (MC and NMC) disease is poorly understood. Furthermore, the receipt of intravenous thrombolysis (IVT) and endovascular... Read More about Prognosis of Acute Ischaemic Stroke Patients with Cancer: A National Inpatient Sample Study.

HYBRID CORONARY REVASCULARIZATION VERSUS CORONARY ARTERY BYPASS GRAFT IN PATIENTS WITH MULTIVESSEL CORONARY ARTERY DISEASE A META-ANALYSIS (2021)
Journal Article
Zghouzi, M., Ullah, W., Sandhyavenu, H., Pacha, H. M., Al-Khadra, Y., Ahmad, B., …Alraies, M. C. (2021). HYBRID CORONARY REVASCULARIZATION VERSUS CORONARY ARTERY BYPASS GRAFT IN PATIENTS WITH MULTIVESSEL CORONARY ARTERY DISEASE A META-ANALYSIS. Journal of the American College of Cardiology, 77(18), 1042. https://doi.org/10.1016/s0735-1097%2821%2902401-3

Background Hybrid coronary artery revascularization (HCR) refers to complete or near complete revascularization using the combination of single vessel CABG and PCI of other significant coronary lesions. The short-term outcomes of HCR compared to CAB... Read More about HYBRID CORONARY REVASCULARIZATION VERSUS CORONARY ARTERY BYPASS GRAFT IN PATIENTS WITH MULTIVESSEL CORONARY ARTERY DISEASE A META-ANALYSIS.

META-ANALYSIS OF SAFETY AND EFFICACY OF RENIN ANGIOTENSIN ALDOSTERONE SYSTEM INHIBITORS IN COVID-19 POPULATION (2021)
Journal Article
Sattar, Y., Mukuntharaj, P., Attique, H., Ullah, W., Sana, M. K., Zaher, N., …Alraies, M. C. (2021). META-ANALYSIS OF SAFETY AND EFFICACY OF RENIN ANGIOTENSIN ALDOSTERONE SYSTEM INHIBITORS IN COVID-19 POPULATION. Journal of the American College of Cardiology, 77(18 S1), 3158. https://doi.org/10.1016/s0735-1097%2821%2904513-7

Background The safety and efficacy of Renin Angiotensin Aldosterone System Inhibitors(RAASi) in COVID 19 patients has been controversial. Methods Digital databases were queried for relevant articles. A random-effect model was used to compute an... Read More about META-ANALYSIS OF SAFETY AND EFFICACY OF RENIN ANGIOTENSIN ALDOSTERONE SYSTEM INHIBITORS IN COVID-19 POPULATION.

THE ASSOCIATION BETWEEN SEX, RACE, SOCIOECONOMIC STATUS, AND IN-HOSPITAL ALL-CAUSE MORTALITY AMONG PATIENTS ADMITTED FOR HEART FAILURE: A RETROSPECTIVE COHORT STUDY (2021)
Journal Article
Averbuch, T., Mohamed, M., Islam, S., Martin, G., Thabane, L., Mamas, M., & Van Spall, H. G. (2021). THE ASSOCIATION BETWEEN SEX, RACE, SOCIOECONOMIC STATUS, AND IN-HOSPITAL ALL-CAUSE MORTALITY AMONG PATIENTS ADMITTED FOR HEART FAILURE: A RETROSPECTIVE COHORT STUDY. Journal of the American College of Cardiology, 77(18), 794. https://doi.org/10.1016/s0735-1097%2821%2902153-7

Background Heart failure (HF) hospitalization is associated with high mortality. We aimed to assess the role of race, sex, and socioeconomic status (SES) in the risk of in-hospital mortality among patients hospitalized for HF. Methods We used th... Read More about THE ASSOCIATION BETWEEN SEX, RACE, SOCIOECONOMIC STATUS, AND IN-HOSPITAL ALL-CAUSE MORTALITY AMONG PATIENTS ADMITTED FOR HEART FAILURE: A RETROSPECTIVE COHORT STUDY.

Clinical phenogroups are more effective than left ventricular ejection fraction categories in stratifying heart failure outcomes (2021)
Journal Article
Gevaert, A. B., Tibebu, S., Mamas, M. A., Ravindra, N. G., Lee, S. F., Ahmad, T., …Van Spall, H. G. (2021). Clinical phenogroups are more effective than left ventricular ejection fraction categories in stratifying heart failure outcomes. ESC Heart Failure, 8(4), 2741-2754. https://doi.org/10.1002/ehf2.13344

Aims Heart failure (HF) guidelines place patients into 3 discrete groups according to left ventricular ejection fraction (LVEF): reduced (

Derivation and validation of a two-variable index to predict 30-day outcomes following heart failure hospitalization (2021)
Journal Article
Mamas, Averbuch, T., Lee, S. F., Mamas, M. A., Oz, U. E., Perez, R., …Van Spall, H. G. C. (2021). Derivation and validation of a two-variable index to predict 30-day outcomes following heart failure hospitalization. ESC Heart Failure, 8(4), 2690-2697. https://doi.org/10.1002/ehf2.13324

Background The LACE index—length of stay (L), acuity (A), Charlson co-morbidities (C), and emergent visits (E)—predicts 30-day outcomes following heart failure (HF) hospitalization but is complex to score. A simpler LE index (length of stay and emer... Read More about Derivation and validation of a two-variable index to predict 30-day outcomes following heart failure hospitalization.

Ethnic disparities in care and outcomes of non-ST-segment elevation myocardial infarction: a nationwide cohort study. (2021)
Journal Article
Mamas, & Rashid. (2021). Ethnic disparities in care and outcomes of non-ST-segment elevation myocardial infarction: a nationwide cohort study. European Heart Journal - Quality of Care and Clinical Outcomes, https://doi.org/10.1093/ehjqcco/qcab030

BACKGROUND: Little is known about ethnic disparities in care and clinical outcomes of patients admitted with non-ST-segment elevation myocardial infarction (NSTEMI) in national cohorts from universal healthcare systems derived from Europe. METHODS &... Read More about Ethnic disparities in care and outcomes of non-ST-segment elevation myocardial infarction: a nationwide cohort study..

Assessing the severity of cardiovascular disease in 213 088 patients with coronary heart disease: a retrospective cohort study. (2021)
Journal Article
Mamas, Mallen, & Chew-Graham. (2021). Assessing the severity of cardiovascular disease in 213 088 patients with coronary heart disease: a retrospective cohort study. Open Heart, https://doi.org/10.1136/openhrt-2020-001498

OBJECTIVE: Most current cardiovascular disease (CVD) risk stratification tools are for people without CVD, but very few are for prevalent CVD. In this study, we developed and validated a CVD severity score in people with coronary heart disease (CHD)... Read More about Assessing the severity of cardiovascular disease in 213 088 patients with coronary heart disease: a retrospective cohort study..

Cost of inpatient heart failure care and 30-day readmissions in the United States (2021)
Journal Article
Mamas, Kwok, C. S., Abramov, D., Parwani, P., Ghosh, R. K., Kittleson, M., …Van Spall, H. G. C. (2021). Cost of inpatient heart failure care and 30-day readmissions in the United States. International Journal of Cardiology, 329, 115-122. https://doi.org/10.1016/j.ijcard.2020.12.020

BACKGROUND: Heart failure hospitalizations are a major financial cost to healthcare systems. This study aimed to evaluate the costs associated with inpatient hospitalization. METHODS: Patients with a primary diagnosis of heart failure during a hospit... Read More about Cost of inpatient heart failure care and 30-day readmissions in the United States.

In-Hospital Outcomes and Trends of Endovascular Intervention vs Surgical Revascularization in Octogenarians With Peripheral Artery Disease. (2021)
Journal Article
Mamas. (2021). In-Hospital Outcomes and Trends of Endovascular Intervention vs Surgical Revascularization in Octogenarians With Peripheral Artery Disease. American Journal of Cardiology, 143 - 150

It is unknown whether endovascular intervention (EVI) is associated with superior outcomes when compared with surgical revascularization in octogenarian. National Inpatient Sample (NIS) database was used to compare the outcomes of limb revascularizat... Read More about In-Hospital Outcomes and Trends of Endovascular Intervention vs Surgical Revascularization in Octogenarians With Peripheral Artery Disease..

Distribution of High-Sensitivity Troponin Taken Without Conventional Clinical Indications in Critical Care Patients and Its Association With Mortality. (2021)
Journal Article
Mamas, M., Hinton, J., Augustine, M., Gabara, L., Mariathas, M., Allan, R., …Curzen, N. (2021). Distribution of High-Sensitivity Troponin Taken Without Conventional Clinical Indications in Critical Care Patients and Its Association With Mortality. Critical Care Medicine, 49(9), 1451 - 1459. https://doi.org/10.1097/ccm.0000000000005024

OBJECTIVES: To describe the distribution of high-sensitivity troponin in a consecutive cohort of patients in critical care units, regardless of clinical indication, and its association with clinical outcomes. DESIGN: Prospective observational study.... Read More about Distribution of High-Sensitivity Troponin Taken Without Conventional Clinical Indications in Critical Care Patients and Its Association With Mortality..

Evidence-based arterial access site practice in patients with acute coronary syndromes: Has SAFARI-STEMI changed the landscape? (2021)
Journal Article
Nagaraja, V., Rao, S. V., George, S., Mamas, M., & Nolan, J. (2021). Evidence-based arterial access site practice in patients with acute coronary syndromes: Has SAFARI-STEMI changed the landscape?. Catheterization and Cardiovascular Interventions, 97(7), 1417 - 1421. https://doi.org/10.1002/ccd.29684

Key Points Access site practice in acute coronary syndrome (ACS) has been extensively investigated with the data favoring a radial approach. SAFARI‐STEMI does not change the recommendation to use radial access in most patients due to methodological i... Read More about Evidence-based arterial access site practice in patients with acute coronary syndromes: Has SAFARI-STEMI changed the landscape?.

Clinical and Economic Burden of Stroke Among Young, Midlife, and Older Adults in the United States, 2002-2017 (2021)
Journal Article
Mamas, & Rashid. (2021). Clinical and Economic Burden of Stroke Among Young, Midlife, and Older Adults in the United States, 2002-2017. https://doi.org/10.1016/j.mayocpiqo.2021.01.015

Objective To assess trends of stroke hospitalization rates, inpatient mortality, and health care resource use in young (aged =44 years), midlife (aged 45-64 years), and older (aged =65 years) adults. Patients and Methods We studied the National... Read More about Clinical and Economic Burden of Stroke Among Young, Midlife, and Older Adults in the United States, 2002-2017.

Questions and answers on antithrombotic therapy and revascularization strategies in non-ST-elevation acute coronary syndrome (NSTE-ACS): a companion document of the 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. (2021)
Journal Article
Barbato, E., Mehilli, J., Sibbing, D., Siontis, G. C. M., Collet, J., Thiele, H., …Mamas, M. (2021). Questions and answers on antithrombotic therapy and revascularization strategies in non-ST-elevation acute coronary syndrome (NSTE-ACS): a companion document of the 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. European Heart Journal, 1368 - 1378. https://doi.org/10.1093/eurheartj/ehaa601

Machine Learning-Augmented Propensity Score Analysis of Percutaneous Coronary Intervention in Over 30 Million Cancer and Non-cancer Patients. (2021)
Journal Article
Mamas. (2021). Machine Learning-Augmented Propensity Score Analysis of Percutaneous Coronary Intervention in Over 30 Million Cancer and Non-cancer Patients. Frontiers in Cardiovascular Medicine, -. https://doi.org/10.3389/fcvm.2021.620857

Background: It is unknown to what extent the clinical benefits of PCI outweigh the risks and costs in patients with vs. without cancer and within each cancer type. We performed the first known nationally representative propensity score analysis of PC... Read More about Machine Learning-Augmented Propensity Score Analysis of Percutaneous Coronary Intervention in Over 30 Million Cancer and Non-cancer Patients..

Thin Strut CoCr Biodegradable Polymer Biolimus A9-Eluting Stents versus Thicker Strut Stainless Steel Biodegradable Polymer Biolimus A9-Eluting Stents: Two-Year Clinical Outcomes. (2021)
Journal Article
Mamas. (2021). Thin Strut CoCr Biodegradable Polymer Biolimus A9-Eluting Stents versus Thicker Strut Stainless Steel Biodegradable Polymer Biolimus A9-Eluting Stents: Two-Year Clinical Outcomes. Journal of Interventional Cardiology, https://doi.org/10.1155/2021/6654515

Background: While thinner struts are associated with improved clinical outcomes in bare-metal stents (BMS), reducing strut thickness may affect drug delivery from drug-eluting stents (DES) and there are limited data comparing otherwise similar thin a... Read More about Thin Strut CoCr Biodegradable Polymer Biolimus A9-Eluting Stents versus Thicker Strut Stainless Steel Biodegradable Polymer Biolimus A9-Eluting Stents: Two-Year Clinical Outcomes..

Proteomic and Mechanistic Analysis of Spironolactone in Patients at Risk for HF. (2021)
Journal Article
Pedro Ferreira, J., Verdonschot, J., Wang, P., Pizard, A., Collier, T., Ahmed, F. Z., …Zannad, F. (2021). Proteomic and Mechanistic Analysis of Spironolactone in Patients at Risk for HF. JACC: Heart Failure, 268 - 277. https://doi.org/10.1016/j.jchf.2020.11.010

OBJECTIVES: This study sought to further understand the mechanisms underlying effect of spironolactone and assessed its impact on multiple plasma protein biomarkers and their respective underlying biologic pathways. BACKGROUND: In addition to their b... Read More about Proteomic and Mechanistic Analysis of Spironolactone in Patients at Risk for HF..

Location of death among patients presenting with cardiovascular disease to the emergency department in the United states. (2021)
Journal Article
Mamas. (2021). Location of death among patients presenting with cardiovascular disease to the emergency department in the United states. https://doi.org/10.1111/ijcp.13798

BACKGROUND: In-hospital deaths are an important outcome and little is known about deaths in the emergency department (ED). Among patients who died of cardiovascular diseases (CVD), we assessed causes of death, temporal trends and the relative distrib... Read More about Location of death among patients presenting with cardiovascular disease to the emergency department in the United states..

Trends, Outcomes, and Predictive Score For Emergency Coronary Artery Bypass Graft Surgery After Elective Percutaneous Coronary Intervention (from a Nationwide Dataset). (2021)
Journal Article
Mamas, M. (2021). Trends, Outcomes, and Predictive Score For Emergency Coronary Artery Bypass Graft Surgery After Elective Percutaneous Coronary Intervention (from a Nationwide Dataset). https://doi.org/10.1016/j.amjcard.2020.12.060

The temporal trends and preprocedural predictors of emergency coronary artery bypass graft surgery (ECABG) after elective percutaneous coronary intervention (PCI) in the contemporary era are largely unknown. From January 2003 to December 2014 electiv... Read More about Trends, Outcomes, and Predictive Score For Emergency Coronary Artery Bypass Graft Surgery After Elective Percutaneous Coronary Intervention (from a Nationwide Dataset)..

Racial, ethnic and socioeconomic disparities in patients undergoing left atrial appendage closure (2021)
Journal Article
Sparrow, R., Sanjoy, S., Choi, Y., Elgendy, I. Y., Jneid, H., Villablanca, P. A., …Bagur, R. (2021). Racial, ethnic and socioeconomic disparities in patients undergoing left atrial appendage closure. Heart, 107(24), 1946-1955. https://doi.org/10.1136/heartjnl-2020-318650

OBJECTIVE: This manuscript aims to explore the impact of race/ethnicity and socioeconomic status on in-hospital complication rates after left atrial appendage closure (LAAC). METHODS: The US National Inpatient Sample was used to identify hospitalisat... Read More about Racial, ethnic and socioeconomic disparities in patients undergoing left atrial appendage closure.

Individual participant data meta-analysis for external validation, recalibration, and updating of a flexible parametric prognostic model. (2021)
Journal Article
Ensor, J., Snell, K. I. E., Debray, T. P. A., Lambert, P. C., Look, M. P., Mamas, M. A., …Riley, R. D. (2021). Individual participant data meta-analysis for external validation, recalibration, and updating of a flexible parametric prognostic model. Statistics in Medicine, 40(13), 3066-3084. https://doi.org/10.1002/sim.8959

Individual participant data (IPD) from multiple sources allows external validation of a prognostic model across multiple populations. Often this reveals poor calibration, potentially causing poor predictive performance in some populations. However, r... Read More about Individual participant data meta-analysis for external validation, recalibration, and updating of a flexible parametric prognostic model..

Revascularisation strategies in patients with significant left main coronary disease during the COVID-19 pandemic. (2021)
Journal Article
Rashid, M., Mamas, Mohamed, M. O., Curzen, N., de Belder, M., Goodwin, A. T., …Mamas, M. A. (2021). Revascularisation strategies in patients with significant left main coronary disease during the COVID-19 pandemic. Catheterization & Cardiovascular Interventions, 98(7), 1252-1261. https://doi.org/10.1002/ccd.29663

BACKGROUND: There are limited data on the impact of the COVID-19 pandemic on left main (LM) coronary revascularisation activity, choice of revascularisation strategy, and post-procedural outcomes. METHODS: All patients with LM disease (=50% stenosis)... Read More about Revascularisation strategies in patients with significant left main coronary disease during the COVID-19 pandemic..

Sex Differences in Ischemic Stroke Outcomes in Patients With Pulmonary Hypertension. (2021)
Journal Article
Mamas. (2021). Sex Differences in Ischemic Stroke Outcomes in Patients With Pulmonary Hypertension. Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, e019341 - ?. https://doi.org/10.1161/JAHA.120.019341

Background The association between systemic hypertension and cerebrovascular disease is well documented. However, the impact of pulmonary hypertension (PH) on acute ischemic stroke outcomes is unknown despite PH being recognized as a risk factor for... Read More about Sex Differences in Ischemic Stroke Outcomes in Patients With Pulmonary Hypertension..

Impact of pre-existent vascular and poly-vascular disease on acute myocardial infarction management and outcomes: An analysis of 2 million patients from the National Inpatient Sample. (2021)
Journal Article
Mamas. (2021). Impact of pre-existent vascular and poly-vascular disease on acute myocardial infarction management and outcomes: An analysis of 2 million patients from the National Inpatient Sample. https://doi.org/10.1016/j.ijcard.2020.11.051

BACKGROUND: Patients with pre-existing vascular disease are known to have worse outcomes after acute myocardial infarction (AMI). However, there is limited data for outcomes stratified by type and number of vascular territories involved. METHODS: Usi... Read More about Impact of pre-existent vascular and poly-vascular disease on acute myocardial infarction management and outcomes: An analysis of 2 million patients from the National Inpatient Sample..

ß-blocker prescription is associated with lower cumulative risk of knee osteoarthritis and knee pain consultations in primary care: a propensity score matched cohort study (2021)
Journal Article
Mamas, & Mallen. (2021). ß-blocker prescription is associated with lower cumulative risk of knee osteoarthritis and knee pain consultations in primary care: a propensity score matched cohort study. Rheumatology, https://doi.org/10.1093/rheumatology/keab234

OBJECTIVES: To examine the association between ß-blocker prescription and first primary-care consultation for knee osteoarthritis (OA), hip OA, knee pain and hip pain. METHODS: Data source: Clinical Practice Research Datalink. Participants aged =40?y... Read More about ß-blocker prescription is associated with lower cumulative risk of knee osteoarthritis and knee pain consultations in primary care: a propensity score matched cohort study.

Prognosis of Acute Ischaemic Stroke in Cancer Patients: A National Inpatient Sample Study (2021)
Journal Article
Mamas. (2021). Prognosis of Acute Ischaemic Stroke in Cancer Patients: A National Inpatient Sample Study

Background and Purpose Whilst cancer is a risk factor for acute ischaemic stroke (AIS), its impact on AIS prognosis between metastatic and non-metastatic (MC and NMC) disease is poorly understood. Furthermore, the receipt of intravenous thrombolysis... Read More about Prognosis of Acute Ischaemic Stroke in Cancer Patients: A National Inpatient Sample Study.

Racial differences in management and outcomes of acute myocardial infarction during COVID19 pandemic (2021)
Journal Article
Rashid, & Mamas. (2021). Racial differences in management and outcomes of acute myocardial infarction during COVID19 pandemic. Heart, 734-740. https://doi.org/10.1136/heartjnl-2020-318356

Objective: There are concerns that health care and outcomes of BAME communities are disproportionately impacted by the COVID19 pandemic. We investigated admission rates, treatment and mortality of Black, Asian and Minority Ethnic (BAME) with acute my... Read More about Racial differences in management and outcomes of acute myocardial infarction during COVID19 pandemic.

Percutaneous coronary intervention in patients with cancer and readmissions within 90 days for acute myocardial infarction and bleeding in the USA. (2021)
Journal Article
Mamas. (2021). Percutaneous coronary intervention in patients with cancer and readmissions within 90 days for acute myocardial infarction and bleeding in the USA. https://doi.org/10.1093/eurheartj/ehaa1032

AIMS: The post-discharge outcomes of patients with cancer who undergo PCI are not well understood. This study evaluates the rates of readmissions within 90?days for acute myocardial infarction (AMI) and bleeding among patients with cancer who undergo... Read More about Percutaneous coronary intervention in patients with cancer and readmissions within 90 days for acute myocardial infarction and bleeding in the USA..

Efficacy and Safety of Ticagrelor Monotherapy in Patients Undergoing Percutaneous Coronary Intervention: A Meta-Analysis (2021)
Journal Article
Gelbenegger, G., Schoergenhofer, C., Jilma, B., Gager, G. M., Dizdarevic, A. M., Mamas, M. A., …Siller‐Matula, J. M. (2021). Efficacy and Safety of Ticagrelor Monotherapy in Patients Undergoing Percutaneous Coronary Intervention: A Meta-Analysis. Clinical Pharmacology and Therapeutics, 110(2), 424-431. https://doi.org/10.1002/cpt.2226

Dual antiplatelet therapy (DAPT) and subsequent P2Y12 inhibitor monotherapy, particularly ticagrelor, is an emerging treatment strategy in patients undergoing percutaneous coronary intervention (PCI). This meta-analysis was designed to investigate wh... Read More about Efficacy and Safety of Ticagrelor Monotherapy in Patients Undergoing Percutaneous Coronary Intervention: A Meta-Analysis.

Medical Therapy Versus Revascularization in Patients with Stable Ischemic Heart Disease and Advanced Chronic Kidney Disease. (2021)
Journal Article
Mamas. (2021). Medical Therapy Versus Revascularization in Patients with Stable Ischemic Heart Disease and Advanced Chronic Kidney Disease. https://doi.org/10.1007/s11886-021-01453-y

PURPOSE OF REVIEW: This article reviews the evidence on optimal medical therapy (OMT) versus coronary revascularization in patients with stable ischemic heart disease (SIHD) and advanced chronic kidney disease (CKD). RECENT FINDINGS: A post hoc analy... Read More about Medical Therapy Versus Revascularization in Patients with Stable Ischemic Heart Disease and Advanced Chronic Kidney Disease..

Medical Therapy Versus Revascularization in Patients with Stable Ischemic Heart Disease and Advanced Chronic Kidney Disease (2021)
Journal Article
Paul, T. K., Mamas, M. A., Shanmugasundaram, M., Nagarajarao, H. S., Ojha, C. P., Jneid, H., …White, C. J. (2021). Medical Therapy Versus Revascularization in Patients with Stable Ischemic Heart Disease and Advanced Chronic Kidney Disease. Current Cardiology Reports, 23(4), https://doi.org/10.1007/s11886-021-01453-y

Purpose of Review This article reviews the evidence on optimal medical therapy (OMT) versus coronary revascularization in patients with stable ischemic heart disease (SIHD) and advanced chronic kidney disease (CKD). Recent Findings A post hoc an... Read More about Medical Therapy Versus Revascularization in Patients with Stable Ischemic Heart Disease and Advanced Chronic Kidney Disease.

Barriers and facilitators of the uptake of digital health technology in cardiovascular care: a systematic scoping review. (2021)
Journal Article
Mamas. (2021). Barriers and facilitators of the uptake of digital health technology in cardiovascular care: a systematic scoping review. European Heart Journal – Digital Health, 62 - 74. https://doi.org/10.1093/ehjdh/ztab005

Digital health technology (DHT) has the potential to revolutionize healthcare delivery but its uptake has been low in clinical and research settings. The factors that contribute to the limited adoption of DHT, particularly in cardiovascular settings,... Read More about Barriers and facilitators of the uptake of digital health technology in cardiovascular care: a systematic scoping review..

Temporal trends in utilization and outcomes of transcatheter aortic valve replacement in different races: an analysis of the national inpatient sample (2021)
Journal Article
Ullah, W., Al-Khadra, Y., Mir, T., Darmoch, F., Pacha, H. M., Sattar, Y., …Alraies, M. C. (2021). Temporal trends in utilization and outcomes of transcatheter aortic valve replacement in different races: an analysis of the national inpatient sample. Journal of Cardiovascular Medicine, 22(7), 586 - 593. https://doi.org/10.2459/JCM.0000000000001172

AIM: We sought to determine the racial and ethnical disparities in the delivery of TAVR and to evaluate the in-hospital outcomes and utilization of TAVR stratified by patient ethnicity. METHOD: Using a national inpatient sample database between 2011... Read More about Temporal trends in utilization and outcomes of transcatheter aortic valve replacement in different races: an analysis of the national inpatient sample.

Prevalence of cardiovascular risk factors in osteoarthritis patients derived from primary care records: a systematic review of observational studies (2021)
Journal Article
Huang, X., Wilkie, R., Mamas, M., & Yu, D. (2021). Prevalence of cardiovascular risk factors in osteoarthritis patients derived from primary care records: a systematic review of observational studies. MedRxiv, https://doi.org/10.1101/2021.02.14.21251130v1

Background People with osteoarthritis are at a high risk of cardiovascular disease (CVD). Detecting CVD risk factors in this high-risk population will help to improve CVD outcomes. Primary care electronic health records (EHRs) provide opportunities f... Read More about Prevalence of cardiovascular risk factors in osteoarthritis patients derived from primary care records: a systematic review of observational studies.

Percutaneous coronary intervention and 30-day unplanned readmission with chest pain in the United States (Nationwide Readmissions Database). (2021)
Journal Article
Mamas, Sykes, R., Mohamed, M. O., Kwok, C. S., Mamas, M. A., & Berry, C. (2021). Percutaneous coronary intervention and 30-day unplanned readmission with chest pain in the United States (Nationwide Readmissions Database). Clinical Cardiology, 44(3), 291 - 306. https://doi.org/10.1002/clc.23543

Percutaneous coronary intervention (PCI) improves anginal chest pain in most, but not all, treated patients. PCI is associated with unplanned readmission for angina and non-specific chest pain within 30-days of index PCI. Patients with an index hospi... Read More about Percutaneous coronary intervention and 30-day unplanned readmission with chest pain in the United States (Nationwide Readmissions Database)..

Place and Underlying Cause of Death During the COVID-19 Pandemic: Retrospective Cohort Study of 3.5 Million Deaths in England and Wales, 2014 to 2020 (2021)
Journal Article
Wu, J., Mafham, M., Mamas, M. A., Rashid, M., Kontopantelis, E., Dean, J. E., …Gale, C. P. (2021). Place and Underlying Cause of Death During the COVID-19 Pandemic: Retrospective Cohort Study of 3.5 Million Deaths in England and Wales, 2014 to 2020. Mayo Clinic Proceedings, 96(4), 952 - 963. https://doi.org/10.1016/j.mayocp.2021.02.007

OBJECTIVE: To describe the place and cause of death during the coronavirus disease 2019 (COVID-19) pandemic to assess its impact on excess mortality. METHODS: This national death registry included all adult (aged =18 years) deaths in England and... Read More about Place and Underlying Cause of Death During the COVID-19 Pandemic: Retrospective Cohort Study of 3.5 Million Deaths in England and Wales, 2014 to 2020.

Meta-Analysis of Transradial vs Transfemoral Access for Percutaneous Coronary Intervention in Patients With ST Elevation Myocardial Infarction. (2021)
Journal Article
Mamas. (2021). Meta-Analysis of Transradial vs Transfemoral Access for Percutaneous Coronary Intervention in Patients With ST Elevation Myocardial Infarction. https://doi.org/10.1016/j.amjcard.2020.11.016

Transradial access (TRA) has emerged as an alternative to transfemoral access (TFA) for percutaneous coronary intervention (PCI) in ST elevation myocardial infarction (STEMI) patients. However, the rate of TRA adoption has been much slower in the acu... Read More about Meta-Analysis of Transradial vs Transfemoral Access for Percutaneous Coronary Intervention in Patients With ST Elevation Myocardial Infarction..

Excess mortality in England and Wales during the first wave of the COVID-19 pandemic (2021)
Journal Article
Mamas. (2021). Excess mortality in England and Wales during the first wave of the COVID-19 pandemic. Journal of epidemiology and community health, 213-223. https://doi.org/10.1136/jech-2020-214764

Background Deaths during the COVID-19 pandemic result directly from infection and exacerbation of other diseases and indirectly from deferment of care for other conditions, and are socially and geographically patterned. We quantified excess mortality... Read More about Excess mortality in England and Wales during the first wave of the COVID-19 pandemic.

Estimating the population health burden of musculoskeletal conditions using primary care electronic health records (2021)
Journal Article
Yu, D., Peat, G., Jordan, K., Bailey, J., Prieto-Alhambra, D., Robinson, D., …Wilkie, R. (2021). Estimating the population health burden of musculoskeletal conditions using primary care electronic health records. Rheumatology, 60(10), 4832-4843. https://doi.org/10.1093/rheumatology/keab109

Objectives Better indicators from affordable, sustainable data sources are needed to monitor population burden of musculoskeletal conditions. We propose five indicators of musculoskeletal health and assessed if routinely available primary care elect... Read More about Estimating the population health burden of musculoskeletal conditions using primary care electronic health records.

Vascular complications associated with intraaortic balloon pump supported percutaneous coronary intervention (PCI) and clinical outcomes from the British Cardiovascular Intervention Society National PCI Database. (2021)
Journal Article
Kinnaird, T., Anderson, R., Gallagher, S., Sharp, A. S. P., Farooq, V., Ludman, P., …Mamas, M. (2021). Vascular complications associated with intraaortic balloon pump supported percutaneous coronary intervention (PCI) and clinical outcomes from the British Cardiovascular Intervention Society National PCI Database. Catheterization and Cardiovascular Interventions, 98(1), E53-E61. https://doi.org/10.1002/ccd.29549

INTRODUCTION: The impact of a vascular complication (VC) in the setting of intraaortic balloon pump (IABP) supported PCI on clinical outcomes is unclear. METHODS: Using data from the BCIS National PCI Database, multivariate logistic regression was us... Read More about Vascular complications associated with intraaortic balloon pump supported percutaneous coronary intervention (PCI) and clinical outcomes from the British Cardiovascular Intervention Society National PCI Database..

The Effect of Spironolactone on Cardiovascular Function and Markers of Fibrosis in People at Increased Risk of Developing Heart Failure: The Heart “OMics” in AGEing (HOMAGE) Randomised Clinical Trial. (2021)
Journal Article
Mamas. (2021). The Effect of Spironolactone on Cardiovascular Function and Markers of Fibrosis in People at Increased Risk of Developing Heart Failure: The Heart “OMics” in AGEing (HOMAGE) Randomised Clinical Trial. European Heart Journal, 684-696. https://doi.org/10.1093/eurheartj/ehaa758

Importance: Cardiovascular accumulation of collagen (fibrosis) may contribute to the progression from ventricular dysfunction to heart failure. Galectin-3, a potential marker of pro-fibrotic activity, might identify those at greater risk. Objective:... Read More about The Effect of Spironolactone on Cardiovascular Function and Markers of Fibrosis in People at Increased Risk of Developing Heart Failure: The Heart “OMics” in AGEing (HOMAGE) Randomised Clinical Trial..

Effect of primary percutaneous coronary intervention on in-hospital outcomes among active cancer patients presenting with ST-elevation myocardial infarction: a propensity score matching analysis (2021)
Journal Article
Mamas. (2021). Effect of primary percutaneous coronary intervention on in-hospital outcomes among active cancer patients presenting with ST-elevation myocardial infarction: a propensity score matching analysis. European Heart Journal: Acute Cardiovascular Care, 829-839. https://doi.org/10.1093/ehjacc/zuaa032

Aims Primary percutaneous coronary intervention (pPCI) is the gold standard, guideline-recommended revascularization strategy in patients presenting with ST-elevation myocardial infarction (STEMI). However, there are limited data on its use and effe... Read More about Effect of primary percutaneous coronary intervention on in-hospital outcomes among active cancer patients presenting with ST-elevation myocardial infarction: a propensity score matching analysis.

Incidence and Predictors of Postoperative Ischemic Stroke after Coronary Artery Bypass Grafting (2021)
Journal Article
Mamas. (2021). Incidence and Predictors of Postoperative Ischemic Stroke after Coronary Artery Bypass Grafting. International Journal of Clinical Practice, https://doi.org/10.1111/ijcp.14067

Background: Data on the incidence and outcomes of ischemic stroke in patients undergoing coronary artery bypass grafting (CABG) in the current era is limited. The goal of this study was to examine contemporary trends, predictors, and outcomes of isch... Read More about Incidence and Predictors of Postoperative Ischemic Stroke after Coronary Artery Bypass Grafting.

Revascularisation Therapies Improve the Outcomes of Ischemic Stroke Patients with Atrial Fibrillation and Heart Failure (2021)
Journal Article
Mamas. (2021). Revascularisation Therapies Improve the Outcomes of Ischemic Stroke Patients with Atrial Fibrillation and Heart Failure. International Journal of Cardiology, 205-213. https://doi.org/10.1016/j.ijcard.2020.09.076

Background – Atrial fibrillation (AF) and heart failure (HF) carry a poor prognosis in acute ischaemic stroke (AIS). The impact of revascularisation therapies on outcomes in these patients is not fully understood. Methods –National Inpatient Samp... Read More about Revascularisation Therapies Improve the Outcomes of Ischemic Stroke Patients with Atrial Fibrillation and Heart Failure.

Acute Myocardial Infarction in Autoimmune Rheumatological Disease: A Nationwide Analysis of Clinical outcomes and Predictors of Management Strategy (2021)
Journal Article
Mamas, Clarson, Roddy, Mallen, & Helliwell. (2021). Acute Myocardial Infarction in Autoimmune Rheumatological Disease: A Nationwide Analysis of Clinical outcomes and Predictors of Management Strategy. Mayo Clinic Proceedings, 388-399. https://doi.org/10.1016/j.mayocp.2020.04.044

Objectives: The present study sought to examine national-level differences in management strategies and outcomes in patients with autoimmune rheumatic disease (AIRD) with acute myocardial infarction (AMI) between 2004 and 2014. Methods: All AMI hos... Read More about Acute Myocardial Infarction in Autoimmune Rheumatological Disease: A Nationwide Analysis of Clinical outcomes and Predictors of Management Strategy.

Outcomes following Percutaneous Coronary Intervention in Renal Transplant Recipients; A Binational collaborative analysis (2021)
Journal Article
Mamas, & Rashid. (2021). Outcomes following Percutaneous Coronary Intervention in Renal Transplant Recipients; A Binational collaborative analysis. Mayo Clinic Proceedings, 363-376. https://doi.org/10.1016/j.mayocp.2020.04.045

Objective: We sought to investigate the clinical and procedural characteristics in patients with a history of Renal Transplant (RT) and compare the outcomes with non-RT patients in two national cohorts of patients undergoing percutaneous coronary int... Read More about Outcomes following Percutaneous Coronary Intervention in Renal Transplant Recipients; A Binational collaborative analysis.

In-Hospital and 30-Day Mortality After Percutaneous Coronary Intervention in England in the Pre-COVID and COVID Eras (2021)
Journal Article
Mamas, M., & Rashid, M. (2021). In-Hospital and 30-Day Mortality After Percutaneous Coronary Intervention in England in the Pre-COVID and COVID Eras. Journal of Invasive Cardiology,

BACKGROUND: Public reporting of percutaneous coronary intervention (PCI) outcomes is a performance metric and a requirement in many healthcare systems. There are inconsistent data on the causes of death after PCI, and the proportion of these deaths t... Read More about In-Hospital and 30-Day Mortality After Percutaneous Coronary Intervention in England in the Pre-COVID and COVID Eras.

Sex-specific in-hospital outcomes of transcatheter aortic valve replacement with third generation transcatheter heart valves. (2021)
Journal Article
Simard, T., Alqahtani, F., Hibbert, B., Mamas, M. A., El‐Hajj, S., El-Hajj, S., …Alkhouli, M. (2021). Sex-specific in-hospital outcomes of transcatheter aortic valve replacement with third generation transcatheter heart valves. Catheterization and Cardiovascular Interventions, 98(1), 176 - 183. https://doi.org/10.1002/ccd.29499

BACKGROUND: Sex-based differences in transcatheter aortic valve replacement (TAVR) outcomes have been previously documented. However, whether these differences persist with contemporary third generation transcatheter heart valves (THVs) is unknown. M... Read More about Sex-specific in-hospital outcomes of transcatheter aortic valve replacement with third generation transcatheter heart valves..

Best Practices of Social Media for the Clinician. (2021)
Journal Article
Mamas. (2021). Best Practices of Social Media for the Clinician. Current Cardiology Reviews, 118 - 121. https://doi.org/10.2174/1573403X16666200128101509

Over recent years, social media use has substantially expanded not only for millennials, but across all generations. Today, it no longer remains a means for simple social networking. It has evolved into a powerful tool that can be used for career dev... Read More about Best Practices of Social Media for the Clinician..

Mobile health applications for the detection of atrial fibrillation: a systematic review. (2021)
Journal Article
Mamas. (2021). Mobile health applications for the detection of atrial fibrillation: a systematic review. https://doi.org/10.1093/europace/euaa139

AIMS: Atrial fibrillation (AF) is the most common sustained arrhythmia and an important risk factor for stroke and heart failure. We aimed to conduct a systematic review of the literature and summarize the performance of mobile health (mHealth) devic... Read More about Mobile health applications for the detection of atrial fibrillation: a systematic review..

Outcomes of COVID-19 Positive Acute Coronary Syndrome Patients; a multisource Electronic Healthcare Records Study from England. (2021)
Journal Article
Rashid, M., Wu, J., Timmis, A., Curzen, N., Clarke, S., Zaman, A., …Mamas, M. A. (2021). Outcomes of COVID-19 Positive Acute Coronary Syndrome Patients; a multisource Electronic Healthcare Records Study from England. Journal of Internal Medicine, 290(1), 88-100. https://doi.org/10.1111/joim.13246

BACKGROUND: Patients with underlying cardiovascular disease and Coronavirus disease 2019 (COVID-19) infection are at increased risk of morbidity and mortality. OBJECTIVES: This study was designed to characterise the presenting profile and outcomes... Read More about Outcomes of COVID-19 Positive Acute Coronary Syndrome Patients; a multisource Electronic Healthcare Records Study from England..

Clinical Characteristics, Management Strategies and Outcomes of Acute Myocardial Infarction Patients With Prior Coronary Artery Bypass Grafting. (2021)
Journal Article
Shoaib, A., Mohamed, M., Rashid, M., Khan, S. U., Parwani, P., Contractor, T., …Mamas, M. A. (2021). Clinical Characteristics, Management Strategies and Outcomes of Acute Myocardial Infarction Patients With Prior Coronary Artery Bypass Grafting. Mayo Clinic Proceedings, 96(1), 120 - 131. https://doi.org/10.1016/j.mayocp.2020.05.047

OBJECTIVE: To investigate the management strategies, temporal trends, and clinical outcomes of patients with a history of coronary artery bypass graft (CABG) surgery and presenting with acute myocardial infarction (MI). PATIENTS AND METHODS: We under... Read More about Clinical Characteristics, Management Strategies and Outcomes of Acute Myocardial Infarction Patients With Prior Coronary Artery Bypass Grafting..

Breaking the deadlock of calcified coronary artery lesions: A contemporary review. (2021)
Journal Article
Mamas. (2021). Breaking the deadlock of calcified coronary artery lesions: A contemporary review. Catheterization and Cardiovascular Interventions, 108 - 120. https://doi.org/10.1002/ccd.29221

Percutaneous coronary intervention (PCI) of severely calcified lesions is known to result in lower procedural success rates, higher complication rates, and worse long-term clinical outcomes compared to noncalcified lesions. Adequate lesion preparatio... Read More about Breaking the deadlock of calcified coronary artery lesions: A contemporary review..

Trial characteristics associated with under-enrolment of females in randomized controlled trials of heart failure with reduced ejection fraction: a systematic review. (2021)
Journal Article
Mamas, M. (2021). Trial characteristics associated with under-enrolment of females in randomized controlled trials of heart failure with reduced ejection fraction: a systematic review. https://doi.org/10.1002/ejhf.2034

AIMS: To evaluate temporal trends in the enrolment of females in randomized controlled trials (RCTs) of heart failure with reduced ejection fraction (HFrEF) published in high-impact journals, and assess RCT characteristics associated with under-enrol... Read More about Trial characteristics associated with under-enrolment of females in randomized controlled trials of heart failure with reduced ejection fraction: a systematic review..

Comparison of distal radial access versus standard transradial access in patients with smaller diameter radial Arteries(The distal radial versus transradial access in small transradial ArteriesStudy: D.A.T.A - S.T.A.R study). (2021)
Journal Article
Chugh, Y., Sasidhar Kanaparthy, N., Piplani, S., Chugh, S., Shroff, A., Vidovich, M., …Kumar Chugh, S. (2021). Comparison of distal radial access versus standard transradial access in patients with smaller diameter radial Arteries(The distal radial versus transradial access in small transradial ArteriesStudy: D.A.T.A - S.T.A.R study). Indian Heart Journal, 73(1), 26 - 34. https://doi.org/10.1016/j.ihj.2020.11.002

AIMS: To evaluate safety and efficacy of distal right radial access (DRRA) compared to right radial access (RRA), for coronary procedures, in patients with smaller diameter radial arteries (SDRA) (radial artery diameter (RAD) 

Place and causes of acute cardiovascular mortality during the COVID-19 pandemic (2021)
Journal Article
Mamas. (2021). Place and causes of acute cardiovascular mortality during the COVID-19 pandemic. Heart, 113-119. https://doi.org/10.1136/heartjnl-2020-317912

OBJECTIVE: To describe the place and causes of acute cardiovascular death during the COVID-19 pandemic. METHODS: Retrospective cohort of adult (age =18 years) acute cardiovascular deaths (n=5?87?225) in England and Wales, from 1 January 2014 to 30 Ju... Read More about Place and causes of acute cardiovascular mortality during the COVID-19 pandemic.

Cost of coronary syndrome treated with percutaneous coronary intervention and 30-day unplanned readmission in the United States (2021)
Journal Article
Nolan, J., Mamas, M., Kwok, C. S., Amin, A. P., Shah, B., Kinnaird, T., …Bagur, R. (2021). Cost of coronary syndrome treated with percutaneous coronary intervention and 30-day unplanned readmission in the United States. Catheterization and Cardiovascular Interventions, 97(1), 80-93. https://doi.org/10.1002/ccd.28660

Objectives: This study aimed to examine the cost of coronary syndrome treated with percutaneous coronary intervention (PCI) and 30-day unplanned readmissions. Background: There is limited understanding of the hospital cost of index PCI and 30-day... Read More about Cost of coronary syndrome treated with percutaneous coronary intervention and 30-day unplanned readmission in the United States.

Sex disparities in the choice of cardiac resynchronization therapy device utilized: an analysis of trends, predictors and outcomes. (2021)
Journal Article
Rashid, & Mamas. (2021). Sex disparities in the choice of cardiac resynchronization therapy device utilized: an analysis of trends, predictors and outcomes. Canadian Journal of Cardiology, 86-93. https://doi.org/10.1016/j.cjca.2020.02.073

Background There is limited evidence on the influence of sex on the decision to implant a cardiac resynchronization therapy device with pacemaker (CRT-P) or defibrillator (CRT-D) and the existence of sex-dependent differences in complications that m... Read More about Sex disparities in the choice of cardiac resynchronization therapy device utilized: an analysis of trends, predictors and outcomes..

Calcium intake, calcium supplementation and cardiovascular disease and mortality in the British population: EPIC-norfolk prospective cohort study and meta-analysis. (2020)
Journal Article
Mamas. (2020). Calcium intake, calcium supplementation and cardiovascular disease and mortality in the British population: EPIC-norfolk prospective cohort study and meta-analysis. European Journal of Epidemiology, https://doi.org/10.1007/s10654-020-00710-8

The role of dietary calcium in cardiovascular disease prevention is unclear. We aimed to determine the association between calcium intake and incident cardiovascular disease and mortality. Data were extracted from the European Prospective Investigati... Read More about Calcium intake, calcium supplementation and cardiovascular disease and mortality in the British population: EPIC-norfolk prospective cohort study and meta-analysis..

Sex differences in distribution, management and outcomes of combined ischemic-bleeding risk following acute coronary syndrome (2020)
Journal Article
Rashid, & Mamas. (2020). Sex differences in distribution, management and outcomes of combined ischemic-bleeding risk following acute coronary syndrome. International Journal of Cardiology, https://doi.org/10.1016/j.ijcard.2020.12.063

Background Risk factors for further bleeding and ischemic events after acute coronary syndrome (ACS) often overlap. Little is known about sex-based differences in the management and outcomes of ACS patients according to their combined bleeding-ische... Read More about Sex differences in distribution, management and outcomes of combined ischemic-bleeding risk following acute coronary syndrome.

Gout Pharmacotherapy in Cardiovascular Diseases: A Review of Utility and Outcomes. (2020)
Journal Article
Roddy, & Mamas. (2020). Gout Pharmacotherapy in Cardiovascular Diseases: A Review of Utility and Outcomes. American Journal of Cardiovascular Drugs, https://doi.org/10.1007/s40256-020-00459-1

Hyperuricemia and gout have been linked to an increased risk for cardiovascular (CV) disease, stroke, hypertension, heart failure, and chronic kidney disease, possibly through a proinflammatory milieu. However, not all the drugs used in gout treatmen... Read More about Gout Pharmacotherapy in Cardiovascular Diseases: A Review of Utility and Outcomes..

Place and causes of acute cardiovascular mortality during the COVID-19 pandemic. (2020)
Journal Article
Mamas. (2020). Place and causes of acute cardiovascular mortality during the COVID-19 pandemic. Heart, 113-119. https://doi.org/10.1101/2020.07.14.20153734

Objective. To describe the place and causes of acute cardiovascular death during the COVID-19 pandemic. Methods. Retrospective cohort of adult (age =18 years) acute cardiovascular deaths (n=587,225) in England and Wales, 1st January 2014 to 30th Jun... Read More about Place and causes of acute cardiovascular mortality during the COVID-19 pandemic..

Percutaneous coronary intervention in octogenarians: A risk scoring system to predict 30-day outcomes in the elderly. (2020)
Journal Article
Mamas. (2020). Percutaneous coronary intervention in octogenarians: A risk scoring system to predict 30-day outcomes in the elderly. Catheterization and Cardiovascular Interventions, 1300 - 1307. https://doi.org/10.1002/ccd.29406

OBJECTIVE: Octogenarians are a high-risk group presenting for percutaneous coronary intervention (PCI). We aimed to create a 30-day mortality risk model for octogenarians presenting with both acute coronary syndrome (ACS) and chronic stable angina (C... Read More about Percutaneous coronary intervention in octogenarians: A risk scoring system to predict 30-day outcomes in the elderly..

The LENT index predicts 30 day outcomes following hospitalization for heart failure (2020)
Journal Article
Mamas. (2020). The LENT index predicts 30 day outcomes following hospitalization for heart failure. ESC Heart Failure, https://doi.org/10.1002/ehf2.13109

AIMS: The LE index (Length of hospitalization plus number of Emergent visits =6 months) predicts 30 day all-cause readmission or death following hospitalization for heart failure (HF). We combined N-terminal pro-B type natriuretic peptide (NT-proBNP)... Read More about The LENT index predicts 30 day outcomes following hospitalization for heart failure.

Cardiac arrest and related mortality in emergency departments in the United States: Analysis of the nationwide emergency department sample. (2020)
Journal Article
Mamas. (2020). Cardiac arrest and related mortality in emergency departments in the United States: Analysis of the nationwide emergency department sample. Resuscitation, 166 - 173. https://doi.org/10.1016/j.resuscitation.2020.10.005

AIMS: The aim of this study is to analyse the causes of cardiac arrests (CA) in the emergency departments (ED) in the United States and their clinical outcomes according to whether they had a primary or a secondary diagnosis of CA. METHODS: Data from... Read More about Cardiac arrest and related mortality in emergency departments in the United States: Analysis of the nationwide emergency department sample..

Trends in sex-based differences in outcomes following coronary artery bypass grafting in the United States between 2004 and 2015 (2020)
Journal Article
Mamas. (2020). Trends in sex-based differences in outcomes following coronary artery bypass grafting in the United States between 2004 and 2015. International Journal of Cardiology, 42-48. https://doi.org/10.1016/j.ijcard.2020.07.039

Background The present study sought to examine the trends of sex-based differences in clinical outcomes after coronary artery bypass grafting (CABG), an area in which the current evidence remains limited. Methods All US adults hospitalized for fir... Read More about Trends in sex-based differences in outcomes following coronary artery bypass grafting in the United States between 2004 and 2015.

Trends, management and outcomes of acute myocardial infarction in chronic liver disease. (2020)
Journal Article
Mamas. (2020). Trends, management and outcomes of acute myocardial infarction in chronic liver disease. International Journal of Clinical Practice, https://doi.org/10.1111/ijcp.13841

AIMS: There are limited data on the management and outcomes of chronic liver disease (CLD) patients presenting with acute myocardial infarction (AMI), particularly according to the subtype of CLD. METHODS: Using the Nationwide Inpatient Sample (2004-... Read More about Trends, management and outcomes of acute myocardial infarction in chronic liver disease..

The association between osteoarthritis and invasive treatment and clinical outcomes in 6.5 million patients presenting with acute myocardial infarction (2020)
Journal Article
Parmar, S., Mohamed, M., Wilkie, R., & Mamas, M. (2020). The association between osteoarthritis and invasive treatment and clinical outcomes in 6.5 million patients presenting with acute myocardial infarction. European Heart Journal, 41(S2), 1660 - 1660. https://doi.org/10.1093/ehjci/ehaa946.1660

Background People with osteoarthritis (OA) have an increased risk of cardiovascular disease, including acute myocardial infarction (AMI). Despite OA being the most common joint condition and the fastest increasing major health condition, there is li... Read More about The association between osteoarthritis and invasive treatment and clinical outcomes in 6.5 million patients presenting with acute myocardial infarction.

Comorbidity burden in patients undergoing left atrial appendage closure (2020)
Journal Article
Sanjoy, S., Choi, Y., Holmes, D., Herrman, H., Terre, J., Alraies, C., …Bagur, R. (2021). Comorbidity burden in patients undergoing left atrial appendage closure. Heart, 107(15), 1246-1253. https://doi.org/10.1136/heartjnl-2020-317741

Objective To estimate the risk of in-hospital complications after left atrial appendage closure (LAAC) in relationship with comorbidity burden. Methods Cohort-based observational study using the US National Inpatient Sample database, 1 October 201... Read More about Comorbidity burden in patients undergoing left atrial appendage closure.

Distribution of contemporary sensitivity troponin in the emergency department and relationship to 30-day mortality: The CHARIOT-ED substudy. (2020)
Journal Article
Mamas. (2020). Distribution of contemporary sensitivity troponin in the emergency department and relationship to 30-day mortality: The CHARIOT-ED substudy. Clinical Medicine, 528 - 534. https://doi.org/10.7861/clinmed.2020-0267

BACKGROUND: Contemporary sensitivity troponin (cs-cTn) concentrations above the upper limit of normal (ULN) are seen in a wide range of clinical conditions and evidence is growing that suggests cs-cTn may be a biomarker of future morbidity and mortal... Read More about Distribution of contemporary sensitivity troponin in the emergency department and relationship to 30-day mortality: The CHARIOT-ED substudy..

Abstract 15368: Index Admission and Thirty-day Readmission Outcomes of Cancer Patients Presenting With Stemi (2020)
Journal Article
Osman, M., Benjamin, M. M., Balla, S., Kheiri, B., Bianco, C., sengupta, P., …Patel, B. (2020). Abstract 15368: Index Admission and Thirty-day Readmission Outcomes of Cancer Patients Presenting With Stemi. Circulation, 142(Suppl_3), https://doi.org/10.1161/circ.142.suppl_3.15368

Introduction: National-level data of cancer patients’ readmissions after a ST-segment elevation myocardial infarction (STEMI) are lacking. Objectives: The primary aim of this study was to describe rates and causes of 30-day readmissions in this po... Read More about Abstract 15368: Index Admission and Thirty-day Readmission Outcomes of Cancer Patients Presenting With Stemi.

Demographic, Regional, and State-Level Trends of Mortality in Patients With Aortic Stenosis in United States, 2008 to 2018. (2020)
Journal Article
Mamas. (2020). Demographic, Regional, and State-Level Trends of Mortality in Patients With Aortic Stenosis in United States, 2008 to 2018. Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, e017433 - ?. https://doi.org/10.1161/JAHA.120.017433

Background Aortic stenosis-related mortality might vary across demographic subsets, regions, and states in the United States. Methods and Results We reviewed the death certificate data from the Centers for Disease Control and Prevention Wide-Ranging... Read More about Demographic, Regional, and State-Level Trends of Mortality in Patients With Aortic Stenosis in United States, 2008 to 2018..

Transcatheter aortic valve replacement and percutaneous coronary intervention versus surgical aortic valve replacement and coronary artery bypass grafting in patients with severe aortic stenosis and concomitant coronary artery disease: A systematic review and meta-analysis. (2020)
Journal Article
Mamas, M. (2020). Transcatheter aortic valve replacement and percutaneous coronary intervention versus surgical aortic valve replacement and coronary artery bypass grafting in patients with severe aortic stenosis and concomitant coronary artery disease: A systematic review and meta-analysis. https://doi.org/10.1002/ccd.29110

OBJECTIVES: We performed a systematic review and meta-analysis to evaluate the early and midterm outcomes of patients who underwent surgical aortic valve replacement (SAVR) and coronary artery bypass grafting (CABG) against patients who had transcath... Read More about Transcatheter aortic valve replacement and percutaneous coronary intervention versus surgical aortic valve replacement and coronary artery bypass grafting in patients with severe aortic stenosis and concomitant coronary artery disease: A systematic review and meta-analysis..

Impact of the COVID-19 Pandemic on Percutaneous Coronary Intervention in England: Insights From the British Cardiovascular Intervention Society PCI Database Cohort. (2020)
Journal Article
Mamas. (2020). Impact of the COVID-19 Pandemic on Percutaneous Coronary Intervention in England: Insights From the British Cardiovascular Intervention Society PCI Database Cohort. Circulation: Cardiovascular Interventions, e009654 - ?. https://doi.org/10.1161/CIRCINTERVENTIONS.120.009654

BACKGROUND: The objective of the study was to evaluate changes in percutaneous coronary intervention (PCI) practice in England by analyzing procedural numbers, changes in the clinical presentation, and characteristics of patients and their clinical o... Read More about Impact of the COVID-19 Pandemic on Percutaneous Coronary Intervention in England: Insights From the British Cardiovascular Intervention Society PCI Database Cohort..

Early intervention or watchful waiting for asymptomatic severe aortic valve stenosis: a systematic review and meta-analysis. (2020)
Journal Article
Rashid, & Mamas. (2020). Early intervention or watchful waiting for asymptomatic severe aortic valve stenosis: a systematic review and meta-analysis. Journal of Cardiovascular Medicine, 897-904. https://doi.org/10.2459/JCM.0000000000001110

BACKGROUND: The management of patients with severe but asymptomatic aortic stenosis is challenging. Evidence on early aortic valve replacement (AVR) versus symptom-driven intervention in these patients is unknown. METHODS: Electronic databases were s... Read More about Early intervention or watchful waiting for asymptomatic severe aortic valve stenosis: a systematic review and meta-analysis..

Safety and Efficacy of Coronary Intravascular Lithotripsy for Calcified Coronary Arteries – A Systematic Review and Meta-Analysis (2020)
Journal Article
Mamas. (2020). Safety and Efficacy of Coronary Intravascular Lithotripsy for Calcified Coronary Arteries – A Systematic Review and Meta-Analysis. Expert Review of Cardiovascular Therapy, https://doi.org/10.1080/14779072.2021.1845143

Objectives: Intravascular lithotripsy (IVL) clinical efficacy and safety in the treatment of calcified coronary artery disease (CAC) is not well known. We sought to assess IVL safety and efficacy in CAC. Methods: A comprehensive online databases s... Read More about Safety and Efficacy of Coronary Intravascular Lithotripsy for Calcified Coronary Arteries – A Systematic Review and Meta-Analysis.

Acute myocardial infarction in several mental illness: a nationwide analysis of prevalence, management strategies and outcomes (2020)
Journal Article
Mohamed, M., Rashid, M., Farooq, S., Siddiqui, N., Parwani, P., Shiers, D., …Mamas, M. (2020). Acute myocardial infarction in several mental illness: a nationwide analysis of prevalence, management strategies and outcomes. European Heart Journal, 41(Supplement_2), https://doi.org/10.1093/ehjci/ehaa946.3146

Background Severe mental illness (SMI) is associated with an increased risk of cardiovascular disease and mortality. However, it is unclear whether SMI patients are just as likely to receive guideline-recommended therapy for AMI as those without men... Read More about Acute myocardial infarction in several mental illness: a nationwide analysis of prevalence, management strategies and outcomes.

Trends of sex differences in outcomes of cardiac electronic device implantations in the United States (2020)
Journal Article
Mohamed, M., Volgman, A., Contractor, T., Sharma, P., Kwok, C., Martin, G., …Mamas, M. (2020). Trends of sex differences in outcomes of cardiac electronic device implantations in the United States. European Heart Journal, 41(Supplement_2), https://doi.org/10.1093/ehjci/ehaa946.0831

Background There is limited evidence on the differences in procedural outcomes between sexes after de novo cardiac implantable electronic device implantation (CIED). Furthermore, it is unclear whether any sex-based disparities have changed over the... Read More about Trends of sex differences in outcomes of cardiac electronic device implantations in the United States.

Characteristics of Heart Failure Trials Associated With Under-Representation of Women as Lead Authors. (2020)
Journal Article
Mamas. (2020). Characteristics of Heart Failure Trials Associated With Under-Representation of Women as Lead Authors. Journal of the American College of Cardiology, 1919 - 1930. https://doi.org/10.1016/j.jacc.2020.08.062

BACKGROUND: Clinical trials change practice in cardiology, and leading them requires research training, mentorship, sponsorship, and networking. Women report challenges in obtaining these opportunities. OBJECTIVES: The purpose of this review was to e... Read More about Characteristics of Heart Failure Trials Associated With Under-Representation of Women as Lead Authors..

TCT CONNECT-41 Impact of Chronic Kidney Disease on Coronary Revascularization and In-Hospital Outcomes in Patients With Acute ST-Segment Elevation Myocardial Infarction (2020)
Journal Article
Panchal, H., Zheng, S., White, C., Leinaar, E., Mukherjee, D., Mamas, M., …Paul, T. (2020). TCT CONNECT-41 Impact of Chronic Kidney Disease on Coronary Revascularization and In-Hospital Outcomes in Patients With Acute ST-Segment Elevation Myocardial Infarction. Journal of the American College of Cardiology, 76(17), B18. https://doi.org/10.1016/j.jacc.2020.09.072

Background Chronic kidney disease (CKD) in patients with ST-segment elevation myocardial infarction (STEMI) has been associated with worse outcomes. Our study sought to assess the impact of CKD on guideline-directed coronary revascularization and ou... Read More about TCT CONNECT-41 Impact of Chronic Kidney Disease on Coronary Revascularization and In-Hospital Outcomes in Patients With Acute ST-Segment Elevation Myocardial Infarction.

TCT CONNECT-247 Outcomes of Percutaneous Coronary Intervention in Cardiac Transplant Patients: A Bi-national Analysis Derived From the United Kingdom and United States (2020)
Journal Article
Nagaraja, V., Rashid, M., Anderson, H., Ludman, P., Kapadia, S., Starling, R., …Mamas, M. (2020). TCT CONNECT-247 Outcomes of Percutaneous Coronary Intervention in Cardiac Transplant Patients: A Bi-national Analysis Derived From the United Kingdom and United States. Journal of the American College of Cardiology, 76(17), B109. https://doi.org/10.1016/j.jacc.2020.09.264

Background Five years after transplantation, coronary allograft vasculopathy and late graft failure account for 32% of all mortality. The current role of percutaneous coronary intervention (PCI) in coronary allograft vasculopathy is unclear and cons... Read More about TCT CONNECT-247 Outcomes of Percutaneous Coronary Intervention in Cardiac Transplant Patients: A Bi-national Analysis Derived From the United Kingdom and United States.

TCT CONNECT-266 Cobalt Chromium Biolimus Drug-Eluting Stents Compared With Stainless Steel Biolimus Drug-Eluting Stents: Final Results of BMX Alpha (2020)
Journal Article
Alexander Menown, I. B., Mamas, M., Cotton, J., Hildick-Smith, D., Eberli, F., Leibundgut, G., …Oldroyd, K. (2020). TCT CONNECT-266 Cobalt Chromium Biolimus Drug-Eluting Stents Compared With Stainless Steel Biolimus Drug-Eluting Stents: Final Results of BMX Alpha. Journal of the American College of Cardiology, 76(17), B116. https://doi.org/10.1016/j.jacc.2020.09.283

Background Thinner stent struts may improve deliverability and conformability and reduce vessel injury. The final clinical outcomes of the thinner strut (84 to 88 μm) cobalt chromium biolimus eluting stent from the BioMatrix (BMX) Alpha registry are... Read More about TCT CONNECT-266 Cobalt Chromium Biolimus Drug-Eluting Stents Compared With Stainless Steel Biolimus Drug-Eluting Stents: Final Results of BMX Alpha.

Impact of COVID-19 on cardiac procedure activity in England and associated 30-day mortality (2020)
Journal Article
Mohamed, M. O., Banerjee, A., Clarke, S., de Belder, M., Patwala, A., Goodwin, A. T., …Mamas, M. (2021). Impact of COVID-19 on cardiac procedure activity in England and associated 30-day mortality. European Heart Journal - Quality of Care and Clinical Outcomes, 7(3), 247-256. https://doi.org/10.1093/ehjqcco/qcaa079

Background: Limited data exists on the impact of COVID-19 on national changes in cardiac procedure activity, including patient characteristics and clinical outcomes before and during the COVID-19 pandemic. Methods and Results: All major cardiac pr... Read More about Impact of COVID-19 on cardiac procedure activity in England and associated 30-day mortality.

Trial characteristics associated with the underrepresentation of women as lead authors in heart failure clinical trials (2020)
Journal Article
Mamas. (2020). Trial characteristics associated with the underrepresentation of women as lead authors in heart failure clinical trials. Journal of the American College of Cardiology, 1919-1930. https://doi.org/10.1016/j.jacc.2020.08.062

Background Clinical trials change practice in cardiology, and leading them requires research training, mentorship, sponsorship, and networking. Women report challenges in obtaining these opportunities. Objectives The purpose of this review was t... Read More about Trial characteristics associated with the underrepresentation of women as lead authors in heart failure clinical trials.

Excess mortality in England and Wales during the first wave of the COVID-19 pandemic. (2020)
Journal Article
Mamas. (2020). Excess mortality in England and Wales during the first wave of the COVID-19 pandemic. Journal of Epidemiology and Community Health, 213 - 223. https://doi.org/10.1136/jech-2020-214764

BACKGROUND: Deaths during the COVID-19 pandemic result directly from infection and exacerbation of other diseases and indirectly from deferment of care for other conditions, and are socially and geographically patterned. We quantified excess mortalit... Read More about Excess mortality in England and Wales during the first wave of the COVID-19 pandemic..

Impact of COVID19 Pandemic on the Incidence and Management of Out of Hospital Cardiac Arrest in Patients Presenting with Acute Myocardial Infarction in England (2020)
Journal Article
Rashid, M., Gale, C. P., Curzen, N., Ludman, P., De Belder, M., Timmis, A., …Mamas, M. (2020). Impact of COVID19 Pandemic on the Incidence and Management of Out of Hospital Cardiac Arrest in Patients Presenting with Acute Myocardial Infarction in England. Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, 9(22), https://doi.org/10.1161/JAHA.120.018379

Background: Studies have reported significant reduction in acute myocardial infarction (AMI) related hospitalizations during the COVID19 pandemic. However, whether these trends are associated with increased incidence of Out of Hospital Cardiac Arrest... Read More about Impact of COVID19 Pandemic on the Incidence and Management of Out of Hospital Cardiac Arrest in Patients Presenting with Acute Myocardial Infarction in England.

Seasonality of stroke: Winter admissions and mortality excess: A Thailand National Stroke population database study. (2020)
Journal Article
Lorking, N., Wood, A. D., Tiamkao, S., Clark, A. B., Kongbunkiat, K., Bettencourt-Silva, J. H., …Myint, P. K. (2020). Seasonality of stroke: Winter admissions and mortality excess: A Thailand National Stroke population database study. Clinical Neurology and Neurosurgery, 106261 - ?. https://doi.org/10.1016/j.clineuro.2020.106261

OBJECTIVES: We examined the existence and potential burden of seasonality of stroke admissions and mortality within a tropical climate using cohort data collected between 1?st November 2003 and 31?st October 2012. PATIENTS AND METHODS: In a prospecti... Read More about Seasonality of stroke: Winter admissions and mortality excess: A Thailand National Stroke population database study..

Meta-Analysis Comparing the Safety and Efficacy of Prasugrel and Ticagrelor in Acute Coronary Syndrome. (2020)
Journal Article
Mamas. (2020). Meta-Analysis Comparing the Safety and Efficacy of Prasugrel and Ticagrelor in Acute Coronary Syndrome. American Journal of Cardiology, 22 - 28. https://doi.org/10.1016/j.amjcard.2020.07.017

Prasugrel and ticagrelor are preferred over clopidogrel for patients with acute coronary syndrome who underwent percutaneous coronary intervention. We sought to determine the relative merits of 1 agent over the other. Multiple databases were queried... Read More about Meta-Analysis Comparing the Safety and Efficacy of Prasugrel and Ticagrelor in Acute Coronary Syndrome..

Epidemiology and Clinical Outcomes of Patients With Inflammatory Bowel Disease Presenting With Acute Coronary Syndrome (2020)
Journal Article
Mamas, Pemmasani, G., Elgendy, I., Leighton, J. A., Aronow, W. S., & Tremaine, W. J. (2021). Epidemiology and Clinical Outcomes of Patients With Inflammatory Bowel Disease Presenting With Acute Coronary Syndrome. Inflammatory Bowel Diseases, 27(7), 1017-1025. https://doi.org/10.1093/ibd/izaa237

BACKGROUND: Inflammatory bowel disease (IBD) is associated with an increased acute coronary syndrome (ACS) risk. Data are limited regarding the epidemiology and outcomes of ACS in patients with IBD. METHODS: A retrospective cohort analysis of patient... Read More about Epidemiology and Clinical Outcomes of Patients With Inflammatory Bowel Disease Presenting With Acute Coronary Syndrome.

Diffuse coronary artery vasospasm in a patient with subarachnoid hemorrhage: A case report (2020)
Journal Article
Mamas. (2020). Diffuse coronary artery vasospasm in a patient with subarachnoid hemorrhage: A case report. World Journal of Cardiology, 468 - 474. https://doi.org/10.4330/wjc.v12.i9.468

BACKGROUND Coronary artery vasospasm (CAV) is a reversible, transient form of vasoconstriction with clinical manifestations ranging from stable angina to acute coronary syndromes (ACS). Vasospasm of epicardial coronary arteries or associated micro-va... Read More about Diffuse coronary artery vasospasm in a patient with subarachnoid hemorrhage: A case report.

Diffuse coronary artery vasospasm in a patient with subarachnoid hemorrhage: A case report (2020)
Journal Article
Mamas. (2020). Diffuse coronary artery vasospasm in a patient with subarachnoid hemorrhage: A case report. World Journal of Cardiology, 468 - 474. https://doi.org/10.4330/wjc.v12.i9.468

BACKGROUND Coronary artery vasospasm (CAV) is a reversible, transient form of vasoconstriction with clinical manifestations ranging from stable angina to acute coronary syndromes (ACS). Vasospasm of epicardial coronary arteries or associated micro-va... Read More about Diffuse coronary artery vasospasm in a patient with subarachnoid hemorrhage: A case report.

Temporal Trends and Outcomes in Utilization of Transcatheter and Surgical Aortic Valve Therapies in Aortic Valve Stenosis Patients with Heart Failure (2020)
Journal Article
Mamas. (2020). Temporal Trends and Outcomes in Utilization of Transcatheter and Surgical Aortic Valve Therapies in Aortic Valve Stenosis Patients with Heart Failure. International Journal of Clinical Practice, e13711 - ?. https://doi.org/10.1111/ijcp.13711

INTRODUCTIONS & AIMS: Heart failure (HF) is a common comorbidity in patients undergoing surgical aortic valve replacement (SAVR) and transcatheter aortic valve replacement (TAVR). We sought to access the temporal trends and outcomes of TAVR or SAVR i... Read More about Temporal Trends and Outcomes in Utilization of Transcatheter and Surgical Aortic Valve Therapies in Aortic Valve Stenosis Patients with Heart Failure.

Excimer laser coronary atherectomy during complex PCI: An analysis of 1,471 laser cases from the British Cardiovascular Intervention Society database. (2020)
Journal Article
Protty, M. B., Hussain, H. I., Gallagher, S., Al-Raisi, S., Aldalati, O., Farooq, V., …Kinnaird, T. (2021). Excimer laser coronary atherectomy during complex PCI: An analysis of 1,471 laser cases from the British Cardiovascular Intervention Society database. Catheterization and Cardiovascular Interventions, 97(5), E653-E660. https://doi.org/10.1002/ccd.29251

INTRODUCTION: Excimer laser coronary atherectomy (ELCA) is a recognized adjunctive therapy utilized in the percutaneous management of complex coronary lesions. Studies examining its safety and utility have been limited by small sample sizes. Our stud... Read More about Excimer laser coronary atherectomy during complex PCI: An analysis of 1,471 laser cases from the British Cardiovascular Intervention Society database..

Exploring variation in the use of feedback from national clinical audits: a realist investigation (2020)
Journal Article
Mamas, M. (2020). Exploring variation in the use of feedback from national clinical audits: a realist investigation. BMC Health Services Research, 859 - ?. https://doi.org/10.1186/s12913-020-05661-0

BACKGROUND: National Clinical Audits (NCAs) are a well-established quality improvement strategy used in healthcare settings. Significant resources, including clinicians' time, are invested in participating in NCAs, yet there is variation in the exten... Read More about Exploring variation in the use of feedback from national clinical audits: a realist investigation.

Early intervention or watchful waiting for asymptomatic severe aortic stenosis: a systematic review and meta-analysis (2020)
Journal Article
Mamas. (2020). Early intervention or watchful waiting for asymptomatic severe aortic stenosis: a systematic review and meta-analysis. European Heart Journal, 1989 - 1989. https://doi.org/10.2459/JCM.0000000000001110

Background The management of patients with severe but asymptomatic aortic stenosis (AS) is a challenge of daily practice. Evidence on early aortic valve replacement (AVR) versus symptom-driven approach is controversial. Methods Electronic databases w... Read More about Early intervention or watchful waiting for asymptomatic severe aortic stenosis: a systematic review and meta-analysis.

Trends of repeat revascularization choice in patients with prior coronary artery bypass surgery (2020)
Journal Article
Rashid, & Mamas. (2020). Trends of repeat revascularization choice in patients with prior coronary artery bypass surgery. Catheterization and Cardiovascular Interventions, https://doi.org/10.1002/ccd.29234

Objective: To examine rates and predictors repeat revascularization strategies (percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG)) in patients with prior CABG. Methods: Using the National Inpatient Sample, patients... Read More about Trends of repeat revascularization choice in patients with prior coronary artery bypass surgery.

Clinical Characteristics and Outcomes From Percutaneous Coronary Intervention of Last Remaining Coronary Artery: An Analysis From the British Cardiovascular Intervention Society Database. (2020)
Journal Article
Shoaib, A., Rashid, M., Kontopantelis, E., Sharp, A., Fahy, E. F., Nolan, J., …Mamas, M. A. (2020). Clinical Characteristics and Outcomes From Percutaneous Coronary Intervention of Last Remaining Coronary Artery: An Analysis From the British Cardiovascular Intervention Society Database. Circulation: Cardiovascular Interventions, 13(9), Article e009049. https://doi.org/10.1161/CIRCINTERVENTIONS.120.009049

BACKGROUND: Patients with complex high-risk coronary anatomy, such as those with a last remaining patent vessel (LRPV), are increasingly revascularized with percutaneous coronary intervention (PCI) in contemporary practice. There are limited data on... Read More about Clinical Characteristics and Outcomes From Percutaneous Coronary Intervention of Last Remaining Coronary Artery: An Analysis From the British Cardiovascular Intervention Society Database..

The Landscape of Medical Literature in the Era of COVID-19: Original Research Versus Opinion Pieces. (2020)
Journal Article
Elgendy, A. Y., Barakat, A. F., Ibrahim, J., Alkukhun, L., Mamas, M. A., & Elgendy, I. Y. (2020). The Landscape of Medical Literature in the Era of COVID-19: Original Research Versus Opinion Pieces. Journal of General Internal Medicine, 2813 - 2815. https://doi.org/10.1007/s11606-020-06021-8

There has been rapidly growing scientific literature related to the coronavirus disease 2019 (COVID-19), in attempts to convey any potential hypotheses or confirmed facts about the disease. Notably, there has been a plethora of viewpoints and other o... Read More about The Landscape of Medical Literature in the Era of COVID-19: Original Research Versus Opinion Pieces..

Outcomes of Percutaneous Coronary Intervention in Cardiac Transplant Patients: A Binational Analysis Derived From the United Kingdom and United States. (2020)
Journal Article
Rashid, & Mamas. (2020). Outcomes of Percutaneous Coronary Intervention in Cardiac Transplant Patients: A Binational Analysis Derived From the United Kingdom and United States. Journal of Invasive Cardiology, 321 - 329

AIMS: To compare and contrast the indications, clinical and procedural characteristics, and periprocedural outcomes of patients with cardiac transplant undergoing percutaneous coronary intervention (PCI) in the United States and United Kingdom. METHO... Read More about Outcomes of Percutaneous Coronary Intervention in Cardiac Transplant Patients: A Binational Analysis Derived From the United Kingdom and United States..

A National Evaluation of Emergency Cardiac Surgery After Percutaneous Coronary Intervention and Postsurgical Patient Outcomes. (2020)
Journal Article
Nolan, & Mamas. (2020). A National Evaluation of Emergency Cardiac Surgery After Percutaneous Coronary Intervention and Postsurgical Patient Outcomes. American Journal of Cardiology, 24-29. https://doi.org/10.1016/j.amjcard.2020.05.041

There is limited national data regarding emergency cardiac surgery for complications sustained after percutaneous coronary intervention (PCI). This study aimed to examine emergency cardiac surgery after PCI in England and Wales and postsurgical patie... Read More about A National Evaluation of Emergency Cardiac Surgery After Percutaneous Coronary Intervention and Postsurgical Patient Outcomes..

Clinical Outcomes of Percutaneous Coronary Intervention for Chronic Total Occlusion in Native Coronary Arteries vs Saphenous Vein Grafts. (2020)
Journal Article
Mamas, M. (2020). Clinical Outcomes of Percutaneous Coronary Intervention for Chronic Total Occlusion in Native Coronary Arteries vs Saphenous Vein Grafts

BACKGROUND: There are limited data comparing outcomes of patients with previous coronary artery bypass grafting (CABG) presenting with stable angina who undergo percutaneous coronary intervention (PCI) to either a saphenous vein grafts (SVG) or a chr... Read More about Clinical Outcomes of Percutaneous Coronary Intervention for Chronic Total Occlusion in Native Coronary Arteries vs Saphenous Vein Grafts..

The impact of COVID-19 on percutaneous coronary intervention for ST-elevation myocardial infarction. (2020)
Journal Article
Mamas. (2020). The impact of COVID-19 on percutaneous coronary intervention for ST-elevation myocardial infarction. Heart, 1805-1811. https://doi.org/10.1136/heartjnl-2020-317650

Background The objective of the study was to identify any changes in primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI) in England by analysing procedural numbers, clinical characteristics and patient outc... Read More about The impact of COVID-19 on percutaneous coronary intervention for ST-elevation myocardial infarction..

Questions and answers on workup diagnosis and risk stratification: a companion document of the 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation (2020)
Journal Article
Mamas, M. (2020). Questions and answers on workup diagnosis and risk stratification: a companion document of the 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. European Heart Journal, https://doi.org/10.1093/eurheartj/ehaa602

Guidelines.

Age-specific differences in patient reported outcomes among adults with atherosclerotic cardiovascular disease: Medical expenditure panel survey 2006–2015 (2020)
Journal Article
Okunrintemi, V., Benson, E. A., Derbal, O., Miedema, M. D., Blumenthal, R. S., Tibuakuu, M., …Michos, E. D. (2020). Age-specific differences in patient reported outcomes among adults with atherosclerotic cardiovascular disease: Medical expenditure panel survey 2006–2015. American Journal of Preventive Cardiology, 3, Article 100083. https://doi.org/10.1016/j.ajpc.2020.100083

Objective The prevalence of atherosclerotic cardiovascular disease (ASCVD) in younger adults has increased over the past decade. However, it is less well established whether patient reported outcomes differ between younger and older adults with ASCV... Read More about Age-specific differences in patient reported outcomes among adults with atherosclerotic cardiovascular disease: Medical expenditure panel survey 2006–2015.

Rotational atherectomy and same day discharge: safety and growth from a national perspective (2020)
Journal Article
Mamas, & Rashid. (2020). Rotational atherectomy and same day discharge: safety and growth from a national perspective. Catheterization and Cardiovascular Interventions, https://doi.org/10.1002/ccd.29228

Objectives We explore whether same day discharge (SDD) is a feasible and safe practice following rotational atherectomy (ROTA) treatment during elective percutaneous coronary intervention (PCI), and examine which baseline characteristics are indepen... Read More about Rotational atherectomy and same day discharge: safety and growth from a national perspective.

Clinical Characteristics and Outcomes of COVID-19 Positive Acute Coronary Syndrome Patients; a multisource Electronic Healthcare Records Study from England (2020)
Journal Article
Mamas, & Rashid. (2020). Clinical Characteristics and Outcomes of COVID-19 Positive Acute Coronary Syndrome Patients; a multisource Electronic Healthcare Records Study from England. MedRxiv, https://doi.org/10.1101/2020.08.20.20175091

Background: Patients with underlying cardiovascular disease and Coronavirus disease 2019 (COVID-19) infection are at increased risk of morbidity and mortality. However, there is limited information on management and outcomes of patients presenting wi... Read More about Clinical Characteristics and Outcomes of COVID-19 Positive Acute Coronary Syndrome Patients; a multisource Electronic Healthcare Records Study from England.

Socioeconomic Status and Differences in the Management and Outcomes of 6.6 Million US patients with Acute Myocardial Infarction (2020)
Journal Article
Mamas. (2020). Socioeconomic Status and Differences in the Management and Outcomes of 6.6 Million US patients with Acute Myocardial Infarction. American Journal of Cardiology, 10-18. https://doi.org/10.1016/j.amjcard.2020.05.025

Little is known about the impact of socioeconomic status (SES) on management strategies and in-hospital clinical outcomes in patients with acute myocardial infarction (AMI) and its subtypes, and whether these trends have changed over time. All AMI ho... Read More about Socioeconomic Status and Differences in the Management and Outcomes of 6.6 Million US patients with Acute Myocardial Infarction.

Place and underlying cause of death during the COVID19 pandemic: retrospective cohort study of 3.5 million deaths in England and Wales, 2014 to 2020 (2020)
Journal Article
Wu, J., Malfam, M., Mamas, M., Rashid, M., Kontopantelis, E., Deanfield, J. E., …Gale, C. P. (2020). Place and underlying cause of death during the COVID19 pandemic: retrospective cohort study of 3.5 million deaths in England and Wales, 2014 to 2020. MedRxiv, https://doi.org/10.1101/2020.08.12.20173302

Background The COVID-19 pandemic has resulted in a high death toll. We aimed to describe the place and cause of death during the COVID-19 pandemic. Methods This national death registry included all adult (aged =18 years) deaths in England and Wales b... Read More about Place and underlying cause of death during the COVID19 pandemic: retrospective cohort study of 3.5 million deaths in England and Wales, 2014 to 2020.

Indirect Impact of the COVID-19 Pandemic on Activity and Outcomes of Transcatheter and Surgical Treatment of Severe Aortic Stenosis in England (2020)
Journal Article
Mamas, & Nolan. (2020). Indirect Impact of the COVID-19 Pandemic on Activity and Outcomes of Transcatheter and Surgical Treatment of Severe Aortic Stenosis in England. MedRxiv, https://doi.org/10.1101/2020.08.05.20168922

Background Aortic stenosis requires timely treatment with either surgical aortic valve replacement (SAVR) or transcatheter aortic valve replacement (TAVR). This study aimed to investigate the indirect impact of COVID-19 on national SAVR and TAVR acti... Read More about Indirect Impact of the COVID-19 Pandemic on Activity and Outcomes of Transcatheter and Surgical Treatment of Severe Aortic Stenosis in England.

Clinical Outcomes of Percutaneous Coronary Intervention for Chronic Total Occlusion in Native Coronary Arteries vs Saphenous Vein Grafts (2020)
Journal Article
Shoaib, A., Johnson, T. W., Banning, A., Ludman, P., Rashid, M., Potts, J., …Mamas, M. A. (2020). Clinical Outcomes of Percutaneous Coronary Intervention for Chronic Total Occlusion in Native Coronary Arteries vs Saphenous Vein Grafts. Journal of Invasive Cardiology,

Background. There are limited data comparing outcomes of patients with previous coronary artery bypass grafting (CABG) presenting with stable angina who undergo percutaneous coronary intervention (PCI) to either a saphenous vein grafts (SVG) or a chr... Read More about Clinical Outcomes of Percutaneous Coronary Intervention for Chronic Total Occlusion in Native Coronary Arteries vs Saphenous Vein Grafts.

The Predictive Value of CHA2DS2-VASc Score on In-Hospital Death and Adverse Periprocedural Events Among Patients With the Acute Coronary Syndrome and Atrial Fibrillation Who Undergo Percutaneous Coronary Intervention: A 10-Year National Inpatient Sample (NIS) Analysis. (2020)
Journal Article
Borovac, J. A., Shing Kwok, C., Mohamed, M. O., Fischman, D. L., Savage, M., Alraies, C., …Mamas, M. A. (2021). The Predictive Value of CHA2DS2-VASc Score on In-Hospital Death and Adverse Periprocedural Events Among Patients With the Acute Coronary Syndrome and Atrial Fibrillation Who Undergo Percutaneous Coronary Intervention: A 10-Year National Inpatient Sample (NIS) Analysis. Cardiovascular Revascularization Medicine, 29, 61 - 68. https://doi.org/10.1016/j.carrev.2020.08.003

BACKGROUND: The predictive value of CHA2DS2-VASc score regarding the in-hospital death and periprocedural adverse events following percutaneous coronary intervention (PCI) among patients with acute coronary syndrome (ACS) and concomitant atrial fibri... Read More about The Predictive Value of CHA2DS2-VASc Score on In-Hospital Death and Adverse Periprocedural Events Among Patients With the Acute Coronary Syndrome and Atrial Fibrillation Who Undergo Percutaneous Coronary Intervention: A 10-Year National Inpatient Sample (NIS) Analysis..

Safety of transradial access compared to transfemoral access with hemostatic devices (vessel plugs and suture devices) after percutaneous coronary interventions: A systematic review and meta-analysis. (2020)
Journal Article
Chugh, Y., Bavishi, C., Mojadidi, M. K., Elgendy, I. Y., Faillace, R. T., Brilakis, E. S., …Kumar Chugh, S. (2020). Safety of transradial access compared to transfemoral access with hemostatic devices (vessel plugs and suture devices) after percutaneous coronary interventions: A systematic review and meta-analysis. https://doi.org/10.1002/ccd.29061

OBJECTIVES: Comparing the safety of transradial access (TRA) and conventional hemostasis with transfemoral access (TFA) and vascular closure devices (vessel plugs and suture devices) in patients undergoing percutaneous coronary interventions. BACKGRO... Read More about Safety of transradial access compared to transfemoral access with hemostatic devices (vessel plugs and suture devices) after percutaneous coronary interventions: A systematic review and meta-analysis..

12 Transcatheter versus surgical approach for severe aortic stenosis with concomitant coronary artery disease: a systematic review and meta-analysis of early and mid-term outcomes (2020)
Presentation / Conference
Kotronias, R., Bray, J., Scarsini, R., Rajasundaram, S., Terentes-Printzios, D., De Maria, G. L., …Bannning, A. (2020, July). 12 Transcatheter versus surgical approach for severe aortic stenosis with concomitant coronary artery disease: a systematic review and meta-analysis of early and mid-term outcomes. Paper presented at Abstracts from the British Cardiovascular Society Annual Conference 2020

Patient response, treatments and mortality for acute myocardial infarction during the COVID-19 pandemic. (2020)
Journal Article
Rashid, & Mamas. (2020). Patient response, treatments and mortality for acute myocardial infarction during the COVID-19 pandemic. European Heart Journal - Quality of Care and Clinical Outcomes, https://doi.org/10.1093/ehjqcco/qcaa062

AIM: COVID-19 might have affected the care and outcomes of hospitalised acute myocardial infarction (AMI). We aimed to determine whether the COVID-19 pandemic changed patient response, hospital treatment and mortality from AMI. METHODS AND RESULTS: A... Read More about Patient response, treatments and mortality for acute myocardial infarction during the COVID-19 pandemic..

Adoption of same day discharge following elective left main stem percutaneous coronary intervention. (2020)
Journal Article
Mamas, & Rashid. (2020). Adoption of same day discharge following elective left main stem percutaneous coronary intervention. International Journal of Cardiology, https://doi.org/10.1016/j.ijcard.2020.07.038

BACKGROUND: This study sought to investigate the safety and feasibility of same day discharge (SDD) practice and compare clinical outcomes to patients admitted for overnight stay (ON) undergoing elective left main stem (LMS) percutaneous coronary int... Read More about Adoption of same day discharge following elective left main stem percutaneous coronary intervention..

Temporal Trends in Pregnancy‐Associated Stroke and Its Outcomes Among Women With Hypertensive Disorders of Pregnancy (2020)
Journal Article
Wu, P., Jordan, K. P., Chew‐Graham, C. A., Coutinho, T., Lundberg, G. P., Park, K. E., …Mamas, M. A. (2020). Temporal Trends in Pregnancy‐Associated Stroke and Its Outcomes Among Women With Hypertensive Disorders of Pregnancy. Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, 9(15), https://doi.org/10.1161/JAHA.120.016182

Background Stroke is a serious complication of hypertensive disorders of pregnancy (HDP), with potentially severe and long-term sequelae. However, the temporal trends, predictors and outcomes of stroke in women with HDP at delivery remain unknown.... Read More about Temporal Trends in Pregnancy‐Associated Stroke and Its Outcomes Among Women With Hypertensive Disorders of Pregnancy.

Trends of in-hospital and 30-day mortality after percutaneous coronary intervention in England before and after the COVID-19 era (2020)
Journal Article
Mamas, & Rashid. (2020). Trends of in-hospital and 30-day mortality after percutaneous coronary intervention in England before and after the COVID-19 era. MedRxiv, https://doi.org/10.1101/2020.07.18.20155549v1

Objectives: To examine short-term primary causes of death after percutaneous coronary intervention (PCI) in a national cohort before and during COVID-19. Background: Public reporting of PCI outcomes is a performance metric and a requirement in many h... Read More about Trends of in-hospital and 30-day mortality after percutaneous coronary intervention in England before and after the COVID-19 era.

Percutaneous Intervention or Bypass Graft for Left Main Coronary Artery Disease? A Systematic Review and Meta-Analysis (2020)
Journal Article
Mamas. (2020). Percutaneous Intervention or Bypass Graft for Left Main Coronary Artery Disease? A Systematic Review and Meta-Analysis. Journal of Interventional Cardiology, https://doi.org/10.1155/2020/4081642

Background. The safety and efficacy of percutaneous coronary intervention (PCI) versus coronary artery bypass grafting (CABG) for stable left main coronary artery disease (LMCAD) remains controversial.Methods. Digital databases were searched to compa... Read More about Percutaneous Intervention or Bypass Graft for Left Main Coronary Artery Disease? A Systematic Review and Meta-Analysis.

Sex-differences in mortality rates and underlying conditions for COVID-19 deaths in England and Wales (2020)
Journal Article
Mamas, & Rashid. (2020). Sex-differences in mortality rates and underlying conditions for COVID-19 deaths in England and Wales. Mayo Clinic Proceedings, 2110-2124. https://doi.org/10.1016/j.mayocp.2020.07.009

Background: Limited national data exists on the prevalence and distribution of underlying conditions among COVID-19 deaths between sexes and across age groups. Methods: All adult (=18 years) deaths recorded in England and Wales (1st March 2020 to 12t... Read More about Sex-differences in mortality rates and underlying conditions for COVID-19 deaths in England and Wales.

Infective endocarditis is associated with worse outcomes in stroke: A Thailand National Database Study. (2020)
Journal Article
Mamas. (2020). Infective endocarditis is associated with worse outcomes in stroke: A Thailand National Database Study. International Journal of Clinical Practice, https://doi.org/10.1111/ijcp.13614

BACKGROUND: There is lack of data on the association between infective endocarditis (IE) and outcomes of mortality and complications is stroke. We aimed to compare characteristics and outcomes of stroke patients with and without IE. METHODS: We retro... Read More about Infective endocarditis is associated with worse outcomes in stroke: A Thailand National Database Study..

26 Distribution of high sensitivity troponin levels in consecutive, unselected patients in the emergency department and relationship to in-hospital mortality (2020)
Journal Article
Hinton, J., Mariathas, M., Gabara, L., Nicholas, Z., Allan, R., Ramamoorthy, S., …Curzen, N. (2020). 26 Distribution of high sensitivity troponin levels in consecutive, unselected patients in the emergency department and relationship to in-hospital mortality. Heart, 106(S2), https://doi.org/10.1136/heartjnl-2020-bcs.26

Introduction The introduction of high-sensitivity troponin assays has facilitated pathways to rapidly exclude myocardial infarction (MI) in patients presenting to the emergency department (ED) with chest pain. However, hs-cTn concentrations above the... Read More about 26 Distribution of high sensitivity troponin levels in consecutive, unselected patients in the emergency department and relationship to in-hospital mortality.

22 Distribution of high sensitivity troponin taken without conventional clinical indications in critical care patients and its association with critical care mortality (2020)
Journal Article
Hinton, J., Augustine, M., Gabara, L., Mariathas, M., Allan, R., Borca, F., …Curzen, N. (2020). 22 Distribution of high sensitivity troponin taken without conventional clinical indications in critical care patients and its association with critical care mortality. Heart, 106(S2), https://doi.org/10.1136/heartjnl-2020-bcs.22

Background High sensitivity troponin (hs-cTn) concentrations above the manufacturer’s upper limit of normal (ULN) are frequently seen outside the context of MI, particularly in critical care patients. The potential value of hs-cTn as a biomarker for... Read More about 22 Distribution of high sensitivity troponin taken without conventional clinical indications in critical care patients and its association with critical care mortality.

Impact of the COVID-19 pandemic on admission rates for, and management of, acute coronary syndromes in England (2020)
Journal Article
Mamas. (2020). Impact of the COVID-19 pandemic on admission rates for, and management of, acute coronary syndromes in England. Lancet, 381-389. https://doi.org/10.1016/S0140-6736%2820%2931356-8

Background Several countries affected by the COVID-19 pandemic have reported a substantial drop in the number of patients attending the emergency department with acute coronary syndromes and a reduced number of cardiac procedures. We aimed to unders... Read More about Impact of the COVID-19 pandemic on admission rates for, and management of, acute coronary syndromes in England.

Multivessel Versus Culprit-Only Revascularization in STEMI and Multivessel Coronary Artery Disease: Meta-Analysis of Randomized Trials. (2020)
Journal Article
Mamas. (2020). Multivessel Versus Culprit-Only Revascularization in STEMI and Multivessel Coronary Artery Disease: Meta-Analysis of Randomized Trials. JACC: Cardiovascular Interventions, 1571 - 1582. https://doi.org/10.1016/j.jcin.2020.04.055

OBJECTIVES: The goal of this systematic review and meta-analysis was to provide a comprehensive evaluation of contemporary randomized trials addressing the efficacy and safety of multivessel versus culprit vessel-only percutaneous coronary interventi... Read More about Multivessel Versus Culprit-Only Revascularization in STEMI and Multivessel Coronary Artery Disease: Meta-Analysis of Randomized Trials..

Role of Intravascular Imaging in the Diagnosis and Treatment of Spontaneous Coronary Artery Dissection (2020)
Journal Article
Swamy, P. M., Parwani, P., Mamas, M. A., & Bharadwaj, A. S. (2020). Role of Intravascular Imaging in the Diagnosis and Treatment of Spontaneous Coronary Artery Dissection. Current Cardiovascular Imaging Reports,

The objective of this article is to review the role of intracoronary imaging in the management of patients with spontaneous coronary artery dissection (SCAD). In this review article, we discuss the types of intracoronary imaging including intravascul... Read More about Role of Intravascular Imaging in the Diagnosis and Treatment of Spontaneous Coronary Artery Dissection.

Interstitial lung disease is a risk factor for ischaemic heart disease and myocardial infarction (2020)
Journal Article
Clarson, L. E., Bajpai, R., Whittle, R., Belcher, J., Abdul Sultan, A., Kwok, C. S., …Mallen, C. D. (2020). Interstitial lung disease is a risk factor for ischaemic heart disease and myocardial infarction. Heart, 106(12), 916-922. https://doi.org/10.1136/heartjnl-2019-315511

Objectives Despite many shared risk factors and pathophysiological pathways, the risk of ischaemic heart disease (IHD) and myocardial infarction (MI) in interstitial lung disease (ILD) remains poorly understood. This lack of data could be preventing... Read More about Interstitial lung disease is a risk factor for ischaemic heart disease and myocardial infarction.

Applications of digital technology in Covid-19 pandemic planning and response (2020)
Journal Article
Mamas. (2020). Applications of digital technology in Covid-19 pandemic planning and response. Lancet, https://doi.org/10.1016/S2589-7500%2820%2930142-4

With high transmissibility and no effective vaccine or therapy, COVID-19 is now a global pandemic. Government-coordinated efforts across the globe have focused on containment and mitigation, with varying degrees of success. Countries that have mainta... Read More about Applications of digital technology in Covid-19 pandemic planning and response.

Impact of coronary lesion complexity in percutaneous coronary intervention: 1-year outcomes from the large, multicenter e-ULTIMASTER registry (2020)
Journal Article
Mamas. (2020). Impact of coronary lesion complexity in percutaneous coronary intervention: 1-year outcomes from the large, multicenter e-ULTIMASTER registry. https://doi.org/10.4244/EIJ-D-20-00361

Aims: The present study sought to examine the prevalence, clinical characteristics and 1-year outcomes of patients undergoing percutaneous coronary intervention (PCI) to complex lesions (multivessel PCI, =3 stents, =3 lesions, bifurcation with =2 ste... Read More about Impact of coronary lesion complexity in percutaneous coronary intervention: 1-year outcomes from the large, multicenter e-ULTIMASTER registry.

A systematic review of the studies that evaluate the performance of the DAPT score. (2020)
Journal Article
Mamas. (2020). A systematic review of the studies that evaluate the performance of the DAPT score. International Journal of Clinical Practice, https://doi.org/10.1111/ijcp.13591

BACKGROUND: The Dual Antiplatelet Therapy (DAPT) score was derived to determine which patients may benefit from prolonged DAPT therapy after 12 months based on the balance between ischemic and bleeding events. Several studies have attempted to valida... Read More about A systematic review of the studies that evaluate the performance of the DAPT score..

Outcomes of Percutaneous Coronary Intervention in Patients with Crohn’s Disease and Ulcerative Colitis (from a nationwide cohort) (2020)
Journal Article
Nolan, & Mamas. (2020). Outcomes of Percutaneous Coronary Intervention in Patients with Crohn’s Disease and Ulcerative Colitis (from a nationwide cohort). American Journal of Cardiology, 30-36. https://doi.org/10.1016/j.amjcard.2020.06.013

Patients with inflammatory bowel disease (IBD) are at an increased risk of ischemic heart disease. However, there is limited evidence on how their outcomes after percutaneous coronary intervention (PCI) compare to those without IBD. All PCI-related h... Read More about Outcomes of Percutaneous Coronary Intervention in Patients with Crohn’s Disease and Ulcerative Colitis (from a nationwide cohort).

Impact of Charlson Comorbidity Index Score on Management and Outcomes after Acute Coronary Syndrome (2020)
Journal Article
Mamas. (2020). Impact of Charlson Comorbidity Index Score on Management and Outcomes after Acute Coronary Syndrome. American Journal of Cardiology, https://doi.org/10.1016/j.amjcard.2020.06.022

Patients presenting with acute coronary syndrome (ACS) are frequently comorbid. However, there is limited data on how comorbidity burden impacts their receipt of invasive management and subsequent outcomes. We analyzed all patients with a discharge d... Read More about Impact of Charlson Comorbidity Index Score on Management and Outcomes after Acute Coronary Syndrome.

Impact of Charlson Comorbidity Index Score on Management and Outcomes after Acute Coronary Syndrome (2020)
Journal Article
Mamas. (2020). Impact of Charlson Comorbidity Index Score on Management and Outcomes after Acute Coronary Syndrome. American Journal of Cardiology, 15-23. https://doi.org/10.1016/j.amjcard.2020.06.022

Patients presenting with acute coronary syndrome (ACS) are frequently comorbid. However, there is limited data on how comorbidity burden impacts their receipt of invasive management and subsequent outcomes. We analyzed all patients with a discharge d... Read More about Impact of Charlson Comorbidity Index Score on Management and Outcomes after Acute Coronary Syndrome.

Proximal Left Anterior Descending Artery Treatment Using a Bioresorbable Polymer Coating Sirolimus-Eluting Stent: Real-World Outcomes From the Multicenter Prospective e-Ultimaster Registry (vol 8, e013786, 2019) (2020)
Journal Article
Mamas. (2020). Proximal Left Anterior Descending Artery Treatment Using a Bioresorbable Polymer Coating Sirolimus-Eluting Stent: Real-World Outcomes From the Multicenter Prospective e-Ultimaster Registry (vol 8, e013786, 2019). Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, https://doi.org/10.1161/JAHA.119.014539

Correction.

FRI0610-HPR Β-ADRENORECEPTOR BLOCKING DRUGS ASSOCIATE WITH LOWER RISK OF KNEE OSTEOARTHRITIS AND KNEE PAIN CONSULTATIONS IN PRIMARY CARE: A PROPENSITY SCORE MATCHED COHORT STUDY USING THE CLINICAL PRACTICE RESEARCH DATALINK. (2020)
Presentation / Conference
Nakafero, G., Grainge, M., Valdes, A., Townsend, N., Mallen, C., Zhang, W., …Abhishek, A. (2020, June). FRI0610-HPR Β-ADRENORECEPTOR BLOCKING DRUGS ASSOCIATE WITH LOWER RISK OF KNEE OSTEOARTHRITIS AND KNEE PAIN CONSULTATIONS IN PRIMARY CARE: A PROPENSITY SCORE MATCHED COHORT STUDY USING THE CLINICAL PRACTICE RESEARCH DATALINK

Background: The pharmacologic management of OA is centred around optimising pain control but first-line analgesics only have modest efficacy1. Findings from several studies suggest that β-adrenoreceptor blocking drugs (β-blockers) have anti-nocicepti... Read More about FRI0610-HPR Β-ADRENORECEPTOR BLOCKING DRUGS ASSOCIATE WITH LOWER RISK OF KNEE OSTEOARTHRITIS AND KNEE PAIN CONSULTATIONS IN PRIMARY CARE: A PROPENSITY SCORE MATCHED COHORT STUDY USING THE CLINICAL PRACTICE RESEARCH DATALINK..

Association between Hospital Cardiac Catheter Laboratory Status, use of an Invasive Strategy and Outcomes after NSTEMI (2020)
Journal Article
Mamas, Nolan, & Rashid. (2020). Association between Hospital Cardiac Catheter Laboratory Status, use of an Invasive Strategy and Outcomes after NSTEMI. Canadian Journal of Cardiology, 868-877. https://doi.org/10.1016/j.cjca.2019.10.010

Background While previous studies report increased use of invasive coronary strategy in patients admitted to hospitals with onsite cardiac catheter laboratory (CCL) facilities, the utility of invasive coronary strategy according to types of CCL faci... Read More about Association between Hospital Cardiac Catheter Laboratory Status, use of an Invasive Strategy and Outcomes after NSTEMI.

Are Higher Operator Volumes for Unprotected Left Main Stem Percutaneous Coronary Intervention Associated With Improved Patient Outcomes?: A Survival Analysis of 6724 Procedures From the British Cardiovascular Intervention Society National Database. (2020)
Journal Article
Mamas. (2020). Are Higher Operator Volumes for Unprotected Left Main Stem Percutaneous Coronary Intervention Associated With Improved Patient Outcomes?: A Survival Analysis of 6724 Procedures From the British Cardiovascular Intervention Society National Database. Circulation: Cardiovascular Interventions, e008782 - ?. https://doi.org/10.1161/CIRCINTERVENTIONS.119.008782

BACKGROUND: The relationship between operator volume and survival after unprotected left main stem percutaneous coronary intervention (uLMS-PCI) is poorly defined. METHODS: Data from the British Cardiovascular Intervention Society national PCI databa... Read More about Are Higher Operator Volumes for Unprotected Left Main Stem Percutaneous Coronary Intervention Associated With Improved Patient Outcomes?: A Survival Analysis of 6724 Procedures From the British Cardiovascular Intervention Society National Database..

Temporal Trends in Comorbidity Burden and Impact on Prognosis in Patients With Acute Coronary Syndrome Using the Elixhauser Comorbidity Index Score. (2020)
Journal Article
Mamas. (2020). Temporal Trends in Comorbidity Burden and Impact on Prognosis in Patients With Acute Coronary Syndrome Using the Elixhauser Comorbidity Index Score. American Journal of Cardiology, 1603-1611. https://doi.org/10.1016/j.amjcard.2020.02.044

Despite current evidence, little is known about the impact of comorbidity burden on invasive management strategies and clinical outcomes in the context of acute coronary syndrome (ACS). All ACS hospitalizations between 2004 and 2014 from the National... Read More about Temporal Trends in Comorbidity Burden and Impact on Prognosis in Patients With Acute Coronary Syndrome Using the Elixhauser Comorbidity Index Score..

Interstitial lung disease is a risk factor for ischaemic heart disease and myocardial infarction. (2020)
Journal Article
Mallen, C., Belcher, J., Mamas, M., Clarson, L., Welsh, V., & Bajpai, R. (2020). Interstitial lung disease is a risk factor for ischaemic heart disease and myocardial infarction. Heart, 916-922. https://doi.org/10.1136/heartjnl-2019-315511

OBJECTIVES: Despite many shared risk factors and pathophysiological pathways, the risk of ischaemic heart disease (IHD) and myocardial infarction (MI) in interstitial lung disease (ILD) remains poorly understood. This lack of data could be preventing... Read More about Interstitial lung disease is a risk factor for ischaemic heart disease and myocardial infarction..

Interstitial lung disease is a risk factor for ischaemic heart disease and myocardial infarction (2020)
Journal Article
Elise Clarson, L., Bajpai, R., Whittle, R., Belcher, J., Abdul Sultan, A., Shing Kwok, C., …Mallen, C. D. (2020). Interstitial lung disease is a risk factor for ischaemic heart disease and myocardial infarction. Heart, Article 12. https://doi.org/10.1136/heartjnl-2019-315511

Objectives Despite many shared risk factors and pathophysiological pathways, the risk of ischaemic heart disease (IHD) and myocardial infarction (MI) in interstitial lung disease (ILD) remains poorly understood. This lack of data could be preventing... Read More about Interstitial lung disease is a risk factor for ischaemic heart disease and myocardial infarction.

Role of Coronary Computed Tomography Angiography in Percutaneous Coronary Intervention of Chronic Total Occlusions (2020)
Journal Article
Velagapudi, P., Abbott, J. D., Mamas, M., Blankstein, R., Chatzizisis, Y. S., Brilakis, E. S., & Jaffer, F. A. (2020). Role of Coronary Computed Tomography Angiography in Percutaneous Coronary Intervention of Chronic Total Occlusions. Current Cardiovascular Imaging Reports, 13(7), Article 20. https://doi.org/10.1007/s12410-020-09541-3

Despite significant advances in procedural techniques for revascularization of chronic total occlusions (CTO), comprehensive procedural planning and accurate prediction of procedural success remain the Achilles’ heels of CTO percutaneous coronary int... Read More about Role of Coronary Computed Tomography Angiography in Percutaneous Coronary Intervention of Chronic Total Occlusions.

Development and validation of the DIabetes Severity SCOre (DISSCO) in 139 626 individuals with type 2 diabetes: a retrospective cohort study. (2020)
Journal Article
Mamas, Chew-Graham, & Mallen. (2020). Development and validation of the DIabetes Severity SCOre (DISSCO) in 139 626 individuals with type 2 diabetes: a retrospective cohort study. BMJ Open Diabetes Research and Care, https://doi.org/10.1136/bmjdrc-2019-000962

OBJECTIVE: Clinically applicable diabetes severity measures are lacking, with no previous studies comparing their predictive value with glycated hemoglobin (HbA1c). We developed and validated a type 2 diabetes severity score (the DIabetes Severity SC... Read More about Development and validation of the DIabetes Severity SCOre (DISSCO) in 139 626 individuals with type 2 diabetes: a retrospective cohort study..

Evaluation of the DAPT score in patients who undergo percutaneous coronary intervention in England and Wales. (2020)
Journal Article
Mamas. (2020). Evaluation of the DAPT score in patients who undergo percutaneous coronary intervention in England and Wales. Cardiovascular Revascularization Medicine, 1509-1514. https://doi.org/10.1016/j.carrev.2020.05.003

This study aims to evaluate the temporal changes in DAPT score and determine whether there is an association between DAPT score and mortality. We analyzed all patients who underwent PCI in England and Wales 2007-2014. Statistical analyses were perfor... Read More about Evaluation of the DAPT score in patients who undergo percutaneous coronary intervention in England and Wales..

Prevalence and in-hospital outcomes of patients with malignancies undergoing de novo cardiac electronic device implantation in the United States (2020)
Journal Article
Mamas. (2020). Prevalence and in-hospital outcomes of patients with malignancies undergoing de novo cardiac electronic device implantation in the United States. EP-Europace, 1083-1096. https://doi.org/10.1093/europace/euaa087

Aims: To study the outcomes of cancer patients undergoing cardiac implantable electronic device (CIED) implantation. Methods: De novo CIED implantations (2004 to 2015; n=2,670,590) from the National Inpatient Sample were analysed for characterist... Read More about Prevalence and in-hospital outcomes of patients with malignancies undergoing de novo cardiac electronic device implantation in the United States.

Institutional use of National Clinical Audits by healthcare providers (2020)
Journal Article
Mamas. (2020). Institutional use of National Clinical Audits by healthcare providers. Journal of Evaluation in Clinical Practice, https://doi.org/10.1111/jep.13403

Abstract Rationale, aims, and objectives Healthcare systems worldwide devote significant resources towards collecting data to support care quality assurance and improvement. In the United Kingdom, National Clinical Audits are intended to contribute t... Read More about Institutional use of National Clinical Audits by healthcare providers.

Dual Versus Triple Therapy for Atrial Fibrillation After Percutaneous Coronary Intervention: A Systematic Review and Meta-analysis. (2020)
Journal Article
Mamas. (2020). Dual Versus Triple Therapy for Atrial Fibrillation After Percutaneous Coronary Intervention: A Systematic Review and Meta-analysis. Annals of Internal Medicine, 474 - 483

BACKGROUND: The safety and effectiveness of dual therapy (direct oral anticoagulant [DOAC] plus P2Y12 inhibitor) versus triple therapy (vitamin K antagonist plus aspirin and P2Y12 inhibitor) in patients with nonvalvular atrial fibrillation (AF) after... Read More about Dual Versus Triple Therapy for Atrial Fibrillation After Percutaneous Coronary Intervention: A Systematic Review and Meta-analysis..

Prevalence of pulmonary hypertension in myelofibrosis. (2020)
Journal Article
Lopez-Mattei, J., Verstovsek, S., Fellman, B., Iliescu, C., Bhatti, K., Hassan, S. A., …Faiz, S. A. (2020). Prevalence of pulmonary hypertension in myelofibrosis. Annals of Hematology, 781 - 789. https://doi.org/10.1007/s00277-020-03962-2

Pulmonary hypertension (PH) has been described in myelofibrosis (MF), but it is rare and typically found in advanced disease. Although the etiology of PH in MF is unclear, early predictors may be detected by echocardiogram. The goals of our study wer... Read More about Prevalence of pulmonary hypertension in myelofibrosis..

COMPARISON OF TRANSRADIAL VERSUS TRANSFEMORAL ACCESS FOR PERCUTANEOUS CORONARY INTERVENTION IN STEMI PATIENTS: A META-ANALYSIS OF RANDOMIZED TRIALS (2020)
Journal Article
Jhand, A., Atti, V., Dhawan, R., Turagam, M., Mamas, M. A., Brilakis, E., …Velagapudi, P. (2020). COMPARISON OF TRANSRADIAL VERSUS TRANSFEMORAL ACCESS FOR PERCUTANEOUS CORONARY INTERVENTION IN STEMI PATIENTS: A META-ANALYSIS OF RANDOMIZED TRIALS. Journal of the American College of Cardiology, 75(11), 1281. https://doi.org/10.1016/s0735-1097%2820%2931908-2

Background Transradial access (TRA) is increasingly being used for percutaneous coronary intervention (PCI) in ST- segment elevation myocardial infarction (STEMI) in lieu of transfemoral access (TFA). We conducted a meta-analysis of randomized contr... Read More about COMPARISON OF TRANSRADIAL VERSUS TRANSFEMORAL ACCESS FOR PERCUTANEOUS CORONARY INTERVENTION IN STEMI PATIENTS: A META-ANALYSIS OF RANDOMIZED TRIALS.

MULTIVESSEL VS CULPRIT VESSEL ONLY PERCUTANEOUS CORONARY INTERVENTION IN ST-ELEVATION MYOCARDIAL INFARCTION AND MULTIVESSEL CORONARY ARTERY DISEASE: A META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS (2020)
Journal Article
Atti, V., Narayanan, M. A., Garcia, S., Sandoval, Y., Brilakis, E., Basir, M., …Velagapudi, P. (2020). MULTIVESSEL VS CULPRIT VESSEL ONLY PERCUTANEOUS CORONARY INTERVENTION IN ST-ELEVATION MYOCARDIAL INFARCTION AND MULTIVESSEL CORONARY ARTERY DISEASE: A META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS. Journal of the American College of Cardiology, 75(11), 171. https://doi.org/10.1016/s0735-1097%2820%2930798-1

Background Approximately half of patients with ST-segment elevation acute myocardial infarction (STEMI) have multivessel coronary artery disease. Evidence from randomized controlled trials (RCT) comparing multivessel to culprit-only percutaneous cor... Read More about MULTIVESSEL VS CULPRIT VESSEL ONLY PERCUTANEOUS CORONARY INTERVENTION IN ST-ELEVATION MYOCARDIAL INFARCTION AND MULTIVESSEL CORONARY ARTERY DISEASE: A META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS.

Temporal Changes in Hypertensive Disorders of Pregnancy and Impact on Cardiovascular and Obstetric Outcomes (2020)
Journal Article
Wu, P., Chew-Graham, C. A., Maas, A. H., Chappell, L. C., Potts, J. E., Gulati, M., …Mamas, M. A. (2020). Temporal Changes in Hypertensive Disorders of Pregnancy and Impact on Cardiovascular and Obstetric Outcomes. American Journal of Cardiology, 125(10), 1508-1516. https://doi.org/10.1016/j.amjcard.2020.02.029

Hypertensive disorders of pregnancy (HDP) are a major cause of maternal morbidity. However, short-term outcomes of HDP subgroups remain unknown. Using National Inpatient Sample database, all delivery hospitalizations between 2004 and 2014 with or wit... Read More about Temporal Changes in Hypertensive Disorders of Pregnancy and Impact on Cardiovascular and Obstetric Outcomes.

Contributors to the Growth of Same Day Discharge After Elective Percutaneous Coronary Intervention (2020)
Journal Article
Taxiarchi, P., Martin, G. P., Kinnaird, T., Curzen, N., Ahmed, J., Ludman, P., …Mamas, M. A. (2020). Contributors to the Growth of Same Day Discharge After Elective Percutaneous Coronary Intervention. Circulation: Cardiovascular Interventions, 13(3), e008458 - ?. https://doi.org/10.1161/CIRCINTERVENTIONS.119.008458

BACKGROUND: Financial pressures for reducing hospitalization costs have driven to a move toward same day discharge (SDD) following uncomplicated percutaneous coronary intervention. The UK healthcare system has transitioned to predominantly SDD for el... Read More about Contributors to the Growth of Same Day Discharge After Elective Percutaneous Coronary Intervention.

Multiple unplanned readmissions after discharge for an admission with percutaneous coronary intervention (2020)
Journal Article
Mamas, Kwok, C. S., Chatterjee, S., Bagur, R., Sharma, K., Alraies, M. C., …Mamas, M. A. (2021). Multiple unplanned readmissions after discharge for an admission with percutaneous coronary intervention. Catheterization and Cardiovascular Interventions, 97(3), 395-408. https://doi.org/10.1002/ccd.28797

Objective This study aims to describe temporal trends, characteristics, and clinical outcomes of patients with more than one unplanned readmission within 30 and 180 days aer admission with percutaneous coronary intervention (PCI). Background There is... Read More about Multiple unplanned readmissions after discharge for an admission with percutaneous coronary intervention.

Association between different methods of assessing blood pressure variability and incident cardiovascular disease, cardiovascular mortality and all-cause mortality: a systematic review. (2020)
Journal Article
Mamas. (2020). Association between different methods of assessing blood pressure variability and incident cardiovascular disease, cardiovascular mortality and all-cause mortality: a systematic review. Age and ageing, 184 - 192. https://doi.org/10.1093/ageing/afz178

BACKGROUND: Blood pressure variability (BPV) is a possible risk factor for adverse cardiovascular outcomes and mortality. There is uncertainty as to whether BPV is related to differences in populations studied, measurement methods or both. We systema... Read More about Association between different methods of assessing blood pressure variability and incident cardiovascular disease, cardiovascular mortality and all-cause mortality: a systematic review..

How, in what contexts, and why do quality dashboards lead to improvements in care quality in acute hospitals? Protocol for a realist feasibility evaluation. (2020)
Journal Article
Mamas. (2020). How, in what contexts, and why do quality dashboards lead to improvements in care quality in acute hospitals? Protocol for a realist feasibility evaluation. BMJ Open, e033208 - ?. https://doi.org/10.1136/bmjopen-2019-033208

INTRODUCTION: National audits are used to monitor care quality and safety and are anticipated to reduce unexplained variations in quality by stimulating quality improvement (QI). However, variation within and between providers in the extent of engage... Read More about How, in what contexts, and why do quality dashboards lead to improvements in care quality in acute hospitals? Protocol for a realist feasibility evaluation..

Corrigendum to: Percutaneous coronary intervention outcomes in patients with rheumatoid arthritis, systemic lupus erythematosus and systemic sclerosis (2020)
Journal Article
Martinez, S. C., Mohamed, M., Potts, J., Abhishek, A., Roddy, E., Savage, M., …Mamas, M. A. (2020). Corrigendum to: Percutaneous coronary intervention outcomes in patients with rheumatoid arthritis, systemic lupus erythematosus and systemic sclerosis. Rheumatology, 59(9), 2655. https://doi.org/10.1093/rheumatology/keaa101

Correction to https://doi.org/10.1093/rheumatology/kez639

In-hospital outcome of peripheral vascular intervention in dialysis-dependent end-stage renal disease patients. (2020)
Journal Article
Mamas. (2020). In-hospital outcome of peripheral vascular intervention in dialysis-dependent end-stage renal disease patients. https://doi.org/10.1002/ccd.28522

BACKGROUND: The impact of end-stage renal disease (ESRD) on peripheral vascular intervention (PVI) outcome remains incompletely elucidated. OBJECTIVES: We sought to compare the outcome of PVI in dialysis patients with those with normal kidney functio... Read More about In-hospital outcome of peripheral vascular intervention in dialysis-dependent end-stage renal disease patients..

Risk Factors for Heart Failure 20-Year Population-Based Trends by Sex, Socioeconomic Status, and Ethnicity (2020)
Journal Article
Mamas. (2020). Risk Factors for Heart Failure 20-Year Population-Based Trends by Sex, Socioeconomic Status, and Ethnicity. Circulation: Heart Failure, https://doi.org/10.1161/CIRCHEARTFAILURE.119.006472

Background: There are multiple risk factors for heart failure, but contemporary temporal trends according to sex, socioeconomic status, and ethnicity are unknown. Methods: Using a national UK general practice database linked to hospitalizations (1998... Read More about Risk Factors for Heart Failure 20-Year Population-Based Trends by Sex, Socioeconomic Status, and Ethnicity.

Intravascular imaging and 12-month mortality after unprotected left main stem PCI: an analysis of 11,624 cases from British Cardiovascular Intervention Society database (2020)
Journal Article
Mamas. (2020). Intravascular imaging and 12-month mortality after unprotected left main stem PCI: an analysis of 11,624 cases from British Cardiovascular Intervention Society database. JACC. Cardiovascular interventions, 346-357. https://doi.org/10.1016/j.jcin.2019.10.007

Background: Limited registry data supports the use of intravascular imaging during unprotected left main-stem PCI (uLMS-PCI) to improve outcomes. We used the BCIS national PCI database to explore temporal changes in the use of intravascular imaging f... Read More about Intravascular imaging and 12-month mortality after unprotected left main stem PCI: an analysis of 11,624 cases from British Cardiovascular Intervention Society database.

Comparison of 30-day Unplanned Readmissions to the Index Versus Non-Index Hospital After Percutaneous Coronary Intervention (2020)
Journal Article
Mamas. (2020). Comparison of 30-day Unplanned Readmissions to the Index Versus Non-Index Hospital After Percutaneous Coronary Intervention. American Journal of Cardiology, 1287-1294. https://doi.org/10.1016/j.amjcard.2020.01.051

There is limited information about readmissions to index compared with nonindex hospitals after percutaneous coronary intervention (PCI). This study aims to evaluate the rates, causes, and outcomes for unplanned readmissions following PCI depending o... Read More about Comparison of 30-day Unplanned Readmissions to the Index Versus Non-Index Hospital After Percutaneous Coronary Intervention.

Impact of Diabetes on Complications, Long Term Mortality and Recurrence in 608,890 Hospitalised Patients with Stroke. (2020)
Journal Article
Mamas. (2020). Impact of Diabetes on Complications, Long Term Mortality and Recurrence in 608,890 Hospitalised Patients with Stroke. Global Heart, 2 - ?. https://doi.org/10.5334/gh.364

Background: Patients with diabetes mellitus (DM) have been found to be at an increased risk of suffering a stroke. However, research on the impact of DM on stroke outcomes is limited. Objectives: We aimed to examine the influence of DM on outcomes in... Read More about Impact of Diabetes on Complications, Long Term Mortality and Recurrence in 608,890 Hospitalised Patients with Stroke..

Outcomes of cardiac implantable electronic device transvenous lead extractions performed in centers without onsite cardiac surgery (2020)
Journal Article
Mohamed, M., Rashid, M., Greenspon, A., Barker, D., Patwala, A., Mamas, M., …Kwok, C. (2020). Outcomes of cardiac implantable electronic device transvenous lead extractions performed in centers without onsite cardiac surgery. International Journal of Cardiology, 154-160. https://doi.org/10.1016/j.ijcard.2019.07.095

Background: While major complications associated with CIED lead extractions are uncommon, they carry a significant risk of morbidity and mortality in the absence of surgical intervention. However, there is limited data on the differences in outcomes... Read More about Outcomes of cardiac implantable electronic device transvenous lead extractions performed in centers without onsite cardiac surgery.

The Hospital Frailty Risk Score and its association with in-hospital mortality, cost, length of stay and discharge location in patients with heart failure (2020)
Journal Article
Shing Kwok, C., Zieroth, S., Van Spall, H. G. C., Helliwell, T., Clarson, L., Mohamed, M., …Mamas, M. A. (2020). The Hospital Frailty Risk Score and its association with in-hospital mortality, cost, length of stay and discharge location in patients with heart failure. International Journal of Cardiology, 184-190. https://doi.org/10.1016/j.ijcard.2019.09.064

Background: Little is known about frailty amongst patients hospitalized with heart failure (HF) on a national level. Methods: We conducted a retrospective cohort study of patients admitted to hospital for HF in the United States. We examined how... Read More about The Hospital Frailty Risk Score and its association with in-hospital mortality, cost, length of stay and discharge location in patients with heart failure.

Percutaneous Coronary Intervention Outcomes in Patients with Rheumatoid Arthritis, Systemic Lupus Erythematosus and Systemic sclerosis (2020)
Journal Article
Martinez, S. C., Mohamed, M., Potts, J., Abhishek, A., Roddy, E., Savage, M., …Mamas, M. A. (2020). Percutaneous Coronary Intervention Outcomes in Patients with Rheumatoid Arthritis, Systemic Lupus Erythematosus and Systemic sclerosis. Rheumatology, 59(9), 2512-2522. https://doi.org/10.1093/rheumatology/kez639

Objective Patients with autoimmune rheumatic disease (AIRD) are at an increased risk of coronary artery disease. The present study sought to examine the prevalence and outcomes of AIRD patients undergoing percutaneous coronary intervention (PCI) fro... Read More about Percutaneous Coronary Intervention Outcomes in Patients with Rheumatoid Arthritis, Systemic Lupus Erythematosus and Systemic sclerosis.

First clinical evidence characterizing safety and efficacy of the new CoCr Biolimus-A9 eluting stent: The Biomatrix Alpha™ registry (2020)
Journal Article
Mamas. (2020). First clinical evidence characterizing safety and efficacy of the new CoCr Biolimus-A9 eluting stent: The Biomatrix Alpha™ registry. https://doi.org/10.1016/j.ijcha.2020.100472

Background The biolimus-eluting stent (BES) was the first to elute anti-proliferative drug from a biodegradable polymer. In the randomized LEADERS trial, a stainless steel BES showed non-inferior efficacy compared to a sirolimus-eluting stent and a l... Read More about First clinical evidence characterizing safety and efficacy of the new CoCr Biolimus-A9 eluting stent: The Biomatrix Alpha™ registry.

Correction to: The comorbidity burden of type 2 diabetes mellitus: patterns, clusters and predictions from a large English primary care cohort. (2020)
Journal Article
Chew-Graham, Mallen, & Mamas. (2020). Correction to: The comorbidity burden of type 2 diabetes mellitus: patterns, clusters and predictions from a large English primary care cohort. BMC Medicine, https://doi.org/10.1186/s12916-020-1492-5

The original article [1] contains an omitted grant acknowledgement and affiliation as relates to the contribution of co-author, Rafael Perera-Salazar. As such, the following two amendments should apply to the original article.

Unplanned hospital readmissions after acute myocardial infarction: A nationwide analysis of rates, trends, predictors and causes in the United States between 2010 and 2014 (2020)
Journal Article
Capers I, Q., Fischmann, D., Kwok, C., Savage, M., Gulati, M., Potts, J., …Mamas, M. (2020). Unplanned hospital readmissions after acute myocardial infarction: A nationwide analysis of rates, trends, predictors and causes in the United States between 2010 and 2014. Coronary Artery Disease, 354-364. https://doi.org/10.1097/MCA.0000000000000844

Background Unplanned hospital readmissions are an important quality metric for benchmarking but there is limited data following an acute myocardial infarction (AMI). This study aims to examine the 30-day unplanned readmission rate, predictors, cause... Read More about Unplanned hospital readmissions after acute myocardial infarction: A nationwide analysis of rates, trends, predictors and causes in the United States between 2010 and 2014.

Management Strategies and Clinical Outcomes of Acute Myocardial Infarction in Leukemia Patients: Insights from Nationwide United States Hospitalizations. (2020)
Journal Article
Mohamed, M., Lopez-Mattei, J., Iliesc, C., Parwani, P., Bharadwaj, A., Kim, P., …Mamas, M. (2020). Management Strategies and Clinical Outcomes of Acute Myocardial Infarction in Leukemia Patients: Insights from Nationwide United States Hospitalizations. International Journal of Clinical Practice, -. https://doi.org/10.1111/ijcp.13476

BACKGROUND: Patients with leukemia are at increased risk of cardiovascular events. There are limited outcomes data for patients with a history of leukemia who present with an acute myocardial infarction (AMI). METHODS: We queried the Nationwide Inpat... Read More about Management Strategies and Clinical Outcomes of Acute Myocardial Infarction in Leukemia Patients: Insights from Nationwide United States Hospitalizations..

Rates, Predictors and the Impact Cannabis Misuse on In-hospital Outcomes Among Patients Undergoing Percutaneous Coronary Intervention (From the National Inpatient Sample). (2020)
Journal Article
Rashid, Mamas, & Nolan. (2020). Rates, Predictors and the Impact Cannabis Misuse on In-hospital Outcomes Among Patients Undergoing Percutaneous Coronary Intervention (From the National Inpatient Sample). International Journal of Clinical Practice, e13477 - ?. https://doi.org/10.1111/ijcp.13477

BACKGROUND: Whether cannabis use worsens outcomes in coronary heart disease is unknown and no previous study has evaluated outcomes for patients who undergo percutaneous coronary intervention (PCI) according to cannabis use. METHODS: We analysed pati... Read More about Rates, Predictors and the Impact Cannabis Misuse on In-hospital Outcomes Among Patients Undergoing Percutaneous Coronary Intervention (From the National Inpatient Sample)..

Complex high-risk and indicated percutaneous coronary intervention for stable angina: Does operator volume influence patient outcome? (2020)
Journal Article
Mamas. (2020). Complex high-risk and indicated percutaneous coronary intervention for stable angina: Does operator volume influence patient outcome?. American Heart Journal, 15 - 25. https://doi.org/10.1016/j.ahj.2019.12.019

BACKGROUND: Complex high-risk and indicated revascularization using percutaneous coronary intervention (CHIP-PCI) is an emerging concept that is poorly studied. OBJECTIVE: To define temporal changes in CHIP-PCI volumes, and the relationship between o... Read More about Complex high-risk and indicated percutaneous coronary intervention for stable angina: Does operator volume influence patient outcome?.

Outcomes of percutaneous coronary interventions in cancer patients. (2020)
Journal Article
Mamas. (2020). Outcomes of percutaneous coronary interventions in cancer patients. Expert Review of Cardiovascular Therapy, 25 - 32. https://doi.org/10.1080/14779072.2020.1718493

Introduction: There are numerous shared risk factors in the etiopathogenesis of coronary artery disease (CAD) and cancer both at epidemiologic and molecular level. Additionally, different modalities of treatment of cancer such as radiation, chemother... Read More about Outcomes of percutaneous coronary interventions in cancer patients..

In-hospital Upper Gastrointestinal Bleeding Following Percutaneous Coronary Intervention (2020)
Journal Article
Zaman, A., Kinnaird, T., Mamas, M., Kontopantelis, E., Potts, J., Ayyaz Ul Haq, M., …Large, A. (2020). In-hospital Upper Gastrointestinal Bleeding Following Percutaneous Coronary Intervention. Catheterization and Cardiovascular Interventions, 109-117. https://doi.org/10.1002/ccd.28222

Objectives This study aims to examine in-hospital gastrointestinal (GI) bleeding, its predictors and clinical outcomes, including long-term outcomes, in a national cohort of patients undergoing percutaneous coronary intervention (PCI) in England and... Read More about In-hospital Upper Gastrointestinal Bleeding Following Percutaneous Coronary Intervention.

Trends of sex differences in outcomes of cardiac electronic device implantations in the United States (2020)
Journal Article
Osama Mohamed, M., Santos Volgman, A., Contractor, T., Sharma, P. S., Shing Kwok, C., Rashid, M., …Mamas, M. A. (2020). Trends of sex differences in outcomes of cardiac electronic device implantations in the United States. Canadian Journal of Cardiology, 69-78. https://doi.org/10.1016/j.cjca.2019.08.012

Background The disparity in outcomes of CIED implantations between sexes has been previously demonstrated in device-specific cohorts (e.g. implantable cardioverter defibrillators (ICD)). However, it is unclear whether sex differences are present with... Read More about Trends of sex differences in outcomes of cardiac electronic device implantations in the United States.

Sex differences in rates and causes of 30-day readmissions after cardiac electronic device implantations: insights from the Nationwide Readmissions Database (2019)
Journal Article
Mamas. (2019). Sex differences in rates and causes of 30-day readmissions after cardiac electronic device implantations: insights from the Nationwide Readmissions Database. International Journal of Cardiology, https://doi.org/10.1016/j.ijcard.2019.12.012

Background Women undergoing cardiac implantable electronic device (CIED) implantation are at a higher risk of procedure-related complications. The present study examined sex differences in rates and causes of 30-day readmissions following CIED imp... Read More about Sex differences in rates and causes of 30-day readmissions after cardiac electronic device implantations: insights from the Nationwide Readmissions Database.

Acute myocardial infarction treatments and outcomes in 6.5 million patients with a current or historical diagnosis of cancer in the USA (2019)
Journal Article
Bharadwaj, A., Potts, J., Mohamed, M. O., Parwani, P., Swamy, P., Lopez-Mattei, J. C., …Mamas, M. A. (2020). Acute myocardial infarction treatments and outcomes in 6.5 million patients with a current or historical diagnosis of cancer in the USA. European Heart Journal, 41(23), 2183-2193. https://doi.org/10.1093/eurheartj/ehz851

Aim: The aim of this study is to evaluate temporal trends, treatment and clinical outcomes of patients who present with an acute myocardial infarction (AMI) and have a current or historical diagnosis of cancer, according to cancer type and presence... Read More about Acute myocardial infarction treatments and outcomes in 6.5 million patients with a current or historical diagnosis of cancer in the USA.

Dedicated Bifurcation Stents for Coronary Bifurcation Lesions: A Systematic Review and Meta-Analysis of Randomized-Controlled Trials. (2019)
Journal Article
Mamas. (2019). Dedicated Bifurcation Stents for Coronary Bifurcation Lesions: A Systematic Review and Meta-Analysis of Randomized-Controlled Trials

BACKGROUND: Percutaneous coronary intervention (PCI) of coronary bifurcation lesions (CBL) remains a challenge in contemporary practice due to the procedural and technical difficulties involved. We sought to review the current evidence on the safety... Read More about Dedicated Bifurcation Stents for Coronary Bifurcation Lesions: A Systematic Review and Meta-Analysis of Randomized-Controlled Trials..

The Influence of the Charlson Comorbidity Index on Procedural Characteristics, VARC-2 Endpoints and 30-Day Mortality Among Patients Who Undergo Transcatheter Aortic Valve Implantation. (2019)
Journal Article
Mamas, & Nolan. (2019). The Influence of the Charlson Comorbidity Index on Procedural Characteristics, VARC-2 Endpoints and 30-Day Mortality Among Patients Who Undergo Transcatheter Aortic Valve Implantation. Heart, Lung and Circulation, 1827-1834. https://doi.org/10.1016/j.hlc.2018.11.006

BACKGROUND: Aortic stenosis (AS) is a common valvular abnormality and transcatheter aortic valve implantation (TAVI) is being increasingly used to treat patients considered too high risk for conventional surgery. We aimed to assess the prevalence of... Read More about The Influence of the Charlson Comorbidity Index on Procedural Characteristics, VARC-2 Endpoints and 30-Day Mortality Among Patients Who Undergo Transcatheter Aortic Valve Implantation..

Proximal Left Anterior Descending Artery Treatment Using a Bioresorbable Polymer Coating Sirolimus-Eluting Stent: Real-World Outcomes From the Multicenter Prospective e-Ultimaster Registry (2019)
Journal Article
Mamas. (2019). Proximal Left Anterior Descending Artery Treatment Using a Bioresorbable Polymer Coating Sirolimus-Eluting Stent: Real-World Outcomes From the Multicenter Prospective e-Ultimaster Registry. Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, https://doi.org/10.1161/JAHA.119.013786

Background Guidelines recommend heart team discussion and coronary artery bypass graft consideration in patients with proximal left anterior descending (LAD) artery stenosis. Evidence suggests that outcomes of proximal LAD angioplasty might not diffe... Read More about Proximal Left Anterior Descending Artery Treatment Using a Bioresorbable Polymer Coating Sirolimus-Eluting Stent: Real-World Outcomes From the Multicenter Prospective e-Ultimaster Registry.

Comparison of Outcomes After Percutaneous Coronary Interventions in Patients of Eighty Years and Above Compared With Those Less Than 80 Years (2019)
Journal Article
Al-khadra, Y., Kajy, M., Idris, A., Darmoch, F., Pacha, H. M., Kabach, A., …Alraies, M. C. (2019). Comparison of Outcomes After Percutaneous Coronary Interventions in Patients of Eighty Years and Above Compared With Those Less Than 80 Years. American Journal of Cardiology, 124(9), 1372-1379. https://doi.org/10.1016/j.amjcard.2019.07.055

Baseline risk, timing of invasive strategy and guideline compliance in NSTEMI: Nationwide analysis from MINAP. (2019)
Journal Article
Mamas, & Rashid. (2019). Baseline risk, timing of invasive strategy and guideline compliance in NSTEMI: Nationwide analysis from MINAP. International Journal of Cardiology, 7 - 13. https://doi.org/10.1016/j.ijcard.2019.11.146

BACKGROUND: International guidelines recommend that for NSTEMI, the timing of invasive strategy (IS) is a function of patient's baseline risk. The extent to which this is delivered across and within healthcare systems is unknown. METHODS: Data were d... Read More about Baseline risk, timing of invasive strategy and guideline compliance in NSTEMI: Nationwide analysis from MINAP..

Outcomes Following Percutaneous Coronary Intervention in Saphenous Vein Grafts With and Without Embolic Protection Devices (2019)
Journal Article
Rashid, M., Mohamed, M., Nolan, J., & Mamas, M. (2019). Outcomes Following Percutaneous Coronary Intervention in Saphenous Vein Grafts With and Without Embolic Protection Devices. JACC: Cardiovascular Interventions, 2286 -2295. https://doi.org/10.1016/j.jcin.2019.08.037

OBJECTIVES: The aim of this study was to describe the early (inpatient and 30-day) and late (1-year) outcomes of percutaneous coronary intervention (PCI) in saphenous vein grafts (SVGs), with and without the use of embolic protection devices (EPD), i... Read More about Outcomes Following Percutaneous Coronary Intervention in Saphenous Vein Grafts With and Without Embolic Protection Devices.

Best Practices for the Prevention of Radial Artery Occlusion After Transradial Diagnostic Angiography and Intervention: An International Consensus Paper. (2019)
Journal Article
Bernat, I., Aminian, A., Pancholy, S., Mamas, M., Gaudino, M., Nolan, J., …International Group, R. (2019). Best Practices for the Prevention of Radial Artery Occlusion After Transradial Diagnostic Angiography and Intervention: An International Consensus Paper. JACC. Cardiovascular interventions, 12(22), 2235 - 2246. https://doi.org/10.1016/j.jcin.2019.07.043

Transradial access (TRA) is increasingly used worldwide for percutaneous interventional procedures and associated with lower bleeding and vascular complications than transfemoral artery access. Radial artery occlusion (RAO) is the most frequent post-... Read More about Best Practices for the Prevention of Radial Artery Occlusion After Transradial Diagnostic Angiography and Intervention: An International Consensus Paper..

Incidence, Predictors, and Prognostic Impact of Bleeding After Hospital Discharge Following Acute Coronary Syndrome: A Cohort Study Within the Clinical Practice Research Datalink (2019)
Presentation / Conference
Ismail, N., Jordan, K. P., Kadam, U. T., Edwards, J. J., & Mamas, M. A. (2019, November). Incidence, Predictors, and Prognostic Impact of Bleeding After Hospital Discharge Following Acute Coronary Syndrome: A Cohort Study Within the Clinical Practice Research Datalink. Presented at American Heart Association's 2019 Scientific Sessions, Philadelphia, Pennsylvania, USA

Introduction: The secondary management of acute coronary syndrome (ACS) with antithrombotic medication achieves the desired goal of reducing adverse ischaemic events, albeit at the expense of increased bleeding complications. However, little is known... Read More about Incidence, Predictors, and Prognostic Impact of Bleeding After Hospital Discharge Following Acute Coronary Syndrome: A Cohort Study Within the Clinical Practice Research Datalink.

Relation of Frailty to Outcomes in Percutaneous Coronary Intervention (2019)
Journal Article
Mamas. (2019). Relation of Frailty to Outcomes in Percutaneous Coronary Intervention. Cardiovascular Revascularization Medicine, 811-818. https://doi.org/10.1016/j.carrev.2019.11.009

There is growing awareness that frailty may be an important marker of adverse outcomes in PCI but there is no literature from national cohorts. This study examines a national cohort of patients who underwent percutaneous coronary intervention (PCI) r... Read More about Relation of Frailty to Outcomes in Percutaneous Coronary Intervention.

Meta- Analysis of Lowering Apolipoprotein B With Mortality and Cardiovascular Outcomes Across Various Lipid Lowering Therapies (2019)
Journal Article
Khan, S. U., Khan, M. U., Valavoor, S., Khan, M. S., Okunrintemi, V., Mamas, M. A., …Michos, E. D. (2019). Meta- Analysis of Lowering Apolipoprotein B With Mortality and Cardiovascular Outcomes Across Various Lipid Lowering Therapies. Circulation, 40(S1), https://doi.org/10.1161/circ.140.suppl_1.13625

Introduction: Apolipoprotein B (apoB) concentration is reflective of the total burden of atherogenic lipoprotein particles, including low-density lipoprotein (LDL). Hypothesis: Association between apoB lowering and cardiovascular (CV) outcomes mig... Read More about Meta- Analysis of Lowering Apolipoprotein B With Mortality and Cardiovascular Outcomes Across Various Lipid Lowering Therapies.

TCT-70 Intravascular Imaging for Unprotected Left Main Stem PCI: A Survival Analysis of 11,264 Cases From the British Cardiovascular Intervention Society National Database (2019)
Journal Article
Kinnaird, T., Gallagher, S., Anderson, R., Sirker, A., Ludman, P., Copt, S., …Curzen, N. (2019). TCT-70 Intravascular Imaging for Unprotected Left Main Stem PCI: A Survival Analysis of 11,264 Cases From the British Cardiovascular Intervention Society National Database. Journal of the American College of Cardiology, 74(13), B70. https://doi.org/10.1016/j.jacc.2019.08.107

TCT-384 Is Higher Operator Volumes for Unprotected Left Main Stem PCI Associated With Improved Patient Outcomes? A Survival Analysis of 6,748 Cases From the British Cardiovascular Intervention Society National Database (2019)
Journal Article
Kinnaird, T., Gallagher, S., Anderson, R., Sharp, A., Ludman, P., Copt, S., …Curzen, N. (2019). TCT-384 Is Higher Operator Volumes for Unprotected Left Main Stem PCI Associated With Improved Patient Outcomes? A Survival Analysis of 6,748 Cases From the British Cardiovascular Intervention Society National Database. Journal of the American College of Cardiology, 74(13), B381. https://doi.org/10.1016/j.jacc.2019.08.473

Bleeding After Hospital Discharge Following Acute Coronary Syndrome: Incidence, Types, Timing, and Predictors (2019)
Journal Article
Ismail, N., Jordan, K. P., Kadam, U. T., Edwards, J. J., Kinnaird, T., & Mamas, M. A. (2019). Bleeding After Hospital Discharge Following Acute Coronary Syndrome: Incidence, Types, Timing, and Predictors. Journal of the American Heart Association, 8(21), Article e013679. https://doi.org/10.1161/JAHA.119.013679

Background The incidence and predictors of bleeding after acute coronary syndrome are unclear within the real-world setting. Our objective was to determine the incidence, types, timing, and predictors of bleeding complications following hospital dis... Read More about Bleeding After Hospital Discharge Following Acute Coronary Syndrome: Incidence, Types, Timing, and Predictors.

Percutaneous Coronary Intervention and Outcomes in Patients with Lymphoma in the United States (Nationwide Inpatient Sample [NIS] analysis) (2019)
Journal Article
Mamas. (2019). Percutaneous Coronary Intervention and Outcomes in Patients with Lymphoma in the United States (Nationwide Inpatient Sample [NIS] analysis). American Journal of Cardiology, 1190-1197. https://doi.org/10.1016/j.amjcard.2019.07.015

Characteristics and outcomes of patients with lymphoma undergoing PCI are unknown. Therefore, we analyzed clinical characteristics and outcomes in patients that underwent percutaneous coronary intervention (PCI) and had a concomitant diagnosis of Hod... Read More about Percutaneous Coronary Intervention and Outcomes in Patients with Lymphoma in the United States (Nationwide Inpatient Sample [NIS] analysis).

Antithrombotic treatment after coronary artery bypass graft surgery: systematic review and network meta-analysis. (2019)
Journal Article
Mamas. (2019). Antithrombotic treatment after coronary artery bypass graft surgery: systematic review and network meta-analysis. BMJ, l5476 -?. https://doi.org/10.1136/bmj.l5476

OBJECTIVE: To assess the effects of different oral antithrombotic drugs that prevent saphenous vein graft failure in patients undergoing coronary artery bypass graft surgery. DESIGN: Systematic review and network meta-analysis. DATA SOURCES: Medli... Read More about Antithrombotic treatment after coronary artery bypass graft surgery: systematic review and network meta-analysis..

Baseline Risk and Timing of Invasive Strategy for 137,265 Patients Presenting With Non-ST-Segment Elevation Acute Myocardial Infarction: Level of Compliance With International Guidelines (2019)
Journal Article
Mamas. (2019). Baseline Risk and Timing of Invasive Strategy for 137,265 Patients Presenting With Non-ST-Segment Elevation Acute Myocardial Infarction: Level of Compliance With International Guidelines. Journal of the American College of Cardiology, B506 -B506. https://doi.org/10.1016/j.jacc.2019.08.610

Conference poster.

P676Percutaneous coronary intervention and clinical outcomes in patients with lymphoma: a 10-year period United States nationwide inpatient sample (NIS) analysis (2019)
Journal Article
Borovac, J. A., Kwok, C. S., Konopleva, M., Kim, P. Y., Palaskas, N. L., Zaman, A., …Mamas, M. A. (2019). P676Percutaneous coronary intervention and clinical outcomes in patients with lymphoma: a 10-year period United States nationwide inpatient sample (NIS) analysis. European Heart Journal, 40(Supplement_1), https://doi.org/10.1093/eurheartj/ehz747.0282

Background Clinical outcomes and characteristics of patients with lymphoma undergoing percutaneous coronary intervention (PCI) are unknown. Purpose To describe clinical characteristics and procedural outcomes in patients that underwent PCI and h... Read More about P676Percutaneous coronary intervention and clinical outcomes in patients with lymphoma: a 10-year period United States nationwide inpatient sample (NIS) analysis.

P6510Frailty and in-hospital outcomes in percutaneous coronary interventions (2019)
Journal Article
Kwok, C. S., Achenbach, S., Curzen, N., Fischman, D. L., Savage, M., Bagur, R., …Mamas, M. A. (2019). P6510Frailty and in-hospital outcomes in percutaneous coronary interventions. European Heart Journal, 40(Supplement_1), https://doi.org/10.1093/eurheartj/ehz746.1100

Background Frailty may be an important marker for poor outcomes in percutaneous coronary intervention (PCI) and there is limited literature on outcomes based on frailty from national cohorts. Purpose This study evaluates the prevalence of frailt... Read More about P6510Frailty and in-hospital outcomes in percutaneous coronary interventions.

P681Acute Myocardial Infarction in patients with Leukaemia: A national analysis of prevalence, predictors and outcomes in United States hospitalisations (2004 to 2014) (2019)
Journal Article
Mohamed, M. O., Lopez-Mattei, J. C., Iliescu, C. A., Purwani, P., Bharadwaj, A., Kim, P. Y., …Mamas, M. (2019). P681Acute Myocardial Infarction in patients with Leukaemia: A national analysis of prevalence, predictors and outcomes in United States hospitalisations (2004 to 2014). European Heart Journal, 40(Supplement_1), https://doi.org/10.1093/eurheartj/ehz747.0287

Background Patients with leukaemia are at increased risk of cardiovascular events. There is limited outcomes data for patients with a history of leukaemia who present with an acute myocardial infarction (AMI). Purpose To examine the prevalence a... Read More about P681Acute Myocardial Infarction in patients with Leukaemia: A national analysis of prevalence, predictors and outcomes in United States hospitalisations (2004 to 2014).

P2807Clinical outcomes with cobalt chromium biolimus eluting drug-eluting stents compared with stainless steel biolimus eluting drug-eluting stents in all-comers patients (2019)
Journal Article
Menown, I. B. A., Mamas, M., Cotton, J., Hildick-Smith, D., Eberli, F., Leibundgut, G., …Sadozai, S. (2019). P2807Clinical outcomes with cobalt chromium biolimus eluting drug-eluting stents compared with stainless steel biolimus eluting drug-eluting stents in all-comers patients. European Heart Journal, 40(Supplement_1), https://doi.org/10.1093/eurheartj/ehz748.1119

Aims Thinner stent struts may improve deliverability, conformability and reduce vessel injury. We report the first clinical outcomes of the thinner strut (84–88um) cobalt chromium biolimus eluting stent from the Biomatrix Alpha registry and compare... Read More about P2807Clinical outcomes with cobalt chromium biolimus eluting drug-eluting stents compared with stainless steel biolimus eluting drug-eluting stents in all-comers patients.

P3611The effect of concomitant AF on in-hospital clinical outcomes of NSTE-ACS related hospitalizations in the United States: an analysis of rates, trends and predictors from 2004 to 2014 (2019)
Journal Article
Mohamed, M. O., Kirchhof, P., Vidovich, M., Savage, M., Rashid, M., Kwok, C. S., …Mamas, M. A. (2019). P3611The effect of concomitant AF on in-hospital clinical outcomes of NSTE-ACS related hospitalizations in the United States: an analysis of rates, trends and predictors from 2004 to 2014. European Heart Journal, 40(Supplement_1), https://doi.org/10.1093/eurheartj/ehz745.0470

Background Atrial fibrillation (AF) is the most common arrhythmia in patients presenting with acute coronary syndrome (ACS). Purpose We sought to examine the rates, trends, and clinical outcomes of non-ST Elevation acute coronary syndrome (NSTE-... Read More about P3611The effect of concomitant AF on in-hospital clinical outcomes of NSTE-ACS related hospitalizations in the United States: an analysis of rates, trends and predictors from 2004 to 2014.

DIabetes Severity SCOre (DISSCO) improves hospitalisation and mortality prediction: model development and validation in 139,626 people with type 2 diabetes (2019)
Presentation / Conference
Zghebi, S., Mamas, M., Ashcroft, D. M., Salisbury, C., Mallen, C., Chew-Graham, C., …Kontopantelis, E. (2019, September). DIabetes Severity SCOre (DISSCO) improves hospitalisation and mortality prediction: model development and validation in 139,626 people with type 2 diabetes. Paper presented at 55th EASD Annual Meeting of the European Association for the Study of Diabetes, Barcelona, Spain

Does prior antithrombotic therapy influence recurrence and bleeding risk in stroke patients with atrial fibrillation or atrial flutter? (2019)
Journal Article
Mamas. (2019). Does prior antithrombotic therapy influence recurrence and bleeding risk in stroke patients with atrial fibrillation or atrial flutter?. European Journal of Preventive Cardiology, 2047487319871709 - 2047487319871709. https://doi.org/10.1177/2047487319871709

Background Whilst antithrombotic therapy is recommended in people with atrial fibrillation, little is known about the survival benefits of antithrombotic treatment in those with both high ischaemic and bleeding risk scores. We aim to describe the dis... Read More about Does prior antithrombotic therapy influence recurrence and bleeding risk in stroke patients with atrial fibrillation or atrial flutter?.

Association of lowering apolipoprotein B with cardiovascular outcomes across various lipid-lowering therapies: Systematic review and meta-analysis of trials (2019)
Journal Article
Khan, S. U., Khan, M. U., Valavoor, S., Khan, M. S., Okunrintemi, V., Mamas, M. A., …Michos, E. D. (2020). Association of lowering apolipoprotein B with cardiovascular outcomes across various lipid-lowering therapies: Systematic review and meta-analysis of trials. European Journal of Preventive Cardiology, 27(12), 1255-1268. https://doi.org/10.1177/2047487319871733

Aims The effect of therapeutic lowering of apolipoprotein B (apoB) on mortality and major adverse cardiovascular events is uncertain. It is also unclear whether these potential effects vary by different lipid-lowering strategies. Methods A total... Read More about Association of lowering apolipoprotein B with cardiovascular outcomes across various lipid-lowering therapies: Systematic review and meta-analysis of trials.

Dietary components and risk of cardiovascular disease and all-cause mortality: A review of evidence from meta-analyses (2019)
Journal Article
Watson, L., Loke, Y., Mallen, C., Mamas, M., Gulati, M., Kwok, C., …Wu, P. (2019). Dietary components and risk of cardiovascular disease and all-cause mortality: A review of evidence from meta-analyses. European Journal of Preventive Cardiology, 26(13), 1415-1429. https://doi.org/10.1177/2047487319843667

Aims The optimal diet for cardiovascular health is controversial. The aim of this review is to summarize the highest level of evidence and rank the risk associated with each individual component of diet within its food group. Methods and results... Read More about Dietary components and risk of cardiovascular disease and all-cause mortality: A review of evidence from meta-analyses.

Early Unplanned Readmissions after Admission to Hospital with Heart Failure (2019)
Journal Article
Helliwell, T., Clarson, L., Mallen, C., & Mamas, M. (2019). Early Unplanned Readmissions after Admission to Hospital with Heart Failure. American Journal of Cardiology, 736-745. https://doi.org/10.1016/j.amjcard.2019.05.053

Hospital readmissions remain a continued challenge in the care of patients with heart failure (HF). This study aims to examine the rates, temporal trends, predictors and causes of 30-day unplanned readmissions after admission with HF. Patients hospit... Read More about Early Unplanned Readmissions after Admission to Hospital with Heart Failure.

Combinations of bleeding and ischemic risk and their association with clinical outcomes in acute coronary syndrome. (2019)
Journal Article
Mamas, M., & Rashid, M. (2019). Combinations of bleeding and ischemic risk and their association with clinical outcomes in acute coronary syndrome. International Journal of Cardiology, 7-14. https://doi.org/10.1016/j.ijcard.2019.05.035

Acute coronary syndromes (ACS) are an important cause of morbidity and mortality worldwide. Current guidelines recommend early management with potent antiplatelet agents and an early invasive coronary intervention strategy for both non-ST elevation m... Read More about Combinations of bleeding and ischemic risk and their association with clinical outcomes in acute coronary syndrome..

Comparison of Routine Versus Selective Glycoprotein IIb/IIIa Inhibitors Usage in Primary Percutaneous Coronary Intervention (from the British Cardiovascular Interventional Society) (2019)
Journal Article
Orzalkiewicz, M., Hodson, J., Kwok, C. S., Ludman, P. F., Giblett, J. P., George, S., …Calvert, P. A. (2019). Comparison of Routine Versus Selective Glycoprotein IIb/IIIa Inhibitors Usage in Primary Percutaneous Coronary Intervention (from the British Cardiovascular Interventional Society). American Journal of Cardiology, 124(3), 373-380. https://doi.org/10.1016/j.amjcard.2019.05.010

The Outcomes of Pulmonary Hypertension Patients With Severe Aortic Stenosis Who Underwent Surgical Aortic Valve Replacement or Transcatheter Aortic Valve Implantation (2019)
Journal Article
Al-khadra, Y., Darmoch, F., Moussa Pacha, H., Soud, M., Kajy, M., Ando, T., …Alraies, M. C. (2019). The Outcomes of Pulmonary Hypertension Patients With Severe Aortic Stenosis Who Underwent Surgical Aortic Valve Replacement or Transcatheter Aortic Valve Implantation. American Journal of Cardiology, 124(4), 586-593. https://doi.org/10.1016/j.amjcard.2019.05.018

Readmission and processes of care across weekend and weekday hospitalisation for acute myocardial infarction, heart failure or stroke: an observational study of the National Readmission Database. (2019)
Journal Article
Mamas. (2019). Readmission and processes of care across weekend and weekday hospitalisation for acute myocardial infarction, heart failure or stroke: an observational study of the National Readmission Database. BMJ Open, e029667 - ?. https://doi.org/10.1136/bmjopen-2019-029667

OBJECTIVES: Variation in hospital resource allocations across weekdays and weekends have led to studies of the 'weekend effect' for ST elevation myocardial infarction (STEMI), non-ST elevation myocardial infarction (NSTEMI), heart failure (HF) and st... Read More about Readmission and processes of care across weekend and weekday hospitalisation for acute myocardial infarction, heart failure or stroke: an observational study of the National Readmission Database..

Variation in National Clinical Audit Data Capture: Is Using Routine Data the Answer? (2019)
Journal Article
Mamas. (2019). Variation in National Clinical Audit Data Capture: Is Using Routine Data the Answer?. https://doi.org/10.3233/SHTI190583

National Clinical Audit (NCA) data are collected from all National Health Service providers in the UK, to measure the quality of care and stimulate quality improvement initatives. As part of a larger study we explored how NHS providers currently coll... Read More about Variation in National Clinical Audit Data Capture: Is Using Routine Data the Answer?.

Effect of Concomitant Atrial Fibrillation on In-Hospital Outcomes of Non-ST-Elevation-Acute Coronary Syndrome Related Hospitalizations in the United States (2019)
Journal Article
Mamas, M., & Rashid, M. (2019). Effect of Concomitant Atrial Fibrillation on In-Hospital Outcomes of Non-ST-Elevation-Acute Coronary Syndrome Related Hospitalizations in the United States. American Journal of Cardiology, 465-475. https://doi.org/10.1016/j.amjcard.2019.05.040

Atrial fibrillation (AF) is the most common arrhythmia in patients presenting with acute coronary syndrome (ACS). The present study examined the rates and trends of clinical outcomes and management strategies of non-ST-elevation ACS (NSTE-ACS) relate... Read More about Effect of Concomitant Atrial Fibrillation on In-Hospital Outcomes of Non-ST-Elevation-Acute Coronary Syndrome Related Hospitalizations in the United States.

Pregnancy as a Predictor of Maternal Cardiovascular Disease: The era of CardioObstetrics (2019)
Journal Article
Mamas, & Wu. (2019). Pregnancy as a Predictor of Maternal Cardiovascular Disease: The era of CardioObstetrics. Journal of Women's Health, 1037-1050. https://doi.org/10.1089/jwh.2018.7480

Globally, cardiovascular disease is the most common cause of mortality in women accounting for 1 in 3 deaths. There remains an under recognition of cardiovascular disease as well as a lack of awareness of risk in women. Promotion of cardiovascular di... Read More about Pregnancy as a Predictor of Maternal Cardiovascular Disease: The era of CardioObstetrics.

Percutaneous coronary intervention and in-hospital outcomes in patients with leukemia: a nationwide analysis (2019)
Journal Article
Potts, J., Mohamed, M., Lopez-Mattei, J., Iliescu, C., Konopleva, M., Mamas, M., …Bagur, R. (2019). Percutaneous coronary intervention and in-hospital outcomes in patients with leukemia: a nationwide analysis. Catheterization and Cardiovascular Interventions, https://doi.org/10.1002/ccd.28432

Objectives: To examine the association between current leukemia diagnosis and in-hospital clinical outcomes in patients undergoing percutaneous coronary intervention (PCI) in the US. Background: Leukemia is most common hematological malignancy and... Read More about Percutaneous coronary intervention and in-hospital outcomes in patients with leukemia: a nationwide analysis.

Pregnancy As a Predictor of Maternal Cardiovascular Disease: The Era of CardioObstetrics (2019)
Journal Article
Mamas, & Wu. (2019). Pregnancy As a Predictor of Maternal Cardiovascular Disease: The Era of CardioObstetrics. Journal of Women's Health, 1037 - 1050. https://doi.org/10.1089/jwh.2018.7480

Globally, cardiovascular disease (CVD) is the most common cause of mortality in women accounting for one in three deaths. There remains an under recognition of CVD as well as a lack of awareness of risk in women. Promotion of CVD prevention is essent... Read More about Pregnancy As a Predictor of Maternal Cardiovascular Disease: The Era of CardioObstetrics.

Same day discharge after elective percutaneous coronary intervention: insights from the British Cardiovascular Intervention Society (2019)
Journal Article
Taxiarchi, P., Kontopantelis, E., Martin, G. P., Kinnaird, T., Curzen, N., Banning, A. P., …Mamas, M. A. (2019). Same day discharge after elective percutaneous coronary intervention: insights from the British Cardiovascular Intervention Society. JACC. Cardiovascular interventions, 1479-1494. https://doi.org/10.1016/j.jcin.2019.03.030

Objectives We aimed to evaluate national temporal trends of same day discharge (SDD) and compare clinical outcomes to patients admitted for overnight stay (ON) undergoing elective PCI for stable angina. Background ON observation has been the st... Read More about Same day discharge after elective percutaneous coronary intervention: insights from the British Cardiovascular Intervention Society.

Prevalence, outcomes and costs according to patient frailty status for 2.9 million cardiac electronic device implantations in the United States (2019)
Journal Article
Mamas, M., & Rashid, M. (2019). Prevalence, outcomes and costs according to patient frailty status for 2.9 million cardiac electronic device implantations in the United States. Canadian Journal of Cardiology, 1465-1474. https://doi.org/10.1016/j.cjca.2019.07.632

Background: Little is known about the impact of frailty on length of stay (LOS), cost and inhospital procedural outcomes of cardiac implantable electronic device (CIED) implantation procedures. Methods: All de novo CIED implantations recorded in t... Read More about Prevalence, outcomes and costs according to patient frailty status for 2.9 million cardiac electronic device implantations in the United States.

Do ß-adrenoreceptor blocking drugs associate with reduced risk of symptomatic osteoarthritis and total joint replacement in the general population? A primary care-based, prospective cohort study using the Clinical Practice Research Datalink. (2019)
Journal Article
Mallen, & Mamas. (2019). Do ß-adrenoreceptor blocking drugs associate with reduced risk of symptomatic osteoarthritis and total joint replacement in the general population? A primary care-based, prospective cohort study using the Clinical Practice Research Datalink. BMJ Open, e032050 - ?. https://doi.org/10.1136/bmjopen-2019-032050

INTRODUCTION: To investigate if ß-adrenoreceptor blocking drug (ß-blocker) prescription reduces the risk of knee or hip osteoarthritis, total joint replacement and analgesic prescription. SETTING: Primary care. METHODS AND ANALYSIS: This is a cohort... Read More about Do ß-adrenoreceptor blocking drugs associate with reduced risk of symptomatic osteoarthritis and total joint replacement in the general population? A primary care-based, prospective cohort study using the Clinical Practice Research Datalink..

Weekend effect in acute coronary syndrome: A meta-analysis of observational studies. (2019)
Journal Article
Mamas. (2019). Weekend effect in acute coronary syndrome: A meta-analysis of observational studies. European Heart Journal: Acute Cardiovascular Care, 432-442. https://doi.org/10.1177/2048872618762634

BACKGROUND: The effect of a weekend compared with a weekday hospital admission on patient outcomes after an acute coronary syndrome is unclear. This study aims to determine whether collectively there is a weekend effect in acute coronary syndrome.... Read More about Weekend effect in acute coronary syndrome: A meta-analysis of observational studies..

The influence of Elixhauser comorbidity index on percutaneous coronary intervention outcomes (2019)
Journal Article
Potts, J., Nagaraja, V., Al suwaidi, J., Brugaletta, S., Martinez, S., Alraies, C., …Kwok, C. (2019). The influence of Elixhauser comorbidity index on percutaneous coronary intervention outcomes. Catheterization and Cardiovascular Interventions, 94(2), 195-203. https://doi.org/10.1002/ccd.28072

Background Clinical outcomes with respect to the evolution of comorbidity burden in national cohorts of patients undergoing PCI have not been reported. Objectives We sought to explore the association between comorbidity burden and periprocedural... Read More about The influence of Elixhauser comorbidity index on percutaneous coronary intervention outcomes.

20-year trends in cause-specific heart failure outcomes by sex, socioeconomic status, and place of diagnosis: a population-based study (2019)
Journal Article
Mamas. (2019). 20-year trends in cause-specific heart failure outcomes by sex, socioeconomic status, and place of diagnosis: a population-based study. The Lancet Public Health, 406-420. https://doi.org/10.1016/S2468-2667%2819%2930108-2

Background: Heart failure (HF) is a global pandemic but contemporary trends in cause-specific outcomes among different population groups are unknown. Methods: In a retrospective cohort of incident HF patients between 1998 and 2017 (N=88,416,... Read More about 20-year trends in cause-specific heart failure outcomes by sex, socioeconomic status, and place of diagnosis: a population-based study.

Individual and Combined Impact of Heart Failure and Atrial Fibrillation on Ischemic Stroke Outcomes: A Prospective Hospital Register Cohort Study (2019)
Journal Article
Pana, T. A., McLernon, D. J., Mamas, M. A., Bettencourt-Silva, J. H., Metcalf, A. K., Potter, J. F., & Myint, P. K. (2019). Individual and Combined Impact of Heart Failure and Atrial Fibrillation on Ischemic Stroke Outcomes: A Prospective Hospital Register Cohort Study. Stroke, 50(7), 1838-1845. https://doi.org/10.1161/strokeaha.119.025481

The comorbidity burden of type 2 diabetes mellitus: patterns, clusters and predictions from a large English primary care cohort. (2019)
Journal Article
Nowakowska, M., Zghebi, S. S., Ashcroft, D. M., Buchan, I., Chew-Graham, C., Holt, T., …Kontopantelis, E. (2019). The comorbidity burden of type 2 diabetes mellitus: patterns, clusters and predictions from a large English primary care cohort. BMC Medicine, https://doi.org/10.1186/s12916-019-1373-y

BACKGROUND: The presence of additional chronic conditions has a significant impact on the treatment and management of type 2 diabetes (T2DM). Little is known about the patterns of comorbidities in this population. The aims of this study are to quanti... Read More about The comorbidity burden of type 2 diabetes mellitus: patterns, clusters and predictions from a large English primary care cohort..

Acute Myocardial Infarction in Severe Mental Illness: prevalence, clinical outcomes and process of care in United States hospitalizations. (2019)
Journal Article
Farooq, S., Chew-Graham, C., Mamas, M., & Rashid, M. (2019). Acute Myocardial Infarction in Severe Mental Illness: prevalence, clinical outcomes and process of care in United States hospitalizations. Canadian Journal of Cardiology, 821-830. https://doi.org/10.1016/j.cjca.2019.04.021

Patients with severe mental illness (SMI) are a high-risk group for cardiovascular disease. The present study examined the prevalence and outcomes of SMI patients in a national AMI cohort. SMI has doubled in prevalence amongst AMI patients, mainly du... Read More about Acute Myocardial Infarction in Severe Mental Illness: prevalence, clinical outcomes and process of care in United States hospitalizations..

Outcomes of nonemergent percutaneous coronary intervention requiring mechanical circulatory support in patients without cardiogenic shock (2019)
Journal Article
Al-khadra, Y., Alraies, M. C., Darmoch, F., Pacha, H. M., Soud, M., Kaki, A., …Kapadia, S. (2020). Outcomes of nonemergent percutaneous coronary intervention requiring mechanical circulatory support in patients without cardiogenic shock. Catheterization and Cardiovascular Interventions, 95(3), 503-512. https://doi.org/10.1002/ccd.28383

Background The utilization of mechanical circulatory support (MCS) for percutaneous coronary intervention (PCI) using percutaneous ventricular assist device (PVAD) or intra-aortic balloon pump (IABP) has been increasing. We sought to evaluate the ou... Read More about Outcomes of nonemergent percutaneous coronary intervention requiring mechanical circulatory support in patients without cardiogenic shock.

Characteristics and outcome of acute heart failure patients according to the severity of peripheral oedema (2019)
Journal Article
Mamas, M., Rashid, M., & Nolan, J. (2019). Characteristics and outcome of acute heart failure patients according to the severity of peripheral oedema. International Journal of Cardiology, 40 -46. https://doi.org/10.1016/j.ijcard.2019.03.020

BACKGROUND: Most trials of patients hospitalized for heart failure focus on breathlessness (alveolar pulmonary oedema) but worsening peripheral oedema is also an important presentation. We investigated the relationship between the severity of periphe... Read More about Characteristics and outcome of acute heart failure patients according to the severity of peripheral oedema.

Coronary perforation complicating percutaneous coronary intervention in patients presenting with an acute coronary syndrome: An analysis of 1013 perforation cases from the British Cardiovascular Intervention Society database (2019)
Journal Article
Kinnaird, T., Kwok, C. S., Davies, R., Calvert, P. A., Anderson, R., Gallagher, S., …Mamas, M. (2020). Coronary perforation complicating percutaneous coronary intervention in patients presenting with an acute coronary syndrome: An analysis of 1013 perforation cases from the British Cardiovascular Intervention Society database. International Journal of Cardiology, 299, 37-42. https://doi.org/10.1016/j.ijcard.2019.06.034

Background The evidence base for coronary perforation occurring during percutaneous coronary intervention in patients presenting with an acute coronary syndrome (ACS-PCI) is limited and the specific role of acute pharmacology in its clinical present... Read More about Coronary perforation complicating percutaneous coronary intervention in patients presenting with an acute coronary syndrome: An analysis of 1013 perforation cases from the British Cardiovascular Intervention Society database.

Cardiovascular risk and risk factor management in type 2 diabetes: a population-based cohort study assessing sex disparities (2019)
Journal Article
Mamas. (2019). Cardiovascular risk and risk factor management in type 2 diabetes: a population-based cohort study assessing sex disparities. Circulation, 2742-2753. https://doi.org/10.1161/CIRCULATIONAHA.118.039100

Background: With recent changes in UK clinical practice for diabetes care, contemporary estimates of sex disparities in cardiovascular risk and risk factor management are needed. Methods: In this retrospective cohort study, using the Clinical P... Read More about Cardiovascular risk and risk factor management in type 2 diabetes: a population-based cohort study assessing sex disparities.

Percutaneous Coronary Intervention in Cancer Patients: A Report of the Prevalence and Outcomes in the United States (2019)
Journal Article
Potts, J., Lopez Mattei, J., Martinez, S., Fischman, D., Mamas, M., Iliescu, C., …Rashid, M. (2019). Percutaneous Coronary Intervention in Cancer Patients: A Report of the Prevalence and Outcomes in the United States. European Heart Journal, 1790-+. https://doi.org/10.1093/eurheartj/ehy769

This study aims to examine the temporal trends and outcomes in patients who undergo percutaneous coronary intervention (PCI) with a previous or current diagnosis of cancer, according to cancer type and the presence of metastases. Methods and resul... Read More about Percutaneous Coronary Intervention in Cancer Patients: A Report of the Prevalence and Outcomes in the United States.

Assessing the Severity of Type 2 Diabetes Using Clinical Data Based Measures: a Systematic Review (2019)
Journal Article
Mallen, Chew-Graham, & Mamas. (2019). Assessing the Severity of Type 2 Diabetes Using Clinical Data Based Measures: a Systematic Review. Diabetic Medicine, 688-701. https://doi.org/10.1111/dme.13905

Aims To identify and critically appraise measures that use clinical data to grade the severity of Type 2 diabetes. Methods We searched MEDLINE, Embase and PubMed between inception and June 2018. Studies reporting on clinical data-based diabetes-... Read More about Assessing the Severity of Type 2 Diabetes Using Clinical Data Based Measures: a Systematic Review.

61 The impact of frailty on in-hospital outcomes among patients undergoing percutaneous coronary intervention in the United States (2019)
Presentation / Conference
Kwok, S., Achenbach, S., Curzen, N., Fischman, D., Savage, M., Bagur, R., …Mamas, M. (2019, May). 61 The impact of frailty on in-hospital outcomes among patients undergoing percutaneous coronary intervention in the United States. Paper presented at British Cardiovascular Society Annual Conference ‘Digital Health Revolution’ 3–5 June 2019

Readmissions to Hospital After Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis of Factors Associated with Readmissions (2019)
Journal Article
Kwok, C. S., Narain, A., Pacha, H. M., Lo, T. S., Holroyd, E. W., Alraies, M. C., …Mamas, M. A. (2020). Readmissions to Hospital After Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis of Factors Associated with Readmissions. Cardiovascular Revascularization Medicine, 21(3), 375-391. https://doi.org/10.1016/j.carrev.2019.05.016

Background Readmissions after PCI are a burden to patients and health services that are not well understood. Methods A systematic review was performed to identify studies of readmission after PCI. Readmission rates and causes of readmission were... Read More about Readmissions to Hospital After Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis of Factors Associated with Readmissions.

British Cardiovascular Intervention Society registry framework: a quality improvement initiative on behalf of the National Institute of Cardiovascular Outcomes Research (NICOR) (2019)
Journal Article
Mamas, M., & Rashid, M. (2019). British Cardiovascular Intervention Society registry framework: a quality improvement initiative on behalf of the National Institute of Cardiovascular Outcomes Research (NICOR). European Heart Journal - Quality of Care and Clinical Outcomes, https://doi.org/10.1093/ehjqcco/qcz023

Aims The British Cardiovascular Intervention Society (BCIS) percutaneous coronary intervention (PCI) registry is hosted by the National Institute of Cardiovascular Outcomes Research (NICOR) at Bart’s Heart Centre and collects clinical characteristic... Read More about British Cardiovascular Intervention Society registry framework: a quality improvement initiative on behalf of the National Institute of Cardiovascular Outcomes Research (NICOR).

In-Hospital Outcomes of Transcatheter Aortic Valve Replacement in Patients with Mitral Valve Stenosis (2019)
Journal Article
Mamas. (2019). In-Hospital Outcomes of Transcatheter Aortic Valve Replacement in Patients with Mitral Valve Stenosis. American Journal of Cardiology, 1510-1516. https://doi.org/10.1016/j.amjcard.2019.02.005

Abstract: Background: Little is known about the outcome of patients with MS undergoing transcatheter aortic valve replacement (TAVR). Therefore, we sought to evaluate the potential impact of MS on the outcome of patients who underwent TAVR using the... Read More about In-Hospital Outcomes of Transcatheter Aortic Valve Replacement in Patients with Mitral Valve Stenosis.

Temporal trends and predictors of time to coronary angiography following non-ST-elevation acute coronary syndrome in the USA (2019)
Journal Article
Fischman, D., Martinez, S., Potts, J., Mohamed, M., Kwok, C., Capers, Q., …Mamas, M. (2019). Temporal trends and predictors of time to coronary angiography following non-ST-elevation acute coronary syndrome in the USA. Coronary Artery Disease, 159-170. https://doi.org/10.1097/MCA.0000000000000693

OBJECTIVE: This study aims to investigate the temporal trends in utilization of invasive coronary angiography (CA) at different time points and changing profiles of patients undergoing CA following non-ST-elevation acute coronary syndrome (NSTEACS)... Read More about Temporal trends and predictors of time to coronary angiography following non-ST-elevation acute coronary syndrome in the USA.

Timing and causes of unplanned readmissions after percutaneous coronary intervention: Insights from the Nationwide Readmission Database (2019)
Journal Article
Mamas, M., & Rashid, M. (2019). Timing and causes of unplanned readmissions after percutaneous coronary intervention: Insights from the Nationwide Readmission Database. JACC. Cardiovascular interventions, 734-748. https://doi.org/10.1016/j.jcin.2019.02.007

The rates and causes of readmission at different time periods after PCI remain incompletely elucidated. Among the 2,412,000 patients, 2.5% were readmitted between 0-7 days, 7.6% between 8 and 30 days, 8.9% between 31 and 90 days, and 8.0% between 91... Read More about Timing and causes of unplanned readmissions after percutaneous coronary intervention: Insights from the Nationwide Readmission Database.

Impact of heart failure on stroke mortality and recurrence (2019)
Journal Article
Mamas. (2019). Impact of heart failure on stroke mortality and recurrence. Heart Asia, https://doi.org/10.1136/heartasia-2018-011139

Objective We aimed to examine the impact of heart failure (HF) on stroke mortality (in-hospital and postdischarge) and recurrence in a national stroke cohort from Thailand. Methods We used a large, insurance-based database including all stroke a... Read More about Impact of heart failure on stroke mortality and recurrence.

Non-specific Chest Pain and 30-day Unplanned Readmissions in the United States: (From the Nationwide Readmission Database) (2019)
Journal Article
Mamas. (2019). Non-specific Chest Pain and 30-day Unplanned Readmissions in the United States: (From the Nationwide Readmission Database). American Journal of Cardiology, 1343-1350. https://doi.org/10.1016/j.amjcard.2019.01.012

Chest pain is a common reason for admission to hospital and little is known regarding 30 day unplanned readmissions after an admission with a primary discharge diagnosis of nonspecific chest pain. We analyzed patients with a primary diagnosis of nons... Read More about Non-specific Chest Pain and 30-day Unplanned Readmissions in the United States: (From the Nationwide Readmission Database).

Does rhythm matter in acute heart failure? An insight from the British Society for Heart Failure National Audit. (2019)
Journal Article
Mamas. (2019). Does rhythm matter in acute heart failure? An insight from the British Society for Heart Failure National Audit. Zeitschrift für Kardiologie, https://doi.org/10.1007/s00392-019-01463-5

BACKGROUND: Atrial fibrillation (AF) is the most common sustained arrhythmia in patients with acute heart failure (AHF). The presence of AF is associated with adverse prognosis in patients with chronic heart failure (CHF) but little is known about it... Read More about Does rhythm matter in acute heart failure? An insight from the British Society for Heart Failure National Audit..

Radial versus Femoral Approach for Saphenous Vein Grafts Angiography and Interventions (2019)
Journal Article
Mamas. (2019). Radial versus Femoral Approach for Saphenous Vein Grafts Angiography and Interventions. American Heart Journal, 1-8. https://doi.org/10.1016/j.ahj.2018.11.014

Aims Coronary angiography and intervention to saphenous venous grafts (SVGs) remains challenging. This study aimed to investigate the feasibility and safety of the radial approach compared to femoral access in a large cohort of patients undergoing S... Read More about Radial versus Femoral Approach for Saphenous Vein Grafts Angiography and Interventions.

Association Between Underweight Body Mass Index and In-Hospital Outcome in Patients Undergoing Endovascular Interventions for Peripheral Artery Disease: A Propensity Score Matching Analysis (2019)
Journal Article
Moussa Pacha, H., Al-khadra, Y., Darmoch, F., Soud, M., Kaki, A., Mamas, M. A., & Alraies, M. C. (2019). Association Between Underweight Body Mass Index and In-Hospital Outcome in Patients Undergoing Endovascular Interventions for Peripheral Artery Disease: A Propensity Score Matching Analysis. Journal of Endovascular Therapy, 26(3), 411-417. https://doi.org/10.1177/1526602819839046

30-DAY UNPLANNED READMISSIONS AFTER ADMISSION WITH A PRIMARY DIAGNOSIS OF NON-SPECIFIC CHEST PAIN: INSIGHTS FROM THE NATIONWIDE READMISSION DATABASE (2019)
Journal Article
Kwok, C. S., Parwani, P., Fischman, D., Thamman, R., Suwaidi, J. A., Mohamed, M., …Mamas, M. A. (2019). 30-DAY UNPLANNED READMISSIONS AFTER ADMISSION WITH A PRIMARY DIAGNOSIS OF NON-SPECIFIC CHEST PAIN: INSIGHTS FROM THE NATIONWIDE READMISSION DATABASE. Journal of the American College of Cardiology, 73(9), 18. https://doi.org/10.1016/s0735-1097%2819%2930627-8

TEMPORAL TRENDS IN TIME TO INVASIVE CORONARY ANGIOGRAPHY AND ASSOCIATION WITH CLINICAL OUTCOMES FOLLOWING NON-ST ELEVATION ACUTE MYOCARDIAL INFARCTION IN UNITED STATES (2019)
Journal Article
Rashid, M., Fischman, D., Martinez, S., Capers, Q., Savage, M., Zaman, A., …Mamas, M. A. (2019). TEMPORAL TRENDS IN TIME TO INVASIVE CORONARY ANGIOGRAPHY AND ASSOCIATION WITH CLINICAL OUTCOMES FOLLOWING NON-ST ELEVATION ACUTE MYOCARDIAL INFARCTION IN UNITED STATES. Journal of the American College of Cardiology, 73(9), 124. https://doi.org/10.1016/s0735-1097%2819%2930732-6

A review of interventions to improve clinical outcomes following hospitalisation for heart failure (2019)
Journal Article
Van Spall, H. G., & Mamas, M. A. A review of interventions to improve clinical outcomes following hospitalisation for heart failure. Polish Heart Journal (Kardiologia Polska), 77(3), 341-346. https://doi.org/10.5603/kp.a2019.0039

Heart failure (HF) is a leading cause of hospitalisation and death among older adults in high-income countries. HF is often accompanied by comorbid conditions, and patients hospitalised for HF commonly die or are readmitted in the weeks follow- ing h... Read More about A review of interventions to improve clinical outcomes following hospitalisation for heart failure.

True 99th centile of high sensitivity cardiac troponin for hospital patients: prospective, observational cohort study (2019)
Journal Article
Mamas. (2019). True 99th centile of high sensitivity cardiac troponin for hospital patients: prospective, observational cohort study. BMJ, https://doi.org/10.1136/bmj.l729

Objective Clinicians use the cardiac troponin (cTn) assay to aid in the diagnosis of an acute myocardial infarction (AMI). Each assay manufacturer provides the 99th percentile for cTn levels in a group of healthy individuals, and this level is taken... Read More about True 99th centile of high sensitivity cardiac troponin for hospital patients: prospective, observational cohort study.

True 99th centile of high sensitivity cardiac troponin for hospital patients: prospective, observational cohort study? (2019)
Journal Article
Mamas. (2019). True 99th centile of high sensitivity cardiac troponin for hospital patients: prospective, observational cohort study?. BMJ, https://doi.org/10.1136/bmj.l729

OBJECTIVE To determine the distribution, and specifically the true 99th centile, of high sensitivity cardiac troponin I (hs-cTnI) for a whole hospital population by applying the hs-cTnI assay currently used routinely at a large teaching hospital.... Read More about True 99th centile of high sensitivity cardiac troponin for hospital patients: prospective, observational cohort study?.

Understanding Social Media: Opportunities for Cardiovascular Medicine (2019)
Journal Article
Mamas. (2019). Understanding Social Media: Opportunities for Cardiovascular Medicine. Journal of the American College of Cardiology, 1089-1093. https://doi.org/10.1016/j.jacc.2018.12.044

Cardiology professionals have used social media platforms such as Twitter to gain exposure to new research, network with experts, share opinions, and engage in scientific debates. The power of social media to communicate openly, with wide-reaching ac... Read More about Understanding Social Media: Opportunities for Cardiovascular Medicine.

A systematic review of measures using clinical data for assessing the severity of Type 2 diabetes (2019)
Presentation / Conference
Zghebi, S., Panagioti, M., Rutter, M., Ashcroft, D., van Marwijk, H., Salisbury, C., …Kontopantelis, E. (2019, March). A systematic review of measures using clinical data for assessing the severity of Type 2 diabetes. Poster presented at Diabetes UK Professional Conference 2019, ACC Liverpool, Liverpool, UK

Background/Aims: The assessment of disease severity in people with diabetes enables identification of patients in need for intensive and targeted therapies, and could help optimise the allocation of healthcare resources. We aimed to identify and appr... Read More about A systematic review of measures using clinical data for assessing the severity of Type 2 diabetes.

Correction: Cardiac implantable electronic device (CIED) infections are expensive and associated with prolonged hospitalisation: UK Retrospective Observational Study (2019)
Journal Article
Ahmed, F. Z., Fullwood, C., Zaman, M., Qamruddin, A., Cunnington, C., Mamas, M. A., …Zaidi, A. (2019). Correction: Cardiac implantable electronic device (CIED) infections are expensive and associated with prolonged hospitalisation: UK Retrospective Observational Study. PloS one, 14(3), Article e0213682. https://doi.org/10.1371/journal.pone.0213682

[This corrects the article DOI: 10.1371/journal.pone.0206611.].

VARIATIONS IN UTILIZATION OF INVASIVE CARDIAC PROCEDURES ACCORDING TO HOSPITAL CARDIAC FACILITIES STATUS IN MANAGEMENT OF NON-ST ELEVATION ACUTE MYOCARDIAL INFARCTION IN THE UNITED KINGDOM (2019)
Journal Article
Rashid, M., Kontopantelis, E., Kinnaird, T., Curzen, N., Gale, C., Mohamed, M., …Mamas, M. A. (2019). VARIATIONS IN UTILIZATION OF INVASIVE CARDIAC PROCEDURES ACCORDING TO HOSPITAL CARDIAC FACILITIES STATUS IN MANAGEMENT OF NON-ST ELEVATION ACUTE MYOCARDIAL INFARCTION IN THE UNITED KINGDOM. Journal of the American College of Cardiology, 73(9), 125. https://doi.org/10.1016/s0735-1097%2819%2930733-8

Incidence and prognostic impact of post discharge bleeding post acute coronary syndrome within an outpatient setting: a systematic review (2019)
Journal Article
Ismail, N., Jordan, K., Rao, S., Kinnaird, T., Potts, J., Kadam, U., & Mamas, M. (2019). Incidence and prognostic impact of post discharge bleeding post acute coronary syndrome within an outpatient setting: a systematic review. BMJ Open, 9(2), Article e023337. https://doi.org/10.1136/bmjopen-2018-023337

Objective The primary objective was to determine the incidence of bleeding events post acute coronary syndrome (ACS) following hospital discharge. The secondary objective was to determine the prognostic impact of bleeding on mortality, major adverse... Read More about Incidence and prognostic impact of post discharge bleeding post acute coronary syndrome within an outpatient setting: a systematic review.

Radial versus Femoral Approach for Left Ventricular Endomyocardial Biopsy. (2019)
Journal Article
Mamas. (2019). Radial versus Femoral Approach for Left Ventricular Endomyocardial Biopsy. EuroIntervention, 678-684. https://doi.org/10.4244/EIJ-D-18-01061

AIMS: Left ventricular endomyocardial biopsy (LV-EMB) is mostly performed via the femoral artery. We assessed the feasibility and safety of radial versus femoral access in patients undergoing LV-EMB. METHODS AND RESULTS: 264 patients from four countr... Read More about Radial versus Femoral Approach for Left Ventricular Endomyocardial Biopsy..

Temporal trends in relative survival following percutaneous coronary intervention (2019)
Journal Article
Mamas. (2019). Temporal trends in relative survival following percutaneous coronary intervention. BMJ Open, e024627 - ?. https://doi.org/10.1136/bmjopen-2018-024627

OBJECTIVE: Percutaneous coronary intervention (PCI) has seen substantial shifts in patient selection in recent years that have increased baseline patient mortality risk. It is unclear to what extent observed changes in mortality are attributable to b... Read More about Temporal trends in relative survival following percutaneous coronary intervention.

Early readmissions after isolated coronary artery bypass grafting. (2019)
Journal Article
Mamas. (2019). Early readmissions after isolated coronary artery bypass grafting. International Journal of Clinical Practice, e13319 - ?. https://doi.org/10.1111/ijcp.13319

Since its introduction, coronary artery bypass grafting (CABG) has been the revascularisation intervention of choice in patients with complex coronary artery disease [1]. CABG is the most common cardiac surgical procedure [3]. Those reshospitalised w... Read More about Early readmissions after isolated coronary artery bypass grafting..

Relative survival and excess mortality following primary percutaneous coronary intervention for ST-elevation myocardial infarction (2019)
Journal Article
Mamas. (2019). Relative survival and excess mortality following primary percutaneous coronary intervention for ST-elevation myocardial infarction. European Heart Journal: Acute Cardiovascular Care, 68-77. https://doi.org/10.1177/2048872617710790

Background: High survival rates are commonly reported following primary percutaneous coronary intervention for ST-elevation myocardial infarction, with most contemporary studies reporting overall survival. Aims: The aim of this study was to d... Read More about Relative survival and excess mortality following primary percutaneous coronary intervention for ST-elevation myocardial infarction.

Discharge Against Medical Advice after Hospitalization for Acute Myocardial Infarction (2019)
Journal Article
Mamas. (2019). Discharge Against Medical Advice after Hospitalization for Acute Myocardial Infarction. Heart, 315-321. https://doi.org/10.1136/heartjnl-2018-313671

Background Discharge against medical advice (AMA) occurs infrequently but is associated with poor outcomes. There are limited descriptions of discharges AMA in national cohorts of patients with acute myocardial infarction (AMI). This study aims to e... Read More about Discharge Against Medical Advice after Hospitalization for Acute Myocardial Infarction.

Temporal trends and inequalities in coronary angiography utilization in the management of non-ST-Elevation acute coronary syndromes in the U.S. (2019)
Journal Article
Savage, M., Rashid, M., Fischman, D., Gulati, M., Tamman, K., Potts, J., …Mamas, M. (2019). Temporal trends and inequalities in coronary angiography utilization in the management of non-ST-Elevation acute coronary syndromes in the U.S. Scientific reports, https://doi.org/10.1038/s41598-018-36504-y

Coronary angiography (CA) is the basis of an invasive management strategy in non-ST elevation acute coronary syndromes (NSTEACS). There are limited contemporary data on national temporal trends in utilization of CA in different patient subgroups. We... Read More about Temporal trends and inequalities in coronary angiography utilization in the management of non-ST-Elevation acute coronary syndromes in the U.S..

Cardiac implantable electronic device (CIED) infections are expensive and associated with prolonged hospitalisation: UK Retrospective Observational Study. (2019)
Journal Article
Mamas. (2019). Cardiac implantable electronic device (CIED) infections are expensive and associated with prolonged hospitalisation: UK Retrospective Observational Study. PloS one, https://doi.org/10.1371/journal.pone.0206611

Background There are limited reports outlining the financial cost of treating cardiac implantable electronic device (CIED) infection outside the United States. This study aimed to determine the average treatment cost of CIED infection in a large UK... Read More about Cardiac implantable electronic device (CIED) infections are expensive and associated with prolonged hospitalisation: UK Retrospective Observational Study..

Relation of Length of Stay to Unplanned Readmissions For Patients Who Undergo Elective Percutaneous Coronary Intervention (2019)
Journal Article
Gunning, M., Nolan, J., Kontopantelis, E., Bertrand, O., Kwok, C., Rao, S., …Mamas, M. (2019). Relation of Length of Stay to Unplanned Readmissions For Patients Who Undergo Elective Percutaneous Coronary Intervention. The American Journal of Cardiology, 123(1), 33-43. https://doi.org/10.1016/j.amjcard.2018.09.028

The cost of inpatient PCI procedure is related to LOS. It is unknown how LOS may be associated with readmission rates and costs of index PCI and readmissions in elective PCI. This study aims to evaluate rates, predictors, causes and costs associated... Read More about Relation of Length of Stay to Unplanned Readmissions For Patients Who Undergo Elective Percutaneous Coronary Intervention.

Erratum to pre-operative use of aspirin in patients undergoing coronary artery bypass grafting: a systematic review and updated meta-analysis (2018)
Journal Article
Solo, K., Lavi, S., Choudhury, T., Martin, J., Nevis, I. F., Kwok, C. S., …Bagur, R. (2018). Erratum to pre-operative use of aspirin in patients undergoing coronary artery bypass grafting: a systematic review and updated meta-analysis. Journal of thoracic disease, 10(12), E860-E860. https://doi.org/10.21037/jtd.2018.10.120

Pre-operative use of aspirin in patients undergoing coronary artery bypass grafting: a systematic review and updated meta-analysis In the article that appeared on Page 3444-3459, Vol 10, No 6 (June 2018) Issue of the Journal of Thoracic Disease (J... Read More about Erratum to pre-operative use of aspirin in patients undergoing coronary artery bypass grafting: a systematic review and updated meta-analysis.

Access site and outcomes for unprotected left main stem PCI: an analysis of the British Cardiovascular Intervention Society database (2018)
Journal Article
Mamas. (2018). Access site and outcomes for unprotected left main stem PCI: an analysis of the British Cardiovascular Intervention Society database. JACC. Cardiovascular interventions, 2480-2491. https://doi.org/10.1016/j.jcin.2018.09.035

Objectives Using the British Cardiovascular Intervention Society percutaneous coronary intervention (PCI) database, temporal trends, predictors, and outcomes of radial access (RA) versus femoral access (FA) for unprotected left main stem percutaneou... Read More about Access site and outcomes for unprotected left main stem PCI: an analysis of the British Cardiovascular Intervention Society database.

Association of Medication Intensity and Stages of Airflow Limitation With the Risk of Hospitalization or Death in Patients With Heart Failure and Chronic Obstructive Pulmonary Disease (2018)
Journal Article
Mamas. (2018). Association of Medication Intensity and Stages of Airflow Limitation With the Risk of Hospitalization or Death in Patients With Heart Failure and Chronic Obstructive Pulmonary Disease. Journal of the American Medical Association, https://doi.org/10.1001/jamanetworkopen.2018.5489

IMPORTANCE In heart failure (HF), chronic obstructive pulmonary disease (COPD) increases the risk of poor outcomes, but the effect of COPD severity is unknown. This information is important for early intervention tailored to the highest-risk groups.... Read More about Association of Medication Intensity and Stages of Airflow Limitation With the Risk of Hospitalization or Death in Patients With Heart Failure and Chronic Obstructive Pulmonary Disease.

Marital status and risk of cardiovascular diseases: A systematic review and meta-analysis (2018)
Journal Article
Wong, C., Kwok, C., Narain, A., Gulati, M., Mihalidou, A., Wu, P., …Mamas, M. (2018). Marital status and risk of cardiovascular diseases: A systematic review and meta-analysis. Heart, 1937-1948. https://doi.org/10.1136/heartjnl-2018-313005

Background The influence of marital status on the incidence of cardiovascular disease (CVD) and prognosis after CVD is inconclusive. We systematically reviewed the literature to determine how marital status influences CVD and prognosis after CVD.... Read More about Marital status and risk of cardiovascular diseases: A systematic review and meta-analysis.

Association of comorbid burden with clinical outcomes after transcatheter aortic valve implantation (2018)
Journal Article
Mamas. (2018). Association of comorbid burden with clinical outcomes after transcatheter aortic valve implantation. Heart, 2058-2066. https://doi.org/10.1136/heartjnl-2018-313356

OBJECTIVES To investigate the association of the CharlsonComorbidity Index (CCI) with clinical outcomes after transcatheter aortic valve implantation (TAVI). BACKGROUND: Patients undergoing TAVI have high comorbid burden; however, there is limite... Read More about Association of comorbid burden with clinical outcomes after transcatheter aortic valve implantation.

Outcomes Following Percutaneous Coronary Intervention (PCI) in Non-ST-segment Elevation Myocardial Infarction Patients with Coronary Artery Bypass Grafts (2018)
Journal Article
Shoaib, A., Kinnaird, T., Curzen, N., Kontopantelis, E., Ludman, P., de Belder, M., …Mamas, M. (2018). Outcomes Following Percutaneous Coronary Intervention (PCI) in Non-ST-segment Elevation Myocardial Infarction Patients with Coronary Artery Bypass Grafts. Circulation: Cardiovascular Interventions, 11(11), https://doi.org/10.1161/circinterventions.118.006824

Background: There are limited data on outcomes of patients with previous CABG presenting with NSTEMI undergoing PCI. We compare clinical characteristics and outcomes in NSTEMI patients undergoing PCI with or without prior CABG surgery in a national c... Read More about Outcomes Following Percutaneous Coronary Intervention (PCI) in Non-ST-segment Elevation Myocardial Infarction Patients with Coronary Artery Bypass Grafts.

The impact of diabetes on the prognostic value of left ventricular function following percutaneous coronary intervention: Insights from the British Cardiovascular Intervention Society. (2018)
Journal Article
Mamas, & Rashid. (2018). The impact of diabetes on the prognostic value of left ventricular function following percutaneous coronary intervention: Insights from the British Cardiovascular Intervention Society. Catheterization and Cardiovascular Interventions, 393-402. https://doi.org/10.1002/ccd.27642

Objectives To study the relationship between diabetes mellitus (DM) and left ventricular (LV) function on outcomes following percutaneous coronary intervention (PCI). Background Methods DM is a growing public health challenge worldwide and a signific... Read More about The impact of diabetes on the prognostic value of left ventricular function following percutaneous coronary intervention: Insights from the British Cardiovascular Intervention Society..

Pre-Procedural Risk Models for Patients Undergoing Transcatheter Aortic Valve Implantation (2018)
Journal Article
Mamas. (2018). Pre-Procedural Risk Models for Patients Undergoing Transcatheter Aortic Valve Implantation. Journal of thoracic disease, https://doi.org/10.21037/jtd.2018.05.67

Transcatheter aortic valve implantation (TAVI) has emerged as the standard treatment option for patients with symptomatic aortic stenosis who are considered intermediate to high surgical risk. Nonetheless, optimal clinical outcomes following the proc... Read More about Pre-Procedural Risk Models for Patients Undergoing Transcatheter Aortic Valve Implantation.

One-Year Outcomes after PCI Strategies in Cardiogenic Shock. (2018)
Journal Article
Mamas. (2018). One-Year Outcomes after PCI Strategies in Cardiogenic Shock. New England Journal of Medicine, 1699 - 1710. https://doi.org/10.1056/NEJMoa1808788

BACKGROUND: Among patients with acute myocardial infarction, cardiogenic shock, and multivessel coronary artery disease, the risk of a composite of death from any cause or severe renal failure leading to renal-replacement therapy at 30 days was found... Read More about One-Year Outcomes after PCI Strategies in Cardiogenic Shock..

Incidence and clinical course of limb dysfunction post cardiac catheterization: a systematic review (2018)
Journal Article
Ayyaz Ul Haq, M., Rashid, M., Gilchrist, I. C., Bertrand, O., Shing Kwok, C., Wai Wong, C., …Mamas, M. A. (2018). Incidence and clinical course of limb dysfunction post cardiac catheterization: a systematic review. Circulation Journal, 82(11), 2736. https://doi.org/10.1253/circj.CJ-18-0389

Background We sought to systematically review the available literature on limb dysfunction after transradial or transfemoral cardiac catheterization. Methods & Results MEDLINE and EMBASE were searched for studies evaluating any transradial or... Read More about Incidence and clinical course of limb dysfunction post cardiac catheterization: a systematic review.

Correction to Lancet Public Health 2018; 3: 567–75 (2018)
Journal Article
Kontopantelis, E., Buchan, I., Webb, R. T., Ashcroft, D. M., Mamas, M. A., & Doran, T. (2018). Correction to Lancet Public Health 2018; 3: 567–75. The Lancet Public Health, 3(12), e566. https://doi.org/10.1016/s2468-2667%2818%2930231-7

Kontopantelis E, Buchan I, Webb RT, Ashcroft DM, Mamas MA, Doran T. Disparities in mortality among 25–44-year-olds in England: a longitudinal population-based study. Lancet Public Health 2018; 3: 567–75—In figure 5 of this Article, the labels on the... Read More about Correction to Lancet Public Health 2018; 3: 567–75.

Explaining North-South disparities in mortality rates among 25-44 year olds in England: a longitudinal population study (2018)
Journal Article
Mamas. (2018). Explaining North-South disparities in mortality rates among 25-44 year olds in England: a longitudinal population study. The Lancet Public Health, https://doi.org/10.1016/s2468-2667%2818%2930177-4

Background: There has been a marked recent increase in excess mortality for adults aged 25-44 in the North compared to the South of England. We examined the underlying causes of the excess mortality and the relative contribution of socioeconomic depr... Read More about Explaining North-South disparities in mortality rates among 25-44 year olds in England: a longitudinal population study.

Ultrasound-guided versus palpation-guided radial artery catheterization in adult population: A systematic review and meta-analysis of randomized controlled trials (2018)
Journal Article
Moussa Pacha, H., Alahdab, F., Al-khadra, Y., Idris, A., Rabbat, F., Darmoch, F., …Alraies, M. C. (2018). Ultrasound-guided versus palpation-guided radial artery catheterization in adult population: A systematic review and meta-analysis of randomized controlled trials. American Heart Journal, 204, 1-8. https://doi.org/10.1016/j.ahj.2018.06.007

From Taxonomy to Requirements: A Task Space Partitioning Approach (2018)
Presentation / Conference
Elshehaly, M., Alvarado, N., McVey, L., Randell, R., Mamas, M., & Ruddle, R. A. (2018, October). From Taxonomy to Requirements: A Task Space Partitioning Approach. Paper presented at 2018 IEEE Evaluation and Beyond - Methodological Approaches for Visualization (BELIV), Berlin, Germany

The following topics are dealt with: data visualisation; human factors; decision making; data analysis; data aggregation; cognition; inference mechanisms; authoring systems; user experience; social networking (online).

Procedural success and outcomes with increasing use of enabling strategies for chronic total occlusion intervention: an analysis of 28,050 cases from the British Cardiovascular Intervention Society database (2018)
Journal Article
Kinnaird, T., Cockburn, J., Sirker, A., Ludman, P., de Belder, M., Smith, E., …Hildick-Smith, D. (2018). Procedural success and outcomes with increasing use of enabling strategies for chronic total occlusion intervention: an analysis of 28,050 cases from the British Cardiovascular Intervention Society database. Circulation: Cardiovascular Interventions, https://doi.org/10.1161/CIRCINTERVENTIONS.118.006436

BACKGROUND Enabling strategies (ESs) are increasingly used during percutaneous coronary intervention for chronic total occlusive disease (CTO-PCI), enhancing procedural success. Using the British Cardiovascular Society dataset, we examined changes i... Read More about Procedural success and outcomes with increasing use of enabling strategies for chronic total occlusion intervention: an analysis of 28,050 cases from the British Cardiovascular Intervention Society database.

Transradial Approach for Left Ventricular Endomyocardial Biopsy (2018)
Journal Article
Mamas. (2018). Transradial Approach for Left Ventricular Endomyocardial Biopsy. Canadian Journal of Cardiology, 1283-1288. https://doi.org/10.1016/j.cjca.2018.05.007

Background Left ventricular endomyocardial biopsy (LV-EMB) may offer a superior diagnostic yield compared with right ventricular endomyocardial biopsy (RV-EMB) in conditions predominantly affecting the LV but is underused compared with RV-EMB. Despi... Read More about Transradial Approach for Left Ventricular Endomyocardial Biopsy.

Association of different antiplatelet therapies with mortality after primary percutaneous coronary intervention (2018)
Journal Article
Mamas, & Rashid. (2018). Association of different antiplatelet therapies with mortality after primary percutaneous coronary intervention. Heart, 1683-1690. https://doi.org/10.1136/heartjnl-2017-312366

Objectives Prasugrel and ticagrelor both reduce ischaemic endpoints in high-risk acute coronary syndromes, compared with clopidogrel. However, comparative outcomes of these two newer drugs in the context of primary percutaneous coronary intervention... Read More about Association of different antiplatelet therapies with mortality after primary percutaneous coronary intervention.

Antiplatelet drug selection in PCI to vein grafts in patients with acute coronary syndrome and adverse clinical outcomes: Insights from the British Cardiovascular Intervention Society Database (2018)
Journal Article
Mamas. (2018). Antiplatelet drug selection in PCI to vein grafts in patients with acute coronary syndrome and adverse clinical outcomes: Insights from the British Cardiovascular Intervention Society Database. Catheterization and Cardiovascular Interventions, 659-665. https://doi.org/10.1002/ccd.27493

Objective This study aims to evaluate outcomes associated with different P2Y12 agents in Saphenous Vein graft (SVG) percutaneous coronary intervention (PCI). Background and Methods SVG PCI is associated with greater risks of ischemic complicat... Read More about Antiplatelet drug selection in PCI to vein grafts in patients with acute coronary syndrome and adverse clinical outcomes: Insights from the British Cardiovascular Intervention Society Database.

TCT-849 Safety of Transradial Access compared to Transfemoral Access with Hemostatic Devices (Vessel Plugs, Suture Devices & Vascular Clips) after Percutaneous Coronary Interventions: A systematic review and meta analysis (2018)
Journal Article
Chugh, Y., Bavishi, C., Faillace, R., Tamis-Holland, J., Mamas, M., & Sanjay Chugh. (2018). TCT-849 Safety of Transradial Access compared to Transfemoral Access with Hemostatic Devices (Vessel Plugs, Suture Devices & Vascular Clips) after Percutaneous Coronary Interventions: A systematic review and meta analysis. Journal of the American College of Cardiology, 72(13), B339. https://doi.org/10.1016/j.jacc.2018.08.2095

TCT-658 Complex High and Indicated Percutaneous Coronary Indication: Does Operator Volume Influence Patient Outcome? (2018)
Journal Article
Kinnaird, T., Gallagher, S., Spratt, J., Ludman, P., de Belder, M., de Belder, M., …Mamas, M. (2018). TCT-658 Complex High and Indicated Percutaneous Coronary Indication: Does Operator Volume Influence Patient Outcome?. Journal of the American College of Cardiology, 72(13), B263. https://doi.org/10.1016/j.jacc.2018.08.1867

Background Complex high-risk and indicated revascularisation using percutaneous coronary intervention (CHIP-PCI) is an emerging concept that is poorly studied. Using the British Intervention Society (BCIS) PCI database, we examined temporal changes... Read More about TCT-658 Complex High and Indicated Percutaneous Coronary Indication: Does Operator Volume Influence Patient Outcome?.

Association of Same-Day Discharge After Elective Percutaneous Coronary Intervention in the United States With Costs and Outcomes (2018)
Journal Article
Mamas. (2018). Association of Same-Day Discharge After Elective Percutaneous Coronary Intervention in the United States With Costs and Outcomes. JAMA Cardiology, https://doi.org/10.1001/jamacardio.2018.3029

Importance Same-day discharge (SDD) after elective percutaneous coronary intervention (PCI) is associated with lower costs and preferred by patients. However, to our knowledge, contemporary patterns of SDD after elective PCI with respect to the inci... Read More about Association of Same-Day Discharge After Elective Percutaneous Coronary Intervention in the United States With Costs and Outcomes.

TCT-148 An international analyses of 122,610 NSTEMI patients with 5 year outcomes: assessing the influence of age and comorbidities on invasively vs medically managed patients between 2004 and 2014. (2018)
Presentation / Conference
Protty, M., Al-zuhairi, K., Kinnaird, T., Mamas, M., Torp-Pedersen, C., Smith, D., & Freeman, P. (2018, September). TCT-148 An international analyses of 122,610 NSTEMI patients with 5 year outcomes: assessing the influence of age and comorbidities on invasively vs medically managed patients between 2004 and 2014. Poster presented at Thirtieth Annual Symposium Transcatheter Cardiovascular Therapeutics (TCT), San Diego, CA, USA

NSTEMI patients are at risk of death, reinfarction and ischaemia, a risk that increases as cardiovascular risk (GRACE) increases. However, data from UK national registries identifies at least 60,000 NSTEMI patients per year not receiving an invasive... Read More about TCT-148 An international analyses of 122,610 NSTEMI patients with 5 year outcomes: assessing the influence of age and comorbidities on invasively vs medically managed patients between 2004 and 2014..

Radial artery access and outcomes for left main stem PCI: an analysis of 19,482 cases from the British Cardiovascular Intervention Society national database (2018)
Presentation / Conference
Kinnaird, T., Anderson, R., Sirker, A., Ludman, P., de Belder, M., Oldroyd, K., …Mamas, M. (2018, September). Radial artery access and outcomes for left main stem PCI: an analysis of 19,482 cases from the British Cardiovascular Intervention Society national database. Presented at 13th Annual Symposium Transcatheter Cardiovascular Therapeutics (TCT)

Background Although the predictors and outcomes of radial versus femoral access are well defined for unselected PCI procedures and certain sub-groups, there are few data for patients undergoing left main stem percutaneous coronary intervention (LMS-... Read More about Radial artery access and outcomes for left main stem PCI: an analysis of 19,482 cases from the British Cardiovascular Intervention Society national database.

TCT-766 Coronary perforation complicating percutaneous coronary intervention in patients presenting with an acute coronary syndrome: an analysis of 1,013 perforation cases from the British Cardiovascular Intervention Society database (2018)
Journal Article
Kinnaird, T., Calvert, P., Anderson, R., Sirker, A., de Belder, M., Ludman, P., …Mamas, M. (2018). TCT-766 Coronary perforation complicating percutaneous coronary intervention in patients presenting with an acute coronary syndrome: an analysis of 1,013 perforation cases from the British Cardiovascular Intervention Society database. Journal of the American College of Cardiology, 72(13), Article B306. https://doi.org/10.1016/j.jacc.2018.08.1994

Background The evidence base for coronary perforation (CP) occurring during percutaneous coronary intervention in patients presenting with an acute coronary syndrome (ACS-PCI) is limited with the specific role of acute pharmacology in its clinical p... Read More about TCT-766 Coronary perforation complicating percutaneous coronary intervention in patients presenting with an acute coronary syndrome: an analysis of 1,013 perforation cases from the British Cardiovascular Intervention Society database.

Changes in Peri-procedural Bleeding Complications Following Percutaneous Coronary Intervention in The United Kingdom Between 2006-2013 (From the British Cardiovascular Interventional Society) (2018)
Journal Article
Mamas, M., Nolan, J., & Rashid, M. (2018). Changes in Peri-procedural Bleeding Complications Following Percutaneous Coronary Intervention in The United Kingdom Between 2006-2013 (From the British Cardiovascular Interventional Society). American Journal of Cardiology, 952-960. https://doi.org/10.1016/j.amjcard.2018.06.016

Major bleeding is a common complication following percutaneous coronary intervention (PCI), although little is known about how bleeding rates have changed over time and what has driven this. We analyzed all patients undergoing PCI in England and Wale... Read More about Changes in Peri-procedural Bleeding Complications Following Percutaneous Coronary Intervention in The United Kingdom Between 2006-2013 (From the British Cardiovascular Interventional Society).

Chronic kidney disease, worsening renal function and outcomes in a heart failure community setting: A UK national study (2018)
Journal Article
Mamas. (2018). Chronic kidney disease, worsening renal function and outcomes in a heart failure community setting: A UK national study. International Journal of Cardiology, 120 - 127. https://doi.org/10.1016/j.ijcard.2018.04.090

Background Routine heart failure (HF) monitoring and management is in the community but the natural course of worsening renal function (WRF) and its influence on HF prognosis is unknown. We investigated the influence of routinely monitored renal decl... Read More about Chronic kidney disease, worsening renal function and outcomes in a heart failure community setting: A UK national study.

Early vs Standard Discharge After Transcatheter Aortic Valve Implantation: A Systematic Review and Meta-analysis (2018)
Journal Article
Mamas. (2018). Early vs Standard Discharge After Transcatheter Aortic Valve Implantation: A Systematic Review and Meta-analysis. JACC. Cardiovascular interventions, 1759-1771. https://doi.org/10.1016/j.jcin.2018.04.042

Objectives: We sought to assess the clinical outcomes of patients undergoing transcatheter aortic valve implantation (TAVI) with early discharge (ED) versus standard discharge (SD) pathways. Background: Minimalist approaches for TAVI have been dev... Read More about Early vs Standard Discharge After Transcatheter Aortic Valve Implantation: A Systematic Review and Meta-analysis.

Persistent sex disparities in clinical outcomes with percutaneous coronary intervention: Insights from 6.6 million PCI precedures in the United States (2018)
Journal Article
Ensor, J., Burke, D., Kwok, C., Riley, R., Holmvang, L., Mamas, M., …Rashid, M. (2018). Persistent sex disparities in clinical outcomes with percutaneous coronary intervention: Insights from 6.6 million PCI precedures in the United States. PloS one, https://doi.org/10.1371/journal.pone.0203325

Background Prior studies have reported inconsistencies in the baseline risk profile, comorbidity burden and their association with clinical outcomes in women compared to men. More importantly, there is limited data around the sex differences and how... Read More about Persistent sex disparities in clinical outcomes with percutaneous coronary intervention: Insights from 6.6 million PCI precedures in the United States.

A feasibility study of transaxillary TAVI with the lotus valve (2018)
Journal Article
Mamas. (2018). A feasibility study of transaxillary TAVI with the lotus valve. Catheterization and Cardiovascular Interventions, 542 -549. https://doi.org/10.1002/ccd.27409

Objectives To assess the feasibility of axillary transcatheter aortic valve implantation (TAVI) using the Lotus valve. Background TAVI is used to treat patients with severe aortic stenosis, with transfemoral (TF) access being the safest and most... Read More about A feasibility study of transaxillary TAVI with the lotus valve.

Self-reported sleep duration and quality and cardiovascular disease and mortality: a dose-response meta-analysis (2018)
Journal Article
Chew-Graham, & Mamas. (2018). Self-reported sleep duration and quality and cardiovascular disease and mortality: a dose-response meta-analysis. Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, https://doi.org/10.1161/jaha.118.008552

Abstract Background: There is growing evidence that sleep duration and quality may be associated with cardiovascular harm and mortality. Methods and Results: We conducted a systematic review, meta-analysis and spline analysis of prospective cohort st... Read More about Self-reported sleep duration and quality and cardiovascular disease and mortality: a dose-response meta-analysis.

P6029Impact of elixhauser comorbidity score on the outcomes of transcatheter aortic valve replacement (2018)
Journal Article
Nagaraja, V., Generaeux, P., Cohen, M., Suh, W., Alasnag, M., Potts, J., …Research Group, K. C. (2018). P6029Impact of elixhauser comorbidity score on the outcomes of transcatheter aortic valve replacement. European Heart Journal, 39(suppl_1), https://doi.org/10.1093/eurheartj/ehy566.p6029

Background: Patients undergoing transcatheter aortic valve replacement (TAVR) are often multi-morbid. Whilst the impact of individual comorbid conditions on clinical outcomes following TAVR have been previously assessed, the impact of more global mea... Read More about P6029Impact of elixhauser comorbidity score on the outcomes of transcatheter aortic valve replacement.

P4592Trends in prognosis and management of acute coronary syndromes using combined bleeding and ischaemic risk assessment - a retrospective analysis of MINAP data (2018)
Journal Article
Mohamed, M. O., Kinnaird, T., Kwok, C. S., Rashid, M., Anderson, R., Martin, G., …Mamas, M. A. (2018). P4592Trends in prognosis and management of acute coronary syndromes using combined bleeding and ischaemic risk assessment - a retrospective analysis of MINAP data. European Heart Journal, 39(suppl_1), https://doi.org/10.1093/eurheartj/ehy563.p4592

Background: Patients presenting with acute coronary syndrome (ACS) represent a heterogeneous population with various risk factors for coronary ischaemia and bleeding. Current ESC guidelines recommend potent dual antiplatelet therapy (DAPT), and cardi... Read More about P4592Trends in prognosis and management of acute coronary syndromes using combined bleeding and ischaemic risk assessment - a retrospective analysis of MINAP data.

5258Trends and outcomes of use of coronary angiography in management of non-ST-Elevation acute coronary syndromes (NSTEACS), a population based cohort study (2018)
Journal Article
Rashid, M., Potts, J., Kwok, C., Mohammed, M., Shoaib, A., Esnsor, J., …Mamas, M. (2018). 5258Trends and outcomes of use of coronary angiography in management of non-ST-Elevation acute coronary syndromes (NSTEACS), a population based cohort study. European Heart Journal, 39(suppl_1), https://doi.org/10.1093/eurheartj/ehy566.5258

Background: Non-ST-elevation acute coronary syndromes (NSTEACS) remains most vulnerable phenotype of acute myocardial infarction despite significant improvements in treatment and provision of guideline-recommended care. Coronary angiography (CA) is t... Read More about 5258Trends and outcomes of use of coronary angiography in management of non-ST-Elevation acute coronary syndromes (NSTEACS), a population based cohort study.

Effect of Antiplatelet Therapy (Aspirin + Dipyridamole Versus Clopidogrel) on Mortality Outcome in Ischemic Stroke (2018)
Journal Article
Barlas, R. S., Loke, Y. K., Mamas, M. A., Bettencourt-Silva, J. H., Ford, I., Clark, A. B., …Myint, P. K. (2018). Effect of Antiplatelet Therapy (Aspirin + Dipyridamole Versus Clopidogrel) on Mortality Outcome in Ischemic Stroke. American Journal of Cardiology, 122(6), 1085-1090. https://doi.org/10.1016/j.amjcard.2018.05.043

The optimal regimen of antiplatelet therapy for secondary prevention in noncardioembolic ischemic stroke remains controversial. We aimed to determine which regimen was associated with the greatest reduction in adverse outcomes. We analysed prospectiv... Read More about Effect of Antiplatelet Therapy (Aspirin + Dipyridamole Versus Clopidogrel) on Mortality Outcome in Ischemic Stroke.

Effect of Comorbidity On Unplanned Readmissions After Percutaneous Coronary Intervention (From The Nationwide Readmission Database). (2018)
Journal Article
Kwok, C., Mamas, M., Martinez, S., Pancholy, S., Ahmed, W., Al-Shaibi, K., …Curzen, N. (2018). Effect of Comorbidity On Unplanned Readmissions After Percutaneous Coronary Intervention (From The Nationwide Readmission Database). Scientific reports, 11156 -?. https://doi.org/10.1038/s41598-018-29303-y

It is unclear how comorbidity influences rates and causes of unplanned readmissions following percutaneous coronary intervention (PCI). We analyzed patients in the Nationwide Readmission Database who were admitted to hospital between 2010 and 2014. T... Read More about Effect of Comorbidity On Unplanned Readmissions After Percutaneous Coronary Intervention (From The Nationwide Readmission Database)..

Discharge Against Medical Advice After Percutaneous Coronary Intervention in the United States (2018)
Journal Article
Al Shaibi, K., Gulati, R., Bell, M., Anderson, V., Potts, J., Rashid, M., …Kwok, C. (2018). Discharge Against Medical Advice After Percutaneous Coronary Intervention in the United States. JACC. Cardiovascular interventions, 1354-1364. https://doi.org/10.1016/j.jcin.2018.03.049

Discharge against medical advice (DAMA) in the context of PCI has not been described in the literature. Among the 2,021,104 patients, the proportion of patients who DAMA was 0.5% (n=10,049). Important predictors of DAMA included diagnosis of acute my... Read More about Discharge Against Medical Advice After Percutaneous Coronary Intervention in the United States.

Relation Between Age and Unplanned Readmissions After Percutaneous Coronary Intervention (Findings From The Nationwide Readmission Database) (2018)
Journal Article
Martinez, S., Rao, S., Gilchrist, I., Kwok, C., Al Ayoubi, F., Myint, P., …Kontopantelis, E. (2018). Relation Between Age and Unplanned Readmissions After Percutaneous Coronary Intervention (Findings From The Nationwide Readmission Database). American Journal of Cardiology, 220-228. https://doi.org/10.1016/j.amjcard.2018.03.367

It is unclear how age affects rates and causes of unplanned early readmissions after per cutaneous coronary intervention (PCI). We analyzed patients in the Nationwide Readmission Database in the United States from 2010 to 2014 and examined the impact... Read More about Relation Between Age and Unplanned Readmissions After Percutaneous Coronary Intervention (Findings From The Nationwide Readmission Database).

Using electronic health records to quantify and stratify the severity of type 2 diabetes in primary care in England: rationale and cohort study design (2018)
Journal Article
Mamas, Chew-Graham, & Mallen. (2018). Using electronic health records to quantify and stratify the severity of type 2 diabetes in primary care in England: rationale and cohort study design. BMJ Open, https://doi.org/10.1136/bmjopen-2017-020926

Introduction: The increasing prevalence of type 2 diabetes (T2DM) presents a significant burden on affected individuals and health-care systems internationally. There is, however, no agreed validated measure to infer diabetes severity from electronic... Read More about Using electronic health records to quantify and stratify the severity of type 2 diabetes in primary care in England: rationale and cohort study design.

Do frailty measures improve prediction of mortality and morbidity following transcatheter aortic valve implantation? An analysis of the UK TAVI registry (2018)
Journal Article
Mamas. (2018). Do frailty measures improve prediction of mortality and morbidity following transcatheter aortic valve implantation? An analysis of the UK TAVI registry. Cardiovascular Medicine, https://doi.org/10.1136/bmjopen-2018-022543

Objectives Previous studies indicate frailty to be associated with poor outcomes following transcatheter aortic valve implantation (TAVI), but there is limited evidence from multicentre registries. The aim was to investigate the independent associat... Read More about Do frailty measures improve prediction of mortality and morbidity following transcatheter aortic valve implantation? An analysis of the UK TAVI registry.

Percutaneous coronary intervention of saphenous vein grafts: where do we stand? (2018)
Journal Article
Bulluck, H., Bagur, R., & Mamas, M. A. (2018). Percutaneous coronary intervention of saphenous vein grafts: where do we stand?. EuroIntervention, 14(2), 142-143. https://doi.org/10.4244/EIJV14I2A22

Saphenous vein grafts (SVG) are known to be more susceptible to accelerated atherosclerosis than native coronary arteries1. Accelerated atherosclerosis in SVG develops from resident foam cells, which then undergo apoptosis to form necrotic cores1. Th... Read More about Percutaneous coronary intervention of saphenous vein grafts: where do we stand?.

NATIONAL ANALYSIS OF RARE BUT CATASTROPHIC BLEEDING COMPLICATIONS AFTER PERCUTANEOUS CORONARY INTERVENTIONS: INSIGHTS FROM THE BRITISH CARDIOVASCULAR INTERVENTION SOCIETY DATABASE (2018)
Journal Article
Kwok, C. S., Kontopantelis, E., Ludman, P., de Belder, M., & Mamas, M. (2018). NATIONAL ANALYSIS OF RARE BUT CATASTROPHIC BLEEDING COMPLICATIONS AFTER PERCUTANEOUS CORONARY INTERVENTIONS: INSIGHTS FROM THE BRITISH CARDIOVASCULAR INTERVENTION SOCIETY DATABASE. Heart, 104, A53-A53. https://doi.org/10.1136/heartjnl-2018-BCS.59

Background Major bleeding is a recognised complication after PCI. This study aims to evaluate the incidence, trends over time, predictors and prognostic significance of intracranial, gastrointestinal and retroperitoneal bleeding after PCI. Methods... Read More about NATIONAL ANALYSIS OF RARE BUT CATASTROPHIC BLEEDING COMPLICATIONS AFTER PERCUTANEOUS CORONARY INTERVENTIONS: INSIGHTS FROM THE BRITISH CARDIOVASCULAR INTERVENTION SOCIETY DATABASE.

Pre-operative use of aspirin in patients undergoing coronary artery bypass grafting: a systematic review and updated meta-analysis (2018)
Journal Article
Solo, K., Lavi, S., Choudhury, T., Martin, J., Nevis, I. F., Kwok, C. S., …Bagur, R. (2018). Pre-operative use of aspirin in patients undergoing coronary artery bypass grafting: a systematic review and updated meta-analysis. Journal of thoracic disease, 10(6), 3444-+. https://doi.org/10.21037/jtd.2018.05.187

Background: Aspirin therapy improves saphenous vein graft (SVG) patency in patients undergoing coronary artery bypass graft (CABG), however, its use in the pre-operative period remains controversial. Therefore, we conducted a systematic review and me... Read More about Pre-operative use of aspirin in patients undergoing coronary artery bypass grafting: a systematic review and updated meta-analysis.

Metabolic risk factors and the incidence and progression of radiographic hand osteoarthritis: a population-based cohort study (2018)
Journal Article
Marshall, M., Peat, G., Nicholls, E., Myers, H. L., Mamas, M. A., & Van Der Windt, D. A. (in press). Metabolic risk factors and the incidence and progression of radiographic hand osteoarthritis: a population-based cohort study. Scandinavian Journal of Rheumatology, 48(1), 52-63. https://doi.org/10.1080/03009742.2018.1459831

OBJECTIVE: To determine whether selected metabolic factors are associated with greater amounts of radiographic hand osteoarthritis (OA) incidence and progression. METHODS: The study identified 706 adults, aged 50-69 years, with hand pain and hand rad... Read More about Metabolic risk factors and the incidence and progression of radiographic hand osteoarthritis: a population-based cohort study.

Temporal Changes in Comorbidity Burden in Patients Having Percutaneous Coronary Intervention and Impact on Prognosis (2018)
Journal Article
Potts, J., Kwok, C., Ensor, J., Rashid, M., Kadam, U., Kinnaird, T., …Mamas, M. (2018). Temporal Changes in Comorbidity Burden in Patients Having Percutaneous Coronary Intervention and Impact on Prognosis. American Journal of Cardiology, 122(5), 712-722. https://doi.org/10.1016/j.amjcard.2018.05.003

This study aims to evaluate the impact of comorbidity burden on outcomes among patients who undergo percutaneous coronary intervention (PCI). We used the Nationwide Inpatient Sample to identify all PCI procedures undertaken in the United States betwe... Read More about Temporal Changes in Comorbidity Burden in Patients Having Percutaneous Coronary Intervention and Impact on Prognosis.

Patient experiences of living with heart failure and diabetes (2018)
Presentation / Conference
Wu, L., Cleator, J., Mamas, M., & Deaton, C. (2018, June). Patient experiences of living with heart failure and diabetes. Poster presented at EuroHeartCare 2018, Dublin, Ireland

Backgrounds: The presence of multi-morbidity makes self management even more complex for those with heart failure (HF). Although diabetes is a common co-morbidity in the HF population, the experiences of living with both HF and diabetes and the impac... Read More about Patient experiences of living with heart failure and diabetes.

Incidence, determinants and outcomes of left and right radial access use in patients undergoing percutaneous coronary intervention in the United Kingdom, a national perspective using the British Cardiovascular Intervention Society (BCIS) dataset (2018)
Journal Article
de Belder, M., Nolan, J., Mamas, M., Kinnaird, T., Ludman, P., Potts, J., …Rashid, M. (2018). Incidence, determinants and outcomes of left and right radial access use in patients undergoing percutaneous coronary intervention in the United Kingdom, a national perspective using the British Cardiovascular Intervention Society (BCIS) dataset. JACC. Cardiovascular interventions, 11(11), 1021-1033. https://doi.org/10.1016/j.jcin.2018.01.252

Objectives The authors sought to determine the relationships between left radial access (LRA) or right radial access (RRA) and clinical outcomes using the British Cardiovascular Intervention Society (BCIS) database. Background LRA has been shown... Read More about Incidence, determinants and outcomes of left and right radial access use in patients undergoing percutaneous coronary intervention in the United Kingdom, a national perspective using the British Cardiovascular Intervention Society (BCIS) dataset.

Health economic analysis of access site practice in England during changes in practice: Insights from the British Cardiovascular Interventional Society (2018)
Journal Article
Mamas, M., Tosh, J., Hulme, W., Hoskins, N., Bungey, G., Ludman, P., …Kontopantelis, E. (2018). Health economic analysis of access site practice in England during changes in practice: Insights from the British Cardiovascular Interventional Society. Circulation: Cardiovascular Quality and Outcomes, 11(5), https://doi.org/10.1161/circoutcomes.117.004482

Background: Transradial access (TRA) for percutaneous coronary intervention (PCI) is associated with a reduced risk of mortality compared with transfemoral access, access site–related bleeding complications, and shorter length of stay. The budget imp... Read More about Health economic analysis of access site practice in England during changes in practice: Insights from the British Cardiovascular Interventional Society.

Type 2 diabetes mellitus and heart failure: a position statement from the Heart Failure Association of the European Society of Cardiology (2018)
Journal Article
Mamas. (2018). Type 2 diabetes mellitus and heart failure: a position statement from the Heart Failure Association of the European Society of Cardiology. European Journal of Heart Failure, 853-872. https://doi.org/10.1002/ejhf.1170

The coexistence of type 2 diabetes mellitus (T2DM) and heart failure (HF), either with reduced (HFrEF) or preserved ejection fraction (HFpEF), is frequent (30–40% of patients) and associated with a higher risk of HF hospitalization, all-cause and car... Read More about Type 2 diabetes mellitus and heart failure: a position statement from the Heart Failure Association of the European Society of Cardiology.

Accelerated patent haemostasis using a procoagulant disk: a protocol designed to minimise the risk of radial artery occlusion following cardiac catheterisation (2018)
Journal Article
Ayyaz Ul Haq, M., Nazir, S. A., Rashid, M., Shing Kwok, C., Mubashiruddin, S., Alisiddiq, Z., …Nolan, J. (2019). Accelerated patent haemostasis using a procoagulant disk: a protocol designed to minimise the risk of radial artery occlusion following cardiac catheterisation. Cardiovascular Revascularization Medicine, 20(2), 137-142. https://doi.org/10.1016/j.carrev.2018.03.026

Purpose Radial artery occlusion flowing cardiac catheterisation has been linked to flow reduction and prolonged compression. We investigate whether these factors can be optimised following transradial cardiac catheterisation by using an accelerated... Read More about Accelerated patent haemostasis using a procoagulant disk: a protocol designed to minimise the risk of radial artery occlusion following cardiac catheterisation.

Preterm delivery and maternal cardiovascular disease future risk: A systematic review and meta-analysis (2018)
Presentation / Conference
Wu, P., Gulati, M., Kwok, C., Wong, C., Narain, A., O'Brien, S., …Mamas, M. (2018, April). Preterm delivery and maternal cardiovascular disease future risk: A systematic review and meta-analysis. Poster presented at British Maternal & Fetal Medicine Society (BMFMS) 20th Annual Conference 2018, Brighton, UK

Objectives We aimed to systematically evaluate and summarise the evidence on the relationship between preterm birth (

Same-day Inter-Facility Transfer for Percutaneous Coronary Intervention (2018)
Journal Article
Israeli, Z., Lavi, S., Bertand, O. F., & Mamas, M. (2018). Same-day Inter-Facility Transfer for Percutaneous Coronary Intervention. Journal of Interventional Cardiology, 230-235. https://doi.org/10.1111/joic.12486

Background: The use of radial approach for coronary angiography, followed by same-day inter-facility transfer for percutaneous coronary intervention (PCI) has not yet been evaluated. We sought to assess the safety and feasibility of using the transra... Read More about Same-day Inter-Facility Transfer for Percutaneous Coronary Intervention.

Heart Failure in Acute Ischaemic Stroke and Intracerebral Haemorrhage - impact on mortality and recurrence A Thailand National Stroke Cohort Study (2018)
Presentation / Conference
Pana, T., Wood, A., Perdomo-Lampignano, J., Tiamkao, S., Clark, A., Kongbunkiat, K., …Myint, P. (2018, April). Heart Failure in Acute Ischaemic Stroke and Intracerebral Haemorrhage - impact on mortality and recurrence A Thailand National Stroke Cohort Study. Paper presented at 27th European Stroke Conference

Background: The interaction between heart failure (HF) and acute cerebrovascular disease is unclear. Data on acute ischaemic stroke (AIS) recurrence and intracerebral haemorrhage (ICH) mortality and recurrence in HF patients are limited. We thus aime... Read More about Heart Failure in Acute Ischaemic Stroke and Intracerebral Haemorrhage - impact on mortality and recurrence A Thailand National Stroke Cohort Study.

Choice of antiplatelet therapy affects mortality outcome in ischemic stroke - a cohort study (2018)
Presentation / Conference
Barlas, R., Loke, Y., Mamas, M., Bettencourt-Silva, J., Ford, I., Clark, A., …Myint, P. (2018, April). Choice of antiplatelet therapy affects mortality outcome in ischemic stroke - a cohort study. Paper presented at European Stroke Conference, Athens, Greece

Background and Purpose: The optimal regimen of antiplatelet therapy for secondary prevention in noncardioembolic ischemic stroke remains controversial. We aimed to determine which regimen was associated with the greatest reduction in adverse outcomes... Read More about Choice of antiplatelet therapy affects mortality outcome in ischemic stroke - a cohort study.

Burden of 30-day readmissions after PCI in 824,747 patients in the USA: predictors, causes and cost. Insights from the Nationwide Readmission Database (2018)
Journal Article
Rashid, M., Curzen, N., Nolan, J., Bagur, R., Mamas, M., Potts, J., …Kwok, C. (2018). Burden of 30-day readmissions after PCI in 824,747 patients in the USA: predictors, causes and cost. Insights from the Nationwide Readmission Database. JACC. Cardiovascular interventions, 655-674. https://doi.org/10.1016/j.jcin.2018.01.248

Objectives This study aimed to examine the 30-day unplanned readmissions rate, predictors of readmission, causes of readmissions, and clinical impact of readmissions after percutaneous coronary intervention (PCI). Background Unplanned rehospital... Read More about Burden of 30-day readmissions after PCI in 824,747 patients in the USA: predictors, causes and cost. Insights from the Nationwide Readmission Database.

Antithrombotic therapy in patients receiving saphenous vein coronary artery bypass grafts: a protocol for a systematic review and network meta-analysis. (2018)
Journal Article
Mamas. (2018). Antithrombotic therapy in patients receiving saphenous vein coronary artery bypass grafts: a protocol for a systematic review and network meta-analysis. BMJ Open, e019555 - ?. https://doi.org/10.1136/bmjopen-2017-019555

INTRODUCTION: The current evidence for the prevention of saphenous vein graft failure (SVGF) after coronary artery bypass graft (CABG) surgery consists of direct head-to-head comparison of treatments (including placebo) in randomised-controlled trial... Read More about Antithrombotic therapy in patients receiving saphenous vein coronary artery bypass grafts: a protocol for a systematic review and network meta-analysis..

A Multiple-Model Generalisation of Updating Clinical Prediction Models (2018)
Journal Article
Mamas. (2018). A Multiple-Model Generalisation of Updating Clinical Prediction Models. Statistics in Medicine, 1343-1358. https://doi.org/10.1002/sim.7586

There is growing interest in developing clinical prediction models (CPMs) to aid local healthcare decision-making. Frequently, these CPMs are developed in isolation across different populations, with repetitive de novo derivation a common modelling s... Read More about A Multiple-Model Generalisation of Updating Clinical Prediction Models.

Effect of Gender On Unplanned Readmissions After Percutaneous Coronary Intervention (From The Nationwide Readmissions Database) (2018)
Journal Article
Kwok, C., Potts, J., Gulati, M., Alasnag, M., Rashid, M., Shoaib, A., …Mamas, M. (2018). Effect of Gender On Unplanned Readmissions After Percutaneous Coronary Intervention (From The Nationwide Readmissions Database). American Journal of Cardiology, 810-817. https://doi.org/10.1016/j.amjcard.2017.12.032

Women who undergo percutaneous coronary intervention (PCI) are at higher risk of adverse outcomes compared with men, but it is unknown whether gender affects early unplanned rehospitalization. We analyzed 832,753 patients who underwent PCI from 2013... Read More about Effect of Gender On Unplanned Readmissions After Percutaneous Coronary Intervention (From The Nationwide Readmissions Database).

Comorbidity health pathways in heart failure patients: A sequences-of-regressions analysis using cross-sectional data from 10,575 patients in the Swedish Heart Failure Registry (2018)
Journal Article
Mamas, & Solis-Trapala. (2018). Comorbidity health pathways in heart failure patients: A sequences-of-regressions analysis using cross-sectional data from 10,575 patients in the Swedish Heart Failure Registry. PLoS Medicine, https://doi.org/10.1371/journal.pmed.1002540

Background Optimally treated heart failure (HF) patients often have persisting symptoms and poor health-related quality of life. Comorbidities are common, but little is known about their impact on these factors, and guideline-driven HF care remains... Read More about Comorbidity health pathways in heart failure patients: A sequences-of-regressions analysis using cross-sectional data from 10,575 patients in the Swedish Heart Failure Registry.

Operator volume is not associated with mortality following Percutaneous Coronary Intervention: insights from the British Cardiovascular Intervention Society registry (2018)
Journal Article
Mamas. (2018). Operator volume is not associated with mortality following Percutaneous Coronary Intervention: insights from the British Cardiovascular Intervention Society registry. European Heart Journal, 1623-1634. https://doi.org/10.1093/eurheartj/ehy125

Aims The relationship between operator volume and outcomes for percutaneous coronary intervention (PCI) has been studied in the past, but recent analyses of national data covering the modern radial, acute coronary syndrome-dominant era are limited.... Read More about Operator volume is not associated with mortality following Percutaneous Coronary Intervention: insights from the British Cardiovascular Intervention Society registry.

Increasing socio-economic gap between the young and old: temporal trends in health and overall deprivation in England by age, sex, urbanity and ethnicity, 2004 to 2015 (2018)
Journal Article
Mamas. (2018). Increasing socio-economic gap between the young and old: temporal trends in health and overall deprivation in England by age, sex, urbanity and ethnicity, 2004 to 2015. Journal of Epidemiology and Community Health, 636-644. https://doi.org/10.1136/jech-2017-209895

Background: At a low geographical level, little is known about the associations between population characteristics and deprivation, and their trends, which would be directly affected by the house market, labour pressures and government policies. We d... Read More about Increasing socio-economic gap between the young and old: temporal trends in health and overall deprivation in England by age, sex, urbanity and ethnicity, 2004 to 2015.

Severity domains for quantifying the severity of Type 2 diabetes using primary care data and linked hospitalisation records from England (2018)
Presentation / Conference
ZGHEBI, S., Rutter, M., Ashcroft, D., Van Marwijk, H., Mallen, C., Chew-Graham, C. A., …Kontopantelis, E. (2018, March). Severity domains for quantifying the severity of Type 2 diabetes using primary care data and linked hospitalisation records from England. Poster presented at Diabetes UK Professional Conference 2018, London ExCeL, London, UK

Aims: Despite the increasing prevalence of Type 2 diabetes, which presents a significant burden on healthcare resources, there is no agreed validated UK measure to infer Type 2 diabetes severity from electronic health records (EHRs). This study aimed... Read More about Severity domains for quantifying the severity of Type 2 diabetes using primary care data and linked hospitalisation records from England.

Multimorbidity and survival for patients with acute myocardial infarction in England and Wales: Latent class analysis of a nationwide population-based cohort (2018)
Journal Article
Mamas. (2018). Multimorbidity and survival for patients with acute myocardial infarction in England and Wales: Latent class analysis of a nationwide population-based cohort. PLoS Medicine, e1002501. https://doi.org/10.1371/journal.pmed.1002501

Background There is limited knowledge of the scale and impact of multimorbidity for patients who have had an acute myocardial infarction (AMI). Therefore, this study aimed to determine the extent to which multimorbidity is associated with long-term... Read More about Multimorbidity and survival for patients with acute myocardial infarction in England and Wales: Latent class analysis of a nationwide population-based cohort.

Vascular access site and outcomes in 58,870 patients undergoing PCI with a previous history of coronary bypass surgery: results from the British Cardiovascular Interventions Society National database (2018)
Journal Article
Mamas, M., & Nolan, J. (2018). Vascular access site and outcomes in 58,870 patients undergoing PCI with a previous history of coronary bypass surgery: results from the British Cardiovascular Interventions Society National database. JACC. Cardiovascular interventions, 482-492. https://doi.org/10.1016/j.jcin.2017.12.020

Objectives Using the British Cardiovascular Intervention Society percutaneous coronary intervention (PCI) database, access site choice and outcomes of patients undergoing PCI with previous coronary artery bypass grafting (CABG) were studied. Back... Read More about Vascular access site and outcomes in 58,870 patients undergoing PCI with a previous history of coronary bypass surgery: results from the British Cardiovascular Interventions Society National database.

The effect of pre-procedure sublingual nitroglycerin on radial artery diameter and Allen’s test outcome - relevance to transradial catheterization (2018)
Journal Article
Chong, A., Lo, T., George, S., Ratib, K., Mamas, M., & Nolan, J. (2018). The effect of pre-procedure sublingual nitroglycerin on radial artery diameter and Allen’s test outcome - relevance to transradial catheterization. Cardiovascular Revascularization Medicine, 19(2), 163-167. https://doi.org/10.1016/j.carrev.2017.07.016

Background The radial artery is increasingly used for cardiac procedures, but is a relatively small vessel that is prone to spasm when instrumented. Intra-arterial nitroglycerine has been shown to reduce radial spasm but first requires arterial acce... Read More about The effect of pre-procedure sublingual nitroglycerin on radial artery diameter and Allen’s test outcome - relevance to transradial catheterization.

Retroperitoneal Hemorrhage After Percutaneous Coronary Intervention: Incidence, Determinants, and Outcomes as Recorded by the British Cardiovascular Intervention Society. (2018)
Journal Article
Kontopantelis, E., Kinnaird, T., Potts, J., Rashid, M., Shoaib, A., Nolan, J., …Cardiovascular Intervention Society (BCIS) and National, B. (2018). Retroperitoneal Hemorrhage After Percutaneous Coronary Intervention: Incidence, Determinants, and Outcomes as Recorded by the British Cardiovascular Intervention Society. Circulation: Cardiovascular Interventions, 11(2), Article e005866. https://doi.org/10.1161/CIRCINTERVENTIONS.117.005866

BACKGROUND: Retroperitoneal hemorrhage (RH) is a rare bleeding complication of percutaneous coronary intervention, which can result as a consequence of femoral access or can occur spontaneously. This study aims to evaluate temporal changes in RH, its... Read More about Retroperitoneal Hemorrhage After Percutaneous Coronary Intervention: Incidence, Determinants, and Outcomes as Recorded by the British Cardiovascular Intervention Society..

Chronic morbidity, deprivation and primary medical care spending in England in 2015-16: a cross-sectional spatial analysis (2018)
Journal Article
Mamas. (2018). Chronic morbidity, deprivation and primary medical care spending in England in 2015-16: a cross-sectional spatial analysis. BMC Medicine, https://doi.org/10.1186/s12916-017-0996-0

Background Primary care provides the foundation for most modern health-care systems, and in the interests of equity, it should be resourced according to local need. We aimed to describe spatially the burden of chronic conditions and primary medical... Read More about Chronic morbidity, deprivation and primary medical care spending in England in 2015-16: a cross-sectional spatial analysis.

Temporal changes in radial access use, associates and outcomes in patients undergoing PCI using rotational atherectomy between 2007 and 2014: results from the British Cardiovascular Intervention Society national database (2018)
Journal Article
Mamas. (2018). Temporal changes in radial access use, associates and outcomes in patients undergoing PCI using rotational atherectomy between 2007 and 2014: results from the British Cardiovascular Intervention Society national database. American Heart Journal, 46-54. https://doi.org/10.1016/j.ahj.2018.01.001

Aims Access site choice for cases requiring rotational atherectomy (PCI-ROTA) is poorly defined. Using the British Cardiovascular Intervention Society PCI database, temporal changes and contemporary associates/outcomes of access site choice for PCI-... Read More about Temporal changes in radial access use, associates and outcomes in patients undergoing PCI using rotational atherectomy between 2007 and 2014: results from the British Cardiovascular Intervention Society national database.

Investigating Heterogeneity of Effects and Associations Using Interaction Terms (2018)
Journal Article
Mamas. (2018). Investigating Heterogeneity of Effects and Associations Using Interaction Terms. Journal of Clinical Epidemiology, 79-83. https://doi.org/10.1016/j.jclinepi.2017.09.012

Effect heterogeneity, the variability of an association or exposure across subgroups, usually warrants further investigation. The aim of this deeper analysis is to identify effect modifiers (or moderators) and quantify their relationship with the exp... Read More about Investigating Heterogeneity of Effects and Associations Using Interaction Terms.

Geographical epidemiology of health and overall deprivation in England, its changes and persistence from 2004 to 2015: a longitudinal spatial population study (2017)
Journal Article
Mamas. (2017). Geographical epidemiology of health and overall deprivation in England, its changes and persistence from 2004 to 2015: a longitudinal spatial population study. Journal of epidemiology and community health, 140-147. https://doi.org/10.1136/jech-2017-209999

Background: Socio-economic deprivation is a key determinant for health. In England, the Index of Multiple Deprivation (IMD) is a widely used composite measure of deprivation. However, little is known about its spatial clustering or persistence acros... Read More about Geographical epidemiology of health and overall deprivation in England, its changes and persistence from 2004 to 2015: a longitudinal spatial population study.

Impact of anaemia on acute stroke outcomes depends on the type of anaemia: Evidence from a UK stroke register (2017)
Journal Article
Mamas. (2017). Impact of anaemia on acute stroke outcomes depends on the type of anaemia: Evidence from a UK stroke register. Journal of the Neurological Sciences, 26-30. https://doi.org/10.1016/j.jns.2017.09.047

AbstractBackground Previous research has demonstrated an association between anaemia and poor outcomes in acute stroke. This study aimed to assess the impact of anaemia on stroke by anaemia subtype. Methods Data from a prospective UK Regional Stroke... Read More about Impact of anaemia on acute stroke outcomes depends on the type of anaemia: Evidence from a UK stroke register.

A Novel UK Prognostic Model for 30-day Mortality following Transcatheter Aortic Valve Implantation (2017)
Journal Article
Mamas. (2017). A Novel UK Prognostic Model for 30-day Mortality following Transcatheter Aortic Valve Implantation. Heart, 1109-1116. https://doi.org/10.1136/heartjnl-2017-312489

Objective Existing clinical prediction models (CPM) for short-term mortality after transcatheter aortic valve implantation (TAVI) have limited applicability in the UK due to moderate predictive performance and inconsistent recording practices across... Read More about A Novel UK Prognostic Model for 30-day Mortality following Transcatheter Aortic Valve Implantation.

Hyperglycaemia and the SOAR stroke score in predicting mortality (2017)
Journal Article
McCall, S. J., Alanazi, T. A., Clark, A. B., Musgrave, S. D., Bettencourt-Silva, J. H., Bachmann, M. O., …Myint, P. K. (2018). Hyperglycaemia and the SOAR stroke score in predicting mortality. Diabetes and Vascular Disease Research, 15(2), 114-121. https://doi.org/10.1177/1479164117743034

Background: We assessed the association between admission blood glucose levels and acute stroke mortality and examined whether there was any incremental value of adding glucose status to the validated acute stroke mortality predictor – the SOAR (str... Read More about Hyperglycaemia and the SOAR stroke score in predicting mortality.

Impact of Access Site Practice on Clinical Outcomes in Patients Undergoing Percutaneous Coronary Intervention Following Thrombolysis for ST-Segment Elevation Myocardial Infarction in the United Kingdom : An Insight From the British Cardiovascular Intervention Society Dataset (2017)
Journal Article
Rashid, M., Rushton, C. A., Kwok, C. S., Kinnaird, T., Kontopantelis, E., Olier, I., …Mamas, M. (2017). Impact of Access Site Practice on Clinical Outcomes in Patients Undergoing Percutaneous Coronary Intervention Following Thrombolysis for ST-Segment Elevation Myocardial Infarction in the United Kingdom : An Insight From the British Cardiovascular Intervention Society Dataset. JACC. Cardiovascular interventions, 10(22), 2258 -2265. https://doi.org/10.1016/j.jcin.2017.07.049

Objectives This study sought to examine the relationship between access site practice and clinical outcomes in patients requiring percutaneous coronary intervention (PCI) following thrombolysis for ST-segment elevation myocardial infarction (STEMI).... Read More about Impact of Access Site Practice on Clinical Outcomes in Patients Undergoing Percutaneous Coronary Intervention Following Thrombolysis for ST-Segment Elevation Myocardial Infarction in the United Kingdom : An Insight From the British Cardiovascular Intervention Society Dataset.

25 Vascular access site and outcomes among 26,807 CTO-PCI cases from the national angioplasty audit (2017)
Journal Article
Kinnaird, T., Anderson, R., Gallagher, S., Large, A., Strange, J., Ludman, P., …Mamas, M. (2017). 25 Vascular access site and outcomes among 26,807 CTO-PCI cases from the national angioplasty audit. Heart, 103(S7), https://doi.org/10.1136/heartjnl-2017-BCIS.25

Background Use of radial access in chronic total occlusion percutaneous coronary intervention (CTO-PCI) warrants further investigation. Using the BCIS PCI database, access site choice and outcomes after CTO-PCI were assessed. Methods Data were ana... Read More about 25 Vascular access site and outcomes among 26,807 CTO-PCI cases from the national angioplasty audit.

Longitudinal deformation bench testing using a coronary artery model: a new standard? (2017)
Journal Article
Mamas. (2017). Longitudinal deformation bench testing using a coronary artery model: a new standard?. Open Heart, https://doi.org/10.1136/openhrt-2016-00053

Objectives To compare susceptibility of five different stent platforms with longitudinal stent deformation (LSD) using a clinically relevant bench testing model simulating both short and long malapposed lengths. Background Recent data suggest that de... Read More about Longitudinal deformation bench testing using a coronary artery model: a new standard?.

Advanced glycation end products reduce the calcium transient in cardiomyocytes by increasing production of reactive oxygen species and nitric oxide (2017)
Journal Article
Mamas. (2017). Advanced glycation end products reduce the calcium transient in cardiomyocytes by increasing production of reactive oxygen species and nitric oxide. FEBS Open Bio, 1672 -1685. https://doi.org/10.1002/2211-5463.12284

Advanced glycation end products (AGE) are central to the development of cardiovascular complications associated with diabetes mellitus. AGE may alter cellular function through cross-linking of cellular proteins or by activating the AGE receptor (RAGE... Read More about Advanced glycation end products reduce the calcium transient in cardiomyocytes by increasing production of reactive oxygen species and nitric oxide.

TCT-434 Economic benefits of transradial percutaneous coronary intervention; a national analysis from the British Cardiovascular Intervention Society database (2017)
Journal Article
Mamas, M., Tosh, J., Hulme, W., Nolan, J., Bungey, G., Ludman, P., …Kontopantelis, E. (2017). TCT-434 Economic benefits of transradial percutaneous coronary intervention; a national analysis from the British Cardiovascular Intervention Society database. Journal of the American College of Cardiology, 70(18), B178. https://doi.org/10.1016/j.jacc.2017.09.539

TCT-606 Operator volume is not associated with mortality following Percutaneous Coronary Intervention: insights from the British Cardiovascular Intervention Society registry (2017)
Journal Article
Hulme, W., Sperrin, M., Curzen, N., Kinnaird, T., de Belder, M., Ludman, P., …Mamas, M. (2017). TCT-606 Operator volume is not associated with mortality following Percutaneous Coronary Intervention: insights from the British Cardiovascular Intervention Society registry. Journal of the American College of Cardiology, 70(18), B250. https://doi.org/10.1016/j.jacc.2017.09.795

Dialysis following Transcatheter Aortic Valve Implantation: risk factors and outcomes: An analysis from the UK TAVI Registry (2017)
Journal Article
Mamas. (2017). Dialysis following Transcatheter Aortic Valve Implantation: risk factors and outcomes: An analysis from the UK TAVI Registry. JACC. Cardiovascular interventions, 2040-2047. https://doi.org/10.1016/j.jcin.2017.05.020

Objectives This study sought to determine the risk factors for post-transcatheter aortic valve replacement (TAVR) dialysis and to determine the impact of pre-TAVR or post-TAVR dialysis on mortality. Background TAVR is now established as an alter... Read More about Dialysis following Transcatheter Aortic Valve Implantation: risk factors and outcomes: An analysis from the UK TAVI Registry.

Relative survival following transcatheter aortic valve implantation: how do TAVI patients fare relative to the general population? (2017)
Journal Article
Mamas. (2017). Relative survival following transcatheter aortic valve implantation: how do TAVI patients fare relative to the general population?. Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, https://doi.org/10.1161/JAHA.117.007229

Background Transcatheter aortic valve implantation (TAVI) is indicated for patients with aortic stenosis who are intermediate-high surgical risk. Although all-cause mortality rates after TAVI are established, survival attributable to the procedure i... Read More about Relative survival following transcatheter aortic valve implantation: how do TAVI patients fare relative to the general population?.

Association Between Type 2 Diabetes and All-Cause Hospitalization and Mortality in the UK General Heart Failure Population (2017)
Journal Article
Lawson, C. A., Jones, P. W., Teece, L., Dunbar, S. B., Seferovic, P. M., Khunti, K., …Kadam, U. T. (2018). Association Between Type 2 Diabetes and All-Cause Hospitalization and Mortality in the UK General Heart Failure Population. JACC: Heart Failure, 6(1), 18-26. https://doi.org/10.1016/j.jchf.2017.08.020

Objectives This study sought to investigate in the general heart failure (HF) population, whether the associations between type 2 diabetes (T2D) and risk of hospitalization and death, are modified by changing glycemic or drug treatment intensity.... Read More about Association Between Type 2 Diabetes and All-Cause Hospitalization and Mortality in the UK General Heart Failure Population.

Effect of weekend admission on process of care and clinical outcomes for the management of acute coronary syndromes: a retrospective analysis of three UK centres. (2017)
Journal Article
Mamas. (2017). Effect of weekend admission on process of care and clinical outcomes for the management of acute coronary syndromes: a retrospective analysis of three UK centres. BMJ Open, e016866 - ?. https://doi.org/10.1136/bmjopen-2017-016866

OBJECTIVES: The effect of weekend versus weekday admission following acute coronary syndrome (ACS) on process of care and mortality remains controversial. This study aimed to investigate the 'weekend-effect' on outcomes using a multicentre dataset of... Read More about Effect of weekend admission on process of care and clinical outcomes for the management of acute coronary syndromes: a retrospective analysis of three UK centres..

Early Readmissions After Acute Myocardial Infarction (2017)
Journal Article
Mamas, Kwok, C. S., Wong, C. W., Shufflebotham, H., Brindley, L., Fatima, T., …Mamas, M. A. (2017). Early Readmissions After Acute Myocardial Infarction. American Journal of Cardiology, 120(5), 723-728. https://doi.org/10.1016/j.amjcard.2017.05.049

This study aims to evaluate the rate, predictors, and causes of 30-day readmissions in a single tertiary hospital in the United Kingdom. We conducted a retrospective study of all patients admitted between 2012 and 2014 with a diagnosis of acute myoca... Read More about Early Readmissions After Acute Myocardial Infarction.

Efficacy And Safety Of The Subcutaneous Implantable Cardioverter Defibrillator: A Systematic Review (2017)
Journal Article
Mamas. (2017). Efficacy And Safety Of The Subcutaneous Implantable Cardioverter Defibrillator: A Systematic Review. Heart, 1315-1322. https://doi.org/10.1136/heartjnl-2016-310852

Background: Subcutaneous implantable cardioverter defibrillators (S-ICD) are an alternative to conventional transvenous implantable cardioverter defibrillators (TV-ICD) in patients not requiring pacing. We sought to define the efficacy and safety of... Read More about Efficacy And Safety Of The Subcutaneous Implantable Cardioverter Defibrillator: A Systematic Review.

Hand dysfunction after transradial artery catheterization for coronary procedures (2017)
Journal Article
Ayyaz Ul Haq, M., Rashid, M., Shing Kwok, C., Wai Wong, C., Nolan, J., & Mamas, M. A. (2017). Hand dysfunction after transradial artery catheterization for coronary procedures. World Journal of Cardiology, 9(7), 609-619. https://doi.org/10.4330/wjc.v9.i7.609

AIM To sythesize the available literature on hand dysfunction after transradial catheterization. METHODS We searched MEDLINE and EMBASE. The search results were reviewed by two independent judicators for studies that met the inclusion criteria a... Read More about Hand dysfunction after transradial artery catheterization for coronary procedures.

The relationship of body mass index to percutaneous coronary intervention outcomes: Does the obesity paradox exist in contemporary PCI cohorts? Insights from the British Cardiovascular Intervention Society registry. (2017)
Journal Article
Mamas. (2017). The relationship of body mass index to percutaneous coronary intervention outcomes: Does the obesity paradox exist in contemporary PCI cohorts? Insights from the British Cardiovascular Intervention Society registry. JACC. Cardiovascular interventions, 1283-1292. https://doi.org/10.1016/j.jcin.2017.03.013

Objectives The aims of this study were to examine the relationship between body mass index (BMI) and clinical outcomes following percutaneous coronary intervention (PCI) and to determine the relevance of different clinical presentations requiring PC... Read More about The relationship of body mass index to percutaneous coronary intervention outcomes: Does the obesity paradox exist in contemporary PCI cohorts? Insights from the British Cardiovascular Intervention Society registry..

Transcatheter Aortic Valve Implantation With or Without Percutaneous Coronary Artery Revascularization Strategy: A Systematic Review and Meta-analysis (2017)
Journal Article
Mamas. (2017). Transcatheter Aortic Valve Implantation With or Without Percutaneous Coronary Artery Revascularization Strategy: A Systematic Review and Meta-analysis. Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, https://doi.org/10.1161/JAHA.117.005960

Background Recent recommendations suggest that in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation and coexistent significant coronary artery disease, the latter should be treated before the index procedure; ho... Read More about Transcatheter Aortic Valve Implantation With or Without Percutaneous Coronary Artery Revascularization Strategy: A Systematic Review and Meta-analysis.

Mortality after percutaneous coronary revascularization: Prior cardiovascular risk factor control and improved outcomes in patients with diabetes mellitus. (2017)
Journal Article
Mamas, M., & Rashid, M. (2017). Mortality after percutaneous coronary revascularization: Prior cardiovascular risk factor control and improved outcomes in patients with diabetes mellitus. Catheterization and Cardiovascular Interventions, 1195-1204. https://doi.org/10.1002/ccd.26882

OBJECTIVES: To assess the mortality in patients with diabetes mellitus (DM) following percutaneous coronary intervention (PCI) according to their insulin requirement and PCI setting (elective, urgent, and emergency). BACKGROUND: DM is a major risk fa... Read More about Mortality after percutaneous coronary revascularization: Prior cardiovascular risk factor control and improved outcomes in patients with diabetes mellitus..

Legacy Effect of Coronary Perforation Complicating Percutaneous Coronary Intervention for Chronic Total Occlusive Disease: An Analysis of 26 807 Cases From the British Cardiovascular Intervention Society Database (2017)
Journal Article
Kinnaird, T., Anderson, R., Ossei-Gerning, N., Cockburn, J., Sirker, A., Ludman, P., …Mamas, M. A. (2017). Legacy Effect of Coronary Perforation Complicating Percutaneous Coronary Intervention for Chronic Total Occlusive Disease: An Analysis of 26 807 Cases From the British Cardiovascular Intervention Society Database. Circulation: Cardiovascular Interventions, 10(5), https://doi.org/10.1161/circinterventions.116.004642

Do patients have a worse outcome with heart failure than cancer? A primary care based cohort study with 10-year follow-up in Scotland (2017)
Journal Article
Mamas. (2017). Do patients have a worse outcome with heart failure than cancer? A primary care based cohort study with 10-year follow-up in Scotland. European Journal of Heart Failure, 1095-1104. https://doi.org/10.1002/ejhf.822

Aims This study was designed to evaluate whether survival rates in patients with heart failure (HF) are better than those in patients with diagnoses of the four most common cancers in men and women, respectively, in a contemporary primary care cohor... Read More about Do patients have a worse outcome with heart failure than cancer? A primary care based cohort study with 10-year follow-up in Scotland.

Cerebral Embolic Protection Devices During Transcatheter Aortic Valve Implantation: Systematic Review and Meta-analysis (2017)
Journal Article
Mamas. (2017). Cerebral Embolic Protection Devices During Transcatheter Aortic Valve Implantation: Systematic Review and Meta-analysis. Stroke, 1306-1315. https://doi.org/10.1161/strokeaha.116.015915

Background and Purpose—Silent ischemic embolic lesions are common after transcatheter aortic valve implantation (TAVI). The use of embolic protection devices (EPD) may reduce the occurrence of these embolic lesions. Thus, a quantitative overview and... Read More about Cerebral Embolic Protection Devices During Transcatheter Aortic Valve Implantation: Systematic Review and Meta-analysis.

Choice of Stent for Percutaneous Coronary Intervention of Saphenous Vein Grafts. (2017)
Journal Article
Mamas. (2017). Choice of Stent for Percutaneous Coronary Intervention of Saphenous Vein Grafts. Circulation: Cardiovascular Interventions, https://doi.org/10.1161/CIRCINTERVENTIONS.116.004457

BACKGROUND: There are limited data on comparison of contemporary drug-eluting stent (DES) platforms, previous generation DES, and bare-metal stents (BMS) for percutaneous coronary intervention in saphenous vein grafts (SVG). We aimed to assess clinic... Read More about Choice of Stent for Percutaneous Coronary Intervention of Saphenous Vein Grafts..

Aortic Stenosis and Non-Cardiac Surgery: A Systematic Review and Meta-Analysis (2017)
Journal Article
Rashid, & Mamas. (2017). Aortic Stenosis and Non-Cardiac Surgery: A Systematic Review and Meta-Analysis. International Journal of Cardiology, 145-153. https://doi.org/10.1016/j.ijcard.2017.04.037

Background Aortic stenosis (AS) poses a perioperative management dilemma to physicians looking after patients who require non-cardiac surgery. The objective of this review is to investigate mortality and adverse cardiovascular events in patients wit... Read More about Aortic Stenosis and Non-Cardiac Surgery: A Systematic Review and Meta-Analysis.

Vascular access site and outcomes among 26,807 chronic total coronary occlusion angioplasty cases from the British Cardiovascular Interventions Society National database (2017)
Journal Article
Mamas, M., & Nolan, J. (2017). Vascular access site and outcomes among 26,807 chronic total coronary occlusion angioplasty cases from the British Cardiovascular Interventions Society National database. JACC: Cardiovascular Interventions, 635-644. https://doi.org/10.1016/j.jcin.2016.11.055

Objectives The aim of this study was to assess, using a national percutaneous coronary intervention (PCI) database, access-site choice and outcomes after chronic total occlusion (CTO) PCI. Background Given the influence of access site on outcome... Read More about Vascular access site and outcomes among 26,807 chronic total coronary occlusion angioplasty cases from the British Cardiovascular Interventions Society National database.

Change in angiogram-derived management strategy of patients with chest pain when some FFR data are available: How consistent is the effect? (2017)
Journal Article
Mamas. (2017). Change in angiogram-derived management strategy of patients with chest pain when some FFR data are available: How consistent is the effect?. Cardiovascular Revascularization Medicine, 320-327. https://doi.org/10.1016/j.carrev.2017.01.014

Background The assessment of patients presenting with angina using invasive angiography alone is imperfect. By contrast, fractional flow reserve (FFR) allows for assessment of lesion-specific ischemia, which is predictive of clinical outcome. A seri... Read More about Change in angiogram-derived management strategy of patients with chest pain when some FFR data are available: How consistent is the effect?.

Preeclampsia and Future Cardiovascular Health (2017)
Journal Article
Wu, P., Haththotuwa, R., Shing Kwok, C., Babu, A., Kotronias, R. A., Rushton, C., …Mamas, M. A. (2017). Preeclampsia and Future Cardiovascular Health. Circulation: Cardiovascular Quality and Outcomes, 10(2), https://doi.org/10.1161/circoutcomes.116.003497

Background— Preeclampsia is a pregnancy-specific disorder resulting in hypertension and multiorgan dysfunction. There is growing evidence that these effects persist after pregnancy. We aimed to systematically evaluate and quantify the evidence on th... Read More about Preeclampsia and Future Cardiovascular Health.

Pre-implantation Balloon Aortic Valvuloplasty and Clinical Outcomes Following Transcatheter Aortic Valve Implantation: A Propensity Score Analysis of the UK Registry (2017)
Journal Article
Mamas. (2017). Pre-implantation Balloon Aortic Valvuloplasty and Clinical Outcomes Following Transcatheter Aortic Valve Implantation: A Propensity Score Analysis of the UK Registry. Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, https://doi.org/10.1161/JAHA.116.004695

Background Aortic valve predilation with balloon aortic valvuloplasty (BAV) is recommended before transcatheter aortic valve implantation (TAVI), despite limited data around the requirement of this preprocedural step and the potential risks of embol... Read More about Pre-implantation Balloon Aortic Valvuloplasty and Clinical Outcomes Following Transcatheter Aortic Valve Implantation: A Propensity Score Analysis of the UK Registry.

Increased radial access is not associated with worse femoral outcomes for PCI in the United Kingdom (2017)
Journal Article
Hulme, W., Sperrin, M., Kontopantelis, E., Ratib, K., Ludman, P., Sirker, A., …Mamas, M. (2017). Increased radial access is not associated with worse femoral outcomes for PCI in the United Kingdom. Circulation: Cardiovascular Interventions, 10(2), 4279. https://doi.org/10.1161/CIRCINTERVENTIONS.116.004279

Background— The radial artery is increasingly adopted as the primary access site for cardiac catheterization because of patient preference, lower bleeding rates, cost effectiveness, and reduced risk of mortality in high-risk patient groups. Concerns... Read More about Increased radial access is not associated with worse femoral outcomes for PCI in the United Kingdom.

Variation in emergency percutaneous coronary intervention in ventilated patients in the UK: insights from a national database (2017)
Journal Article
Mamas. (2017). Variation in emergency percutaneous coronary intervention in ventilated patients in the UK: insights from a national database. Cardiovascular Revascularization Medicine, 250-254. https://doi.org/10.1016/j.carrev.2017.02.005

Aims Pre-procedural ventilation is a marker of high risk in PCI patients. Causes include out-of-hospital cardiac arrest (OHCA) and cardiogenic shock. OHCA occurs in approximately 60,000 patients in the UK per annum. No consensus exists regarding the... Read More about Variation in emergency percutaneous coronary intervention in ventilated patients in the UK: insights from a national database.

Impact of HIV on inpatient mortality and complications in stroke in Thailand; A National Database Study (2017)
Journal Article
Mamas. (2017). Impact of HIV on inpatient mortality and complications in stroke in Thailand; A National Database Study. Epidemiology and Infection, 1285-1291. https://doi.org/10.1017/S095026881600340X

The co-existence of stroke and HIV has increased in recent years, but the impact of HIV on post-stroke outcomes is poorly understood. We examined the impact of HIV on inpatient mortality, length of acute hospital stay and complications (pneumonia, re... Read More about Impact of HIV on inpatient mortality and complications in stroke in Thailand; A National Database Study.

5-Fr sheathless transradial cardiac catheterization using conventional catheters and balloon assisted tracking; a new approach to downsizing (2017)
Journal Article
Mamas, M. A., George, S., Ratib, K., Kwok, C. S., Elkhazin, A., Sandhu, K., …Nolan, J. (2017). 5-Fr sheathless transradial cardiac catheterization using conventional catheters and balloon assisted tracking; a new approach to downsizing. Cardiovascular Revascularization Medicine, 18(1), 28-32. https://doi.org/10.1016/j.carrev.2016.09.003

Response to letter by Dziewierz et al. on “Influence of access site choice for cardiac catheterization on risk of adverse neurological events: A systematic review and meta- analysis” (2017)
Journal Article
Mamas. (2017). Response to letter by Dziewierz et al. on “Influence of access site choice for cardiac catheterization on risk of adverse neurological events: A systematic review and meta- analysis”. American Heart Journal, 107-119. https://doi.org/10.1016/j.ahj.2017.01.013

Letter to the editor.

Endothelial progenitor cells: exploring the pleiotropic effects of statins (2017)
Journal Article
Mamas. (2017). Endothelial progenitor cells: exploring the pleiotropic effects of statins. World Journal of Cardiology, 1-13. https://doi.org/10.4330/wjc.v9.i1.1

Statins have become a cornerstone of risk modification for ischaemic heart disease patients. A number of studies have shown that they are effective and safe. However studies have observed an early benefit in terms of a reduction in recurrent infarct... Read More about Endothelial progenitor cells: exploring the pleiotropic effects of statins.

One-month global longitudinal strain identifies patients who will develop pacing-induced left ventricular dysfunction over time: the pacing and ventricular dysfunction (PAVD) study (2017)
Journal Article
Mamas. (2017). One-month global longitudinal strain identifies patients who will develop pacing-induced left ventricular dysfunction over time: the pacing and ventricular dysfunction (PAVD) study. PloS one, https://doi.org/10.1371/journal.pone.0162072

Background Predicting which individuals will have a decline in left ventricular (LV) function after pacemaker implantation remains an important challenge. We investigated whether LV global longitudinal strain (GLS), measured by 2D speckle tracking s... Read More about One-month global longitudinal strain identifies patients who will develop pacing-induced left ventricular dysfunction over time: the pacing and ventricular dysfunction (PAVD) study.

Radiotherapy-induced cardiac implantable electronic device disorders in cancer patients (2017)
Journal Article
Mamas. (2017). Radiotherapy-induced cardiac implantable electronic device disorders in cancer patients. American Journal of Cardiology, 284-289. https://doi.org/10.1016/j.amjcard.2016.09.036

Radiotherapy can affect the electronic components of a cardiac implantable electronic device (CIED) resulting in malfunction and/or damage. We sought to assess the incidence, predictors, and clinical impact of CIED dysfunction (CIED-D) after radiothe... Read More about Radiotherapy-induced cardiac implantable electronic device disorders in cancer patients.

Clinical Prediction in Defined Populations: a simulation study investigating when and how to aggregate existing models (2017)
Journal Article
Mamas. (2017). Clinical Prediction in Defined Populations: a simulation study investigating when and how to aggregate existing models. BMC medical research methodology, 1-11. https://doi.org/10.1186/s12874-016-0277-1

Background Clinical prediction models (CPMs) are increasingly deployed to support healthcare decisions but they are derived inconsistently, in part due to limited data. An emerging alternative is to aggregate existing CPMs developed for similar sett... Read More about Clinical Prediction in Defined Populations: a simulation study investigating when and how to aggregate existing models.

Impact of Co-morbid burden on mortality in patients with coronary heart disease, heart failure and cerebrovascular accident: a systematic review and meta-analysis (2017)
Journal Article
Mamas, M., & Rashid, M. (2017). Impact of Co-morbid burden on mortality in patients with coronary heart disease, heart failure and cerebrovascular accident: a systematic review and meta-analysis. European Heart Journal - Quality of Care and Clinical Outcomes, 20-36. https://doi.org/10.1093/ehjqcco/qcw025

Aims: We sought to investigate the prognostic impact of co-morbid burden as defined by the Charlson comorbidity index (CCI) in patients with a range of prevalent cardiovascular diseases. Methods & Results: We searched MEDLINE and EMBASE to identify s... Read More about Impact of Co-morbid burden on mortality in patients with coronary heart disease, heart failure and cerebrovascular accident: a systematic review and meta-analysis.

Cancer event rate and mortality with thienopyridines: a systematic review and meta-analysis (2016)
Journal Article
Mamas. (2016). Cancer event rate and mortality with thienopyridines: a systematic review and meta-analysis. Drug Safety, 229-240. https://doi.org/10.1007/s40264-016-0481-2

Introduction Thienopyridines are a class of antiplatelet drugs widely used in cardiovascular disease prevention and treatment. A recent concern has come to light regarding the safety of thienopyridines because of the possible risk of malignancy. We... Read More about Cancer event rate and mortality with thienopyridines: a systematic review and meta-analysis.

Impact of incomplete percutaneous revascularization in patients with multi-vessel coronary artery disease: a systematic review and meta-analysis (2016)
Journal Article
Nagaraja, V., Ooi, S., Nolan, J., Large, A., De Belder, M., Ludman, P., …Mamas, M. A. (2016). Impact of incomplete percutaneous revascularization in patients with multi-vessel coronary artery disease: a systematic review and meta-analysis. Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, 5(12), https://doi.org/10.1161/JAHA.116.004598

Background Up to half of patients undergoing percutaneous coronary intervention have multivessel coronary artery disease (MVD) with conflicting data regarding optimal revascularization strategy in such patients. This paper assesses the evidence for... Read More about Impact of incomplete percutaneous revascularization in patients with multi-vessel coronary artery disease: a systematic review and meta-analysis.

Relationship Between Anemia and Mortality Outcomes in a National Acute Coronary Syndrome Cohort: Insights from the UK Myocardial Ischemia National Audit Project Registry (2016)
Journal Article
Mamas, M. A., Shing Kwok, C., Kontopantelis, E., Fryer, A. A., Buchan, I., Bachmann, M. O., …Myint, P. K. (2016). Relationship Between Anemia and Mortality Outcomes in a National Acute Coronary Syndrome Cohort: Insights from the UK Myocardial Ischemia National Audit Project Registry. Journal of the American Heart Association, 5(11), https://doi.org/10.1161/JAHA.116.003348

BACKGROUND: We aim to determine the prevalence of anemia in acute coronary syndrome (ACS) patients and compare their clinical characteristics, management, and clinical outcomes to those without anemia in an unselected national ACS cohort. METHODS AND... Read More about Relationship Between Anemia and Mortality Outcomes in a National Acute Coronary Syndrome Cohort: Insights from the UK Myocardial Ischemia National Audit Project Registry.

Relationship between anemia and mortality outcomes in a national ACS cohort: insights from the UK MINAP registry (2016)
Journal Article
Mamas. (2016). Relationship between anemia and mortality outcomes in a national ACS cohort: insights from the UK MINAP registry. Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, https://doi.org/10.1161/JAHA.116.003348

Background We aim to determine the prevalence of anemia in acute coronary syndrome (ACS) patients and compare their clinical characteristics, management, and clinical outcomes to those without anemia in an unselected national ACS cohort. Methods... Read More about Relationship between anemia and mortality outcomes in a national ACS cohort: insights from the UK MINAP registry.

Ultrafiltration for acute decompensated cardiac failure: A systematic review and meta-analysis (2016)
Journal Article
Davies, & Mamas. (2016). Ultrafiltration for acute decompensated cardiac failure: A systematic review and meta-analysis. International Journal of Cardiology, 122-128. https://doi.org/10.1016/j.ijcard.2016.11.136

Background Ultrafiltration is a method used to achieve diuresis in acute decompensated heart failure (ADHF) when there is diuretic resistance, but its efficacy in other settings is unclear. We therefore conducted a systematic review and meta-analysi... Read More about Ultrafiltration for acute decompensated cardiac failure: A systematic review and meta-analysis.

Review of early hospitalization after percutaneous coronary intervention (2016)
Journal Article
Mamas. (2016). Review of early hospitalization after percutaneous coronary intervention. International Journal of Cardiology, 370-377. https://doi.org/10.1016/j.ijcard.2016.11.050

Background Percutaneous coronary intervention (PCI) is the most common modality of revascularization in patients with coronary artery disease. Understanding the readmission rates and reasons for readmission after PCI is important because readmission... Read More about Review of early hospitalization after percutaneous coronary intervention.

Inadequacy of Existing Clinical Prediction Models for Predicting Mortality after Transcatheter Aortic Valve Implantation (2016)
Journal Article
Mamas. (2016). Inadequacy of Existing Clinical Prediction Models for Predicting Mortality after Transcatheter Aortic Valve Implantation. American Heart Journal, 97-105. https://doi.org/10.1016/j.ahj.2016.10.020

Background The performance of emerging transcatheter aortic valve implantation (TAVI) clinical prediction models (CPMs) in national TAVI cohorts distinct from those where they have been derived is unknown. This study aimed to investigate the perform... Read More about Inadequacy of Existing Clinical Prediction Models for Predicting Mortality after Transcatheter Aortic Valve Implantation.

Predicting Mortality from Change-over-time in the Charlson Comorbidity Index: A retrospective cohort study in a data-intensive UK health system (2016)
Journal Article
Mamas, M., & Mallen, C. (2016). Predicting Mortality from Change-over-time in the Charlson Comorbidity Index: A retrospective cohort study in a data-intensive UK health system. Medicine, e4973. https://doi.org/10.1097/md.0000000000004973

Multimorbidity is common among older people and presents a major challenge to health systems worldwide. Metrics of multimorbidity are, however, crude: focusing on measuring comorbid conditions at single time-points rather than reflecting the longitud... Read More about Predicting Mortality from Change-over-time in the Charlson Comorbidity Index: A retrospective cohort study in a data-intensive UK health system.

Comparison of the Effects of Incomplete Revascularization on 12-month Mortality in Patients <80 compared to =80 Years of Age Undergoing Percutaneous Coronary Intervention (2016)
Journal Article
Mamas. (2016). Comparison of the Effects of Incomplete Revascularization on 12-month Mortality in Patients

Although randomized trial data suggest that complete revascularization improves outcomes after percutaneous coronary intervention (PCI), the impact of differing revascularization strategies in octogenarians is not well defined. We performed a retrosp... Read More about Comparison of the Effects of Incomplete Revascularization on 12-month Mortality in Patients <80 compared to =80 Years of Age Undergoing Percutaneous Coronary Intervention.

Rheumatic mitral valve disease is associated with worse outcomes in stroke: a Thailand National Database Study (2016)
Journal Article
Mamas. (2016). Rheumatic mitral valve disease is associated with worse outcomes in stroke: a Thailand National Database Study. Stroke, 2695-2701. https://doi.org/10.1161/STROKEAHA.116.014512

Background and Purpose— Rheumatic valvular heart disease is associated with the increased risk of cerebrovascular events, although there are limited data on the prognosis of patients with rheumatic mitral valve disease (RMVD) after stroke. Method... Read More about Rheumatic mitral valve disease is associated with worse outcomes in stroke: a Thailand National Database Study.

The oxoglutarate receptor 1 (OXGR1) modulates pressure overload-induced cardiac hypertrophy in mice (2016)
Journal Article
Mamas. (2016). The oxoglutarate receptor 1 (OXGR1) modulates pressure overload-induced cardiac hypertrophy in mice. Biochemical and Biophysical Research Communications, 708-714. https://doi.org/10.1016/j.bbrc.2016.09.147

The G-protein-coupled receptors (GPCRs) family of proteins play essential roles in the heart, including in the regulation of cardiac hypertrophy. One member of this family, the oxoglutarate receptor 1 (OXGR1), may have a crucial role in the heart bec... Read More about The oxoglutarate receptor 1 (OXGR1) modulates pressure overload-induced cardiac hypertrophy in mice.

Pre-eclampsia is associated with a twofold increase in diabetes: a systematic review and meta-analysis (2016)
Journal Article
Wu, P., Shing Kwok, C., Haththotuwa, R., Kotronias, R. A., Babu, A., Fryer, A. A., …Mamas, M. A. (2016). Pre-eclampsia is associated with a twofold increase in diabetes: a systematic review and meta-analysis. Diabetologia, 59, 2518-2526. https://doi.org/10.1007/s00125-016-4098-x

Aims/hypothesis: Pre-eclampsia is a pregnancy-specific multi-system disorder and a state of physiological insulin resistance. Our aim is to systematically evaluate and quantify the evidence on the relationship between pre-eclampsia and the future ris... Read More about Pre-eclampsia is associated with a twofold increase in diabetes: a systematic review and meta-analysis.

Influence of access site choice for cardiac catheterization on risk of adverse neurological events: a systematic review and meta-analysis (2016)
Journal Article
Mamas, & Nolan. (2016). Influence of access site choice for cardiac catheterization on risk of adverse neurological events: a systematic review and meta-analysis. American Heart Journal, 107-119. https://doi.org/10.1016/j.ahj.2016.06.027

Background: Stroke is a rare but potentially catastrophic complication of cardiac catheterization. While some procedural aspects are known to influence stroke risk, the impact of radial versus femoral access site use is unclear. Early observational s... Read More about Influence of access site choice for cardiac catheterization on risk of adverse neurological events: a systematic review and meta-analysis.

Impact of hemoglobin levels and anemia on mortality in acute stroke: analysis of UK regional registry data, systematic review and meta-analysis (2016)
Journal Article
Mamas. (2016). Impact of hemoglobin levels and anemia on mortality in acute stroke: analysis of UK regional registry data, systematic review and meta-analysis. Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, https://doi.org/10.1161/JAHA.115.003019

Background: The impact of hemoglobin levels and anemia on stroke mortality remains controversial. We aimed to systematically assess this association and quantify the evidence. Methods and Results: We analysed data from a cohort of 8,013 stroke patien... Read More about Impact of hemoglobin levels and anemia on mortality in acute stroke: analysis of UK regional registry data, systematic review and meta-analysis.

The incidence, determinants and outcomes of coronary perforation during percutaneous coronary intervention in the United Kingdom between 2006–2013: an analysis of 527,121 cases from the British Cardiovascular Intervention Society database (2016)
Journal Article
Mamas. (2016). The incidence, determinants and outcomes of coronary perforation during percutaneous coronary intervention in the United Kingdom between 2006–2013: an analysis of 527,121 cases from the British Cardiovascular Intervention Society database. Circulation: Cardiovascular Interventions, https://doi.org/10.1161/CIRCINTERVENTIONS.115.003449

Background: As coronary perforation (CP) is a rare but serious complication of percutaneous coronary intervention (PCI) the current evidence base is limited to small series. Using a national PCI database the incidence, predictors and outcomes of CP a... Read More about The incidence, determinants and outcomes of coronary perforation during percutaneous coronary intervention in the United Kingdom between 2006–2013: an analysis of 527,121 cases from the British Cardiovascular Intervention Society database.

Meta-analysis of Percutaneous Coronary Intervention with Drug Eluting Stent Versus Coronary Artery Bypass Grafting for Isolated Proximal Left Anterior Descending Coronary Disease (2016)
Journal Article
Mamas. (2016). Meta-analysis of Percutaneous Coronary Intervention with Drug Eluting Stent Versus Coronary Artery Bypass Grafting for Isolated Proximal Left Anterior Descending Coronary Disease. American Journal of Cardiology, 1171-1177. https://doi.org/10.1016/j.amjcard.2016.07.030

We performed a meta-analysis of the studies comparing the efficacy and safety of coronary artery bypass surgery (CABG) against percutaneous coronary intervention with drug-eluting stents (PCI-DES) among patients with isolated LAD disease. Due to limi... Read More about Meta-analysis of Percutaneous Coronary Intervention with Drug Eluting Stent Versus Coronary Artery Bypass Grafting for Isolated Proximal Left Anterior Descending Coronary Disease.

Soft drinks and sweetened beverages and the risk of cardiovascular disease and mortality: a systematic review and meta-analysis (2016)
Journal Article
Mamas. (2016). Soft drinks and sweetened beverages and the risk of cardiovascular disease and mortality: a systematic review and meta-analysis. International Journal of Clinical Practice, 791-805. https://doi.org/10.1111/ijcp.12841

Background Soft drink consumption is associated with adverse health behaviours that predispose to adverse cardiovascular risk factor profiles; however, it is unclear whether their intake independently leads to an increased risk of cardiovascular eve... Read More about Soft drinks and sweetened beverages and the risk of cardiovascular disease and mortality: a systematic review and meta-analysis.

Radial artery perforation treated with balloon tracking and guide catheter tamponade - A case series. (2016)
Journal Article
George, S., Mamas, M., Nolan, J., & Ratib, K. (2016). Radial artery perforation treated with balloon tracking and guide catheter tamponade - A case series. Cardiovascular Revascularization Medicine, 17(7), 480-486. https://doi.org/10.1016/j.carrev.2016.06.005

A 78year old woman was admitted with an acute coronary syndrome. She underwent coronary angiography via the left radial artery which was complicated by a guide catheter induced radial artery perforation confirmed by extravasation of contrast into the... Read More about Radial artery perforation treated with balloon tracking and guide catheter tamponade - A case series..

Transcatheter Aortic Valve Implantation With or Without Preimplantation Balloon Aortic Valvuloplasty: A Systematic Review and Meta‐Analysis (2016)
Journal Article
Bagur, R., Kwok, C. S., Nombela‐Franco, L., Ludman, P. F., de Belder, M. A., Sponga, S., …Mamas, M. A. (2016). Transcatheter Aortic Valve Implantation With or Without Preimplantation Balloon Aortic Valvuloplasty: A Systematic Review and Meta‐Analysis. Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, 5(6), https://doi.org/10.1161/jaha.115.003191

THE PREVALENCE, PREDICTORS AND OUTCOMES ASSOCIATED WITH ANAEMIA AMONG PATIENTS THAT PRESENT WITH ACS: INSIGHTS FROM THE UK MINAP REGISTRY (2016)
Journal Article
Kwok, C. S., Mamas, A. M., Kontopantelis, E., Fryer, A. A., Buchan, I., Bachmann, M. O., …Myint, P. K. (2016). THE PREVALENCE, PREDICTORS AND OUTCOMES ASSOCIATED WITH ANAEMIA AMONG PATIENTS THAT PRESENT WITH ACS: INSIGHTS FROM THE UK MINAP REGISTRY. Heart, 102(S6), A76-A76. https://doi.org/10.1136/heartjnl-2016-309890.107

Background Data from both registry and post-hoc analysis of randomised controlled trials have suggested that the burden of anaemia among patients admitted with acute coronary syndrome (ACS) is significant. However, current guidelines fail to offer fi... Read More about THE PREVALENCE, PREDICTORS AND OUTCOMES ASSOCIATED WITH ANAEMIA AMONG PATIENTS THAT PRESENT WITH ACS: INSIGHTS FROM THE UK MINAP REGISTRY.

Association between osteoarthritis and cardiovascular disease: systematic review and meta-analysis (2016)
Journal Article
Mamas. (2016). Association between osteoarthritis and cardiovascular disease: systematic review and meta-analysis. European Journal of Preventive Cardiology, 938-946. https://doi.org/10.1177/2047487315610663

Background To examine for a possible relationship between osteoarthritis and cardiovascular disease. Design A systematic review and meta-analysis. Methods Published and unpublished literature from: MEDLINE, EMBASE, CINAHL, the Cochrane Libra... Read More about Association between osteoarthritis and cardiovascular disease: systematic review and meta-analysis.

The importance of interactions between atrial fibrillation and heart failure (2016)
Journal Article
Mamas. (2016). The importance of interactions between atrial fibrillation and heart failure. Clinical Medicine, 272 -276. https://doi.org/10.7861/clinmedicine.16-3-272

Heart failure (HF) and atrial fibrillation (AF) are among the commonest cardiovascular conditions encountered in clinical practice and frequently coexist. Over the last decade, they have evolved into global cardiovascular epidemics. This, in turn, ha... Read More about The importance of interactions between atrial fibrillation and heart failure.

Meta-analysis of the prognostic impact of anemia in patients undergoing percutaneous coronary intervention (2016)
Journal Article
Mamas, & Nolan. (2016). Meta-analysis of the prognostic impact of anemia in patients undergoing percutaneous coronary intervention. American Journal of Cardiology, 610-620. https://doi.org/10.1016/j.amjcard.2016.05.059

Anemia is common in patients undergoing percutaneous coronary intervention (PCI), and current guidelines fail to offer recommendations for its management. This review aims to examine the relation between baseline anemia and mortality, major adverse c... Read More about Meta-analysis of the prognostic impact of anemia in patients undergoing percutaneous coronary intervention.

Determinants and outcomes of stroke following percutaneous coronary intervention by indication (2016)
Journal Article
Roffe, & Mamas. (2016). Determinants and outcomes of stroke following percutaneous coronary intervention by indication. Stroke, 1500-1507. https://doi.org/10.1161/strokeaha.116.012700

Background and Purpose—Stroke after percutaneous coronary intervention (PCI) is a serious complication, but its determinants and outcomes after PCI in different clinical settings are poorly documented. Methods—The British Cardiovascular Interventi... Read More about Determinants and outcomes of stroke following percutaneous coronary intervention by indication.

A contemporary risk model for predicting 30-day mortality following percutaneous coronary intervention in England and Wales (2016)
Journal Article
Mamas. (2016). A contemporary risk model for predicting 30-day mortality following percutaneous coronary intervention in England and Wales. International Journal of Cardiology, 125-132. https://doi.org/10.1016/j.ijcard.2016.02.085

Aims: The current risk model for percutaneous coronary intervention (PCI) in the UK is based on outcomes of patients who were treated in a different era of interventional cardiology. This study aimed to create a new model, based on a contemporary coh... Read More about A contemporary risk model for predicting 30-day mortality following percutaneous coronary intervention in England and Wales.

Is there a relationship of operator and center volume with access site related outcomes?: an analysis from the British Cardiovascular Intervention Society (2016)
Journal Article
Nolan, & Mamas. (2016). Is there a relationship of operator and center volume with access site related outcomes?: an analysis from the British Cardiovascular Intervention Society. Circulation: Cardiovascular Interventions, https://doi.org/10.1161/circinterventions.115.003333

Background: Transradial access (TRA) is associated with reduced access site related bleeding complications and mortality post percutaneous coronary intervention (PCI). The objective of this study is to examine the relationship between access site pra... Read More about Is there a relationship of operator and center volume with access site related outcomes?: an analysis from the British Cardiovascular Intervention Society.

Outcomes following primary percutaneous coronary intervention in patients with previous coronary artery bypass surgery (2016)
Journal Article
Mamas. (2016). Outcomes following primary percutaneous coronary intervention in patients with previous coronary artery bypass surgery. Circulation: Cardiovascular Interventions, https://doi.org/10.1161/circinterventions.115.003151

Background: There are limited data on outcomes of patients with previous coronary artery bypass grafting (CABG) presenting with ST-segment elevation myocardial infarction (STEMI) and undergoing primary percutaneous coronary intervention (PPCI). We re... Read More about Outcomes following primary percutaneous coronary intervention in patients with previous coronary artery bypass surgery.

Transcatheter Aortic Valve Implantation With or Without Pre-implantation Balloon Aortic Valvuloplasty: A Systematic Review and Meta-analysis (2016)
Journal Article
Bagur, R., Shing Kwok, C., Nombela-Franco, L., Ludman, P., de Belder, M., Sponga, S., …Mamas, M. (2016). Transcatheter Aortic Valve Implantation With or Without Pre-implantation Balloon Aortic Valvuloplasty: A Systematic Review and Meta-analysis. Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, 67(13), 411-411. https://doi.org/10.1016/S0735-1097%2816%2930412-0

Objectives: Pre-implantation balloon-aortic valvuloplasty (BAV) is considered routine procedure during transcatheter aortic valve implantation (TAVI) to facilitate prosthesis implantation and expansion; however, it has been speculated that fewer embo... Read More about Transcatheter Aortic Valve Implantation With or Without Pre-implantation Balloon Aortic Valvuloplasty: A Systematic Review and Meta-analysis.

Metabolic risk factors were not associated with greater amounts of radiographic hand OA progression over 6-years in a community-dwelling population (2016)
Journal Article
Marshall, M., Peat, G., Nicholls, E., Myers, H., Mamas, M., Dziedzic, K., & van der Windt, D. (2016). Metabolic risk factors were not associated with greater amounts of radiographic hand OA progression over 6-years in a community-dwelling population. Osteoarthritis and Cartilage, 24(S1), S201-S202. https://doi.org/10.1016/j.joca.2016.01.394

Explaining inequalities in receipt of care in the older patient with acute coronary syndrome (2016)
Journal Article
Mamas. (2016). Explaining inequalities in receipt of care in the older patient with acute coronary syndrome. European Heart Journal - Quality of Care and Clinical Outcomes, 59-61. https://doi.org/10.1093/ehjqcco/qcw011

The world's population is ageing and patients with acute coronary syndromes (ACS) are presenting later in life such that a third or more are now aged =70.1 ACS mortality rates are higher in older patients,1 and absolute benefits of treatment are, the... Read More about Explaining inequalities in receipt of care in the older patient with acute coronary syndrome.

Changes in arterial access site and association with mortality in the United Kingdom: observations from a national percutaneous coronary intervention database (2016)
Journal Article
Mamas, M. A., Nolan, J., de Belder, M. A., Zaman, A., Kinnaird, T., Curzen, N., …Kontopantelis, E. (2016). Changes in arterial access site and association with mortality in the United Kingdom: observations from a national percutaneous coronary intervention database. Circulation, 133(17), 1655-1667. https://doi.org/10.1161/CIRCULATIONAHA.115.018083

Background The transradial access (TRA) site has become the default access site for PCI in the UK with randomized trials and national registry data showing reductions in mortality associated with TRA utilization. This study evaluates regional changes... Read More about Changes in arterial access site and association with mortality in the United Kingdom: observations from a national percutaneous coronary intervention database.

Prolonged PR interval, first-degree heart block and adverse cardiovascular outcomes: a systematic review and meta-analysis (2016)
Journal Article
Mamas, Rashid, M., & Nolan, J. (2016). Prolonged PR interval, first-degree heart block and adverse cardiovascular outcomes: a systematic review and meta-analysis. Heart, https://doi.org/10.1136/heartjnl-2015-308956

Abstract Objective: First-degree atrioventricular block is frequently encountered in clinical practice and is generally considered a benign process. However, there is emerging evidence that prolonged PR interval may be associated with adverse outcome... Read More about Prolonged PR interval, first-degree heart block and adverse cardiovascular outcomes: a systematic review and meta-analysis.

Habitual chocolate consumption and the risk of incident heart failure among healthy men and women (2016)
Journal Article
Mamas. (2016). Habitual chocolate consumption and the risk of incident heart failure among healthy men and women. Nutrition, Metabolism and Cardiovascular Diseases, 722-734. https://doi.org/10.1016/j.numecd.2016.01.003

Background: We aimed to examine the association between chocolate intake and the risk of incident heart failure in a UK general population. We conducted a systematic review and meta-analysis to quantify this association. Methods and results: We used... Read More about Habitual chocolate consumption and the risk of incident heart failure among healthy men and women.

Habitual chocolate consumption and the risk of incident heart failure among healthy men and women (2016)
Journal Article
Mamas. (2016). Habitual chocolate consumption and the risk of incident heart failure among healthy men and women. Nutrition, Metabolism and Cardiovascular Diseases, 722 -734. https://doi.org/10.1016/j.numecd.2016.01.003

BACKGROUND: We aimed to examine the association between chocolate intake and the risk of incident heart failure in a UK general population. We conducted a systematic review and meta-analysis to quantify this association. METHODS AND RESULTS: We used... Read More about Habitual chocolate consumption and the risk of incident heart failure among healthy men and women.

Radial artery occlusion after transradial interventions: a systematic review and meta-analysis (2016)
Journal Article
Rashid, M., Shing Kwok, C., Pancholy, S., Chugh, S., Kedev, S. A., Bernat, I., …Mamas, M. (2016). Radial artery occlusion after transradial interventions: a systematic review and meta-analysis. Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, 51(1), https://doi.org/10.1161/JAHA.115.002686

Abstract Objectives: To investigate the incidence and factors influencing radial artery occlusion (RAO) post trans-radial access (TRA) for cardiac catheterization. Background: RAO may occur post trans-radial intervention and limits the radial artery... Read More about Radial artery occlusion after transradial interventions: a systematic review and meta-analysis.

Revascularization for Left Anterior Descending Artery Stenosis: A Review of the Evidence That Supports Practice (2016)
Journal Article
Mamas. (2016). Revascularization for Left Anterior Descending Artery Stenosis: A Review of the Evidence That Supports Practice. Cardiology in Review, https://doi.org/10.1097/CRD.0000000000000097

Disease of the proximal left anterior descending (LAD) artery is a common pathological finding often combined with disease in other coronary arteries. In this article we review specifically the evidence (and the guidelines arising from the data) for... Read More about Revascularization for Left Anterior Descending Artery Stenosis: A Review of the Evidence That Supports Practice.

Impact of operator volume for percutaneous coronary intervention (PCI) on clinical outcomes: what do the numbers say? (2016)
Journal Article
Mamas, M., & Rashid, M. (2016). Impact of operator volume for percutaneous coronary intervention (PCI) on clinical outcomes: what do the numbers say?. European Heart Journal, 16-22. https://doi.org/10.1093/ehjqcco/qcv030

The impact of operator and centre volume on clinical outcomes and quality of care has been of considerable debate in recent years in a number of surgical- and procedural-based specialities. A relationship between higher volumes at both the institutio... Read More about Impact of operator volume for percutaneous coronary intervention (PCI) on clinical outcomes: what do the numbers say?.

Risk Related to Pre–Diabetes Mellitus and Diabetes Mellitus in Heart Failure With Reduced Ejection Fraction (2016)
Journal Article
Mamas. (2016). Risk Related to Pre–Diabetes Mellitus and Diabetes Mellitus in Heart Failure With Reduced Ejection Fraction. Circulation: Heart Failure, https://doi.org/10.1161/CIRCHEARTFAILURE.115.002560

Background— The prevalence of pre–diabetes mellitus and its consequences in patients with heart failure and reduced ejection fraction are not known. We investigated these in the Prospective Comparison of ARNI With ACEI to Determine Impact on Global... Read More about Risk Related to Pre–Diabetes Mellitus and Diabetes Mellitus in Heart Failure With Reduced Ejection Fraction.

Major Bleeding and Adverse Outcome following Percutaneous Coronary Intervention (2015)
Journal Article
Holroyd, E. W., Khoo, C. W., Butler, R., Fraser, D. G., Nolan, J., & Mamas, M. A. (2015). Major Bleeding and Adverse Outcome following Percutaneous Coronary Intervention. Interventional Cardiology: Reviews, Research, Resources, 10(1), 22-25. https://doi.org/10.15420/icr.2015.10.1.22

Advances in anti-thrombotic and anti-platelet therapies have improved outcomes in patients undergoing percutaneous coronary interventions (PCIs) through a reduction in ischaemic events, at the expense of peri-procedural bleeding complications. These... Read More about Major Bleeding and Adverse Outcome following Percutaneous Coronary Intervention.

Bivalirudin, glycoprotein inhibitor and heparin use and association with outcomes of primary percutaneous coronary intervention in the United Kingdom (2015)
Journal Article
Mamas. (2015). Bivalirudin, glycoprotein inhibitor and heparin use and association with outcomes of primary percutaneous coronary intervention in the United Kingdom. European Heart Journal, 1312-1320. https://doi.org/10.1093/eurheartj/ehv631

The HORIZONS trial reported a survival advantage for bivalirudin over heparin-with-glycoprotein inhibitors (GPIs) in primary PCI for ST elevation myocardial infarction. This drove an international shift in clinical practice. Subsequent studies have p... Read More about Bivalirudin, glycoprotein inhibitor and heparin use and association with outcomes of primary percutaneous coronary intervention in the United Kingdom.

Effect of age on the prognostic value of left ventricular function in patients with acute coronary syndrome: a prospective registry study (2015)
Journal Article
Mamas. (2015). Effect of age on the prognostic value of left ventricular function in patients with acute coronary syndrome: a prospective registry study. European Heart Journal: Acute Cardiovascular Care, 191-198. https://doi.org/10.1177/2048872615623038

Objective: This study aims to study the prognostic impact of LV function on mortality and examine the effect of age on the prognostic value of left ventricular function. Methods: We examined the Myocardial Ischaemia National Audit Project (MINAP) reg... Read More about Effect of age on the prognostic value of left ventricular function in patients with acute coronary syndrome: a prospective registry study.

Long-term glycaemic variability and risk of adverse outcomes: a systematic review and meta-analysis (2015)
Journal Article
Mamas. (2015). Long-term glycaemic variability and risk of adverse outcomes: a systematic review and meta-analysis. Diabetes Care, 2354-2369. https://doi.org/10.2337/dc15-1188

OBJECTIVE Glycemic variability is emerging as a measure of glycemic control, which may be a reliable predictor of complications. This systematic review and meta-analysis evaluates the association between HbA1c variability and micro- and macrovascular... Read More about Long-term glycaemic variability and risk of adverse outcomes: a systematic review and meta-analysis.

Letter to the Editor Regarding “Efficacy of Radial Versus Femoral Access in the Acute Coronary Syndrome: Is it the operator or the operation that matters?” by Michel LeMay MD and colleagues (2015)
Journal Article
Mamas, M., & Nolan, J. (2015). Letter to the Editor Regarding “Efficacy of Radial Versus Femoral Access in the Acute Coronary Syndrome: Is it the operator or the operation that matters?” by Michel LeMay MD and colleagues. JACC: Cardiovascular Interventions, 1405-1409. https://doi.org/10.1016/j.jcin.2015.06.016

In the recently published MATRIX (Minimizing Adverse Haemorrhagic Events by TRansradial Access Site and Systemic Implementation of angioX) trial, the use of transradial access (TRA) compared to transfemoral access (TFA) during percutaneous coronary i... Read More about Letter to the Editor Regarding “Efficacy of Radial Versus Femoral Access in the Acute Coronary Syndrome: Is it the operator or the operation that matters?” by Michel LeMay MD and colleagues.

Coronary perforation complicating percutaneous coronary intervention in patients with a history of coronary artery bypass surgery: an analysis of 309 perforation cases from the British Cardiovascular Intervention Society database (2015)
Journal Article
Mamas. (2015). Coronary perforation complicating percutaneous coronary intervention in patients with a history of coronary artery bypass surgery: an analysis of 309 perforation cases from the British Cardiovascular Intervention Society database. Circulation: Cardiovascular Interventions, https://doi.org/10.1161/CIRCINTERVENTIONS.117.005581

Background: The evidence base for coronary perforation (CP) occurring during percutaneous coronary intervention in patients with a history of bypass surgery (PCI-CABG) is limited and the long-term effects unclear. Using a national PCI database, the i... Read More about Coronary perforation complicating percutaneous coronary intervention in patients with a history of coronary artery bypass surgery: an analysis of 309 perforation cases from the British Cardiovascular Intervention Society database.

Intra-arterial vasodilators to prevent radial artery spasm: a systematic review and pooled analysis of clinical studies (2015)
Journal Article
Nolan, Rashid, & Mamas. (2015). Intra-arterial vasodilators to prevent radial artery spasm: a systematic review and pooled analysis of clinical studies. Cardiovascular Revascularization Medicine, 484-490. https://doi.org/10.1016/j.carrev.2015.08.008

Objectives The aim of this study is to review the available literature on the efficacy and safety of agents used for prevention of RAS. Background Different vasodilator agents have been used to prevent radial artery spasm (RAS) in patients under... Read More about Intra-arterial vasodilators to prevent radial artery spasm: a systematic review and pooled analysis of clinical studies.

Effect of access site, gender, and indication on clinical outcomes after percutaneous coronary intervention: Insights from the British Cardiovascular Intervention Society (BCIS) (2015)
Journal Article
Mamas, & Nolan. (2015). Effect of access site, gender, and indication on clinical outcomes after percutaneous coronary intervention: Insights from the British Cardiovascular Intervention Society (BCIS). American Heart Journal, 164-172. https://doi.org/10.1016/j.ahj.2015.04.018

Background Gender is a strong predictor of periprocedural major bleeding complications after percutaneous coronary intervention (PCI). The access site represents an important site of such bleeding complications, which has driven adoption of the tran... Read More about Effect of access site, gender, and indication on clinical outcomes after percutaneous coronary intervention: Insights from the British Cardiovascular Intervention Society (BCIS).

Prevalence and Impact of Co-morbidity Burden as Defined by the Charlson Co-morbidity Index on 30-Day and 1- and 5-Year Outcomes After Coronary Stent Implantation (from the Nobori-2 Study). (2015)
Journal Article
Mamas. (2015). Prevalence and Impact of Co-morbidity Burden as Defined by the Charlson Co-morbidity Index on 30-Day and 1- and 5-Year Outcomes After Coronary Stent Implantation (from the Nobori-2 Study). American Journal of Cardiology, 364-371. https://doi.org/10.1016/j.amjcard.2015.04.047

Influenza, influenza-like symptoms and their association with cardiovascular risks: a systematic review and meta-analysis of observational studies (2015)
Journal Article
Kwok, C. S., Aslam, S., Kontopantelis, E., Myint, P. K., Zaman, M. J. S., Buchan, I., …Mamas, M. A. (2015). Influenza, influenza-like symptoms and their association with cardiovascular risks: a systematic review and meta-analysis of observational studies. International Journal of Clinical Practice, 69(9), 928-937. https://doi.org/10.1111/ijcp.12646

Early diagnosis of cardiac implantable electronic device generator pocket infection using 18F-FDG-PET/CT (2015)
Journal Article
Mamas. (2015). Early diagnosis of cardiac implantable electronic device generator pocket infection using 18F-FDG-PET/CT. European Heart Journal - Cardiovascular Imaging, 521 - 530. https://doi.org/10.1093/ehjci/jeu295

AIMS: To examine the utility of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) in the early diagnosis of cardiac implantable electronic device (CIED) generator pocket infection. METHODS AND RESULTS: A tot... Read More about Early diagnosis of cardiac implantable electronic device generator pocket infection using 18F-FDG-PET/CT.

Incidence and mechanisms of longitudinal stent deformation associated with Biomatrix, Resolute, Element, and Xience stents: Angiographic and case‐by‐case review of 1,800 PCIs (2015)
Journal Article
Arnous, S., Shakhshir, N., Wiper, A., Ordoubadi, F., Williams, P., Clarke, B., …Fraser, D. (2015). Incidence and mechanisms of longitudinal stent deformation associated with Biomatrix, Resolute, Element, and Xience stents: Angiographic and case‐by‐case review of 1,800 PCIs. Catheterization and Cardiovascular Interventions, 86(6), 1002-1011. https://doi.org/10.1002/ccd.25790

Stroke following percutaneous coronary intervention: type-specific incidence, outcomes and determinants seen by the British Cardiovascular Intervention Society 2007-12 (2015)
Journal Article
Shing Kwok, C., Kontopantelis, E., Myint, P. K., Zaman, A., Berry, C., Keavney, B., …Mamas, M. (2015). Stroke following percutaneous coronary intervention: type-specific incidence, outcomes and determinants seen by the British Cardiovascular Intervention Society 2007-12. European Heart Journal, 36(25), 1618 -1628. https://doi.org/10.1093/eurheartj/ehv113

AIMS: This study aims to evaluate temporal changes in stroke complications and their association with mortality and MACE outcomes in a national cohort of patients undergoing percutaneous coronary interventions (PCIs) in England and Wales. METHODS AND... Read More about Stroke following percutaneous coronary intervention: type-specific incidence, outcomes and determinants seen by the British Cardiovascular Intervention Society 2007-12.

Access and Non–Access Site Bleeding After Percutaneous Coronary Intervention and Risk of Subsequent Mortality and Major Adverse Cardiovascular Events: Systematic Review and Meta-Analysis (2015)
Journal Article
Kwok, C. S., Khan, M. A., Rao, S. V., Kinnaird, T., Sperrin, M., Buchan, I., …Mamas, M. A. (2015). Access and Non–Access Site Bleeding After Percutaneous Coronary Intervention and Risk of Subsequent Mortality and Major Adverse Cardiovascular Events: Systematic Review and Meta-Analysis. Circulation: Cardiovascular Interventions, 8(4), https://doi.org/10.1161/circinterventions.114.001645

Background— The prognostic impact of site-specific major bleeding complications after percutaneous coronary intervention (PCI) has yielded conflicting data. The aim of this study is to provide an overview of site-specific major bleeding events in co... Read More about Access and Non–Access Site Bleeding After Percutaneous Coronary Intervention and Risk of Subsequent Mortality and Major Adverse Cardiovascular Events: Systematic Review and Meta-Analysis.

Impact of age on access site‐related outcomes in 469,983 percutaneous coronary intervention procedures: Insights from the British Cardiovascular Intervention Society (2015)
Journal Article
Anderson, S. G., Ratib, K., Myint, P. K., Keavney, B., Kwok, C. S., Zaman, A., …Mamas, M. A. (2015). Impact of age on access site‐related outcomes in 469,983 percutaneous coronary intervention procedures: Insights from the British Cardiovascular Intervention Society. Catheterization and Cardiovascular Interventions, 86(6), 965-972. https://doi.org/10.1002/ccd.25896

We investigate adoption of the TRA in different age groups and study the relationship between age and access site related outcomes in a national cohort of patients undergoing PCI in the UK. Previous studies have reported conflicting data on radial ac... Read More about Impact of age on access site‐related outcomes in 469,983 percutaneous coronary intervention procedures: Insights from the British Cardiovascular Intervention Society.

Cardiac resynchronisation therapy is not associated with a reduction in mortality or heart failure hospitalisation in patients with non-left bundle branch block QRS morphology: meta-analysis of randomised controlled trials (2015)
Journal Article
Cunnington, C., Kwok, C. S., Satchithananda, D. K., Patwala, A., Khan, M. A., Zaidi, A., …Mamas, M. A. (2015). Cardiac resynchronisation therapy is not associated with a reduction in mortality or heart failure hospitalisation in patients with non-left bundle branch block QRS morphology: meta-analysis of randomised controlled trials. Heart, 101(18), 1456-1462. https://doi.org/10.1136/heartjnl-2014-306811

Access Site Practice and Procedural Outcomes in Relation to Clinical Presentation in 439,947 Patients Undergoing Percutaneous Coronary Intervention in the United Kingdom (2015)
Journal Article
Ratib, K., Mamas, M. A., Anderson, S. G., Bhatia, G., Routledge, H., De Belder, M., …Nolan, J. (2015). Access Site Practice and Procedural Outcomes in Relation to Clinical Presentation in 439,947 Patients Undergoing Percutaneous Coronary Intervention in the United Kingdom. JACC: Cardiovascular Interventions, 8(1), 20-29. https://doi.org/10.1016/j.jcin.2014.06.026

Objectives This study sought to determine the relationships among access site practice, clinical presentation, and procedural outcomes in a large patient population. Background Transradial access (TRA) has been associated with improved patient o... Read More about Access Site Practice and Procedural Outcomes in Relation to Clinical Presentation in 439,947 Patients Undergoing Percutaneous Coronary Intervention in the United Kingdom.

A Two-stage Dynamic Model to Enable Updating of Clinical Risk Prediction from Longitudinal Health Record Data: illustrated with Kidney Function (2015)
Book Chapter
Mamas. (2015). A Two-stage Dynamic Model to Enable Updating of Clinical Risk Prediction from Longitudinal Health Record Data: illustrated with Kidney Function. In Medinfo 2015: Proceedings of the 15th World Congress on Health and Biomedical Informatics (696-700). https://doi.org/10.3233/978-1-61499-564-7-696

We demonstrate the use of electronic records and repeated measures of risk factors therein, to enable deeper understanding of the relationship between the full longitudinal trajectory of risk factors and outcomes. To illustrate, dynamic mixed effect... Read More about A Two-stage Dynamic Model to Enable Updating of Clinical Risk Prediction from Longitudinal Health Record Data: illustrated with Kidney Function.

Impact of age on the prognostic value of left ventricular function in relation to procedural outcomes following percutaneous coronary intervention: Insights from the British cardiovascular intervention society (2014)
Journal Article
Kwok, C. S., Anderson, S. G., McAllister, K. S., Sperrin, M., O'Kane, P. D., Keavney, B., …Mamas, M. A. (2015). Impact of age on the prognostic value of left ventricular function in relation to procedural outcomes following percutaneous coronary intervention: Insights from the British cardiovascular intervention society. Catheterization and Cardiovascular Interventions, 85(6), 944-951. https://doi.org/10.1002/ccd.25732

Background Around one third of patients undergoing percutaneous coronary intervention (PCI) have left ventricular (LV) dysfunction. Whilst the prevalence of LV dysfunction is known to increase with age, the prevalence of LV dysfunction in different... Read More about Impact of age on the prognostic value of left ventricular function in relation to procedural outcomes following percutaneous coronary intervention: Insights from the British cardiovascular intervention society.

Baseline Bleeding Risk and Arterial Access Site Practice in Relation to Procedural Outcomes After Percutaneous Coronary Intervention (2014)
Journal Article
Mamas, M. A., Anderson, S. G., Carr, M., Ratib, K., Buchan, I., Sirker, A., …Nolan, J. (2014). Baseline Bleeding Risk and Arterial Access Site Practice in Relation to Procedural Outcomes After Percutaneous Coronary Intervention. Journal of the American College of Cardiology, 64(15), 1554-1564. https://doi.org/10.1016/j.jacc.2014.05.075

Background Transradial access (TRA) has been associated with reduced access site–related bleeding complications and mortality after percutaneous coronary intervention (PCI). It is unclear, however, whether these observed benefits are influenced by b... Read More about Baseline Bleeding Risk and Arterial Access Site Practice in Relation to Procedural Outcomes After Percutaneous Coronary Intervention.

Heart 'omics' in AGEing (HOMAGE): design, research objectives and characteristics of the common database (2014)
Journal Article
Mamas. (2014). Heart 'omics' in AGEing (HOMAGE): design, research objectives and characteristics of the common database. Journal of Biomedical Research, 349 -359. https://doi.org/10.7555/JBR.28.20140045

Heart failure is common in older people and its prevalence is increasing. The Heart 'omics' in AGEing (HOMAGE) project aims to provide a biomarker approach that will improve the early diagnosis of heart failure. A large clinical database, based on (1... Read More about Heart 'omics' in AGEing (HOMAGE): design, research objectives and characteristics of the common database.

Impact of left ventricular function in relation to procedural outcomes following percutaneous coronary intervention: insights from the British Cardiovascular Intervention Society (2014)
Journal Article
Mamas, M. A., Anderson, S. G., O'Kane, P. D., Keavney, B., Nolan, J., Oldroyd, K. G., …de Belder, M. A. (2014). Impact of left ventricular function in relation to procedural outcomes following percutaneous coronary intervention: insights from the British Cardiovascular Intervention Society. European Heart Journal, 35(43), 3004-3012. https://doi.org/10.1093/eurheartj/ehu303

Aim Between 10 and 30% of patients undergoing percutaneous coronary intervention (PCI) have left ventricular (LV) dysfunction. We investigate the association between LV function on early and late mortality outcomes in a national ‘real-world’ cohort... Read More about Impact of left ventricular function in relation to procedural outcomes following percutaneous coronary intervention: insights from the British Cardiovascular Intervention Society.

Renal denervation and blood pressure reduction in resistant hypertension: a systematic review and meta-analysis (2014)
Journal Article
Mamas. (2014). Renal denervation and blood pressure reduction in resistant hypertension: a systematic review and meta-analysis. Open Heart, e000092 -?. https://doi.org/10.1136/openhrt-2014-000092

OBJECTIVE: The objective of this study is to evaluate the efficacy and safety of renal denervation in patients with resistant hypertension. METHODS: We searched MEDLINE and EMBASE for studies that evaluated the use of catheter-based renal sympathetic... Read More about Renal denervation and blood pressure reduction in resistant hypertension: a systematic review and meta-analysis.

Arterial access site utilization in cardiogenic shock in the United Kingdom: Is radial access feasible? (2014)
Journal Article
Mamas, M. A., Anderson, S. G., Ratib, K., Routledge, H., Neyses, L., Fraser, D. G., …Nolan, J. (2014). Arterial access site utilization in cardiogenic shock in the United Kingdom: Is radial access feasible?. American Heart Journal, 167(6), 900-908.e1. https://doi.org/10.1016/j.ahj.2014.03.007

Background Cardiogenic shock (CS) remains the leading cause of mortality in patients hospitalized with acute myocardial infarction (AMI). The transradial access site (TRA) has become increasingly adopted as a default access site for percutaneous cor... Read More about Arterial access site utilization in cardiogenic shock in the United Kingdom: Is radial access feasible?.

Outcomes in patients with acute and stable coronary syndromes: insights from the prospective NOBORI-2 study (2014)
Journal Article
Mamas. (2014). Outcomes in patients with acute and stable coronary syndromes: insights from the prospective NOBORI-2 study. PloS one, e88577 -?. https://doi.org/10.1371/journal.pone.0088577

BACKGROUND: Contemporary data remains limited regarding mortality and major adverse cardiac events (MACE) outcomes in patients undergoing PCI for different manifestations of coronary artery disease. OBJECTIVES: We evaluated mortality and MACE outcome... Read More about Outcomes in patients with acute and stable coronary syndromes: insights from the prospective NOBORI-2 study.

Major bleeding after percutaneous coronary intervention and risk of subsequent mortality: a systematic review and meta-analysis. (2014)
Journal Article
Mamas, M., & Nolan, J. (2014). Major bleeding after percutaneous coronary intervention and risk of subsequent mortality: a systematic review and meta-analysis. Open Heart, e000021 -?. https://doi.org/10.1136/openhrt-2013-000021

OBJECTIVES: To examine the relationship between periprocedural bleeding complications and major adverse cardiovascular events (MACEs) and mortality outcomes following percutaneous coronary intervention (PCI) and study differences in the prognostic im... Read More about Major bleeding after percutaneous coronary intervention and risk of subsequent mortality: a systematic review and meta-analysis..

TCT-40 BASELINE BLEEDING RISK AND ARTERIAL ACCESS SITE PRACTICE IN RELATION TO PROCEDURAL OUTCOMES FOLLOWING PERCUTANEOUS CORONARY INTERVENTION (2013)
Journal Article
Mamas, M., Anderson, S. G., Ratib, K., Fraser, D. G., de Belder, M., Ludman, P., & Nolan, J. (2013). TCT-40 BASELINE BLEEDING RISK AND ARTERIAL ACCESS SITE PRACTICE IN RELATION TO PROCEDURAL OUTCOMES FOLLOWING PERCUTANEOUS CORONARY INTERVENTION. Journal of the American College of Cardiology, 62(18), B14. https://doi.org/10.1016/j.jacc.2013.08.771

Serum sphingolipids level as a novel potential marker for early detection of human myocardial ischaemic injury (2013)
Journal Article
Mamas. (2013). Serum sphingolipids level as a novel potential marker for early detection of human myocardial ischaemic injury. Frontiers in Physiology, 130 - ?. https://doi.org/10.3389/fphys.2013.00130

BACKGROUND: Ventricular tachyarrhythmias are the most common and often the first manifestation of coronary heart disease and lead to sudden cardiac death (SCD). Early detection/identification of acute myocardial ischaemic injury at risk for malignant... Read More about Serum sphingolipids level as a novel potential marker for early detection of human myocardial ischaemic injury.

Atrial fibrillation in heart failure: an innocent bystander? (2012)
Journal Article
Mamas. (2012). Atrial fibrillation in heart failure: an innocent bystander?. Current Cardiology Reviews, 273 - 280. https://doi.org/10.2174/157340312803760839

Heart failure (HF) and atrial fibrillation (AF) frequently coexist and each complicates the course of the other. The purpose of this review is to analyse the prognostic impact of AF in patients with HF and assess whether there is an advantage in targ... Read More about Atrial fibrillation in heart failure: an innocent bystander?.

Automated workflows for accurate mass-based putative metabolite identification in LC/MS-derived metabolomic datasets (2011)
Journal Article
Mamas. (2011). Automated workflows for accurate mass-based putative metabolite identification in LC/MS-derived metabolomic datasets. Bioinformatics, 1108 -1112. https://doi.org/10.1093/bioinformatics/btr079

MOTIVATION: The study of metabolites (metabolomics) is increasingly being applied to investigate microbial, plant, environmental and mammalian systems. One of the limiting factors is that of chemically identifying metabolites from mass spectrometric... Read More about Automated workflows for accurate mass-based putative metabolite identification in LC/MS-derived metabolomic datasets.

Outcomes following percutaneous coronary intervention in Non-ST-segment elevation myocardial infarction patients with previous coronary artery bypass grafts surgery
Presentation / Conference
Shoaib, A., Kinnaird, T., Curzen, N., Ludman, P., Belder, M., Rashid, M., …Mamas, M. Outcomes following percutaneous coronary intervention in Non-ST-segment elevation myocardial infarction patients with previous coronary artery bypass grafts surgery. Paper presented at European-Society-of-Cardiology Congress 2018 - AUG 25-29, 2018, Munich, GERMANY

The impact of musculoskeletal conditions on outcomes of other illnesses (the MSKCOM study): a linked electronic health record study - Code lists
Dataset
Marshall, M., Mason, K., Bailey, J., Heron, N., Achanca, F., Chen, Y., …Jordan, K. (2022). The impact of musculoskeletal conditions on outcomes of other illnesses (the MSKCOM study): a linked electronic health record study - Code lists. [Dataset]

Marshall M, Mason K, Bailey J, Heron N, Achana F, Chen Y, Edwards J, Frisher M, Huntley A, Mallen C, Mamas M, Png ME, Tatton S, White S, Jordan KP. MSKCOM: main Public Output: The impact of musculoskeletal conditions on outcomes of other illnesses: a... Read More about The impact of musculoskeletal conditions on outcomes of other illnesses (the MSKCOM study): a linked electronic health record study - Code lists.

Outcomes from selective use of thrombectomy in patients undergoing primary percutaneous coronary intervention for ST elevation myocardial infarction: an analysis of the British Cardiovascular Intervention Society/National Institute for Cardiovascular Outcomes Research (BCIS-NICOR) registry 2006-2013
Journal Article
Mamas. (2016). Outcomes from selective use of thrombectomy in patients undergoing primary percutaneous coronary intervention for ST elevation myocardial infarction: an analysis of the British Cardiovascular Intervention Society/National Institute for Cardiovascular Outcomes Research (BCIS-NICOR) registry 2006-2013. JACC: Cardiovascular Interventions, 126-134. https://doi.org/10.1016/j.jcin.2015.10.047

Objectives This study used a large national cohort to examine patterns of thrombectomy use in ST-segment elevation myocardial infarction (STEMI) and the relationship to mortality. Background The impact of coronary thrombectomy on mortality in ST... Read More about Outcomes from selective use of thrombectomy in patients undergoing primary percutaneous coronary intervention for ST elevation myocardial infarction: an analysis of the British Cardiovascular Intervention Society/National Institute for Cardiovascular Outcomes Research (BCIS-NICOR) registry 2006-2013.

SEX DIFFERENCES IN HIGH-RISK BUT INDICATED CORONARY INTERVENTIONS. NATIONAL REPORT FROM THE BRITISH CARDIOVASCULAR INTERVENTION SOCIETY REGISTRY
Presentation / Conference
Mamas, & Rashid. SEX DIFFERENCES IN HIGH-RISK BUT INDICATED CORONARY INTERVENTIONS. NATIONAL REPORT FROM THE BRITISH CARDIOVASCULAR INTERVENTION SOCIETY REGISTRY. Presented at ACC.22

Background: Complex and high-risk but indicated percutaneous coronary intervention (CHiP) is increasingly common in contemporary PCI practice. Data on sex differences in the type of CHiP procedures undertaken or their associated clinical outcomes are... Read More about SEX DIFFERENCES IN HIGH-RISK BUT INDICATED CORONARY INTERVENTIONS. NATIONAL REPORT FROM THE BRITISH CARDIOVASCULAR INTERVENTION SOCIETY REGISTRY.

Fifteen-Year Trends in the Rates of Elective Percutaneous Coronary Intervention and Impact of COURAGE and ORBITA Trials: Insights From British Cardiovascular Intervention Society Dataset
Presentation / Conference
Mamas, & Rashid. Fifteen-Year Trends in the Rates of Elective Percutaneous Coronary Intervention and Impact of COURAGE and ORBITA Trials: Insights From British Cardiovascular Intervention Society Dataset. Presented at Transcatheter Cardiovascular Therapeutics

Background This study was designed to evaluate temporal trends in elective rates of percutaneous coronary intervention (PCI) for stable angina and, specifically, to study the impact of the COURAGE and ORBITA trials on real-life practice. Methods We a... Read More about Fifteen-Year Trends in the Rates of Elective Percutaneous Coronary Intervention and Impact of COURAGE and ORBITA Trials: Insights From British Cardiovascular Intervention Society Dataset.

Prevalence of cardiovascular risk factors in osteoarthritis patients derived from primary care records: a systematic review of observational studies
Journal Article
Huang, X., Wilkie, R., Mamas, M. A., & Yu, D. Prevalence of cardiovascular risk factors in osteoarthritis patients derived from primary care records: a systematic review of observational studies. arXiv, https://doi.org/10.1101/2021.02.14.21251130

Background People with osteoarthritis are at a high risk of cardiovascular disease (CVD). Detecting CVD risk factors in this high-risk population will help to improve CVD outcomes. Primary care electronic health records (EHRs) provide opportunities f... Read More about Prevalence of cardiovascular risk factors in osteoarthritis patients derived from primary care records: a systematic review of observational studies.

Is the Current Threshold for Diagnosis of 'Abnormality', Including Non ST Elevation Myocardial Infarction, Using Raised High Sensitivity Troponin Appropriate for a Hospital Population? The CHARIOT Study
Journal Article
Mariathas, M., Allan, R., Ramamoorthy, S., Olechowski, B., Hinton, J., Azor, M., …Curzen, N. Is the Current Threshold for Diagnosis of 'Abnormality', Including Non ST Elevation Myocardial Infarction, Using Raised High Sensitivity Troponin Appropriate for a Hospital Population? The CHARIOT Study. Lancet, https://doi.org/10.2139/ssrn.3228899