Christine Roffe's Outputs (32)

Suction force-suction distance relation during aspiration thrombectomy for ischemic stroke: A computational fluid dynamics study (2016)
Journal Article
Roffe. (2016). Suction force-suction distance relation during aspiration thrombectomy for ischemic stroke: A computational fluid dynamics study. https://doi.org/10.1016/j.phmed.2016.11.001

Acute Ischemic Stroke (AIS) is the major type of stroke occurring in patients. Aspiration thrombectomy, which uses suction to remove the thrombosis, is a promising technique in the clinical treatment of AIS patients. In this research a computational... Read More about Suction force-suction distance relation during aspiration thrombectomy for ischemic stroke: A computational fluid dynamics study.

Principles of practice parameters for the treatment of sleep disordered breathing in the elderly and frail elderly: the consensus of the International Geriatric Sleep Medicine Task Force (2016)
Journal Article
Roffe. (2016). Principles of practice parameters for the treatment of sleep disordered breathing in the elderly and frail elderly: the consensus of the International Geriatric Sleep Medicine Task Force. European Respiratory Journal, 992-1018. https://doi.org/10.1183/13993003.01975-2015

Sleep disordered breathing (SDB) is a leading cause of morbidity worldwide. Its prevalence increases with age. Due to the demographic changes in industrial societies, pulmonologists and sleep physicians are confronted with a rapidly growing number of... Read More about Principles of practice parameters for the treatment of sleep disordered breathing in the elderly and frail elderly: the consensus of the International Geriatric Sleep Medicine Task Force.

Clinical risk scores for predicting stroke-associated pneumonia: A systematic review (2016)
Journal Article
Roffe. (2016). Clinical risk scores for predicting stroke-associated pneumonia: A systematic review. European Stroke Journal, 76 - 84. https://doi.org/10.1177/2396987316651759

Purpose
Several risk stratification scores for predicting stroke-associated pneumonia have been derived. We aimed to evaluate the performance and clinical usefulness of such scores for predicting stroke-associated pneumonia.

Method
A systematic... Read More about Clinical risk scores for predicting stroke-associated pneumonia: A systematic review.

Low-Dose versus Standard-Dose Intravenous Alteplase in Acute Ischemic Stroke (2016)
Journal Article
Roffe. (2016). Low-Dose versus Standard-Dose Intravenous Alteplase in Acute Ischemic Stroke. New England Journal of Medicine, 2313-2323. https://doi.org/10.1056/NEJMoa1515510

BACKGROUND
Thrombolytic therapy for acute ischemic stroke with a lower-than-standard dose of intravenous alteplase may improve recovery along with a reduced risk of intracerebral hemorrhage.

METHODS
Using a 2-by-2 quasi-factorial open-label desi... Read More about Low-Dose versus Standard-Dose Intravenous Alteplase in Acute Ischemic Stroke.

Determinants and outcomes of stroke following percutaneous coronary intervention by indication (2016)
Journal Article
Roffe, & Mamas. (2016). Determinants and outcomes of stroke following percutaneous coronary intervention by indication. Stroke, 1500-1507. https://doi.org/10.1161/strokeaha.116.012700

Background and Purpose—Stroke after percutaneous coronary intervention (PCI) is a serious complication, but its determinants and outcomes after PCI in different clinical settings are poorly documented.

Methods—The British Cardiovascular Interventi... Read More about Determinants and outcomes of stroke following percutaneous coronary intervention by indication.

Intravenous tranexamic acid for hyperacute primary intracerebral hemorrhage: Protocol for a randomized, placebo-controlled trial (2016)
Journal Article
Roffe. (2016). Intravenous tranexamic acid for hyperacute primary intracerebral hemorrhage: Protocol for a randomized, placebo-controlled trial. International Journal of Stroke, 683-694. https://doi.org/10.1177/1747493016641960

Rationale
Outcome after intracerebral hemorrhage remains poor. Tranexamic acid is easy to administer, readily available, inexpensive, and effective in other hemorrhagic conditions.

Aim
This randomized trial aims to test the hypothesis that intra... Read More about Intravenous tranexamic acid for hyperacute primary intracerebral hemorrhage: Protocol for a randomized, placebo-controlled trial.

Post-stroke dysphagia: A review and design considerations for future trials (2016)
Journal Article
Roffe. (2016). Post-stroke dysphagia: A review and design considerations for future trials. International Journal of Stroke, 399 - 411. https://doi.org/10.1177/1747493016639057

Post-stroke dysphagia (a difficulty in swallowing after a stroke) is a common and expensive complication of acute stroke and is associated with increased mortality, morbidity, and institutionalization due in part to aspiration, pneumonia, and malnutr... Read More about Post-stroke dysphagia: A review and design considerations for future trials.

In vitro experiments of cerebral blood flow during aspiration thrombectomy: potential effects on cerebral perfusion pressure and collateral flow (2015)
Journal Article
Roffe, Yang, & Naire. (2015). In vitro experiments of cerebral blood flow during aspiration thrombectomy: potential effects on cerebral perfusion pressure and collateral flow. Journal of NeuroInterventional Surgery, 969-972. https://doi.org/10.1136/neurintsurg-2015-011909

BACKGROUND: Mechanical thrombectomy with stent retriever devices is associated with significantly better outcomes than thrombolysis alone in the treatment of acute ischemic stroke. Thrombus aspiration achieves high patency rates, but clinical outcome... Read More about In vitro experiments of cerebral blood flow during aspiration thrombectomy: potential effects on cerebral perfusion pressure and collateral flow.

Differences in Factors Predicting Outcome and Mortality after Mechanical Thrombectomy for Acute Large Vessel Stroke Between Patients over and Under 70 Years of Age: A Five Year Retrospective Study (2015)
Journal Article
Roffe. (2015). Differences in Factors Predicting Outcome and Mortality after Mechanical Thrombectomy for Acute Large Vessel Stroke Between Patients over and Under 70 Years of Age: A Five Year Retrospective Study. Symbiosis, 1-8. https://doi.org/10.15226/2374-6858/2/1/00114

Aim: To assess the differences in risk factors between different age groups after mechanical thrombectomy (MT) for ischaemic stroke, including recanalization time and functional and radiological scoring.

Methods: Patients treated between December... Read More about Differences in Factors Predicting Outcome and Mortality after Mechanical Thrombectomy for Acute Large Vessel Stroke Between Patients over and Under 70 Years of Age: A Five Year Retrospective Study.

Statistical analysis plan for the Stroke Oxygen Study (SO2S): a multi-center randomized controlled trial to assess whether routine oxygen supplementation in the first 72 hours after a stroke improves long-term outcome. (2014)
Journal Article
Ives, N., Sim, J., Gray, R., Roffe, C., Nevatte, T., & Howman, A. (2014). Statistical analysis plan for the Stroke Oxygen Study (SO2S): a multi-center randomized controlled trial to assess whether routine oxygen supplementation in the first 72 hours after a stroke improves long-term outcome. Trials, 15, Article ARTN 229. https://doi.org/10.1186/1745-6215-15-229

BACKGROUND: The Stroke Oxygen Study (SO2S) is a multi-center randomized controlled trial of oxygen supplementation in patients with acute stroke. The main hypothesis for the trial is that fixed-dose oxygen treatment during the first 3 days after an a... Read More about Statistical analysis plan for the Stroke Oxygen Study (SO2S): a multi-center randomized controlled trial to assess whether routine oxygen supplementation in the first 72 hours after a stroke improves long-term outcome..

The Stroke Oxygen Study (SO2S) - a multi-center, study to assess whether routine oxygen treatment in the first 72 hours after a stroke improves long-term outcome: study protocol for a randomized controlled trial. (2014)
Journal Article
Roffe, C., Nevatte, T., Crome, P., Gray, R., Sim, J., Pountain, S., …Handy, P. (2014). The Stroke Oxygen Study (SO2S) - a multi-center, study to assess whether routine oxygen treatment in the first 72 hours after a stroke improves long-term outcome: study protocol for a randomized controlled trial. Trials, 15, Article 99. https://doi.org/10.1186/1745-6215-15-99

BACKGROUND: Mild hypoxia is common in stroke patients and may have significant adverse effects on the ischemic brain after stroke. The use of oxygen treatment is rapidly increasing in European stroke units but is not without side effects. It impedes... Read More about The Stroke Oxygen Study (SO2S) - a multi-center, study to assess whether routine oxygen treatment in the first 72 hours after a stroke improves long-term outcome: study protocol for a randomized controlled trial..

The stroke oxygen pilot study: a randomized controlled trial of the effects of routine oxygen supplementation early after acute stroke--effect on key outcomes at six months (2013)
Journal Article
Ali, K., Warusevitane, A., Lally, F., Sim, J., Sills, S., Pountain, S., …Roffe, C. (2013). The stroke oxygen pilot study: a randomized controlled trial of the effects of routine oxygen supplementation early after acute stroke--effect on key outcomes at six months. PloS one, 8(6), Article e59274. https://doi.org/10.1371/journal.pone.0059274

INTRODUCTION: Post-stroke hypoxia is common, and may adversely affect outcome. We have recently shown that oxygen supplementation may improve early neurological recovery. Here, we report the six-month outcomes of this pilot study. METHODS: Patients w... Read More about The stroke oxygen pilot study: a randomized controlled trial of the effects of routine oxygen supplementation early after acute stroke--effect on key outcomes at six months.