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Christine Roffe's Outputs (76)

Early Diagnosis of Pneumonia in Severe Stroke: Clinical Features and the Diagnostic Role of C-Reactive Protein (2016)
Journal Article
Warusevitane, A., Karunatilake, D., Sim, J., Smith, C., & Roffe, C. (2016). Early Diagnosis of Pneumonia in Severe Stroke: Clinical Features and the Diagnostic Role of C-Reactive Protein. PloS one, 0150269-?. https://doi.org/10.1371/journal.pone.0150269

Background
Accurate diagnosis of pneumonia complicating severe stroke is challenging due to difficulties in physical examination, altered immune responses and delayed manifestations of radiological changes. The aims of this study were to describe ea... Read More about Early Diagnosis of Pneumonia in Severe Stroke: Clinical Features and the Diagnostic Role of C-Reactive Protein.

In vitro experiments of cerebral blood flow during aspiration thrombectomy: potential effects on cerebral perfusion pressure and collateral flow (2015)
Journal Article
Roffe, Yang, & Naire. (2015). In vitro experiments of cerebral blood flow during aspiration thrombectomy: potential effects on cerebral perfusion pressure and collateral flow. Journal of NeuroInterventional Surgery, 969-972. https://doi.org/10.1136/neurintsurg-2015-011909

BACKGROUND: Mechanical thrombectomy with stent retriever devices is associated with significantly better outcomes than thrombolysis alone in the treatment of acute ischemic stroke. Thrombus aspiration achieves high patency rates, but clinical outcome... Read More about In vitro experiments of cerebral blood flow during aspiration thrombectomy: potential effects on cerebral perfusion pressure and collateral flow.

Differences in Factors Predicting Outcome and Mortality after Mechanical Thrombectomy for Acute Large Vessel Stroke Between Patients over and Under 70 Years of Age: A Five Year Retrospective Study (2015)
Journal Article
Roffe. (2015). Differences in Factors Predicting Outcome and Mortality after Mechanical Thrombectomy for Acute Large Vessel Stroke Between Patients over and Under 70 Years of Age: A Five Year Retrospective Study. Symbiosis, 1-8. https://doi.org/10.15226/2374-6858/2/1/00114

Aim: To assess the differences in risk factors between different age groups after mechanical thrombectomy (MT) for ischaemic stroke, including recanalization time and functional and radiological scoring.

Methods: Patients treated between December... Read More about Differences in Factors Predicting Outcome and Mortality after Mechanical Thrombectomy for Acute Large Vessel Stroke Between Patients over and Under 70 Years of Age: A Five Year Retrospective Study.

Abstract W MP9: Preliminary Results from the Survival and Outcome After Stroke (SOS) Trial: Natural History of Acute Ischemic Stroke from Large Vessel Occlusion (2015)
Journal Article
Grunwald, I. Q., Sneade, M., Clarke, A., Yarnold, J., Warburton, E., Nagel, S., …Trial Investigators, S. (2015). Abstract W MP9: Preliminary Results from the Survival and Outcome After Stroke (SOS) Trial: Natural History of Acute Ischemic Stroke from Large Vessel Occlusion. Stroke, 46(suppl_1), https://doi.org/10.1161/str.46.suppl_1.wmp9

Statistical analysis plan for the Stroke Oxygen Study (SO2S): a multi-center randomized controlled trial to assess whether routine oxygen supplementation in the first 72 hours after a stroke improves long-term outcome. (2014)
Journal Article
Ives, N., Sim, J., Gray, R., Roffe, C., Nevatte, T., & Howman, A. (2014). Statistical analysis plan for the Stroke Oxygen Study (SO2S): a multi-center randomized controlled trial to assess whether routine oxygen supplementation in the first 72 hours after a stroke improves long-term outcome. Trials, 15, Article ARTN 229. https://doi.org/10.1186/1745-6215-15-229

BACKGROUND: The Stroke Oxygen Study (SO2S) is a multi-center randomized controlled trial of oxygen supplementation in patients with acute stroke. The main hypothesis for the trial is that fixed-dose oxygen treatment during the first 3 days after an a... Read More about Statistical analysis plan for the Stroke Oxygen Study (SO2S): a multi-center randomized controlled trial to assess whether routine oxygen supplementation in the first 72 hours after a stroke improves long-term outcome..

The Stroke Oxygen Study (SO2S) - a multi-center, study to assess whether routine oxygen treatment in the first 72 hours after a stroke improves long-term outcome: study protocol for a randomized controlled trial. (2014)
Journal Article
Roffe, C., Nevatte, T., Crome, P., Gray, R., Sim, J., Pountain, S., …Handy, P. (2014). The Stroke Oxygen Study (SO2S) - a multi-center, study to assess whether routine oxygen treatment in the first 72 hours after a stroke improves long-term outcome: study protocol for a randomized controlled trial. Trials, 15, Article 99. https://doi.org/10.1186/1745-6215-15-99

BACKGROUND: Mild hypoxia is common in stroke patients and may have significant adverse effects on the ischemic brain after stroke. The use of oxygen treatment is rapidly increasing in European stroke units but is not without side effects. It impedes... Read More about The Stroke Oxygen Study (SO2S) - a multi-center, study to assess whether routine oxygen treatment in the first 72 hours after a stroke improves long-term outcome: study protocol for a randomized controlled trial..

Extending the role of peritoneal dialysis: can we win hearts and minds? (2014)
Journal Article
Davies, S., Lally, F., Satchithananda, D., Kadam, U., & Roffe, C. (2014). Extending the role of peritoneal dialysis: can we win hearts and minds?. Nephrology Dialysis Transplantation, 29(9), 1648-1654. https://doi.org/10.1093/ndt/gfu001

Background
The ability of peritoneal dialysis (PD) to achieve low-molecular weight solute clearance and ultrafiltration at low haemodynamic cost makes it an attractive therapy in situations where more aggressive therapy may be undesirable due to sud... Read More about Extending the role of peritoneal dialysis: can we win hearts and minds?.

Incidence of Venous Thromboembolism in the Wake of the Clots in Legs Or sTockings after Stroke (CLOTS) Study (2013)
Journal Article
Jain, P., Ward, E., Nevatte, T., & Roffe, C. (2013). Incidence of Venous Thromboembolism in the Wake of the Clots in Legs Or sTockings after Stroke (CLOTS) Study. Stroke, 44(10), 2910-2912. https://doi.org/10.1161/strokeaha.113.001458

Background and Purpose—
In the United Kingdom, compressive stockings were standard care in all stroke units until the publication of the Clots in Legs Or sTockings after Stroke (CLOTS) trial results in May 2009, which concluded that stockings were i... Read More about Incidence of Venous Thromboembolism in the Wake of the Clots in Legs Or sTockings after Stroke (CLOTS) Study.

The stroke oxygen pilot study: a randomized controlled trial of the effects of routine oxygen supplementation early after acute stroke--effect on key outcomes at six months (2013)
Journal Article
Ali, K., Warusevitane, A., Lally, F., Sim, J., Sills, S., Pountain, S., …Roffe, C. (2013). The stroke oxygen pilot study: a randomized controlled trial of the effects of routine oxygen supplementation early after acute stroke--effect on key outcomes at six months. PloS one, 8(6), Article e59274. https://doi.org/10.1371/journal.pone.0059274

INTRODUCTION: Post-stroke hypoxia is common, and may adversely affect outcome. We have recently shown that oxygen supplementation may improve early neurological recovery. Here, we report the six-month outcomes of this pilot study. METHODS: Patients w... Read More about The stroke oxygen pilot study: a randomized controlled trial of the effects of routine oxygen supplementation early after acute stroke--effect on key outcomes at six months.

A randomized controlled trial of surface neuromuscular electrical stimulation applied early after acute stroke: effects on wrist pain, spasticity and contractures (2012)
Journal Article
Malhotra, S., Rosewilliam, S., Hermens, H., Roffe, C., Jones, P., & Pandyan, A. D. (2013). A randomized controlled trial of surface neuromuscular electrical stimulation applied early after acute stroke: effects on wrist pain, spasticity and contractures. Clinical Rehabilitation, 27(7), 579-590. https://doi.org/10.1177/0269215512464502

The role of reality monitoring in anosognosia for hemiplegia. (2011)
Journal Article
Roffe, & Edelstyn. (2011). The role of reality monitoring in anosognosia for hemiplegia. Behavioural Neurology, 241 - 243. https://doi.org/10.3233/BEN-2010-0305

Background: The aim was to assess the feasibility of a single-centre, single-blind, randomized, crossover design to explore the effects of two slow-release dopamine agonists, ropinirole and pramipexole, on cued recall in Parkinson’s disease.
As the... Read More about The role of reality monitoring in anosognosia for hemiplegia..