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Emerging Approaches to Investigate the Influence of Transition Metals in the Proteinopathies (2019)
Journal Article
Telling, & Everett, J. (2019). Emerging Approaches to Investigate the Influence of Transition Metals in the Proteinopathies. Cells, https://doi.org/10.3390/cells8101231

Transition metals have essential roles in brain structure and function, and are associated with pathological processes in neurodegenerative disorders classed as proteinopathies. Synchrotron X-ray techniques, coupled with ultrahigh-resolution mass spe... Read More about Emerging Approaches to Investigate the Influence of Transition Metals in the Proteinopathies.

Metal Ion Binding to the Amyloid ß Monomer Studied by Native Top-Down FTICR Mass Spectrometry. (2019)
Journal Article
Lermyte, F., Everett, J., Lam, Y., Wootton, C., Brooks, J., Barrow, M., …Collingwood, J. (2019). Metal Ion Binding to the Amyloid ß Monomer Studied by Native Top-Down FTICR Mass Spectrometry. Journal of The American Society for Mass Spectrometry, 30(10), 2123-2134. https://doi.org/10.1007/s13361-019-02283-7

Native top-down mass spectrometry is a fast, robust biophysical technique that can provide molecular-scale information on the interaction between proteins or peptides and ligands, including metal cations. Here we have analyzed complexes of the full-l... Read More about Metal Ion Binding to the Amyloid ß Monomer Studied by Native Top-Down FTICR Mass Spectrometry..

Correlative Spectromicroscopy and Tomography for Biomedical Applications involving Electron, Ion, and Soft X-ray Microscopies (2019)
Journal Article
Hitchcock, A. P., Wang, X., Grandfield, K., Everett, J., Collingwood, J. F., & Telling, N. D. (2019). Correlative Spectromicroscopy and Tomography for Biomedical Applications involving Electron, Ion, and Soft X-ray Microscopies. Microscopy Today, 27(2), https://doi.org/10.1017/S1551929518001256

Many important scientific and technical problems are best addressed using multiple, microscopy-based analytical techniques that combine the strengths of complementary methods. Here, we provide two examples from biomedical challenges: unravelling the... Read More about Correlative Spectromicroscopy and Tomography for Biomedical Applications involving Electron, Ion, and Soft X-ray Microscopies.