Correlative Spectromicroscopy and Tomography for Biomedical Applications involving Electron, Ion, and Soft X-ray Microscopies

Hitchcock, Adam P; Wang, Xiaoyue; Grandfield, Kathryn; Everett, James; Collingwood, Joanna F; Telling, Neil D

Abstract

Many important scientific and technical problems are best addressed using multiple, microscopy-based analytical techniques that combine the strengths of complementary methods. Here, we provide two examples from biomedical challenges: unravelling the attachment zone between dental implants and bone, and uncovering the mechanism of Alzheimer's disease. They combine synchrotron-based scanning transmission X-ray microscopy (STXM) with transmission electron microscopy ((S)TEM), electron tomography (ET), EELS tomography, and/or atom probe tomography (APT). STXM provides X-ray absorption based chemical sensitivity at mesoscale resolution (10–30 nm), which complements higher spatial resolution electron microscopy and APT.

Citation

Hitchcock, A. P., Wang, X., Grandfield, K., Everett, J., Collingwood, J. F., & Telling, N. D. (2019). Correlative Spectromicroscopy and Tomography for Biomedical Applications involving Electron, Ion, and Soft X-ray Microscopies. Microscopy Today, 27(2), https://doi.org/10.1017/S1551929518001256

• Journal Article Type: Article
• Acceptance Date: Mar 1, 2019
• Publication Date: Mar 1, 2019
• Publicly Available Date: May 26, 2023
• Journal: Microscopy Today
• Print ISSN: 1551-9295
• Electronic ISSN: 2150-3583
• Publisher: Cambridge University Press
• Peer Reviewed: Peer Reviewed
• Volume: 27
• Issue: 2
• DOI: https://doi.org/10.1017/S1551929518001256
• Keywords: scanning transmission X-ray microscopy; scanning transmission electron microscopy; atom probe tomography; titanium implants; Alzheimer's disease
• Public URL: https://keele-repository.worktribe.com/output/413324
• Publisher URL: https://www.cambridge.org/core/journals/microscopy-today/article/correlative-spectromicroscopy-and-tomography-for-biomedical-applications-involving-electron-ion-and-soft-xray-microscopies/1CFAC59353E5E2F0CBF685EE73AAB7C1