Correlative Spectromicroscopy and Tomography for Biomedical Applications involving Electron, Ion, and Soft X-ray Microscopies

Hitchcock, Adam P; Wang, Xiaoyue; Grandfield, Kathryn; Everett, James; Collingwood, Joanna F; Telling, Neil D

Abstract

Many important scientific and technical problems are best addressed using multiple, microscopy-based analytical techniques that combine the strengths of complementary methods. Here, we provide two examples from biomedical challenges: unravelling the attachment zone between dental implants and bone, and uncovering the mechanism of Alzheimer's disease. They combine synchrotron-based scanning transmission X-ray microscopy (STXM) with transmission electron microscopy ((S)TEM), electron tomography (ET), EELS tomography, and/or atom probe tomography (APT). STXM provides X-ray absorption based chemical sensitivity at mesoscale resolution (10–30 nm), which complements higher spatial resolution electron microscopy and APT.

Citation

Hitchcock, A. P., Wang, X., Grandfield, K., Everett, J., Collingwood, J. F., & Telling, N. D. (2019). Correlative Spectromicroscopy and Tomography for Biomedical Applications involving Electron, Ion, and Soft X-ray Microscopies. Microscopy Today, 27(2), https://doi.org/10.1017/S1551929518001256

• Journal Article Type: Article
• Acceptance Date: Mar 14, 2019
• Publication Date: Mar 14, 2019
• Journal: Microscopy Today
• Print ISSN: 1551-9295
• Publisher: Cambridge University Press
• Peer Reviewed: Peer Reviewed
• Volume: 27
• Issue: 2
• DOI: https://doi.org/10.1017/S1551929518001256
• Keywords: scanning transmission X-ray microscopy; scanning transmission electron microscopy; atom probe tomography; titanium implants; Alzheimer's disease
• Publisher URL: https://www.cambridge.org/core/journals/microscopy-today/article/correlative-spectromicroscopy-and-tomography-for-biomedical-applications-involving-electron-ion-and-soft-xray-microscopies/1CFAC59353E5E2F0CBF685EE73AAB7C1