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Alastair Channon's Outputs (4)

Critical Mutation Rate has an Exponential Dependence on Population Size for Eukaryotic-length Genomes with Crossover (2017)
Journal Article
Channon. (2017). Critical Mutation Rate has an Exponential Dependence on Population Size for Eukaryotic-length Genomes with Crossover. Scientific reports, https://doi.org/10.1038/s41598-017-14628-x

The critical mutation rate (CMR) determines the shift between survival-of-the-fittest and survival of individuals with greater mutational robustness (“flattest”). We identify an inverse relationship between CMR and sequence length in an in silico sys... Read More about Critical Mutation Rate has an Exponential Dependence on Population Size for Eukaryotic-length Genomes with Crossover.

Critical Mutation Rate in a Population with Horizontal Gene Transfer (2017)
Book Chapter
Channon. (2017). Critical Mutation Rate in a Population with Horizontal Gene Transfer. In Proceedings of ECAL 2017: the 14th European Conference on Artificial Life (446-453). https://doi.org/10.7551/ecal_a_074

Horizontal gene transfer (HGT) enables segments of DNA to be transferred between individuals in a population in addition to from parent to child. It is a prominent process in bacterial reproduction. Existing in silico models have succeeded in predict... Read More about Critical Mutation Rate in a Population with Horizontal Gene Transfer.

Spontaneous mutation rate is a plastic trait associated with population density across domains of life. (2017)
Journal Article
Aston, E., McBain, A., Knight, C., Krašovec, R., Richards, H., Hatcher, C., …Gifford, D. (2017). Spontaneous mutation rate is a plastic trait associated with population density across domains of life. PLoS Biology, e2002731 - ?. https://doi.org/10.1371/journal.pbio.2002731

Rates of random, spontaneous mutation can vary plastically, dependent upon the environment. Such plasticity affects evolutionary trajectories and may be adaptive. We recently identified an inverse plastic association between mutation rate and populat... Read More about Spontaneous mutation rate is a plastic trait associated with population density across domains of life..