Outputs (15)

Insulin resistance in cardiovascular disease, uremia, and peritoneal dialysis. (2021)
Journal Article
Lambie, & Davies. (2021). Insulin resistance in cardiovascular disease, uremia, and peritoneal dialysis. Trends in Endocrinology and Metabolism, 721 - 730. https://doi.org/10.1016/j.tem.2021.06.001

Diabetic nephropathy is highly correlated with the occurrence of other complications of type 1 diabetes (T1D) and type 2 diabetes (T2D) mellitus; for example, hypertension with cardiovascular disease (CVD) being the most frequent cause of death in pa... Read More about Insulin resistance in cardiovascular disease, uremia, and peritoneal dialysis..

Estimating risk of encapsulating peritoneal sclerosis accounting for the competing risk of death (2019)
Journal Article
Lambie, M., Teece, L., Johnson, D. W., Petrie, M., Mactier, R., Solis-Trapala, I., …Davies, S. J. (2019). Estimating risk of encapsulating peritoneal sclerosis accounting for the competing risk of death. Nephrology Dialysis Transplantation, 1585-1591. https://doi.org/10.1093/ndt/gfz034

Background Risk of Encapsulating Peritoneal Sclerosis (EPS) is strongly associated with the duration of peritoneal dialysis (PD), such that patients who have been on PD for some time may consider elective transfer to haemodialysis to mitigate risk o... Read More about Estimating risk of encapsulating peritoneal sclerosis accounting for the competing risk of death.

International Variations in Peritoneal Dialysis Utilization and Implications for Practice (2019)
Journal Article
Davies. (2019). International Variations in Peritoneal Dialysis Utilization and Implications for Practice. American Journal of Kidney Diseases, https://doi.org/10.1053/j.ajkd.2018.12.033

In many countries, the use of peritoneal dialysis (PD) remains low despite arguments that support its greater use, including dialysis treatment away from hospital settings, avoidance of central venous catheters, and potential health economic advantag... Read More about International Variations in Peritoneal Dialysis Utilization and Implications for Practice.

Local solutions save young lives. (2019)
Journal Article
Davies. (2019). Local solutions save young lives. Nature Reviews Nephrology, 127-128. https://doi.org/10.1038/s41581-018-0109-0

Peritoneal dialysis has many advantages over haemodialysis in the treatment of acute kidney injury (AKI) in low-resource settings. One limitation, however, is the availability of commercial dialysis fluid. Following the International Society of Perit... Read More about Local solutions save young lives..

Does alanyl-glutamine supplementation offer potential to improve peritoneal dialysate biocompatibility? (2018)
Journal Article
Davies. (2018). Does alanyl-glutamine supplementation offer potential to improve peritoneal dialysate biocompatibility?. Kidney International, 1050 -1052. https://doi.org/10.1016/j.kint.2018.09.012

Peritoneal dialysis technique survival remains challenging due to peritonitis and long-term alterations to peritoneal membrane function and integrity. Up to now, the development of less bio-incompatible dialysis solutions have not had a major impact... Read More about Does alanyl-glutamine supplementation offer potential to improve peritoneal dialysate biocompatibility?.

Biocompatible Solutions and Long-Term Changes in Peritoneal Solute Transport (2018)
Journal Article
Davies, & Lambie. (2018). Biocompatible Solutions and Long-Term Changes in Peritoneal Solute Transport. Clinical Journal of the American Society of Nephrology, 1526-1533. https://doi.org/10.2215/%3FCJN.02380218

Background and objectives The inflammation-driven increase in peritoneal solute transport rate that occurs during long-term peritoneal dialysis is associated with higher mortality, hospitalization, and encapsulating peritoneal sclerosis. Because bio... Read More about Biocompatible Solutions and Long-Term Changes in Peritoneal Solute Transport.

Bioimpedance-defined overhydration predicts survival in end stage kidney failure (ESKF): systematic review and subgroup meta-analysis. (2018)
Journal Article
Tabinor, M., Elphick, E., Dudson, M., Shing Kwok, C., Lambie, M., & Davies, S. J. (2018). Bioimpedance-defined overhydration predicts survival in end stage kidney failure (ESKF): systematic review and subgroup meta-analysis. Scientific reports, 8, Article 4441. https://doi.org/10.1038/s41598-018-21226-y

Both overhydration and comorbidity predict mortality in end-stage kidney failure (ESKF) but it is not clear whether these are independent of one another. We undertook a systematic review of studies reporting outcomes in adult dialysis patients in whi... Read More about Bioimpedance-defined overhydration predicts survival in end stage kidney failure (ESKF): systematic review and subgroup meta-analysis..

United Kingdom Catheter Study - Protocol Synopsis. (2018)
Journal Article
Briggs, V., Solis-Trapala, I., Wailloo, A., McCulloch, K., Lambie, M., Caskey, F., …Wilkie, M. (2018). United Kingdom Catheter Study - Protocol Synopsis. https://doi.org/10.3747/pdi.2017.00083

BACKGROUND: High-quality peritoneal dialysis (PD) catheter insertion pathways are essential for optimal access to the therapy. Dialysis outcomes are influenced by a range of patient and center-related factors, and there is a need to better understand... Read More about United Kingdom Catheter Study - Protocol Synopsis..

A prospective, proteomics study identified potential biomarkers of encapsulating peritoneal sclerosis in peritoneal effluent (2017)
Journal Article
Lambie, & Davies. (2017). A prospective, proteomics study identified potential biomarkers of encapsulating peritoneal sclerosis in peritoneal effluent. Kidney International, 988-1002. https://doi.org/10.1016/j.kint.2017.03.030

Encapsulating peritoneal sclerosis (EPS) is a potentially devastating complication of peritoneal dialysis (PD). Diagnosis is often delayed due to the lack of effective and accurate diagnostic tools. We therefore examined peritoneal effluent for pot... Read More about A prospective, proteomics study identified potential biomarkers of encapsulating peritoneal sclerosis in peritoneal effluent.

miR-21 Promotes Fibrogenesis in Peritoneal Dialysis. (2017)
Journal Article
Lambie, & Davies. (2017). miR-21 Promotes Fibrogenesis in Peritoneal Dialysis. American Journal of Pathology, 1537-1550. https://doi.org/10.1016/j.ajpath.2017.03.007

Peritoneal dialysis (PD) is a life-saving form of renal replacement therapy for those with end-stage kidney disease. Mesothelial cells (MCs) line the peritoneal cavity and help define peritoneal response to treatment-associated injury, a major reason... Read More about miR-21 Promotes Fibrogenesis in Peritoneal Dialysis..

Ultrafiltration for acute decompensated cardiac failure: A systematic review and meta-analysis (2016)
Journal Article
Davies, & Mamas. (2016). Ultrafiltration for acute decompensated cardiac failure: A systematic review and meta-analysis. International Journal of Cardiology, 122-128. https://doi.org/10.1016/j.ijcard.2016.11.136

Background Ultrafiltration is a method used to achieve diuresis in acute decompensated heart failure (ADHF) when there is diuretic resistance, but its efficacy in other settings is unclear. We therefore conducted a systematic review and meta-analysi... Read More about Ultrafiltration for acute decompensated cardiac failure: A systematic review and meta-analysis.

Longitudinal bioimpedance vector plots add little value to fluid management of peritoneal dialysis patients (2016)
Journal Article
Tan, B. K., Yu, Z., Fang, W., Lin, A., Ni, Z., Qian, J., …Davies, S. J. (2016). Longitudinal bioimpedance vector plots add little value to fluid management of peritoneal dialysis patients. Kidney International, 89(2), https://doi.org/10.1038/ki.2015.294

Bioimpedance (BI) has the potential to enable better management of fluid balance, which can worsen over time on peritoneal dialysis (PD) due to loss of residual kidney function and progressive muscle wasting. We undertook a prospective, randomized, o... Read More about Longitudinal bioimpedance vector plots add little value to fluid management of peritoneal dialysis patients.

Heart failure and chronic obstructive pulmonary disease multimorbidity at hospital discharge transition: a study of patient and carer experience (2015)
Journal Article
Davies. (2015). Heart failure and chronic obstructive pulmonary disease multimorbidity at hospital discharge transition: a study of patient and carer experience. Health Expectations, 2401 -2412. https://doi.org/10.1111/hex.12208

BACKGROUND: Care for patients with multimorbidity represents a major challenge not only for patients and carers but to health-care systems. Hospital discharge transition is a critical point at which challenges for multimorbidity may amplify. OBJECTIV... Read More about Heart failure and chronic obstructive pulmonary disease multimorbidity at hospital discharge transition: a study of patient and carer experience.

Transition between home dialysis modalities: another piece in the jigsaw of the integrated care pathway (2015)
Journal Article
Davies, & Lambie. (2015). Transition between home dialysis modalities: another piece in the jigsaw of the integrated care pathway. Nephrology Dialysis Transplantation, 30(11), 1781 -1783. https://doi.org/10.1093/ndt/gfv279

No abstract

Independent effects of systemic and peritoneal inflammation on peritoneal dialysis survival (2013)
Journal Article
Davies, S. (2013). Independent effects of systemic and peritoneal inflammation on peritoneal dialysis survival. Journal of the American Society of Nephrology, 2071 - 2080. https://doi.org/10.1681/ASN.2013030314

Systemic inflammation, as evidenced by elevated inflammatory cytokines, is a feature of advanced renal failure and predicts worse survival. Dialysate IL-6 concentrations associate with variability in peritoneal small solute transport rate (PSTR), whi... Read More about Independent effects of systemic and peritoneal inflammation on peritoneal dialysis survival.