Edward Roddy's Outputs (264)

Should all people starting urate-lowering therapy for gout receive anti-inflammatory prophylaxis? (2024)
Journal Article
Roddy, E., Prior, J. A., & Mallen, C. D. (2024). Should all people starting urate-lowering therapy for gout receive anti-inflammatory prophylaxis?. Exploration of Musculoskeletal Diseases, 2, 521-528. https://doi.org/10.37349/emd.2024.00076

Co-prescription of anti-inflammatory prophylaxis with colchicine, non-steroidal anti-inflammatory drugs (NSAIDs), or corticosteroids when initiating urate-lowering therapy (ULT) for gout is recommended in clinical guidelines to prevent ULT-induced fl... Read More about Should all people starting urate-lowering therapy for gout receive anti-inflammatory prophylaxis?.

Publisher Correction: A genome-wide association analysis reveals new pathogenic pathways in gout. (2024)
Journal Article
Major, T. J., Takei, R., Matsuo, H., Leask, M. P., Sumpter, N. A., Topless, R. K., …Merriman, T. R. (2024). Publisher Correction: A genome-wide association analysis reveals new pathogenic pathways in gout. Nature Genetics, 56(11), Article 2577. https://doi.org/10.1038/s41588-024-02017-w

In the version of the article originally published, there were errors in the consortium lists at the end of the paper. Maureen Rischmueller, Hyon K. Choi, Masahiro Nakatochi, Jeff N. Miner, Daniel H. Solomon, Kathleen M. Giacomini and Deanna J. Brack... Read More about Publisher Correction: A genome-wide association analysis reveals new pathogenic pathways in gout..

A genome-wide association analysis reveals new pathogenic pathways in gout. (2024)
Journal Article
Major, T. J., Takei, R., Matsuo, H., Leask, M. P., Sumpter, N. A., Topless, R. K., …Merriman, T. R. (in press). A genome-wide association analysis reveals new pathogenic pathways in gout. Nature Genetics, https://doi.org/10.1038/s41588-024-01921-5

Gout is a chronic disease that is caused by an innate immune response to deposited monosodium urate crystals in the setting of hyperuricemia. Here, we provide insights into the molecular mechanism of the poorly understood inflammatory component of go... Read More about A genome-wide association analysis reveals new pathogenic pathways in gout..

Pain Reduction With Oral Methotrexate in Knee Osteoarthritis (2024)
Journal Article
Kingsbury, S. R., Tharmanathan, P., Keding, A., Watt, F. E., Scott, D. L., Roddy, E., …Conaghan, P. G. (in press). Pain Reduction With Oral Methotrexate in Knee Osteoarthritis. Annals of Internal Medicine, 177(9), https://doi.org/10.7326/m24-0303

AB0105 ‘..THERE’S TOO MUCH TO PUT IN A LEAFLET’: A QUALITATIVE EXPLORATION OF STAKEHOLDER VIEWS OF LIFESTYLE INTERVENTIONS FOR GOUT (2024)
Presentation / Conference
Watson, L., Cornwall, N., Jinks, C., Bradbury, K., Goff, L., Little, P., …Roddy, E. (2024, June). AB0105 ‘..THERE’S TOO MUCH TO PUT IN A LEAFLET’: A QUALITATIVE EXPLORATION OF STAKEHOLDER VIEWS OF LIFESTYLE INTERVENTIONS FOR GOUT. Paper presented at EULAR 2024 European Congress of Rheumatology, 12-15 June. Vienna, Austria, Vienna

P086 Trends in the Incidence and Management of Gout in England: A Nationwide Study using the OpenSAFELY Platform (2024)
Presentation / Conference
Russell, M. D., Massey, J., Roddy, E., MacKenna, B., Bacon, S., Goldacre, B., …Galloway, J. (2024, April). P086 Trends in the Incidence and Management of Gout in England: A Nationwide Study using the OpenSAFELY Platform. Poster presented at British Society for Rheumatology Annual Conference 2024

Background/Aims Gout is the most common inflammatory arthritis worldwide, yet one of the worst managed. Few population-level studies have evaluated how the COVID-19 pandemic impacted on incidence, prevalence, management and hospitalisations for peopl... Read More about P086 Trends in the Incidence and Management of Gout in England: A Nationwide Study using the OpenSAFELY Platform.

P085 Implementing treat-to-target urate-lowering therapy during hospitalisations for gout flares: a prospective cohort study (2024)
Presentation / Conference
Russell, M. D., Ameyaw-Kyeremeh, L., Dell'Accio, F., Lapham, H., Head, N., Stovin, C., …Galloway, J. B. (2024, April). P085 Implementing treat-to-target urate-lowering therapy during hospitalisations for gout flares: a prospective cohort study. Poster presented at British Society for Rheumatology Annual Conference 2024

Background/Aims Hospitalisations for gout flares have doubled in England during the last 15 years. Despite this, no studies have evaluated strategies designed to increase the uptake of urate-lowering therapy (ULT) in people hospitalised for gout flar... Read More about P085 Implementing treat-to-target urate-lowering therapy during hospitalisations for gout flares: a prospective cohort study.

P082 Nephrolithiasis associated with uricosuric therapies for the treatment of gout: a systematic review (2024)
Presentation / Conference
Dahanayake, C., Bajpai, R., Jordan, K. M., Lambie, M., & Roddy, E. (2024, April). P082 Nephrolithiasis associated with uricosuric therapies for the treatment of gout: a systematic review. Poster presented at British Society for Rheumatology Annual Conference 2024

Background/Aims
Uric acid nephrolithiasis is a recognised side-effect of uricosuric therapies and a contraindication to their use. The objective of this systematic review was to assess the incidence and risk of nephrolithiasis in people with gout re... Read More about P082 Nephrolithiasis associated with uricosuric therapies for the treatment of gout: a systematic review.

Effectiveness of footwear and foot orthoses in reducing medial metatarsophalangeal joint pressure in women with hallux valgus (2024)
Journal Article
Roddy, E., Menz, H., Lim, P., Hurn, S., Mickle, K., Buldt, A., …Munteanu, S. (2024). Effectiveness of footwear and foot orthoses in reducing medial metatarsophalangeal joint pressure in women with hallux valgus. Gait and Posture, 111, 156-161. https://doi.org/10.1016/j.gaitpost.2024.04.021

Background
Hallux valgus is a common condition where the subluxation of the first metatarsophalangeal joint and lateral deviation of the hallux at the interphalangeal joint creates difficulty with footwear fit. Footwear and foot orthoses are commonl... Read More about Effectiveness of footwear and foot orthoses in reducing medial metatarsophalangeal joint pressure in women with hallux valgus.

Effectiveness of footwear and foot orthoses in reducing medial metatarsophangeal joint pressure in women with hallux valgus (2024)
Journal Article
Menz, H. B., Lim, P. Q., Hurn, S. E., Mickle, K. J., Buldt, A. K., Cotchett, M. P., …Munteanu, S. E. (in press). Effectiveness of footwear and foot orthoses in reducing medial metatarsophangeal joint pressure in women with hallux valgus. Gait & Posture, 111, 156-161. https://doi.org/10.1016/j.gaitpost.2024.04.021

Background
Hallux valgus is a common condition where the subluxation of the first metatarsophalangeal joint and lateral deviation of the hallux at the interphalangeal joint creates difficulty with footwear fit. Fo... Read More about Effectiveness of footwear and foot orthoses in reducing medial metatarsophangeal joint pressure in women with hallux valgus.

Prognostic factors for colchicine prophylaxis-related adverse events when initiating allopurinol for gout: retrospective cohort study (2024)
Journal Article
Bajpai, R., Partington, R., Muller, S., Forrester, H., Mallen, C. D., Clarson, L., …Roddy, E. (2024). Prognostic factors for colchicine prophylaxis-related adverse events when initiating allopurinol for gout: retrospective cohort study. Rheumatology, Article keae229. https://doi.org/10.1093/rheumatology/keae229

Objectives
Colchicine is commonly used to prevent flares when starting urate-lowering therapy for gout. Patients with gout are frequently concurrently prescribed other medications (such as statins) that may interact with colchicine, increasing the r... Read More about Prognostic factors for colchicine prophylaxis-related adverse events when initiating allopurinol for gout: retrospective cohort study.

269 CLINICAL GUIDELINE RESEARCH RECOMMENDATIONS FOR THE NON-SURGICAL MANAGEMENT OF OSTEOARTHRITIS: A THEMATIC SYNTHESIS. (2024)
Presentation / Conference
Woodcock, C., English, E., Jinks, C., Healey, E. L., Parry, E., Paskins, Z., …Holden, M. (2024, April). 269 CLINICAL GUIDELINE RESEARCH RECOMMENDATIONS FOR THE NON-SURGICAL MANAGEMENT OF OSTEOARTHRITIS: A THEMATIC SYNTHESIS. Poster presented at 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria

How common are side effects of treatment to prevent gout flares when starting allopurinol? (2024)
Journal Article
Saul, H., Deeney, B., Swaithes, L., & Roddy, E. (in press). How common are side effects of treatment to prevent gout flares when starting allopurinol?. BMJ, 384, Article q514. https://doi.org/10.1136/bmj.q514

The studyRoddy E, Bajpai R, Forrester H, et al. Safety of colchicine and NSAID prophylaxis when initiating urate-lowering therapy for gout: propensity score-matched cohort studies in the UK Clinical Practice Research Datalink. 2023;82:1618-25.To re... Read More about How common are side effects of treatment to prevent gout flares when starting allopurinol?.

Health Literacy and Gout Characteristics in a Primary Care Cohort (2024)
Journal Article
Watson, L., Protheroe, J., Mallen, C., Muller, S., & Roddy, E. (2024). Health Literacy and Gout Characteristics in a Primary Care Cohort. Rheumatology Advances in Practice, 8(2), Article rkae034. https://doi.org/10.1093/rap/rkae034

Objectives
To examine the cross-sectional association between health literacy and gout characteristics.

Methods
In a primary care cohort of adults living with gout, the prevalence of poor health literacy was defined using the Single-Item Literac... Read More about Health Literacy and Gout Characteristics in a Primary Care Cohort.

Diagnosis and management of gout: are the British Society for Rheumatology and National Institute for Health and Care Excellence guidelines both needed? (2024)
Journal Article
Roddy, E., Jordan, K. M., & Giles, I. (in press). Diagnosis and management of gout: are the British Society for Rheumatology and National Institute for Health and Care Excellence guidelines both needed?. Rheumatology Advances in Practice, 8(1), Article rkae007. https://doi.org/10.1093/rap/rkae007

Ankle osteoarthritis: an online survey of current treatment practices of UK-based podiatrists and physiotherapists (2023)
Journal Article
Callaghan, M. J., Gala, J. P., & Roddy, E. (in press). Ankle osteoarthritis: an online survey of current treatment practices of UK-based podiatrists and physiotherapists. Journal of Foot and Ankle Research, 16(1), Article 89. https://doi.org/10.1186/s13047-023-00683-3

Background: Patients with painful ankle osteoarthritis (OA) have a mixed experience of non-surgical management which they may attribute to a lack of guidance for clinicians on usual care treatment. Therefore, the purpose of this study was to survey t... Read More about Ankle osteoarthritis: an online survey of current treatment practices of UK-based podiatrists and physiotherapists.

Plantar pressures in people with midfoot osteoarthritis: cross-sectional findings from the Clinical Assessment Study of the Foot (2023)
Journal Article
Lithgow, M. J., Buldt, A. K., Munteanu, S. E., Marshall, M., Thomas, M. J., Peat, G., …Menz, H. B. (2024). Plantar pressures in people with midfoot osteoarthritis: cross-sectional findings from the Clinical Assessment Study of the Foot. Gait & Posture, 108, 243-249. https://doi.org/10.1016/j.gaitpost.2023.12.008

Background
Midfoot osteoarthritis (OA) is a common condition, however its aetiology is not well understood. Understanding how plantar pressures differ between people with and without midfoot OA may provide insight... Read More about Plantar pressures in people with midfoot osteoarthritis: cross-sectional findings from the Clinical Assessment Study of the Foot.

The cost-effectiveness of adding an ultrasound corticosteroid and local anaesthetic injection to advice and education for hip osteoarthritis (2023)
Journal Article
Kigozi, J., Oppong, R., Paskins, Z., Bromley, K., Lewis, M., Hughes, G., …Roddy, E. (2023). The cost-effectiveness of adding an ultrasound corticosteroid and local anaesthetic injection to advice and education for hip osteoarthritis. Rheumatology, https://doi.org/10.1093/rheumatology/kead659

Objectives. Evidence for the comparative cost-effectiveness of intra-articular corticosteroid injection in people with hip osteoarthritis (OA) remains unclear. This study investigated the cost-effectiveness of best current treatment (BCT) comprising... Read More about The cost-effectiveness of adding an ultrasound corticosteroid and local anaesthetic injection to advice and education for hip osteoarthritis.

Cohort study investigating gout flares and management in UK general practice (2023)
Journal Article
Finnikin, S., Mallen, C. D., & Roddy, E. (in press). Cohort study investigating gout flares and management in UK general practice. BMC Primary Care, 24(1), 246. https://doi.org/10.1186/s12875-023-02201-7

Background: Gout is the most common inflammatory arthritis and is almost exclusively managed in primary care, however the course and severity of the condition is variable and poorly characterised. This research aims improve understanding about the fr... Read More about Cohort study investigating gout flares and management in UK general practice.

How do clinicians prescribe bridging glucocorticoids in people starting or escalating disease-modifying anti-rheumatic drugs for rheumatoid arthritis: a service evaluation survey (2023)
Journal Article
Prior, J. A., Roddy, E., Solis-Trapala, I., Cornwall, N., Jinks, C., Abhishek, A., …Hider, S. (in press). How do clinicians prescribe bridging glucocorticoids in people starting or escalating disease-modifying anti-rheumatic drugs for rheumatoid arthritis: a service evaluation survey. Rheumatology Advances in Practice, 7(3), Article rkad102. https://doi.org/10.1093/rap/rkad102