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Dr Rebecca Kingsbury's Outputs (3)

Future directions in flow biocatalysis: The impact of new technology on sustainability (2024)
Journal Article
Ruscoe, R. E., & Cosgrove, S. C. (2024). Future directions in flow biocatalysis: The impact of new technology on sustainability. Current Opinion in Green and Sustainable Chemistry, 49, Article 100954. https://doi.org/10.1016/j.cogsc.2024.100954

Flow chemistry is now a key technology for synthetic chemistry, with the different operating windows available allowing new chemistry to be optimised and discovered. The related area of flow biocatalysis is also becoming increasingly recognised as an... Read More about Future directions in flow biocatalysis: The impact of new technology on sustainability.

Multicomponent Synthesis of the SARS-CoV-2 Main Protease Inhibitor Nirmatrelvir (2023)
Journal Article
Preschel, H. D., Otte, R. T., Zhuo, Y., Ruscoe, R. E., Burke, A. J., Kellerhals, R., Horst, B., Hennig, S., Janssen, E., Green, A. P., Turner, N. J., & Ruijter, E. (2023). Multicomponent Synthesis of the SARS-CoV-2 Main Protease Inhibitor Nirmatrelvir. Journal of Organic Chemistry, 88(17), 12565-12571. https://doi.org/10.1021/acs.joc.3c01274

In the wake of the Covid-19 pandemic, it has become clear that global access to efficacious antiviral drugs will be critical to combat future outbreaks of SARS-CoV-2 or related viruses. The orally available SARS-CoV-2 main protease inhibitor nirmatre... Read More about Multicomponent Synthesis of the SARS-CoV-2 Main Protease Inhibitor Nirmatrelvir.

One-Pot Chemoenzymatic Cascade for the Enantioselective C(1)-Allylation of Tetrahydroisoquinolines (2023)
Journal Article
Sangster, J. J., Ruscoe, R. E., Cosgrove, S. C., Mangas-Sánchez, J., & Turner, N. J. (2023). One-Pot Chemoenzymatic Cascade for the Enantioselective C(1)-Allylation of Tetrahydroisoquinolines. Journal of the American Chemical Society, 145(8), 4431-4437. https://doi.org/10.1021/jacs.2c09176

Herein, we report a one-pot, chemoenzymatic process for the synthesis of enantioenriched C(1)-allylated tetrahydroisoquinolines. This transformation couples a monoamine oxidase (MAO-N)-catalyzed oxidation with a metal catalyzed allylboration, followe... Read More about One-Pot Chemoenzymatic Cascade for the Enantioselective C(1)-Allylation of Tetrahydroisoquinolines.