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Ian Scott's Outputs (43)

The Longitudinal Relationship Between Pain and Depression in People with Inflammatory Arthritis: a Narrative Review (2025)
Journal Article
Cox, N., Farooq, S., Twohig, H., & Scott, I. C. (in press). The Longitudinal Relationship Between Pain and Depression in People with Inflammatory Arthritis: a Narrative Review. Arthritis Care & Research, 1-32. https://doi.org/10.1002/acr.25532

As many patients with inflammatory arthritis (IA) have chronic pain, understanding how to best assess and manage pain in IA is a priority. Co-morbid depression is prevalent in adults with IA, affecting 15 to 39% of people. Whilst pain and depression... Read More about The Longitudinal Relationship Between Pain and Depression in People with Inflammatory Arthritis: a Narrative Review.

Pharmacological pain management in patients with rheumatoid arthritis: a narrative literature review (2025)
Journal Article
Cox, N., Mallen, C. D., & Scott, I. C. (2025). Pharmacological pain management in patients with rheumatoid arthritis: a narrative literature review. BMC Medicine, 23(1), Article 54. https://doi.org/10.1186/s12916-025-03870-0

Background: Pain is a major challenge for patients with rheumatoid arthritis (RA), with many people suffering chronic pain. Current RA management guidelines focus on assessing and reducing disease activity using disease-modifying anti-rheumatic drugs... Read More about Pharmacological pain management in patients with rheumatoid arthritis: a narrative literature review.

Characteristics of refractory disease and persistent symptoms in inflammatory arthritis: Qualitative framework analysis of interviews with patients and health care professionals (2025)
Journal Article
Chaplin, H., Simpson, C., Wilkins, K., Meehan, J., Ng, N., Galloway, J., Scott, I. C., Sen, D., Tattersall, R., Moss‐Morris, R., Lempp, H., & Norton, S. (2025). Characteristics of refractory disease and persistent symptoms in inflammatory arthritis: Qualitative framework analysis of interviews with patients and health care professionals. British Journal of Health Psychology, 30(1), Article e12780. https://doi.org/10.1111/bjhp.12780

Objectives: This study aims to explore patients' and clinicians' understanding and experiences of refractory disease (RD) and persistent physical and emotional symptoms (PPES) in patients with inflammatory arthritis (IA), namely rheumatoid arthritis... Read More about Characteristics of refractory disease and persistent symptoms in inflammatory arthritis: Qualitative framework analysis of interviews with patients and health care professionals.

OP0284 AN AGENT-BASED SIMULATION OF THE EFFECTS OF VARYING TIME TO TREATMENT WITH BIOLOGICAL AGENTS ON PATIENT HEALTH AND COST IN AXIAL SPONDYLOARTHRITIS USING NATIONAL REGISTER DATA (2025)
Presentation / Conference Contribution
Roach, A., Scott, I., Macfarlane, G., Jones, G., & Macgregor, A. OP0284 AN AGENT-BASED SIMULATION OF THE EFFECTS OF VARYING TIME TO TREATMENT WITH BIOLOGICAL AGENTS ON PATIENT HEALTH AND COST IN AXIAL SPONDYLOARTHRITIS USING NATIONAL REGISTER DATA. Presented at EULAR 2020, online

Background:
Evaluating the long-term impacts of healthcare policies on patient's health and treatment costs for people with axial spondyloarthritis (axSpA) is challenging due to its chronic nature, and the variati... Read More about OP0284 AN AGENT-BASED SIMULATION OF THE EFFECTS OF VARYING TIME TO TREATMENT WITH BIOLOGICAL AGENTS ON PATIENT HEALTH AND COST IN AXIAL SPONDYLOARTHRITIS USING NATIONAL REGISTER DATA.

Gabapentinoid use and the risk of fractures in patients with inflammatory arthritis: nested case–control study in the Clinical Practice Research Datalink Aurum (2024)
Journal Article
Scott, I. C., Daud, N., Bailey, J., Twohig, H., Hider, S. L., Mallen, C. D., Jordan, K. P., & Muller, S. (2024). Gabapentinoid use and the risk of fractures in patients with inflammatory arthritis: nested case–control study in the Clinical Practice Research Datalink Aurum. BMC Medicine, 22(1), 575. https://doi.org/10.1186/s12916-024-03774-5

Background: Gabapentinoids are increasingly prescribed in inflammatory arthritis (IA), despite no trial evidence for efficacy at managing pain in this population. Observational studies in non-IA populations suggest gabapentinoids are associated with... Read More about Gabapentinoid use and the risk of fractures in patients with inflammatory arthritis: nested case–control study in the Clinical Practice Research Datalink Aurum.

Pain management in people with inflammatory arthritis: British Society for Rheumatology guideline scope (2024)
Journal Article
Scott, I. C., Babatunde, O., Barker, C., Beesley, R., Beesley, R., Birkinshaw, H., Brooke, M., Chaplin, H., Chapman, L., Ciurtin, C., Dale, J., Dockrell, D., Dures, E., Harrison, K., Jani, M., Lee, C., McCarron, M., Mallen, C. D., O’Connor, A., Pidgeon, C., …Shenker, N. G. (in press). Pain management in people with inflammatory arthritis: British Society for Rheumatology guideline scope. Rheumatology Advances in Practice, 8(4), Article rkae128. https://doi.org/10.1093/rap/rkae128

Lay Summary: What does this mean for patients? Inflammatory arthritis includes conditions causing swollen and painful joints. The main types are rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis and juvenile idiopathic arthritis. It... Read More about Pain management in people with inflammatory arthritis: British Society for Rheumatology guideline scope.

Genome-wide Association of Rheumatoid Arthritis in the African Ancestry Identifies HLA Amino Acid Polymorphisms of Risk (2024)
Presentation / Conference Contribution
Zhang, H., Sakaue, . S., Posner, D., Cui, . J., Yang, D., Budu-Aggrey, A., Ho, Y.-L., Costa, L., Matty, R., Huang, S., Monach, P., Ishaigaki, K., Maripuri, M., Melley, C., Tanukonda, V., Sangar, R., McDermott, G., Jeffway, M., Laufer, V., Okada, Y., … Liao, K. Genome-wide Association of Rheumatoid Arthritis in the African Ancestry Identifies HLA Amino Acid Polymorphisms of Risk. Presented at ACR Convergence 2024, Washington DC

Background/Purpose: The association between RA and the MHC is largely explained by five amino acid (AA) positions: DRB1 positions 11, 13, 71, and 74, HLA-B position 9, and DPB1 position 9. However, these prior studies are from populations genetically... Read More about Genome-wide Association of Rheumatoid Arthritis in the African Ancestry Identifies HLA Amino Acid Polymorphisms of Risk.

Google Internet searches related to inflammatory arthritis: An observational study using Google Trends data (2024)
Journal Article
Akthar, M., Mason, K. J., & Scott, I. C. (2024). Google Internet searches related to inflammatory arthritis: An observational study using Google Trends data. Musculoskeletal Care, 22(3), Article e1916. https://doi.org/10.1002/msc.1916

Objective: The Internet has transformed how patients access health information. We examined Google search engine data to understand which aspects of health are most often searched for in combination with inflammatory arthritis (IA). Methods: Using Go... Read More about Google Internet searches related to inflammatory arthritis: An observational study using Google Trends data.

The Relationship Between Obesity and Patient-Reported Outcome Measures in People with Polymyalgia Rheumatica (2024)
Journal Article
Scott, I. C., Bajpai, R., Hider, S. L., Helliwell, T., Mallen, C. D., & Muller, S. (in press). The Relationship Between Obesity and Patient-Reported Outcome Measures in People with Polymyalgia Rheumatica. Rheumatology Advances in Practice, 8(3), Article rkae081. https://doi.org/10.1093/rap/rkae081

Objective
To examine the association between obesity and patient-reported outcomes measures (PROMs) in a primary care-based cohort of people with polymyalgia rheumatica (PMR).

Methods
The PMR Cohort Study recruited people with incident PMR from... Read More about The Relationship Between Obesity and Patient-Reported Outcome Measures in People with Polymyalgia Rheumatica.

AB0228 GABAPENTINOID USE AND THE RISK OF FRACTURES IN PEOPLE WITH INFLAMMATORY ARTHRITIS: NESTED CASE-CONTROL STUDY IN THE CLINICAL PRACTICE RESEARCH DATALINK (CPRD) AURUM (2024)
Presentation / Conference Contribution
Scott, I., Daud, N., Bailey, J., Twohig, H., Hider, S., Mallen, C., Jordan, K., & Muller, S. AB0228 GABAPENTINOID USE AND THE RISK OF FRACTURES IN PEOPLE WITH INFLAMMATORY ARTHRITIS: NESTED CASE-CONTROL STUDY IN THE CLINICAL PRACTICE RESEARCH DATALINK (CPRD) AURUM. Presented at EULAR 2024 European Congress of Rheumatology, 12-15 June. Vienna, Austria, Vienna

Background: Recent observational studies suggest gabapentinoids associate with an increased risk of fractures. The potential for confounding inherent to non-randomised studies of interventions, however, alongside th... Read More about AB0228 GABAPENTINOID USE AND THE RISK OF FRACTURES IN PEOPLE WITH INFLAMMATORY ARTHRITIS: NESTED CASE-CONTROL STUDY IN THE CLINICAL PRACTICE RESEARCH DATALINK (CPRD) AURUM.

Management of Refractory Disease and Persistent Symptoms in Inflammatory Arthritis: Qualitative Framework analysis of interviews with patients and healthcare professionals (2024)
Journal Article
Chaplin, H., Simpson, C., Wilkins, K., Meehan, J., Ng, N., Galloway, J., Lempp, H., Scott, I. C., Sen, D., Tattersall, R., Moss-Morris, R., & Norton, S. (2024). Management of Refractory Disease and Persistent Symptoms in Inflammatory Arthritis: Qualitative Framework analysis of interviews with patients and healthcare professionals. Rheumatology Advances in Practice, 8(3), Article rkae076. https://doi.org/10.1093/rap/rkae076

Objectives
This study aims to explore patients’ and clinicians’ experiences in managing and living with refractory disease (RD) and persistent physical and emotional symptoms (PPES) in patients with RA or polyarticular JIA from their perspectives th... Read More about Management of Refractory Disease and Persistent Symptoms in Inflammatory Arthritis: Qualitative Framework analysis of interviews with patients and healthcare professionals.

E041 Feasibility and acceptability of electronic patient reported outcome measures in the routine care of people with inflammatory arthritis: Haywood Arthritis Portal study (2024)
Presentation / Conference Contribution
Cox, N., Kettle, C., Wang, H., Dutta, S., Packham, J., Galloway, J., Hill, J., Muller, S., Hider, S., Paskins, Z., Bullock, L., & Scott, I. C. (2024, April). E041 Feasibility and acceptability of electronic patient reported outcome measures in the routine care of people with inflammatory arthritis: Haywood Arthritis Portal study. Poster presented at British Society for Rheumatology Annual Conference 2024

Background/Aims Electronic patient-reported outcome measures (ePROMs) assessing disease activity, function, pain, and quality of life can facilitate innovative inflammatory arthritis (IA) care, such as automating patient-initiated follow-up. This mix... Read More about E041 Feasibility and acceptability of electronic patient reported outcome measures in the routine care of people with inflammatory arthritis: Haywood Arthritis Portal study.

P045 Google Internet Searches Related to Inflammatory Arthritis: an Observational Study Using Google Trends Data (2024)
Presentation / Conference
Akthar, M., Mason, K. J., & Scott, I. C. (2024, April). P045 Google Internet Searches Related to Inflammatory Arthritis: an Observational Study Using Google Trends Data. Poster presented at British Society for Rheumatology Annual Conference 2024

Background/Aims Inflammatory arthritis (IA) care involves a paradox. Rheumatologists focus on reducing disease activity through treat-to-target (T2T). But surveys/qualitative studies show patients’ main concern is pain. As these studies include a min... Read More about P045 Google Internet Searches Related to Inflammatory Arthritis: an Observational Study Using Google Trends Data.

Analgesic Prescribing in Patients with Inflammatory Arthritis in England: Observational Studies in the Clinical Practice Research Datalink (2023)
Journal Article
Scott, I. C., Jordan, K. P., Twohig, H., Whittle, R., Muller, S., Hider, S. L., Mallen, C. D., & Bailey, J. (2023). Analgesic Prescribing in Patients with Inflammatory Arthritis in England: Observational Studies in the Clinical Practice Research Datalink. Rheumatology, Article kead463. https://doi.org/10.1093/rheumatology/kead463

Despite little evidence that analgesics are effective in inflammatory arthritis (IA), studies report substantial opioid prescribing. The extent this applies to other analgesics is uncertain. We undertook a comprehensive evaluation of analgesic prescr... Read More about Analgesic Prescribing in Patients with Inflammatory Arthritis in England: Observational Studies in the Clinical Practice Research Datalink.

Heterogeneity of treatment responses in rheumatoid arthritis using group based trajectory models: secondary analysis of clinical trial data (2023)
Journal Article
Ibrahim, F., Scott, I. C., Scott, D. L., & Ayis, S. A. (in press). Heterogeneity of treatment responses in rheumatoid arthritis using group based trajectory models: secondary analysis of clinical trial data. BMC Rheumatology, 7(1), Article 33. https://doi.org/10.1186/s41927-023-00348-5

Background
Traditionally rheumatoid arthritis (RA) trials classify patients as responders and non-responders; they ignore the potential range of treatment responses. Group Based Trajectory Models (GBTMs) provide a more refined approach. They identif... Read More about Heterogeneity of treatment responses in rheumatoid arthritis using group based trajectory models: secondary analysis of clinical trial data.

The relationship between pain and depression and anxiety in patients with inflammatory arthritis: a systematic review protocol (2023)
Journal Article
Cox, N., Hawarden, A., Bajpai, R., Farooq, S., Twohig, H., Muller, S., & Scott, I. C. (2024). The relationship between pain and depression and anxiety in patients with inflammatory arthritis: a systematic review protocol. Rheumatology International, 44, 435–440. https://doi.org/10.1007/s00296-023-05450-y

Pain is a major challenge for patients with inflammatory arthritis (IA). Depression and anxiety are common comorbidities in IA, associating with worse outcomes. How they relate to pain is uncertain, with existing systematic reviews (a) mainly conside... Read More about The relationship between pain and depression and anxiety in patients with inflammatory arthritis: a systematic review protocol.

P100 The Impact of Intensive Management on Pain Intensity in Patients with Rheumatoid Arthritis and Psoriatic Arthritis: Secondary Analysis of Three Clinical Trials (2023)
Presentation / Conference
Scott, I. C., Scott, D. L., & Ibrahim, F. (2023, April). P100 The Impact of Intensive Management on Pain Intensity in Patients with Rheumatoid Arthritis and Psoriatic Arthritis: Secondary Analysis of Three Clinical Trials. Poster presented at British Society for Rheumatology Annual Conference 2023, Manchester Central Convention Complex, Manchester, UK

P098 Changes in Analgesic Prescribing in Patients with Inflammatory Arthritis in England: An Observational Study in CPRD Aurum (2023)
Presentation / Conference Contribution
C Scott, I., Whittle, R., Bailey, J., Twohig, H., L Hider, S., D Mallen, C., Muller, S., & P Jordan, K. (2023, April). P098 Changes in Analgesic Prescribing in Patients with Inflammatory Arthritis in England: An Observational Study in CPRD Aurum. Poster presented at British Society for Rheumatology Annual Conference 2023, Manchester Central Convention Complex, Manchester, UK

Background/Aims
Pain is a common symptom experienced by patients with inflammatory arthritis (IA). Emerging data indicate IA pain treatment focuses on prescribing analgesics despite an absence of evidence for long-term efficacy. Delivering optimal,... Read More about P098 Changes in Analgesic Prescribing in Patients with Inflammatory Arthritis in England: An Observational Study in CPRD Aurum.

Digital exclusion as a potential cause of inequalities in access to care: a survey in people with inflammatory rheumatic diseases (2023)
Journal Article
Hider, S., Muller, S., Gray, L., Manning, F., Heining, D., Menon, A., Packham, J., Raghuvanshi, S., Roddy, E., Ryan, S., Brooks, M., Scott, I., & Paskins, Z. (2023). Digital exclusion as a potential cause of inequalities in access to care: a survey in people with inflammatory rheumatic diseases. Rheumatology Advances in Practice, 7(1), https://doi.org/10.1093/rap/rkac109

Objectives: COVID-19 led to rapid uptake of digital healthcare. We sought to examine digital access, health and digital literacy, and impact on confidence and satisfaction with remote consultations in people with inflammatory rheumatic diseases (IRDs... Read More about Digital exclusion as a potential cause of inequalities in access to care: a survey in people with inflammatory rheumatic diseases.