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Professor William Parry-Smith's Outputs (44)

Managing obstetric bleeding in Wales: A qualitative evaluation of the OBS Cymru care bundle using Normalisation Process Theory (2025)
Journal Article
Rai, T., Hinton, L. E., Mackay, R., Black, M., Sanders, J., Slade, P., Elsmore, A., Dhadda, A., Parry-Smith, W., Collis, R., Petrou, S., Stanworth, S., Pallman, P., Townson, J., Fye, H., Geden, A. G., Collins, P., & Bell, S. (2025). Managing obstetric bleeding in Wales: A qualitative evaluation of the OBS Cymru care bundle using Normalisation Process Theory. PLoS ONE, 20(4), Article e0320754. https://doi.org/10.1371/journal.pone.0320754

Background: Post-partum haemorrhage (PPH) is one of the leading causes of maternal mortality and morbidity worldwide. The Obstetric Bleeding Strategy (OBS) care bundle for PPH management was adopted into Welsh national guidelines in 2019 (as OBS Cymr... Read More about Managing obstetric bleeding in Wales: A qualitative evaluation of the OBS Cymru care bundle using Normalisation Process Theory.

Ethnic and Socioeconomic Variation in Pre-Conception Long-Term Conditions: A Cross-Sectional Electronic Health Record Study of 3.4 Million Pregnancies in Cprd Aurum (2025)
Preprint / Working Paper
Cockburn, N., Singh, M., Wambua, S., Gonzalez-Izquierdo, A., Ing Lee, S., Phillips, K., Elsmore, A., Ilaalagan, R., Holland, R., Hanley, S. J., Laws, E., Hodgetts-Morton, V., Gibbon, M., Judd, N. A., Seymour, R. G., Taylor, B., Singh Chandan, J., Parry-Smith, W., & Nirantharakumar, K. (2025). Ethnic and Socioeconomic Variation in Pre-Conception Long-Term Conditions: A Cross-Sectional Electronic Health Record Study of 3.4 Million Pregnancies in Cprd Aurum

Background: Inequalities in pregnancy outcomes between different ethnic groups and backgrounds of deprivation have been observed in the UK and elsewhere for several decades. Pre-existing long-term health conditions increase risks of adverse outcomes... Read More about Ethnic and Socioeconomic Variation in Pre-Conception Long-Term Conditions: A Cross-Sectional Electronic Health Record Study of 3.4 Million Pregnancies in Cprd Aurum.

The OBS UK Dashboard: an interactive tool for representative trial site selection to facilitate equality and diversity in maternity research (2024)
Journal Article
Elsmore, A., Rai, T., Pallmann, P., Townson, J., Kotecha, S., Black, M., Sanders, J., Collis, R., Collins, P., Karunakaran, B., Wu, P., Bell, S., & Parry-Smith, W. (2024). The OBS UK Dashboard: an interactive tool for representative trial site selection to facilitate equality and diversity in maternity research. Trials, 25(1), Article 629. https://doi.org/10.1186/s13063-024-08487-x

Background: Obstetric Bleeding Study UK (OBS UK) (award ID: 152057) is a National Institute for Health and Care Research (NIHR)-funded stepped wedge cluster randomised controlled trial of a complex intervention for postpartum haemorrhage. This was de... Read More about The OBS UK Dashboard: an interactive tool for representative trial site selection to facilitate equality and diversity in maternity research.

Clinical decision support systems for maternity care: a systematic review and meta-analysis (2024)
Journal Article
Cockburn, N., Osborne, C., Withana, S., Elsmore, A., Nanjappa, R., South, M., Parry-Smith, W., Taylor, B., Chandan, J. S., & Nirantharakumar, K. (2024). Clinical decision support systems for maternity care: a systematic review and meta-analysis. EClinicalMedicine, 76, Article 102822. https://doi.org/10.1016/j.eclinm.2024.102822

Background The use of Clinical Decision Support Systems (CDSS) is increasing throughout healthcare and may be able to improve safety and outcomes in maternity care, but maternity care has key differences to other di... Read More about Clinical decision support systems for maternity care: a systematic review and meta-analysis.

Automating incidence and prevalence analysis in open cohorts (2024)
Journal Article
Cockburn, N., Hammond, B., Gani, I., Cusworth, S., Acharya, A., Gokhale, K., Thayakaran, R., Crowe, F., Minhas, S., Parry-Smith, W., Taylor, B., Nirantharakumar, K., & Chandan, J. S. (in press). Automating incidence and prevalence analysis in open cohorts. BMC medical research methodology, 24, Article 144. https://doi.org/10.1186/s12874-024-02266-7

Motivation
Data is increasingly used for improvement and research in public health, especially administrative data such as that collected in electronic health records. Patients enter and exit these typically open-cohort datasets non-uniformly; this... Read More about Automating incidence and prevalence analysis in open cohorts.

Defining an Ageing-Related Pathology, Disease or Syndrome: International Consensus Statement (2024)
Preprint / Working Paper
Short, E., Adcock, I. M., Al-Sarireh, B., Ager, A., Ajjan, R., Akbar, N., Akeroyd, M. A., Alsaleh, G., Al-Sharbatee, G., Alavian, K., Amoaku, W., Andersen, J., Antoniades, C., Arends, M. J., Astley, S., Atan, D., Attanoos, R., Attems, J., Bain, S., Balaskas, K., …Bentley, B. L. Defining an Ageing-Related Pathology, Disease or Syndrome: International Consensus Statement

Automating incidence and prevalence analysis in open cohorts (2024)
Preprint / Working Paper
Cockburn, N., Hammond, B., Ghani, I., Cusworth, S., Acharya, A., Gokhale, K., Thayakaran, R., Crowe, F., Minhas, S., Parry-Smith, W., Taylor, B., Nirantharakumar, K., & Singh Chandan, J. Automating incidence and prevalence analysis in open cohorts

Motivation

Increasingly vast quantities of data support improvement and research in public health, and growth is especially seen in administrative data such as that collected in electronic health records. Patients enter and exit these typically o... Read More about Automating incidence and prevalence analysis in open cohorts.

Endocervical crypt involvement by high-grade cervical intraepithelial neoplasia and its association with high-grade histopathological recurrence after cervical excision in women with negative excision margins: a systematic review and meta-analysis (2023)
Journal Article
Papoutsis, D., Underwood, M., Parry-Smith, W., & Tzavara, C. (2024). Endocervical crypt involvement by high-grade cervical intraepithelial neoplasia and its association with high-grade histopathological recurrence after cervical excision in women with negative excision margins: a systematic review and meta-analysis. Archives of Gynecology and Obstetrics, 309, 939–948. https://doi.org/10.1007/s00404-023-07242-y

Background
There is a growing body of evidence suggesting that endocervical crypt involvement by high-grade cervical intraepithelial neoplasia (CIN) may represent a risk factor for disease recurrence after cervical treatment.

Objectives
To provi... Read More about Endocervical crypt involvement by high-grade cervical intraepithelial neoplasia and its association with high-grade histopathological recurrence after cervical excision in women with negative excision margins: a systematic review and meta-analysis.

The association between menstrual cycle characteristics and cardiometabolic outcomes in later life: a retrospective matched cohort study of 704,743 women from the UK. (2023)
Journal Article
Okoth, K., Parry-Smith, W., Thomas, G. N., Nirantharakumar, K., & Adderley, N. J. (2023). The association between menstrual cycle characteristics and cardiometabolic outcomes in later life: a retrospective matched cohort study of 704,743 women from the UK. BMC Medicine, 21, Article 104. https://doi.org/10.1186/s12916-023-02794-x

Outcomes of gynecologic cancer surgery during the COVID-19 pandemic: an international, multicenter, prospective CovidSurg-Gynecologic Oncology Cancer study. (2022)
Journal Article
Fotopoulou, C., Khan, T., Bracinik, J., Glasbey, J., Abu-Rustum, N., Chiva, L., Fagotti, A., Fujiwara, K., Ghebre, R., Gutelkin, M., Konney, T. O., Ng, J., Pareja, R., Kottayasamy Seenivasagam, R., Sehouli, J., Surappa, S. T., Bhangu, A., Leung, E., Sundar, S., Cancer Collaborators, C. G., & Parry-Smith, W. (2022). Outcomes of gynecologic cancer surgery during the COVID-19 pandemic: an international, multicenter, prospective CovidSurg-Gynecologic Oncology Cancer study. American Journal of Obstetrics and Gynecology, 227(5), 735.e1-735.e25. https://doi.org/10.1016/j.ajog.2022.06.052

Worth the paper it's written on- A cross-sectional study of Medical Certificate of Stillbirth accuracy in the UK (2022)
Journal Article
Rimmer, M. P., Henderson, I., Parry-Smith, W., Raglan, O., Tamblyn, J., Heazell, A. E. P., Higgins, L. E., & working group, T. U. N. (2023). Worth the paper it's written on- A cross-sectional study of Medical Certificate of Stillbirth accuracy in the UK. International Journal of Epidemiology, 52(1), 295–308. https://doi.org/10.1093/ije/dyac100

Background
The Medical Certificate of Stillbirth (MCS) records data about a baby’s death after 24 weeks of gestation but before birth. Major errors that could alter interpretation of the MCS were widespread in two UK-based regional studies.

Metho... Read More about Worth the paper it's written on- A cross-sectional study of Medical Certificate of Stillbirth accuracy in the UK.

Effectiveness of a web-based virtual journal club to promote medical education (Web-Ed): protocol of a multicentre pragmatic randomised trial (2022)
Journal Article
Rimmer, M., Elfaki, N., Dunlop, C., Coleburt, D., Cowan, N., Raglan, O., Teh, J., Fisher, M., McRobbie, S., Murugesu, N., Ramcharn, M., Abdelrahman, M., Jibrel, Y., Wood, M., Parry-Smith, W., & Al Wattar, B. (2022). Effectiveness of a web-based virtual journal club to promote medical education (Web-Ed): protocol of a multicentre pragmatic randomised trial. BMJ Open, 12(6), Article e058610. https://doi.org/10.1136/bmjopen-2021-058610

Introduction A journal club (JC) is a commonly used medical educational tool. Videoconferencing technology can facilitate the delivery of JCs, however, there remains no evidence on the role of web-based virtual JCs in promoting the acquisition and re... Read More about Effectiveness of a web-based virtual journal club to promote medical education (Web-Ed): protocol of a multicentre pragmatic randomised trial.

Healing pattern of the cervical stroma following cold coagulation treatment for cervical intraepithelial neoplasia: A case report (2022)
Journal Article
Papoutsis, D., Williams, J., Underwood, M., & Parry-Smith, W. (2022). Healing pattern of the cervical stroma following cold coagulation treatment for cervical intraepithelial neoplasia: A case report. Oncology Letters, 23, Article 81. https://doi.org/10.3892/ol.2022.13201

Cold coagulation of the cervix for cervical intraepithelial neoplasia (CIN), when compared with cervical excision, has previously demonstrated comparable cure rates and a reduction in the rate of spontaneous preterm birth. In the present report the h... Read More about Healing pattern of the cervical stroma following cold coagulation treatment for cervical intraepithelial neoplasia: A case report.

Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study (2021)
Journal Article
Collaborative*, C., & Parry-Smith, W. (2021). Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study. Lancet Oncology, 22(11), 1507-1517. https://doi.org/10.1016/S1470-2045%2821%2900493-9

Background
Surgery is the main modality of cure for solid cancers and was prioritised to continue during COVID-19 outbreaks. This study aimed to identify immediate areas for system strengthening by comparing the delivery of elective cancer surgery d... Read More about Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study.

SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study. (2021)
Journal Article
Collaborative, C., Collaborative, G., & Parry-Smith, W. (2022). SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study. Anaesthesia, 77(1), 28-39. https://doi.org/10.1111/anae.15563

SARS-CoV-2 has been associated with an increased rate of venous thromboembolism in critically ill patients. Since surgical patients are already at higher risk of venous thromboembolism than general populations, this study aimed to determine if patien... Read More about SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study..

Effects of pre-operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study. (2021)
Journal Article
Collaborative, C., Collaborative, G., & Parry-Smith, W. (2021). Effects of pre-operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study. Anaesthesia, 76(11), 1454-1464. https://doi.org/10.1111/anae.15560

We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing el... Read More about Effects of pre-operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study..

The patient with abnormal cervical cytology (2021)
Book Chapter
Underwood, M., & Parry-Smith, W. (2021). The patient with abnormal cervical cytology. In Assisted Reproduction Techniques: Challenges and Management Options (123-126). Wiley. https://doi.org/10.1002/9781119622215.ch19

This chapter includes clinical cases, background, evidence-based practical management options, preventive measures, key-point summaries of abnormal cervical cytology and answers to questions patients ask. Cervical screening programs around the world... Read More about The patient with abnormal cervical cytology.

SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study (2021)
Journal Article
Collaborative, C., Collaborative, G., & Parry-Smith, W. (2021). SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study. British Journal of Surgery, 108(9), 1056-1063. https://doi.org/10.1093/bjs/znab101

Background
Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling.

Methods
The primary outcome was the number needed to vaccinate (NNV... Read More about SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.

Postpartum haemorrhage and risk of mental ill health: A population-based longitudinal study using linked primary and secondary care databases (2021)
Journal Article
Parry-Smith, W., Okoth, K., Subramanian, A., Gokhale, K. M., Chandan, J. S., Humpston, C., Coomarasamy, A., Nirantharakumar, K., & Šumilo, D. (2021). Postpartum haemorrhage and risk of mental ill health: A population-based longitudinal study using linked primary and secondary care databases. Journal of Psychiatric Research, 137, 419-425. https://doi.org/10.1016/j.jpsychires.2021.03.022