Outputs (73)

Absence of gemin5 from SMN complexes in nuclear Cajal bodies (2007)
Journal Article
Hao, L. T., Fuller, H. R., Lam, L. T., Le, T. T., Burghes, A. H., & Morris, G. E. (2007). Absence of gemin5 from SMN complexes in nuclear Cajal bodies. BMC Cell Biology, 8(1), https://doi.org/10.1186/1471-2121-8-28

Background Spinal muscular atrophy is caused by reduced levels of the survival of motor neurons (SMN) protein. SMN is found in large complexes with Sm proteins and at least eight other proteins, including seven "gemins". These complexes are involved... Read More about Absence of gemin5 from SMN complexes in nuclear Cajal bodies.

Remyelination In Multiple Sclerosis (2007)
Book Chapter
Chari, D. M. (2007). Remyelination In Multiple Sclerosis. In International Review of Neurobiology (589-620). (79). Elsevier. https://doi.org/10.1016/s0074-7742%2807%2979026-8

Remyelination is the phenomenon by which new myelin sheaths are generated around axons in the adult central nervous system (CNS). This follows the pathological loss of myelin in diseases like multiple sclerosis (MS). Remyelination can restore conduct... Read More about Remyelination In Multiple Sclerosis.

IPSE/alpha-1: A major immunogenic component secreted from Schistosoma mansoni eggs (2006)
Journal Article
Schramm, G., Gronow, A., Knobloch, J., Wippersteg, V., Grevelding, C., Galle, J., …Doenhoff, M. (2006). IPSE/alpha-1: A major immunogenic component secreted from Schistosoma mansoni eggs. Molecular and Biochemical Parasitology, 147(1), 9-19. https://doi.org/10.1016/j.molbiopara.2006.01.003

During infection with Schistosoma mansoni the egg stage of this parasite modulates the initial T helper (Th1) response into a Th2 response. This suggests that schistosome eggs contain factors responsible for that effect. We have recently described a... Read More about IPSE/alpha-1: A major immunogenic component secreted from Schistosoma mansoni eggs.

An enzyme-linked immunosorbent assay (ELISA) for the major crustacean allergen, tropomyosin, in food (2006)
Journal Article
Fuller, H. R., Goodwin, P. R., & Morris, G. E. (2006). An enzyme-linked immunosorbent assay (ELISA) for the major crustacean allergen, tropomyosin, in food. Food and Agricultural Immunology, 17(1), 43-52. https://doi.org/10.1080/09540100600572651

Shellfish are a common cause of food reactions in hypersensitive individuals and are among the eight foods that account for over 90% of food allergies. At present, the only way to prevent these serious consequences of food allergies is to avoid the f... Read More about An enzyme-linked immunosorbent assay (ELISA) for the major crustacean allergen, tropomyosin, in food.

Corticosteroids delay remyelination of experimental demyelination in the rodent central nervous system (2006)
Journal Article
Chari, D. M., Zhao, C., Kotter, M. R., Blakemore, W. F., & Franklin, R. J. (2006). Corticosteroids delay remyelination of experimental demyelination in the rodent central nervous system. Journal of Neuroscience Research, 83(4), 594-605. https://doi.org/10.1002/jnr.20763

High dose corticosteroid (CS) administration is a common mode of therapy in treatment of acute relapses in multiple sclerosis (MS) but the effects of CS on remyelination and the cellular mechanisms mediating this repair process are controversial. We... Read More about Corticosteroids delay remyelination of experimental demyelination in the rodent central nervous system.

Oligodendrocyte progenitor cell (OPC) transplantation is unlikely to offer a means of preventing X-irradiation induced damage in the CNS (2006)
Journal Article
Chari, D. M., Gilson, J. M., Franklin, R. J., & Blakemore, W. F. (2006). Oligodendrocyte progenitor cell (OPC) transplantation is unlikely to offer a means of preventing X-irradiation induced damage in the CNS. Experimental Neurology, 198(1), 145-153. https://doi.org/10.1016/j.expneurol.2005.11.023

Oligodendrocyte lineage cells [oligodendrocytes and their parent cells, the oligodendrocyte progenitor cells (OPCs)] are depleted by X-irradiation and progenitor cell transplantation has been proposed as a therapeutic strategy to counteract radiation... Read More about Oligodendrocyte progenitor cell (OPC) transplantation is unlikely to offer a means of preventing X-irradiation induced damage in the CNS.

Decline in Rate of Colonization of Oligodendrocyte Progenitor Cell (OPC)-Depleted Tissue by Adult OPCs with Age (2003)
Journal Article
Chari, D. M., Crang, A. J., & Blakemore, W. F. (2003). Decline in Rate of Colonization of Oligodendrocyte Progenitor Cell (OPC)-Depleted Tissue by Adult OPCs with Age. Journal of Neuropathology and Experimental Neurology, 62(9), 908-916. https://doi.org/10.1093/jnen/62.9.908

Rates of remyelination decline with age and this has been attributed to slower recruitment of oligodendrocyte progenitor cells (OPCs) into areas of demyelination and slower differentiation of OPCs into remyelinating oligodendrocytes. When considering... Read More about Decline in Rate of Colonization of Oligodendrocyte Progenitor Cell (OPC)-Depleted Tissue by Adult OPCs with Age.

Dysfunctional oligodendrocyte progenitor cell (OPC) populations may inhibit repopulation of OPC depleted tissue (2003)
Journal Article
Chari, D., Huang, W., & Blakemore, W. (2003). Dysfunctional oligodendrocyte progenitor cell (OPC) populations may inhibit repopulation of OPC depleted tissue. Journal of Neuroscience Research, 73(6), 787-793. https://doi.org/10.1002/jnr.10700

We have attempted to extend a previously described rat model of focal oligodendrocyte progenitor cell (OPC) depletion, using 40 Gy X-irradiation (Chari and Blakemore [2002] Glia 37:307–313), to the adult mouse spinal cord, to examine the ability of O... Read More about Dysfunctional oligodendrocyte progenitor cell (OPC) populations may inhibit repopulation of OPC depleted tissue.

New insights into remyelination failure in multiple sclerosis: implications for glial cell transplantation (2002)
Journal Article
Chari, D., & Blakemore, W. (2002). New insights into remyelination failure in multiple sclerosis: implications for glial cell transplantation. Multiple Sclerosis, 8(4), 271-277. https://doi.org/10.1191/1352458502ms842oa

This review considers aspects of remyelination that require further clarification if successful strategies are to be devised to enhance remyelination in multiple sclerosis (MS). We speculate, based on our understanding of the rate with which oligoden... Read More about New insights into remyelination failure in multiple sclerosis: implications for glial cell transplantation.

Modelling large areas of demyelination in the rat reveals the potential and possible limitations of transplanted glial cells for remyelination in the CNS (2002)
Journal Article
Blakemore, W., Chari, D., Gilson, J., & Crang, A. (2002). Modelling large areas of demyelination in the rat reveals the potential and possible limitations of transplanted glial cells for remyelination in the CNS. Glia, 38(2), 155-168. https://doi.org/10.1002/glia.10067

Transplantation of myelin-forming glial cells may provide a means of achieving remyelination in situations in which endogenous remyelination fails. For this type of cell therapy to be successful, cells will have to migrate long distances in normal ti... Read More about Modelling large areas of demyelination in the rat reveals the potential and possible limitations of transplanted glial cells for remyelination in the CNS.