Outputs (134)

Morning Salivary Cortisone Versus Serum Cortisol in the Overnight Dexamethasone Suppression Test (ODNST): Evaluation in a Clinical Setting (2025)
Journal Article
Mordaunt, M., Heald, A., Majeed, W., Kochhar, R., Syed, A., Mudaliar, R. N., Alshames, R., Hanna, F., Marshall, D., Keevil, B., & Fryer, A. A. (in press). Morning Salivary Cortisone Versus Serum Cortisol in the Overnight Dexamethasone Suppression Test (ODNST): Evaluation in a Clinical Setting. Clinical Endocrinology, 1-8. https://doi.org/10.1111/cen.15233

Introduction: Saliva hormone measurement is increasingly being applied in everyday clinical practice. In relation to salivary cortisone measurement, there is a particular advantage, with minimal chance of cross‐reaction with prescribed glucocorticoid... Read More about Morning Salivary Cortisone Versus Serum Cortisol in the Overnight Dexamethasone Suppression Test (ODNST): Evaluation in a Clinical Setting.

The Impact of Age and Sex on Fasting Plasma Glucose and Glycated Haemoglobin (HbA1c) in the Non-diabetes Population. (2024)
Journal Article
Stedman, M., Heald, A. H., Holland, D., Halsall, I., Green, L., Wu, P., Patel, K., Scargill, J., Gibson, M., Hanna, F. W. F., & Fryer, A. A. (in press). The Impact of Age and Sex on Fasting Plasma Glucose and Glycated Haemoglobin (HbA1c) in the Non-diabetes Population. Diabetes Therapy, https://doi.org/10.1007/s13300-024-01680-w

We previously reported sex differences in the distribution of glycated haemoglobin (HbA1c) for men/women aged < 50 years vs older individuals, with implications for delayed diabetes diagnosis. Here, we explored whether this pattern was also seen in m...

How Does Thyroid Hormone Profile Differ on and Off Replacement Treatment? (2024)
Journal Article
Heald, A. H., Premawardhana, L. D., Taylor, P. N., Baker, A., Chaudhury, N., Fryer, A. A., Okosieme, O. E., Dayan, C. M., & Stedman, M. (in press). How Does Thyroid Hormone Profile Differ on and Off Replacement Treatment?. Clinical Endocrinology, 1-6. https://doi.org/10.1111/cen.15185

Introduction: There continues to be much discussion around optimisation of thyroid hormone status in hypothyroid individuals. We here looked the way that free T4(FT4) and thyroid‐stimulating hormone (TSH) related to each other in a large laboratory s... Read More about How Does Thyroid Hormone Profile Differ on and Off Replacement Treatment?.

The link between age, sex, fasting plasma glucose and glycated haemoglobin (HbA 1c ) (2024)
Presentation / Conference Contribution
Stedman, M., Heald, A., Holland, D., Halsall, I., Green, L., Wu, P., Scargill, J., Hanna, F., Colclough, K., Gibson, M., & Fryer, A. The link between age, sex, fasting plasma glucose and glycated haemoglobin (HbA 1c ). Presented at 60th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Madrid, Spain

Using maternal glycosylated haemoglobin as well as glucose tolerance tests identified significantly more mothers with high birth weight in their offspring (2024)
Presentation / Conference Contribution
Wu, P., Stedman, M., Fryer, A., Green, L., Holland, D., Scargill, J., Pankaja, S., Christian, S., & Heald, A. Using maternal glycosylated haemoglobin as well as glucose tolerance tests identified significantly more mothers with high birth weight in their offspring. Presented at 60th EASD Annual Meeting of the European Association for the Study of Diabetes, Madrid, Spain

Counting the Lifetime Cost of Obesity: Analysis based on National England Data (2024)
Journal Article
Fryer, A. A., Heald, A., Stedman, M., Stedman, M., Davies, M. B., Rutter, M. K., Gibson, J. M., & Whyte, M. (2024). Counting the Lifetime Cost of Obesity: Analysis based on National England Data. Diabetes, Obesity and Metabolism, 26(4), 1464-1478. https://doi.org/10.1111/dom.15447

Aim
Obesity has a significant impact on all-cause mortality rate and overall health care resource use (HCRU). These outcomes are also strongly linked to age, sex and local deprivation of the population. We aimed to establish the lifetime costs of ob... Read More about Counting the Lifetime Cost of Obesity: Analysis based on National England Data.

The INSIGHT project: reflections on the co-production of a quality recognition programme to showcase excellence in public involvement in health and care research (2023)
Journal Article
Blackburn, S., Hine, R., Fairbanks, S., Parkes, P., Murinas, D., Meakin, A., Taylor, R., Parton, L., Jones, M., Tunmore, J., Lench, J., Evans, N., Lewney, K., O’Mara, L., & Fryer, A. A. (2023). The INSIGHT project: reflections on the co-production of a quality recognition programme to showcase excellence in public involvement in health and care research. Research Involvement and Engagement, 9(1), 99. https://doi.org/10.1186/s40900-023-00508-4

Background: The quality of Patient and Public Involvement (PPI) in healthcare research varies considerably and is frequently tokenistic. We aimed to co-produce the Insight | Public Involvement Quality Recognition and Awards programme, based on the UK... Read More about The INSIGHT project: reflections on the co-production of a quality recognition programme to showcase excellence in public involvement in health and care research.

Is the Current Cut Point for Glycated Haemoglobin (HbA1c) Correct for Diagnosing Diabetes Mellitus in Premenopausal Women? Evidence to Inform Discussion (2023)
Journal Article
Holland, D., Fryer, A. A., Stedman, M., Hanna, F. W. F., Duff, C. J., Green, L., Scargill, J., Halsall, I., Gaskell, N., Howe, J. D., Heald, A. H., & Wu, P. (2023). Is the Current Cut Point for Glycated Haemoglobin (HbA1c) Correct for Diagnosing Diabetes Mellitus in Premenopausal Women? Evidence to Inform Discussion. Diabetes Therapy, https://doi.org/10.1007/s13300-023-01482-6

Women are on average diagnosed with diabetes mellitus at later age than men but have higher mortality. As the diagnosis of diabetes mellitus is primarily based on HbA1c, the use of a non-specific reference range and cut point for diabetes mellitus th... Read More about Is the Current Cut Point for Glycated Haemoglobin (HbA1c) Correct for Diagnosing Diabetes Mellitus in Premenopausal Women? Evidence to Inform Discussion.

Failure to control conventional cardiovascular risk factors in women with type 2 diabetes might explain worse mortality (2023)
Journal Article
Stedman, M., Whyte, M. B., Laing, I., Fryer, A. A., Torres, B. M., Robinson, A., Mannan, F., Gibson, J. M., Rayman, G., & Heald, A. H. (2023). Failure to control conventional cardiovascular risk factors in women with type 2 diabetes might explain worse mortality. Diabetes/Metabolism Research and Reviews, 39(8), Article e3695. https://doi.org/10.1002/dmrr.3695

Introduction: The standardised mortality rate (SMR) for people with diabetes in England is 1.5–1.7, with differences in outcomes between sexes. There has been little work examining the factors that could have an impact on this or on what may determin... Read More about Failure to control conventional cardiovascular risk factors in women with type 2 diabetes might explain worse mortality.

Diabetes detection in women with gestational diabetes and polycystic ovarian syndrome (2023)
Journal Article
Hanna, F., Wu, P., Heald, A., & Fryer, A. (2023). Diabetes detection in women with gestational diabetes and polycystic ovarian syndrome. BMJ, 382, Article e071675. https://doi.org/10.1136/bmj-2022-071675

Gestational diabetes mellitus (GDM) and polycystic ovarian syndrome (PCOS) represent two of the highest risk factors for development of type 2 diabetes mellitus in young women. As these increasingly common conditions generally affect younger women, e... Read More about Diabetes detection in women with gestational diabetes and polycystic ovarian syndrome.