Outputs (33)

In vitro model of neurotrauma using the chick embryo to test regenerative bioimplantation. (2023)
Journal Article
Mogas Barcons, A., Chari, D. M., & Adams, C. (in press). In vitro model of neurotrauma using the chick embryo to test regenerative bioimplantation. Alternatives to animal experimentation : a journal for new paths in biomedical science / edited by the Swiss Society ALTEX Edition, 41(2), 202-212. https://doi.org/10.14573/altex.2304171

Effective repair of spinal cord injury sites remains a major clinical challenge. One promising strategy is the implantation of multifunctional bioscaffolds to enhance nerve fibre growth, guide regenerating tissue and modulate scarring/inflammation pr... Read More about In vitro model of neurotrauma using the chick embryo to test regenerative bioimplantation..

Evaluating the Feasibility of Hydrogel-Based Neural Cell Sprays (2023)
Journal Article
Evans, D., Barcons, A. M., Basit, R. H., Adams, C., & Chari, D. M. (in press). Evaluating the Feasibility of Hydrogel-Based Neural Cell Sprays. Journal of Functional Biomaterials, 14(10), Article 527. https://doi.org/10.3390/jfb14100527

Neurological injuries have poor prognoses with serious clinical sequelae. Stem cell transplantation enhances neural repair but is hampered by low graft survival (<ca. 5%), necessitating the development of approaches to enhance post-transplant cell... Read More about Evaluating the Feasibility of Hydrogel-Based Neural Cell Sprays.

A benchtop brain injury model using resected donor tissue from patients with Chiari malformation. (2023)
Journal Article
Tickle, J., Sen, J., Adams, C., Furness, D., Price, R., Kandula, V., …Chari, D. (2023). A benchtop brain injury model using resected donor tissue from patients with Chiari malformation. Neural Regeneration Research, 1057 - 1061. https://doi.org/10.4103/1673-5374.355761

The use of live animal models for testing new therapies for brain and spinal cord repair is a controversial area. Live animal models have associated ethical issues and scientific concerns regarding the predictability of human responses. Alternative m... Read More about A benchtop brain injury model using resected donor tissue from patients with Chiari malformation..

EP-273 Magnetic nanoparticle administration to a model of penetrating neurotrauma in vitro (2022)
Journal Article
Chari, D., Basit, R. H., Wiseman, J., & Chari, D. M. (2022). EP-273 Magnetic nanoparticle administration to a model of penetrating neurotrauma in vitro. British Journal of Surgery, 109(Supplement_5), https://doi.org/10.1093/bjs/znac245.072

Introduction/Aims Functional recovery in penetrating traumatic brain injury (pTBI) is hampered due to the lack of clinically approved regenerative therapies. Although a surgical emergency, pTBI management is largely supportive, with no targeted neuro... Read More about EP-273 Magnetic nanoparticle administration to a model of penetrating neurotrauma in vitro.

SP5.1.1 Novel in vitro model of neurotrauma to study neurotherapeutics (2022)
Journal Article
Chari, Basit, R. H., Wiseman, J., & Chari, D. M. (2022). SP5.1.1 Novel in vitro model of neurotrauma to study neurotherapeutics. British Journal of Surgery, 109(Supplement_5), https://doi.org/10.1093/bjs/znac247.047

Introduction/Aims Penetrating traumatic brain injury (pTBI) is a surgical emergency, with poor clinical outcomes. Management is supportive including surgical wound debridement, anti-epileptic administration and infection prophylaxis; no clinical neur... Read More about SP5.1.1 Novel in vitro model of neurotrauma to study neurotherapeutics.

Transplantation of encapsulated autologous olfactory ensheathing cell populations expressing chondroitinase for spinal cord injury: A safety and feasibility study in companion dogs (2022)
Journal Article
Prager, J., Fenn, J., Plested, M., Escauriaza, L., Merwe, T. V. D., King, B., …Granger, N. (2022). Transplantation of encapsulated autologous olfactory ensheathing cell populations expressing chondroitinase for spinal cord injury: A safety and feasibility study in companion dogs. Journal of Tissue Engineering and Regenerative Medicine, 16(9), 788-798. https://doi.org/10.1002/term.3328

Spinal cord injury (SCI) can cause irreversible paralysis, with no regenerative treatment clinically available. Dogs with natural SCI present an established model and can facilitate translation of experimental findings in rodents to people. We cond... Read More about Transplantation of encapsulated autologous olfactory ensheathing cell populations expressing chondroitinase for spinal cord injury: A safety and feasibility study in companion dogs.

Developing a New Strategy for Delivery of Neural Transplant Populations Using Precursor Cell Sprays and Specialized Cell Media (2021)
Journal Article
Woods, W. A., Chowdhury, F., Tzerakis, N., Adams, C. F., & Chari, D. M. (2021). Developing a New Strategy for Delivery of Neural Transplant Populations Using Precursor Cell Sprays and Specialized Cell Media. Advanced NanoBiomed Research, 1(9), 2100051 - 2100051. https://doi.org/10.1002/anbr.202100051

Neural precursor/stem cell transplantation therapies promote regeneration in neurological injuries, but current cell delivery methods have drawbacks. These include risks with surgical microinjection (e.g., hemorrhage, embolism) and high cell loss wit... Read More about Developing a New Strategy for Delivery of Neural Transplant Populations Using Precursor Cell Sprays and Specialized Cell Media.

Stem cell sprays for neurological injuries: a perspective (2021)
Journal Article
Woods, W., Evans, D., Mogas Barcons, A., Tzerakis, N., Adams, C., & Chari, D. (2021). Stem cell sprays for neurological injuries: a perspective. Emerging Topics in Life Sciences, https://doi.org/10.1042/ETLS20210113

Injuries to the brain and spinal cord have major clinical consequences with high costs for healthcare systems. Neural cell transplantation therapies have significant translational potential to promote regeneration post-injury with clinical trials com... Read More about Stem cell sprays for neurological injuries: a perspective.

Delivery of chondroitinase by canine mucosal olfactory ensheathing cells alongside rehabilitation enhances recovery after spinal cord injury (2021)
Journal Article
Prager, J., Ito, D., Carwardine, D. R., Jiju, P., Chari, D. M., Granger, N., & Wong, L. (2021). Delivery of chondroitinase by canine mucosal olfactory ensheathing cells alongside rehabilitation enhances recovery after spinal cord injury. Experimental Neurology, 1- 14. https://doi.org/10.1016/j.expneurol.2021.113660

Spinal cord injury (SCI) can cause chronic paralysis and incontinence and remains a major worldwide healthcare burden, with no regenerative treatment clinically available. Intraspinal transplantation of olfactory ensheathing cells (OECs) and injectio... Read More about Delivery of chondroitinase by canine mucosal olfactory ensheathing cells alongside rehabilitation enhances recovery after spinal cord injury.

Safe nanoengineering and incorporation of transplant populations in a neurosurgical grade biomaterial, DuraGen PlusTM, for protected cell therapy applications (2020)
Journal Article
Finch, L., Harris, S., Solomou, G., Sen, J., Tzerakis, N., Emes, R. D., …Chari, D. M. (2020). Safe nanoengineering and incorporation of transplant populations in a neurosurgical grade biomaterial, DuraGen PlusTM, for protected cell therapy applications. Journal of Controlled Release, 321, 553-563. https://doi.org/10.1016/j.jconrel.2020.02.028

High transplant cell loss is a major barrier to translation of stem cell therapy for pathologies of the brain and spinal cord. Encapsulated delivery of stem cells in biomaterials for cell therapy is gaining popularity but experimental research has ov... Read More about Safe nanoengineering and incorporation of transplant populations in a neurosurgical grade biomaterial, DuraGen PlusTM, for protected cell therapy applications.