Outputs (48)

Centre-level fluid management practices in the BISTRO trial and their lack of association with participant fluid status and blood pressure in non-anuric haemodialysis patients (2024)
Journal Article
Johal, N., Sharma, R., Belcher, J., Coyle, D., Lindley, E. J., Keane, D., Caskey, F. J., Dasgupta, I., Davenport, A., Farrington, K., Mitra, S., Ormandy, P., Wilkie, M., Macdonald, J., Solis-Trapala, I., Sim, J., & Davies, S. J. (2024). Centre-level fluid management practices in the BISTRO trial and their lack of association with participant fluid status and blood pressure in non-anuric haemodialysis patients. BMC Nephrology, 25(1), Article 398. https://doi.org/10.1186/s12882-024-03837-y

Introduction: Fluid assessment and management is a key aspect of good dialysis care and is affected by patient-level characteristics and potentially centre-level practices. In this secondary analysis of the BISTRO trial we wished to establish whether... Read More about Centre-level fluid management practices in the BISTRO trial and their lack of association with participant fluid status and blood pressure in non-anuric haemodialysis patients.

Impact of the Preservation of Residual Kidney Function on Hemodialysis Survival: Results from the BISTRO Trial (2024)
Journal Article
Belcher, J., Coyle, D., Lindley, E. J., Keane, D., Caskey, F. J., Dasgupta, I., Davenport, A., Farrington, K., Mitra, S., Ormandy, P., Wilkie, M., Macdonald, J., Hugo Macdonald, J., Solis-Trapala, I., Sim, J., & Davies, S. J. (2024). Impact of the Preservation of Residual Kidney Function on Hemodialysis Survival: Results from the BISTRO Trial. Kidney360, https://doi.org/10.34067/kid.0000000596

Preservation of residual kidney function (RKF) in dialysis patients has been associated with improved survival. RKF in the BISTRO trial was relatively well preserved and here we describe its association with survival during the trial and extended fol... Read More about Impact of the Preservation of Residual Kidney Function on Hemodialysis Survival: Results from the BISTRO Trial.

Cost-effectiveness of bioimpedance-guided fluid management in patients undergoing haemodialysis: the BISTRO RCT (2024)
Journal Article
Zanganeh, M., Belcher, J., Fotheringham, J., Coyle, D., Lindley, E. J., Keane, D. F., Caskey, F. J., Dasgupta, I., Davenport, A., Farrington, K., Mitra, S., Ormandy, P., Wilkie, M., Macdonald, J. H., Solis-Trapala, I., Sim, J., Davies, S. J., & Andronis, L. (2024). Cost-effectiveness of bioimpedance-guided fluid management in patients undergoing haemodialysis: the BISTRO RCT. Health Technology Assessment, 1-45. https://doi.org/10.3310/jypr4287

Background
The BioImpedance Spectroscopy to maintain Renal Output randomised controlled trial investigated the effect of bioimpedance spectroscopy added to a standardised fluid management protocol on the risk of anuria and preservation of residual k... Read More about Cost-effectiveness of bioimpedance-guided fluid management in patients undergoing haemodialysis: the BISTRO RCT.

What do RCTs tell us, and could they tell us more? Looking within and beyond the study sample (2024)
Book Chapter
Sim, J., Lancaster, G., & Lewis, M. (2024). What do RCTs tell us, and could they tell us more? Looking within and beyond the study sample. In A Medical Educator's Guide to Thinking Critically about Randomised Controlled Trials: Deconstructing the "Gold Standard" (109-144). Springer Nature [academic journals on nature.com]. https://doi.org/10.1007/978-3-031-25859-6_5

Randomised controlled trials (RCTs) are generally regarded as the gold-standard method to answer questions of treatment effectiveness. Carefully designed and rigorously implemented, they can provide unbiased estimates of average treatment effectivene... Read More about What do RCTs tell us, and could they tell us more? Looking within and beyond the study sample.

Metoclopramide for Avoiding Pneumonia after Stroke (MAPS-2) Trial (2023)
Presentation / Conference Contribution
Roffe, C., Warusevitane, A., Smith, C., Dixit, A., Sprigg, N., Ogollah, R., Sim, J., Jowett, S., Helliwell, B., Phillips, N., Mhlanga, I., Havard, D., Kurlak, L., Skinner, C., Palmer, J., Thomson, M., Latulipe, C., Haywood, L., Woodhouse, L., & Bath, P. (2023, October). Metoclopramide for Avoiding Pneumonia after Stroke (MAPS-2) Trial. Poster presented at 15th World Stroke Congress, Toronto, Canada

The research study is designed to assess a treatment which might prevent pneumonia and improve survival in patients that have had a stroke.
Pneumonia is a major cause of death after stroke and delays recovery in survivors. The most important cause o... Read More about Metoclopramide for Avoiding Pneumonia after Stroke (MAPS-2) Trial.

Bio-impedance spectroscopy added to a fluid management protocol does not improve preservation of residual kidney function in incident hemodialysis patients in a randomized controlled trial (2023)
Journal Article
Davies, S. J., Coyle, D., Lindley, E. J., Keane, D., Belcher, J., Caskey, F. J., Dasgupta, I., Davenport, A., Farrington, K., Mitra, S., Ormandy, P., Wilkie, M., Macdonald, J., Zanganeh, M., Andronis, L., Solis-Trapala, I., & Sim, J. (2023). Bio-impedance spectroscopy added to a fluid management protocol does not improve preservation of residual kidney function in incident hemodialysis patients in a randomized controlled trial. Kidney International, 104(3), 587-598. https://doi.org/10.1016/j.kint.2023.05.016

Avoiding excessive dialysis-associated volume depletion may help preserve residual kidney function (RKF). To establish whether knowledge of the estimated normally hydrated weight from bioimpedance measurements (BI-NHW) when setting the post-hemodialy... Read More about Bio-impedance spectroscopy added to a fluid management protocol does not improve preservation of residual kidney function in incident hemodialysis patients in a randomized controlled trial.

Psychosocial factors affecting COVID-19 vaccine uptake in the UK: a prospective cohort study (CoVAccS – wave 3) (2023)
Journal Article
Smith, L., Sim, J., Cutts, M., Dasch, H., Amlôt, R., Sevdalis, N., Rubin, G., & Sherman, S. (2023). Psychosocial factors affecting COVID-19 vaccine uptake in the UK: a prospective cohort study (CoVAccS – wave 3). https://doi.org/10.1016/j.jvacx.2023.100276

Background
We investigated factors associated with COVID-19 vaccine uptake, future vaccination intentions, and changes in beliefs and attitudes over time.

Methods
Prospective cohort study. 1500 participants completed an online survey in January... Read More about Psychosocial factors affecting COVID-19 vaccine uptake in the UK: a prospective cohort study (CoVAccS – wave 3).

The Effect of the COVID-19 Pandemic on HbA1c Testing: Prioritization of High-Risk Cases and Impact of Social Deprivation (2023)
Journal Article
Holland, D., Heald, A. H., Hanna, F. F., Stedman, M., Wu, P., Sim, J., Duff, C. J., Duce, H., Green, L., Scargill, J., Howe, J. D., Robinson, S., Halsall, I., Gaskell, N., Davison, A., Simms, M., Denny, A., Langan, M., & Fryer, A. A. (2023). The Effect of the COVID-19 Pandemic on HbA1c Testing: Prioritization of High-Risk Cases and Impact of Social Deprivation. Diabetes Therapy, 14, 691-707. https://doi.org/10.1007/s13300-023-01380-x

INTRODUCTION: Studies show that the COVID-19 pandemic disproportionately affected people with diabetes and those from disadvantaged backgrounds. During the first 6 months of the UK lockdown,?>?6.6 M glycated haemoglobin (HbA1c) tests were missed. We... Read More about The Effect of the COVID-19 Pandemic on HbA1c Testing: Prioritization of High-Risk Cases and Impact of Social Deprivation.

Metasynthesis: issues of empirical and theoretical context (2022)
Journal Article
Sim, J., & Marit Mengshoel, A. (2023). Metasynthesis: issues of empirical and theoretical context. Quality and Quantity, 57(4), 3339-3361. https://doi.org/10.1007/s11135-022-01502-w

Metasynthesis is an approach to synthesizing primary qualitative research, and may take either an aggregative or an interpretive approach. In either case, the resulting synthesis inevitably occurs at a remove from both the empirical and the theoretic... Read More about Metasynthesis: issues of empirical and theoretical context.

Side-effect expectations from COVID-19 vaccination: findings from a nationally representative cross-sectional survey (CoVAccS – wave 2) (2022)
Journal Article
Smith, L., Sim, J., Amlôt, R., Cutts, M., Dasch, H., Sevdalis, N., Rubin, G., & Sherman, S. (2022). Side-effect expectations from COVID-19 vaccination: findings from a nationally representative cross-sectional survey (CoVAccS – wave 2). Journal of Psychosomatic Research, https://doi.org/10.1016/j.jpsychores.2021.110679

Objectives: Concern about side effects is one of the most common reasons for refusing vaccination. Side-effect expectations are also known to predict perception of side effects. We aimed to investigate the percentage of people who thought side effect... Read More about Side-effect expectations from COVID-19 vaccination: findings from a nationally representative cross-sectional survey (CoVAccS – wave 2).