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Outputs (91)

Evaluating a primary care pharmacist-led intervention to reduce opioid use for persistent non-cancer pain: the PROMPPT cluster randomised controlled trial protocol [version 1; peer review: awaiting peer review] (2025)
Journal Article
Ashworth, J., Cornwall, N., Harrisson, S. A., Woodcock, C., Nicholls, E., Hughes, G., Marshall, E., Lawton, S. A., Wathall, S., Helliwell, T., Jowett, S., Avery, A. J., Knaggs, R., Hussain, B., Santer, M., Pincus, T., White, S., Sillitto, C., Jinks, C., & Mallen, C. D. (2025). Evaluating a primary care pharmacist-led intervention to reduce opioid use for persistent non-cancer pain: the PROMPPT cluster randomised controlled trial protocol [version 1; peer review: awaiting peer review]. NIHR Open Research, 5(54), https://doi.org/10.3310/nihropenres.13961.1

Background
Addressing the need for evidence-based interventions to reduce opioid use for persistent pain, we developed the PROMPPT intervention (Proactive clinical Review of patients taking Opioid Medicines long-term for persistent Pain led by clini... Read More about Evaluating a primary care pharmacist-led intervention to reduce opioid use for persistent non-cancer pain: the PROMPPT cluster randomised controlled trial protocol [version 1; peer review: awaiting peer review].

Exploring factors underlying the use of nyaope in Tshwane, South Africa: A qualitative study (2025)
Journal Article
Nzaumvila, D. K., Mash, R., & Helliwell, T. (2025). Exploring factors underlying the use of nyaope in Tshwane, South Africa: A qualitative study. Journal of the Colleges of Medicine of South Africa, 3(1), https://doi.org/10.4102/jcmsa.v3i1.129

Background: Nyaope increasing use has become a major public health concern, not only because of its detrimental health effects but also because of its far-reaching social consequences. This situation has caused distress for families, communities and... Read More about Exploring factors underlying the use of nyaope in Tshwane, South Africa: A qualitative study.

Case-finding for depression in primary care (CAIRO): a multicentre, cross-sectional study in England (2025)
Journal Article
Lawton, S. A., Mallen, C., Chew-Graham, C., Kingstone, T., Muller, S., Lewis, S., Bajpai, R., & Helliwell, T. (2025). Case-finding for depression in primary care (CAIRO): a multicentre, cross-sectional study in England. BMJ Open, 15(6), 1-7. https://doi.org/10.1136/bmjopen-2024-095040

To examine the number of patients screening positive for depression, while self-completing an automated check-in screen prior to a general practice consultation. A descriptive cross-sectional study. 10 general practices in the West Midlands, England.... Read More about Case-finding for depression in primary care (CAIRO): a multicentre, cross-sectional study in England.

Patterns of pain and stiffness over 5 years in polymyalgia rheumatica: results from the PMR Cohort Study (2025)
Journal Article
Hamad, N., Muller, S., Hider, S., Partington, R., Helliwell, T., Butt, H., Hay, C., & Mallen, C. (2025). Patterns of pain and stiffness over 5 years in polymyalgia rheumatica: results from the PMR Cohort Study. Rheumatology Advances in Practice, 1-19. https://doi.org/10.1093/rap/rkaf060

Objectives
To investigate the anatomical locations of pain and stiffness in people with polymyalgia rheumatica (PMR) and how it compares to the general population.

Methods
739 people with PMR were invited to complete a postal survey at the time... Read More about Patterns of pain and stiffness over 5 years in polymyalgia rheumatica: results from the PMR Cohort Study.

Remote digital health interventions to support physical, functional and/or psychological rehabilitation of adult patients with major traumatic injuries: Protocol for a systematic review of randomised controlled trials (Preprint) (2025)
Journal Article
Al-Jabr, H., Salt, E., Stephenson, J., Hamdan, E., & Helliwell, T. (in press). Remote digital health interventions to support physical, functional and/or psychological rehabilitation of adult patients with major traumatic injuries: Protocol for a systematic review of randomised controlled trials (Preprint). JMIR Research Protocols, https://doi.org/10.2196/67675

Background:

Digital health (DH) interventions have increased across the past two decades, providing patients with alternative remote pathways to receiving healthcare services. Patients with major trauma frequently require long-term access to healt... Read More about Remote digital health interventions to support physical, functional and/or psychological rehabilitation of adult patients with major traumatic injuries: Protocol for a systematic review of randomised controlled trials (Preprint).

Proactive clinical review of patients taking opioid medicines long term for persistent pain led by clinical pharmacists in primary care teams (PROMPPT): a non-randomised mixed methods feasibility study (2025)
Journal Article
Ashworth, J., Cornwall, N., Harrisson, S., Woodcock, C., Nicholls, E., Lancaster, G., Wathall, S., Laing, L., Helliwell, T., Jowett, S., Kigozi, J., Mallen, C., Avery, A., Knaggs, R., Pincus, T., White, S., & Jinks, C. (2025). Proactive clinical review of patients taking opioid medicines long term for persistent pain led by clinical pharmacists in primary care teams (PROMPPT): a non-randomised mixed methods feasibility study. Pilot and Feasibility Studies, 11(1), Article 53. https://doi.org/10.1186/s40814-025-01636-2

Background: Given the poor long-term effectiveness of opioids for persistent non-cancer pain, and their potential for harm, evidence-based interventions to address opioid overprescribing for persistent pain are needed. This study aimed to explore the... Read More about Proactive clinical review of patients taking opioid medicines long term for persistent pain led by clinical pharmacists in primary care teams (PROMPPT): a non-randomised mixed methods feasibility study.

Stakeholder Involvement in the Development of a New Proactive Clinical Review of Patients Prescribed Opioid Medicines Long‐Term for Persistent Pain in Primary Care (2025)
Journal Article
Harrisson, S. A., Jinks, C., Cornwall, N., Woodcock, C., Dikomitis, L., Helliwell, T., Higginbottom, A., Lefroy, J., Knaggs, R., Pincus, T., Santar, M., Sillitto, C., Webb, M., White, S., Mallen, C. D., & Ashworth, J. (2025). Stakeholder Involvement in the Development of a New Proactive Clinical Review of Patients Prescribed Opioid Medicines Long‐Term for Persistent Pain in Primary Care. Health Expectations, 28(3), Article e70264. https://doi.org/10.1111/hex.70264

Background: Stakeholder involvement is a core element of the Medical Research Council (MRC) framework for developing and evaluating complex interventions, but approaches to involve stakeholders are not well‐reported. We outline how stakeholders contr... Read More about Stakeholder Involvement in the Development of a New Proactive Clinical Review of Patients Prescribed Opioid Medicines Long‐Term for Persistent Pain in Primary Care.

Family’s perceptions of their members who use nyaope in Tshwane, South Africa (2025)
Journal Article
Nzaumvila, D. K., Mash, R., & Helliwell, T. (in press). Family’s perceptions of their members who use nyaope in Tshwane, South Africa. PLoS ONE, 20(3), Article e0318794. https://doi.org/10.1371/journal.pone.0318794

Introduction : Over the last two decades, nyaope use has evolved to become a prominent substance use disorder in South Africa, posing a significant public health burden. The majority of users are young people who are solely concerned with their next... Read More about Family’s perceptions of their members who use nyaope in Tshwane, South Africa.

Proactive clinical Review of patients taking Opioid Medicines long-term for persistent Pain led by clinical Pharmacists in primary care Teams (PROMPPT). A non-randomised Mixed Methods Feasibility Study. (2024)
Preprint / Working Paper
Ashworth, J., Cornwall, N., Harrisson, S. A., Woodcock, C., Nicholls, E., Lancaster, G., Wathall, S., Laing, L., Helliwell, T., Jowett, S., Kigozi, J., Mallen, C. D., Avery, A., Knaggs, R., Pincus, T., White, S., & Jinks, C. (2024). Proactive clinical Review of patients taking Opioid Medicines long-term for persistent Pain led by clinical Pharmacists in primary care Teams (PROMPPT). A non-randomised Mixed Methods Feasibility Study

Background:

Given the poor long-term effectiveness of opioids for persistent non-cancer pain, and their potential for harm, evidence–based interventions to address opioid overprescribing for persistent pain are needed. This study aimed to explore... Read More about Proactive clinical Review of patients taking Opioid Medicines long-term for persistent Pain led by clinical Pharmacists in primary care Teams (PROMPPT). A non-randomised Mixed Methods Feasibility Study..