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Outputs (382)

Clinical decision support systems for maternity care: a systematic review and meta-analysis (2024)
Journal Article
Cockburn, N., Osborne, C., Withana, S., Elsmore, A., Nanjappa, R., South, M., …Nirantharakumar, K. (2024). Clinical decision support systems for maternity care: a systematic review and meta-analysis. EClinicalMedicine, 76, Article 102822. https://doi.org/10.1016/j.eclinm.2024.102822

Summary
Background
The use of Clinical Decision Support Systems (CDSS) is increasing throughout healthcare and may be able to improve safety and outcomes in maternity care, but maternity care has key differences to other disciplines that complicate... Read More about Clinical decision support systems for maternity care: a systematic review and meta-analysis.

Extracellular vesicle bioactivity and potential clinical utility is determined by mesenchymal stromal cell clonal subtype (2024)
Journal Article
Ioannou, S., G Kay, A., P Stone, A., Rand, E., Elberfeld, S., Bolton, W., …Genever, P. (in press). Extracellular vesicle bioactivity and potential clinical utility is determined by mesenchymal stromal cell clonal subtype. bioRxiv, https://doi.org/10.1101/2024.09.05.609844

Mesenchymal stromal cells (MSCs) are a promising source of therapeutic extracellular vesicles (EVs), however it is not clear how heterogeneity within a non-clonal MSC population will affect the collective EV pool. Here we used immortalised clonal MSC... Read More about Extracellular vesicle bioactivity and potential clinical utility is determined by mesenchymal stromal cell clonal subtype.

In‐hospital outcomes of ad hoc versus planned PCI for unprotected left‐main disease: An analysis of 8574 cases from British Cardiovascular Intervention Society database 2006–2018 (2024)
Journal Article
Kinnaird, T., Gallagher, S., Farooq, V., Protty, M. B., Cranch, H., Devlin, P., …Mamas, M. A. (in press). In‐hospital outcomes of ad hoc versus planned PCI for unprotected left‐main disease: An analysis of 8574 cases from British Cardiovascular Intervention Society database 2006–2018. Catheterization and Cardiovascular Interventions, https://doi.org/10.1002/ccd.31210

Background: Although data suggests ad hoc percutaneous coronary intervention (PCI) results in similar patient outcomes compared to planned PCI in nonselected patients, data for ad hoc unprotected left main stem PCI (uLMS‐PCI) are lacking. Aim: To det... Read More about In‐hospital outcomes of ad hoc versus planned PCI for unprotected left‐main disease: An analysis of 8574 cases from British Cardiovascular Intervention Society database 2006–2018.

Aripiprazole/Sertraline Combination: Clinical and Cost‐Effectiveness in Comparison With Quetiapine for the Treatment of Bipolar Depression (ASCEnD Trial)—Protocol for a Nested Qualitative Study (2024)
Journal Article
Hoppe, I., Watson, S., Kemp, C., Turnbull, F., Davies, F., Gibson, J., …Chew‐Graham, C. A. (2024). Aripiprazole/Sertraline Combination: Clinical and Cost‐Effectiveness in Comparison With Quetiapine for the Treatment of Bipolar Depression (ASCEnD Trial)—Protocol for a Nested Qualitative Study. Health Expectations, 27(5), Article e70018. https://doi.org/10.1111/hex.70018

Introduction: Bipolar disorder is a recurrent mental health disorder with a prevalence rate of 1.4%. On average, there can be a delay of 9.5 years from the initial presentation of symptoms to a confirmed diagnosis. Individuals living with bipolar dis... Read More about Aripiprazole/Sertraline Combination: Clinical and Cost‐Effectiveness in Comparison With Quetiapine for the Treatment of Bipolar Depression (ASCEnD Trial)—Protocol for a Nested Qualitative Study.

Safety, efficacy, and optical coherence tomography insights into intravascular lithotripsy for the modification of non‐eruptive calcified nodules: A prospective observational study (2024)
Journal Article
Gupta, A., Shrivastava, A., Chhikara, S., Revaiah, P. C., Mamas, M. A., Vijayvergiya, R., …Mahesh, N. K. (in press). Safety, efficacy, and optical coherence tomography insights into intravascular lithotripsy for the modification of non‐eruptive calcified nodules: A prospective observational study. Catheterization and Cardiovascular Interventions, https://doi.org/10.1002/ccd.31217

Background: Non‐eruptive calcium nodules (CNs) are commonly seen in heavily calcified coronary artery disease. They are the most difficult subset for modification, and may result in stent damage, malapposition and under‐expansion. There are only limi... Read More about Safety, efficacy, and optical coherence tomography insights into intravascular lithotripsy for the modification of non‐eruptive calcified nodules: A prospective observational study.

State-of-the-art in sub-phenotyping midbrain dopamine neurons (2024)
Journal Article
Basso, V., Dobrossy, M., Thompson, L., Kirik, D., Fuller, H., & Gates, M. (2024). State-of-the-art in sub-phenotyping midbrain dopamine neurons. Biology, 13(9),

Dopaminergic neurons in the ventral tegmental area (VTA) and the substantia nigra pars compacta (SNpc) comprise around 75% of all dopaminergic neurons in the human brain. While both groups of dopaminergic neurons are in close proximity in the midbrai... Read More about State-of-the-art in sub-phenotyping midbrain dopamine neurons.

Identification of variables and development of a prediction model for DIBH eligibility in left-sided breast cancer radiotherapy: a prospective cohort study with temporal validation (2024)
Journal Article
Ahmad, I., Chufal, K. S., Miller, A. A., Bajpai, R., Umesh, P., Sokhal, B. S., …Gairola, M. (in press). Identification of variables and development of a prediction model for DIBH eligibility in left-sided breast cancer radiotherapy: a prospective cohort study with temporal validation. Radiation Oncology, 19(1), Article 115. https://doi.org/10.1186/s13014-024-02512-8

Objective: To identify variables associated with a patients’ ability to reproducibly hold their breath for deep-inspiration breath-hold (DIBH) radiotherapy (RT) and to develop a predictive model for DIBH eligibility. Methods: This prospective, single... Read More about Identification of variables and development of a prediction model for DIBH eligibility in left-sided breast cancer radiotherapy: a prospective cohort study with temporal validation.

Physical Health Checks and Follow‐Up Care in Deprived and Ethnically Diverse People With Severe Mental Illness: Co‐Designed Recommendations for Better Care (2024)
Journal Article
Joury, E., Beveridge, E., Littlejohns, J., Burns, A., Copsey, G., Philips, J., …Chin, J. (2024). Physical Health Checks and Follow‐Up Care in Deprived and Ethnically Diverse People With Severe Mental Illness: Co‐Designed Recommendations for Better Care. Health Expectations, 27(5), Article e70005. https://doi.org/10.1111/hex.70005

Background: There is wide variation in premature mortality rates in adults with severe mental illness (SMI) across London, with Tower Hamlets (a highly deprived and ethnically diverse area) scoring the highest. Objective: To identify examples of best... Read More about Physical Health Checks and Follow‐Up Care in Deprived and Ethnically Diverse People With Severe Mental Illness: Co‐Designed Recommendations for Better Care.

An Assessment of the Efficacy of an Online Pain Management Programme During the Covid‐19 Pandemic (2024)
Journal Article
P. Thompson, D., Ramshead, M., & Antcliff, D. (2024). An Assessment of the Efficacy of an Online Pain Management Programme During the Covid‐19 Pandemic. Musculoskeletal Care, 22(3), Article e1929. https://doi.org/10.1002/msc.1929

Background: Following the outbreak of the Covid‐19 pandemic and associated social distancing requirements, Pain Services were no longer able to deliver face‐to‐face Pain Management Programmes (PMP). As an alternative, the Bury Integrated Pain Service... Read More about An Assessment of the Efficacy of an Online Pain Management Programme During the Covid‐19 Pandemic.