Skip to main content

Research Repository

Advanced Search

Outputs (5778)

Association of Frailty Status on the Causes and Outcomes of Patients Admitted With Cardiovascular Disease. (2023)
Journal Article
Sokhal, B., Matetić, A., Rashid, M., Protheroe, J., Partington, R., Mallen, C., & Mamas, M. (2023). Association of Frailty Status on the Causes and Outcomes of Patients Admitted With Cardiovascular Disease. American Journal of Cardiology, 7 - 15. https://doi.org/10.1016/j.amjcard.2022.12.029

Data are limited about the contemporary association between frailty and the causes and outcomes of patients admitted with cardiovascular diseases (CVD). Using the US National Inpatient Sample, CVD admissions of interest (acute myocardial infarction,... Read More about Association of Frailty Status on the Causes and Outcomes of Patients Admitted With Cardiovascular Disease..

Psychosocial factors affecting COVID-19 vaccine uptake in the UK: a prospective cohort study (CoVAccS – wave 3) (2023)
Journal Article
Smith, L., Sim, J., Cutts, M., Dasch, H., Amlôt, R., Sevdalis, N., Rubin, G., & Sherman, S. (2023). Psychosocial factors affecting COVID-19 vaccine uptake in the UK: a prospective cohort study (CoVAccS – wave 3). https://doi.org/10.1016/j.jvacx.2023.100276

Background
We investigated factors associated with COVID-19 vaccine uptake, future vaccination intentions, and changes in beliefs and attitudes over time.

Methods
Prospective cohort study. 1500 participants completed an online survey in January... Read More about Psychosocial factors affecting COVID-19 vaccine uptake in the UK: a prospective cohort study (CoVAccS – wave 3).

Study protocol of DIVERGE, the first genetic epidemiological study of major depressive disorder in Pakistan. (2023)
Journal Article
Valkovskaya, M., Hassan, A., Zartaloudi, E., Hussain, F., Umar, M., Khizar, B., Khattak, I., Gill, S. A., Khan, S.-U.-D. A., Dogar, I. A., Mustafa, A. B., Ansari, M. A., Qalb I Hyder, S., Ali, M., Ilyas, N., Channar, P., Mughal, N., Channa, S., Mufti, K., Mufti, A. A., …Kuchenbaecker, K. (2023). Study protocol of DIVERGE, the first genetic epidemiological study of major depressive disorder in Pakistan. Psychiatric Genetics, 33(2), 69-78. https://doi.org/10.1097/ypg.0000000000000333

INTRODUCTION: Globally, 80% of the burdenof major depressive disorder (MDD) pertains to low- and middle-income countries. Research into genetic and environmental risk factors has the potential to uncover disease mechanisms that may contribute to bett... Read More about Study protocol of DIVERGE, the first genetic epidemiological study of major depressive disorder in Pakistan..

Short-term risk of periprocedural stroke relative to radial vs. femoral access: systematic review, meta-analysis, study sequential analysis and meta-regression of 2,188,047 real-world cardiac catheterizations. (2023)
Journal Article
Tužil, J., Matějka, J., Mamas, M. A., & Doležal, T. (2023). Short-term risk of periprocedural stroke relative to radial vs. femoral access: systematic review, meta-analysis, study sequential analysis and meta-regression of 2,188,047 real-world cardiac catheterizations. Expert Review of Cardiovascular Therapy, 293 - 304. https://doi.org/10.1080/14779072.2023.2187378

OBJECTIVES: To verify whether transradial (TRA) compared to transfemoral (TFA) cardiac catheterization reduces the risk of periprocedural stroke (PS). METHODS: We reviewed (CRD42021277918) published real-world cohorts reporting the incidence of PS wi... Read More about Short-term risk of periprocedural stroke relative to radial vs. femoral access: systematic review, meta-analysis, study sequential analysis and meta-regression of 2,188,047 real-world cardiac catheterizations..

Impact of different practice patterns on solute transport in peritoneal dialysis (2023)
Thesis
Brenna, I. Impact of different practice patterns on solute transport in peritoneal dialysis. (Thesis). Keele University. https://keele-repository.worktribe.com/output/425831

Long term peritoneal dialysis (PD) is associated with increased peritoneal solute transport rate (PSTR) and loss of ultrafiltration capacity [1,2], both reflecting acquired structural alterations of the peritoneal membrane. Peritoneal functional chan... Read More about Impact of different practice patterns on solute transport in peritoneal dialysis.

Investigating the therapeutic potential of the glucocorticoid antagonist, mifepristone, for the treatment of spinal muscular atrophy (2023)
Thesis
Sutton, E. R. Investigating the therapeutic potential of the glucocorticoid antagonist, mifepristone, for the treatment of spinal muscular atrophy. (Thesis). Keele University. https://keele-repository.worktribe.com/output/425841

Spinal muscular atrophy (SMA) is a neuromuscular disease characterised by loss of alpha motor neurons and muscle atrophy. When untreated, mortality occurs within the first two years of life in the most severe cases. Extensive research has led to thre... Read More about Investigating the therapeutic potential of the glucocorticoid antagonist, mifepristone, for the treatment of spinal muscular atrophy.

The association between gout and psychological co-morbidity: results from a prospective cohort study (2023)
Thesis
Higgs, J. J. R. The association between gout and psychological co-morbidity: results from a prospective cohort study. (Thesis). Keele University. https://keele-repository.worktribe.com/output/425842

Gout is associated with an increased risk of both physical-health co-morbidities and a reduction in physical health-related quality of life. However, the association between gout and psychological comorbidity (depression and anxiety) has received lit... Read More about The association between gout and psychological co-morbidity: results from a prospective cohort study.

Exploring cardiovascular risk and outcomes in primary care consulters for osteoarthritis using longitudinal electronic primary care data (2023)
Thesis
Huang, X. Exploring cardiovascular risk and outcomes in primary care consulters for osteoarthritis using longitudinal electronic primary care data. (Thesis). Keele University. https://keele-repository.worktribe.com/output/425844

For adults aged 45 and over in the United Kingdom (UK), osteoarthritis is a common reason for consultation with primary care. Cardiovascular disease (CVD) is a common comorbidity with osteoarthritis; two in five people with osteoarthritis also have C... Read More about Exploring cardiovascular risk and outcomes in primary care consulters for osteoarthritis using longitudinal electronic primary care data.

Data from Combined Perioperative Lapatinib and Trastuzumab in Early HER2-Positive Breast Cancer Identifies Early Responders: Randomized UK EPHOS-B Trial Long-Term Results (2023)
Data
Bundred, N., Porta, N., Brunt, A. M., Cramer, A., Hanby, A., Shaaban, A. M., Rakha, E. A., Armstrong, A., Cutress, R. I., Dodwell, D., Emson, M. A., Evans, A., Hartup, S. M., Horgan, K., Miller, S. E., McIntosh, S. A., Morden, J. P., Naik, J., Narayanan, S., Ooi, J., …Bliss, J. M. (2023). Data from Combined Perioperative Lapatinib and Trastuzumab in Early HER2-Positive Breast Cancer Identifies Early Responders: Randomized UK EPHOS-B Trial Long-Term Results. [Data]. https://doi.org/10.1158/1078-0432.c.6532623.v1

Purpose:
EPHOS-B aimed to determine whether perioperative anti-HER2 therapy inhibited proliferation and/or increased apoptosis in HER2-positive breast cancer.

Patients and Methods:
This randomized phase II, two-part, multicenter trial included n... Read More about Data from Combined Perioperative Lapatinib and Trastuzumab in Early HER2-Positive Breast Cancer Identifies Early Responders: Randomized UK EPHOS-B Trial Long-Term Results.