Outputs (5131)

The potential of closed circuit lung clearance index (LCI) to provide longitudinal clinical utility in cystic fibrosis (CF)
Presentation / Conference
Gilchrist. The potential of closed circuit lung clearance index (LCI) to provide longitudinal clinical utility in cystic fibrosis (CF). Presented at https://erj.ersjournals.com/content/54/suppl_63/PA332

Background: Closed circuit washin offers a quicker test with the advantages of an exogenous tracer to measure FRC and LCI. We measured LCI in CF paediatric and adult outpatient clinics to assess repeatability of LCI and track changes over time, and i... Read More about The potential of closed circuit lung clearance index (LCI) to provide longitudinal clinical utility in cystic fibrosis (CF).

REPRODUCIBILITY OF LUNG CLEARANCE INDEX (LCI) IN CLINICALLY STABLE ADULTS WITH MILD CYSTIC FIBROSIS (CF)
Presentation / Conference
Gilchrist. REPRODUCIBILITY OF LUNG CLEARANCE INDEX (LCI) IN CLINICALLY STABLE ADULTS WITH MILD CYSTIC FIBROSIS (CF). Presented at British Thoracic Society Winter Meeting 2016

Background In order for lung clearance index (LCI) to be a clinically useful measurement, a better understanding is required of short-term variability. LCI-SEARCH is a longitudinal study in children and adults with CF, with LCI measured at each clini... Read More about REPRODUCIBILITY OF LUNG CLEARANCE INDEX (LCI) IN CLINICALLY STABLE ADULTS WITH MILD CYSTIC FIBROSIS (CF).

Female sex is associated with increased risk of early readmission with asthma in Staffordshire children
Presentation / Conference
Gilchrist. Female sex is associated with increased risk of early readmission with asthma in Staffordshire children. Presented at ERS International Congress 2017

Background: Asthma is the commonest medical reason for a child to be admitted to hospital in the UK. c.15% are readmitted within 3 months. Aim: We undertook a retrospective case-control study to determine the predictors of readmission. Methods:... Read More about Female sex is associated with increased risk of early readmission with asthma in Staffordshire children.

The British Lung Foundation asthma management programme improving children's asthma control
Presentation / Conference
Gilchrist. The British Lung Foundation asthma management programme improving children's asthma control. Presented at ERS International Congress 2017

Background: The 10-year Finland asthma programme showed that educating healthcare workers, patients and families reduces hospital admissions and asthma-related deaths (1). Aim: The Department of Health and the Scottish Government funded a 2-year p... Read More about The British Lung Foundation asthma management programme improving children's asthma control.

Incidence of post-procedure complications in children undergoing elective flexible bronchoscopy
Presentation / Conference
Gilchrist. Incidence of post-procedure complications in children undergoing elective flexible bronchoscopy. Presented at ERS International Congress 2019

Background: Paediatric flexible bronchoscopy with bronchoalveolar lavage (FB-BAL) is a safe procedure with a low incidence of intra-procedure complications. There is a paucity of data on the incidence of post-procedure complications. Aim: To inves... Read More about Incidence of post-procedure complications in children undergoing elective flexible bronchoscopy.

Fifteen-Year Trends in the Rates of Elective Percutaneous Coronary Intervention and Impact of COURAGE and ORBITA Trials: Insights From British Cardiovascular Intervention Society Dataset
Presentation / Conference
Mamas, & Rashid. Fifteen-Year Trends in the Rates of Elective Percutaneous Coronary Intervention and Impact of COURAGE and ORBITA Trials: Insights From British Cardiovascular Intervention Society Dataset. Presented at Transcatheter Cardiovascular Therapeutics

Background This study was designed to evaluate temporal trends in elective rates of percutaneous coronary intervention (PCI) for stable angina and, specifically, to study the impact of the COURAGE and ORBITA trials on real-life practice. Methods We a... Read More about Fifteen-Year Trends in the Rates of Elective Percutaneous Coronary Intervention and Impact of COURAGE and ORBITA Trials: Insights From British Cardiovascular Intervention Society Dataset.

THU0650 Early help seeking or self-management: a quantitative assessment in the context of rheumatoid arthritis
Journal Article
Simons, G., Belcher, J., Kumar, K., Falahee, M., Mallen, C., Stack, R., & Raza, K. (2018). THU0650 Early help seeking or self-management: a quantitative assessment in the context of rheumatoid arthritis. Annals of the Rheumatic Diseases, 77(2), https://doi.org/10.1136/annrheumdis-2018-eular.2529

Background Rheumatoid arthritis (RA) should be treated with DMARDs in its earliest stages to reduce the likelihood of permanent joint damage and disability1. This therapeutic window is often missed. One important cause is delayed help seeking by pati... Read More about THU0650 Early help seeking or self-management: a quantitative assessment in the context of rheumatoid arthritis.

Prevalence of cardiovascular risk factors in osteoarthritis patients derived from primary care records: a systematic review of observational studies
Journal Article
Huang, X., Wilkie, R., Mamas, M. A., & Yu, D. Prevalence of cardiovascular risk factors in osteoarthritis patients derived from primary care records: a systematic review of observational studies. arXiv, https://doi.org/10.1101/2021.02.14.21251130

Background People with osteoarthritis are at a high risk of cardiovascular disease (CVD). Detecting CVD risk factors in this high-risk population will help to improve CVD outcomes. Primary care electronic health records (EHRs) provide opportunities f... Read More about Prevalence of cardiovascular risk factors in osteoarthritis patients derived from primary care records: a systematic review of observational studies.

The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding
Journal Article
Mycroft-West, C., Su, D., Elli, S., Li, Y., Guimond, S., Miller, G., …Skidmore, M. (2020). The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding. arXiv, https://doi.org/10.1101/2020.02.29.971093

Many pathogens take advantage of the dependence of the host on the interaction of hundreds of extracellular proteins with the glycosaminoglycans heparan sulphate to regulate homeostasis and use heparan sulphate as a means to adhere and gain access to... Read More about The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding.

042 Challenges Faced in Primary Care During the Early Stages of Rheumatoid Arthritis: A Cross-Sectional Survey of General Practitioners
Presentation / Conference
Mangat, N. S., Raza, K., Clarkson, K., Stack, R., Mallen, C., Belcher, J., & Hider, S. 042 Challenges Faced in Primary Care During the Early Stages of Rheumatoid Arthritis: A Cross-Sectional Survey of General Practitioners. Poster presented at Rheumatology 2016

Background: Early treatment can reduce morbidity and mortality in patients with RA. However, identifying early RA can be challenging, in part because many of its initial symptoms are non-specific. Delays in recognising RA and referral to secondary ca... Read More about 042 Challenges Faced in Primary Care During the Early Stages of Rheumatoid Arthritis: A Cross-Sectional Survey of General Practitioners.