Skip to main content

Research Repository

Advanced Search

Outputs (5813)

The cause and effect of mood disturbance in patients with ankylosing spondylitis
Thesis
The cause and effect of mood disturbance in patients with ankylosing spondylitis. https://keele-repository.worktribe.com/output/423996

Ankylosing spondylitis (AS) is a chronic inflammatory disorder, causing progressive pain and stiffness of the spine and peripheral joints. A systematic review of the literature revealed a high prevalence of possible depression (23-36%) and possible a... Read More about The cause and effect of mood disturbance in patients with ankylosing spondylitis.

Exploring 'risk' and self-management in relation to chronic joint pain
Thesis
Exploring 'risk' and self-management in relation to chronic joint pain. https://keele-repository.worktribe.com/output/423999

Chronic joint pain, specifically knee pain, is a prevalent disabling chronic condition. Policy and clinical guidelines promote education of risk factors and supported self-management to ameliorate predicted demands upon state, society and the individ... Read More about Exploring 'risk' and self-management in relation to chronic joint pain.

Identifying and rectifying prescriptions of long-acting antimuscarinic and beta-agonist inhalers without inhaled corticosteroids to asthma patients: an audit from a UK general practice surgery
Presentation / Conference
Identifying and rectifying prescriptions of long-acting antimuscarinic and beta-agonist inhalers without inhaled corticosteroids to asthma patients: an audit from a UK general practice surgery. Presented at BJGP Research Conference

Background In the UK 5.4 million people receive treatment for asthma. Patients diagnosed with asthma should not be prescribed a long-acting muscarinic antagonist (LAMA), or a long-acting beta 2 agonist (LABA) without co-prescription of an inhaled cor... Read More about Identifying and rectifying prescriptions of long-acting antimuscarinic and beta-agonist inhalers without inhaled corticosteroids to asthma patients: an audit from a UK general practice surgery.

The impact of musculoskeletal conditions on outcomes of other illnesses (the MSKCOM study): a linked electronic health record study - Code lists
Data
Marshall, M., Mason, K., Bailey, J., Heron, N., Achanca, F., Chen, Y., Edwards, J., Frisher, M., Huntley, A., Mallen, C., Mamas, M., Png, M., Tatton, S., White, S., & Jordan, K. (2022). The impact of musculoskeletal conditions on outcomes of other illnesses (the MSKCOM study): a linked electronic health record study - Code lists. [Data]

Marshall M, Mason K, Bailey J, Heron N, Achana F, Chen Y, Edwards J, Frisher M, Huntley A, Mallen C, Mamas M, Png ME, Tatton S, White S, Jordan KP. MSKCOM: main Public Output: The impact of musculoskeletal conditions on outcomes of other illnesses: a... Read More about The impact of musculoskeletal conditions on outcomes of other illnesses (the MSKCOM study): a linked electronic health record study - Code lists.

THU0650 Early help seeking or self-management: a quantitative assessment in the context of rheumatoid arthritis
Presentation / Conference Contribution
Simons, G., Belcher, J., Kumar, K., Falahee, M., Mallen, C., Stack, R., & Raza, K. THU0650 Early help seeking or self-management: a quantitative assessment in the context of rheumatoid arthritis. Presented at Annual European Congress of Rheumatology, EULAR 2018, Amsterdam, 13–16 June 2018

Background Rheumatoid arthritis (RA) should be treated with DMARDs in its earliest stages to reduce the likelihood of permanent joint damage and disability1. This therapeutic window is often missed. One important cause is delayed help seeking by pati... Read More about THU0650 Early help seeking or self-management: a quantitative assessment in the context of rheumatoid arthritis.

Prevalence of cardiovascular risk factors in osteoarthritis patients derived from primary care records: a systematic review of observational studies
Journal Article
Huang, X., Wilkie, R., Mamas, M. A., & Yu, D. Prevalence of cardiovascular risk factors in osteoarthritis patients derived from primary care records: a systematic review of observational studies. arXiv, https://doi.org/10.1101/2021.02.14.21251130

Background People with osteoarthritis are at a high risk of cardiovascular disease (CVD). Detecting CVD risk factors in this high-risk population will help to improve CVD outcomes. Primary care electronic health records (EHRs) provide opportunities f... Read More about Prevalence of cardiovascular risk factors in osteoarthritis patients derived from primary care records: a systematic review of observational studies.

The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding
Journal Article
Mycroft-West, C., Su, D., Elli, S., Li, Y., Guimond, S., Miller, G., Turnbull, J., Yates, E., Guerrini, M., Fernig, D., Lima, M., & Skidmore, M. (2020). The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding. arXiv, https://doi.org/10.1101/2020.02.29.971093

Many pathogens take advantage of the dependence of the host on the interaction of hundreds of extracellular proteins with the glycosaminoglycans heparan sulphate to regulate homeostasis and use heparan sulphate as a means to adhere and gain access to... Read More about The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding.

Using bioinformatics for the identification of key peptides to engineer dopamine neurons. Towards a therapy for Parkinson’s disease.
Journal Article
Mitchell​, W. D., Orme, R. P., Hart, S. R., & Fricker, R. A. (2018). Using bioinformatics for the identification of key peptides to engineer dopamine neurons. Towards a therapy for Parkinson’s disease. PeerJ PrePrints, https://doi.org/10.7287/peerj.preprints.26443v2


Parkinson’s disease is a widespread condition caused by degeneration of dopamine neurons in the midbrain. A number of proteins are known to be important to signalling mechanisms present in the midbrain during natural dopamine neuron development, an... Read More about Using bioinformatics for the identification of key peptides to engineer dopamine neurons. Towards a therapy for Parkinson’s disease..

042 Challenges Faced in Primary Care During the Early Stages of Rheumatoid Arthritis: A Cross-Sectional Survey of General Practitioners
Presentation / Conference
Mangat, N. S., Raza, K., Clarkson, K., Stack, R., Mallen, C., Belcher, J., & Hider, S. 042 Challenges Faced in Primary Care During the Early Stages of Rheumatoid Arthritis: A Cross-Sectional Survey of General Practitioners. Poster presented at Rheumatology 2016

Background: Early treatment can reduce morbidity and mortality in patients with RA. However, identifying early RA can be challenging, in part because many of its initial symptoms are non-specific. Delays in recognising RA and referral to secondary ca... Read More about 042 Challenges Faced in Primary Care During the Early Stages of Rheumatoid Arthritis: A Cross-Sectional Survey of General Practitioners.