Outputs (5)

Identification of synovial fluid proteins that are associated with early osteoarthritis treatment failure: the search for novel markers leads us back to matrix metalloproteinases (MMPs) (2018)
Presentation / Conference
Hulme, C., Wilson, E., Fuller, H., Roberts, S., Richardson, J., Gallacher, P., …Wright, K. (2018, July). Identification of synovial fluid proteins that are associated with early osteoarthritis treatment failure: the search for novel markers leads us back to matrix metalloproteinases (MMPs). Poster presented at Matrix Biology Europe – July 2018 Meeting Celebrating 50 years of Federation of European Connective Tissue Societies Meetings, Manchester, United Kingdom

Introduction: Autologous chondrocyte implantation (ACI) is a cell therapy used to treat cartilage defects and early osteoarthritis. During initial surgery (Stage I), healthy cartilage is harvested from the joint. Chondrocytes are isolated and culture... Read More about Identification of synovial fluid proteins that are associated with early osteoarthritis treatment failure: the search for novel markers leads us back to matrix metalloproteinases (MMPs).

Two independent proteomic approaches provide a comprehensive analysis of the synovial fluid proteome response to Autologous Chondrocyte Implantation (2018)
Journal Article
Hulme, C., Wilson, E., Fuller, H., Roberts, S., Richardson, J., Gallacher, P., …Wright, K. (2018). Two independent proteomic approaches provide a comprehensive analysis of the synovial fluid proteome response to Autologous Chondrocyte Implantation. Arthritis Research and Therapy, 20, Article 87. https://doi.org/10.1186/s13075-018-1573-4

Background
Autologous chondrocyte implantation (ACI) has a failure rate of approximately 20%, but it is yet to be fully understood why. Biomarkers are needed that can pre-operatively predict in which patients it is likely to fail, so that alternativ... Read More about Two independent proteomic approaches provide a comprehensive analysis of the synovial fluid proteome response to Autologous Chondrocyte Implantation.

Acute phase response signalling is altered following cartilage harvest in non-responders to Autologous Chondrocyte Implantation (2018)
Journal Article
Hulme, C., Wilson, E., Fuller, H., Roberts, S., Richardson, J., Gallacher, P., …Wright, K. (2018). Acute phase response signalling is altered following cartilage harvest in non-responders to Autologous Chondrocyte Implantation. Osteoarthritis and Cartilage, 26(S1), S167. https://doi.org/10.1016/j.joca.2018.02.363

Background: Autologous chondrocyte implantation (ACI) has a failure rate of approximately 20%, but it is yet to be
fully understood why. Biomarkers are needed that can pre-operatively predict in which patients it is likely to fail, so
that alternat... Read More about Acute phase response signalling is altered following cartilage harvest in non-responders to Autologous Chondrocyte Implantation.

Assessing The Characteristics Of Human Mesenchymal Stromal Cells Derived From Bone Marrow And Umbilical Cord Following Expansion In The Quantum® Hollow-fibre Bioreactor System (2018)
Journal Article
Mennan, C., Roberts, S., Garcia, J., Hulme, C., & Wright, K. (2018). Assessing The Characteristics Of Human Mesenchymal Stromal Cells Derived From Bone Marrow And Umbilical Cord Following Expansion In The Quantum® Hollow-fibre Bioreactor System. Osteoarthritis and Cartilage, 26(S1), S146-S147. https://doi.org/10.1016/j.joca.2018.02.316

No abstract

Assessment of candidate predictive protein biomarkers for microfracture and osteotomy (2018)
Journal Article
Hulme, C., Richardson, J., Gallacher, P., Roberts, S., & Wright, K. (2018). Assessment of candidate predictive protein biomarkers for microfracture and osteotomy. Osteoarthritis and Cartilage, 26(S1), S191-S192. https://doi.org/10.1016/j.joca.2018.02.410

PlumX Metrics

Purpose: Biomarkers that can predict clinical outcome for surgeries to prevent the progression of osteoarthritis (OA) are needed to ensure patients can be better stratified to receive the most appropriate treatment. We have previousl... Read More about Assessment of candidate predictive protein biomarkers for microfracture and osteotomy.