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Mesenchymal stromal cells from human umbilical cords display poor chondrogenic potential in scaffold-free three dimensional cultures. (2016)
Journal Article
Islam, A., Hansen, A., Mennan, C., & Martinez-Zubiaurre, I. (2016). Mesenchymal stromal cells from human umbilical cords display poor chondrogenic potential in scaffold-free three dimensional cultures. European cells & materials, 407 - 424. https://doi.org/10.22203/eCM.v031a26

Many researchers world over are currently investigating the suitability of stromal cells harvested from foetal tissues for allogeneic cell transplantation therapies or for tissue engineering purposes. In this study, we have investigated the chondroge... Read More about Mesenchymal stromal cells from human umbilical cords display poor chondrogenic potential in scaffold-free three dimensional cultures..

Characterisation of synovial fluid and infrapatellar fat pad derived mesenchymal stromal cells: The influence of tissue source and inflammatory stimulus. (2016)
Journal Article
Garcia, J., Wright, K., Roberts, S., Herman Kuiper, J., Mangham, C., Richardson, J., & Mennan, C. (2016). Characterisation of synovial fluid and infrapatellar fat pad derived mesenchymal stromal cells: The influence of tissue source and inflammatory stimulus. Scientific reports, 6, 24295 -?. https://doi.org/10.1038/srep24295

The infrapatellar fat pad (FP) and synovial fluid (SF) in the knee serve as reservoirs of mesenchymal stromal cells (MSCs) with potential therapeutic benefit. We determined the influence of the donor on the phenotype of donor matched FP and SF derive... Read More about Characterisation of synovial fluid and infrapatellar fat pad derived mesenchymal stromal cells: The influence of tissue source and inflammatory stimulus..

Obesity does not affect the size of infrapatellar fat pad adipocytes: implications for the pathogenesis of knee osteoarthritis (2016)
Journal Article
Garcia, J., Wei, W., Runhaar, J., Wright, K., Mennan, C., Roberts, S., …Bastiaansen-Jenniskens, Y. (2016). Obesity does not affect the size of infrapatellar fat pad adipocytes: implications for the pathogenesis of knee osteoarthritis. Osteoarthritis and Cartilage, 24(S1), S334-S335. https://doi.org/10.1016/j.joca.2016.01.599

Purpose: Obesity is known to be a risk factor for the development of osteoarthritis (OA). Obesity is accompanied by adipocyte hypertrophy and elevated inflammation in subcutaneous and visceral adipose tissue. The infrapatellar fat pad (IPFP) is an ad... Read More about Obesity does not affect the size of infrapatellar fat pad adipocytes: implications for the pathogenesis of knee osteoarthritis.

Cells isolated from fat pad and synovial fluid. are they suitable for cartilage repair? (2014)
Journal Article
Garica, J., Mennan, C., Richardson, J., Wright, K., & Roberts, S. (2014). Cells isolated from fat pad and synovial fluid. are they suitable for cartilage repair?. Osteoarthritis and Cartilage, 22, S445. https://doi.org/10.1016/j.joca.2014.02.843

Purpose: Autologous Chondrocyte Implantation (ACI) is used as a cellular therapy for treating defects in articular cartilage. Successful ACI depends on high cell number and quality of the cells which varies between patients. Alternative cell sources... Read More about Cells isolated from fat pad and synovial fluid. are they suitable for cartilage repair?.

Characterization of the cells in repair tissue following autologous chondrocyte implantation in mankind: a novel report of two cases (2013)
Journal Article
Wright, K. T., Mennan, C., Fox, H., Richardson, J. B., Banerjee, R., & Roberts, S. (2013). Characterization of the cells in repair tissue following autologous chondrocyte implantation in mankind: a novel report of two cases. Regenerative Medicine, 8(6), 699 - 709. https://doi.org/10.2217/rme.13.67

AIM: Autologous chondrocyte implantation (ACI) is used worldwide for the treatment of cartilage defects. This study has aimed to assess for the first time the cells that are contained within human ACI repair tissues several years post-treatment. We h... Read More about Characterization of the cells in repair tissue following autologous chondrocyte implantation in mankind: a novel report of two cases.

Isolation and characterisation of mesenchymal stem cells from different regions of the human umbilical cord. (2013)
Journal Article
Mennan, C., Wright, K., Bhattacharjee, A., Balain, B., Richardson, J., & Roberts, S. (2013). Isolation and characterisation of mesenchymal stem cells from different regions of the human umbilical cord. BioMed Research International, 2013, Article 916136. https://doi.org/10.1155/2013/916136

Umbilical cords as a source of stem cells are of increasing interest for cell therapies as they present little ethical consideration and are reported to contain immune privileged cells which may be suitable for allogeneic based therapies. Mesenchymal... Read More about Isolation and characterisation of mesenchymal stem cells from different regions of the human umbilical cord..