Outputs (2)

Identification of pyrazolo-pyrimidinones as GHS-R1a antagonists and inverse agonists for the treatment of obesity (2012)
Journal Article
McCoull, W., Barton, P., Broo, A., Brown, A. J. H., Clarke, D. S., Coope, G., …Williams, E. J. (2013). Identification of pyrazolo-pyrimidinones as GHS-R1a antagonists and inverse agonists for the treatment of obesity. MedChemComm, 4(2), 456. https://doi.org/10.1039/c2md20340e

A pyrazolo-pyrimidinone based series of growth hormone secretagogue receptor type 1a (GHS-R1a) antagonists and inverse agonists were identified using a scaffold hop from known quinazolinone GHS-R1a modulators. Lipophilicity was reduced to decrease hE... Read More about Identification of pyrazolo-pyrimidinones as GHS-R1a antagonists and inverse agonists for the treatment of obesity.

Arcuate Nucleus Homeostatic Systems are Not Altered Immediately Prior to the Scheduled Consumption of Large, Binge-Type Meals of Palatable Solid or Liquid Diet in Rats and Mice (2012)
Journal Article
Bake, T., Duncan, J. S., Morgan, D. G. A., & Mercer, J. G. (2013). Arcuate Nucleus Homeostatic Systems are Not Altered Immediately Prior to the Scheduled Consumption of Large, Binge-Type Meals of Palatable Solid or Liquid Diet in Rats and Mice. Journal of Neuroendocrinology, 25(4), 357-371. https://doi.org/10.1111/jne.12008

Meal feeding is a critical issue in the over-consumption of calories leading to human obesity. To investigate the mechanisms involved in the regulation of meal feeding in rodents, we studied a scheduled feeding regime that induces substantial food in... Read More about Arcuate Nucleus Homeostatic Systems are Not Altered Immediately Prior to the Scheduled Consumption of Large, Binge-Type Meals of Palatable Solid or Liquid Diet in Rats and Mice.