Outputs (32)

Fourier Transform Infrared microspectroscopy identifies single cancer cells in blood. A feasibility study towards liquid biopsy (2023)
Journal Article
Dowling, L. M., Roach, P., Magnussen, E. A., Kohler, A., Pillai, S., van Pittius, D. G., …Sulé-Suso, J. (in press). Fourier Transform Infrared microspectroscopy identifies single cancer cells in blood. A feasibility study towards liquid biopsy. PLoS ONE, 18(8), Article e0289824. https://doi.org/10.1371/journal.pone.0289824

The management of cancer patients has markedly improved with the advent of personalised medicine where treatments are given based on tumour antigen expression amongst other. Within this remit, liquid biopsies will no doubt improve this personalised c... Read More about Fourier Transform Infrared microspectroscopy identifies single cancer cells in blood. A feasibility study towards liquid biopsy.

Fourier transform infrared spectroscopy as a non-destructive method for analysing herbarium specimens. (2023)
Journal Article
Barnes, M., Sule-Suso, J., Millett, J., & Roach, P. (2023). Fourier transform infrared spectroscopy as a non-destructive method for analysing herbarium specimens. Biology Letters, 19(3), Article 20220546. https://doi.org/10.1098/rsbl.2022.0546

Dried plant specimens stored in herbaria are an untapped treasure chest of information on environmental conditions, plant evolution and change over many hundreds of years. Owing to their delicate nature and irreplaceability, there is limited access f... Read More about Fourier transform infrared spectroscopy as a non-destructive method for analysing herbarium specimens..

Domes and semi-capsules as model systems for infrared microspectroscopy of biological cells. (2023)
Journal Article
Solheim, J., Brandsrud, M., Kong, B., Banyasz, A., Borondics, F., Micouin, G., …Kohler, A. (2023). Domes and semi-capsules as model systems for infrared microspectroscopy of biological cells. Scientific reports, 13(1), Article 3165. https://doi.org/10.1038/s41598-023-30130-z

It is well known that infrared microscopy of micrometer sized samples suffers from strong scattering distortions, attributed to Mie scattering. The state-of-the-art preprocessing technique for modelling and removing Mie scattering features from infra... Read More about Domes and semi-capsules as model systems for infrared microspectroscopy of biological cells..

Detection of lipid efflux from foam cell models using a label-free infrared method (2022)
Journal Article
Xie, B., Njoroge, W., Dowling, L. M., Sulé-Suso, J., Cinque, G., & Yang, Y. (2022). Detection of lipid efflux from foam cell models using a label-free infrared method. Analyst, 147(23), 5372-5385. https://doi.org/10.1039/D2AN01041K

Cardiovascular diseases are still among the leading causes of mortality and morbidity worldwide. The build-up of fatty plaques in the arteries, leading to atherosclerosis, is the most common cause of cardiovascular diseases. The central player in ath... Read More about Detection of lipid efflux from foam cell models using a label-free infrared method.

Physiological Oxygen Causes the Release of Volatile Organic Compounds from Human Pluripotent Stem Cells with Possible Roles in Maintaining Self-Renewal and Pluripotency (2022)
Journal Article
Barreto, S., Al-Zubaidi, M., Dale, T., Worrall, A., Kapacee, Z., Kimber, S., …Rutter, A. (2022). Physiological Oxygen Causes the Release of Volatile Organic Compounds from Human Pluripotent Stem Cells with Possible Roles in Maintaining Self-Renewal and Pluripotency. Preprints, https://doi.org/10.20944/preprints202203.0143.v1

<jats:p>Human pluripotent stem cells (hPSCs) have widespread potential biomedical applications. There is a need for large-scale in vitro production of hPSCs, and optimal culture methods are vital in achieving this. Physiological oxygen (2% O2) improv... Read More about Physiological Oxygen Causes the Release of Volatile Organic Compounds from Human Pluripotent Stem Cells with Possible Roles in Maintaining Self-Renewal and Pluripotency.

Clinical applications of infrared and Raman spectroscopy in the fields of cancer and infectious diseases (2021)
Journal Article
Paraskevaidi, M., Baker, M., Butler, H., Byrne, H., Chakkumpulakkal, T., Loren, C., …Wood, B. (2021). Clinical applications of infrared and Raman spectroscopy in the fields of cancer and infectious diseases. Applied Spectroscopy Reviews, https://doi.org/10.1080/05704928.2021.1946076

Analytical technologies that can improve disease diagnosis are highly sought after. Current screening/diagnostic tests for several diseases are limited by their moderate diagnostic performance, invasiveness, costly and laborious methodologies or the... Read More about Clinical applications of infrared and Raman spectroscopy in the fields of cancer and infectious diseases.

Optimisation of sample preparation using glass slides for spectral pathology (2020)
Journal Article
Dowling, L., Roach, P., Rutter, A., Yousef, I., Pillai, S., Latham, D., …Sule-Suso, J. (2020). Optimisation of sample preparation using glass slides for spectral pathology. Applied Spectroscopy, 75(3), 343-350. https://doi.org/10.1177/0003702820945748

The clinical translation of Fourier Transform Infrared (FTIR) microspectroscopy in pathology will require bringing this technique as close as possible to standard practice in pathology departments. An important step is sample preparation for both FTI... Read More about Optimisation of sample preparation using glass slides for spectral pathology.

Striking lung cancer response to self-administration of cannabidiol: a case report and literature review (2019)
Journal Article
Sule-Suso, J., Watson, N., van Pittius, D., & Jegannathen, A. (2019). Striking lung cancer response to self-administration of cannabidiol: a case report and literature review. SAGE Open Medical Case Reports, https://doi.org/10.1177/2050313X19832160

In spite of new drugs, lung cancer is associated with a very poor prognosis. Whilst targeted therapies are improving outcomes, it is not uncommon for many patients to have only a partial response, and relapse during follow up. Thus, new drugs or re-e... Read More about Striking lung cancer response to self-administration of cannabidiol: a case report and literature review.

Vibrational spectroscopic monitoring and biochemical analysis of pericellular matrix formation and maturation in a 3-dimensional chondrocyte culture model. (2018)
Journal Article
Owida, H., Rutter, A., Cinque, G., Kuiper, N., Sule-Suso, J., & Yang, Y. (2018). Vibrational spectroscopic monitoring and biochemical analysis of pericellular matrix formation and maturation in a 3-dimensional chondrocyte culture model. Analyst, 5979-5986. https://doi.org/10.1039/c8an01272e

Isolated and monolayer expanded chondrocytes are not the ideal cell form to produce a cartilage matrix. In articular cartilage, each chondrocyte is surrounded by a 2-4 µm thick collagen VI-rich pericellular matrix (PCM) forming a chondron. Freshly ex... Read More about Vibrational spectroscopic monitoring and biochemical analysis of pericellular matrix formation and maturation in a 3-dimensional chondrocyte culture model..

Clinical applications of infrared and Raman spectroscopy: state of play and future challenges. (2018)
Journal Article
Baker, M., Byrne, H., Chalmers, J., Gardner, P., Goodacre, R., Henderson, A., …Sule-Suso, J. (2018). Clinical applications of infrared and Raman spectroscopy: state of play and future challenges. Analyst, 1735 - 1757. https://doi.org/10.1039/C7AN01871A

Vibrational spectroscopies, based on infrared absorption and/or Raman scattering provide a detailed fingerprint of a material, based on the chemical content. Diagnostic and prognostic tools based on these technologies have the potential to revolution... Read More about Clinical applications of infrared and Raman spectroscopy: state of play and future challenges..