Outputs (7)

Autologous chondrocyte implantation- derived synovial fluids display distinct responder and non-responder proteomic profiles (2017)
Journal Article
Hulme, C., Wilson, E., Fuller, H., Roberts, S., Richardson, J., Gallacher, P., …Wright, K. (2017). Autologous chondrocyte implantation- derived synovial fluids display distinct responder and non-responder proteomic profiles. Arthritis Research and Therapy, 19, Article 150. https://doi.org/10.1186/s13075-017-1336-7

Background Autologous chondrocyte implantation (ACI) can be used in the treatment of focal cartilage injuries to prevent the onset of osteoarthritis (OA). However, we are yet to understand fully why some individuals do not respond well to this interv... Read More about Autologous chondrocyte implantation- derived synovial fluids display distinct responder and non-responder proteomic profiles.

Similar phenotypes of cells in the repair tissues following microfracture or autologous chondrocyte implantation (2017)
Journal Article
Garcia, J., Hulme, C., Roberts, S., Richardson, J., Kuiper, J., & Wright, K. (2017). Similar phenotypes of cells in the repair tissues following microfracture or autologous chondrocyte implantation. International Journal of Experimental Pathology, 98(3), A23

Introduction

Autologous chondrocyte implantation (ACI) and microfracture are both used in the treatment of cartilage injuries. Previous findings suggest that the efficacy of these two therapies is similar in terms of short-term clinical outcome, h... Read More about Similar phenotypes of cells in the repair tissues following microfracture or autologous chondrocyte implantation.

Efficacy and safety of autologous cell therapies for knee cartilage defects (autologous stem cells, chondrocytes or the two): randomized controlled trial design. (2017)
Journal Article
Richardson, J. B., Wright, K. T., Wales, J., Herman Kuiper, J., McCarthy, H. S., Gallacher, P., …Roberts, S. (2017). Efficacy and safety of autologous cell therapies for knee cartilage defects (autologous stem cells, chondrocytes or the two): randomized controlled trial design. Regenerative Medicine, 12(5), 493-501. https://doi.org/10.2217/rme-2017-0032

AIM: The main aim of this trial is to test the safety and efficacy of autologous stromal/stem cells, chondrocytes or the two combined in the treatment of knee cartilage defects. PATIENTS & METHODS: Patients with symptomatic chondral/osteochondral def... Read More about Efficacy and safety of autologous cell therapies for knee cartilage defects (autologous stem cells, chondrocytes or the two): randomized controlled trial design..

Facilitating the operational readiness of the NHS for the in-house manufacture and delivery of autologous cell therapy (2017)
Presentation / Conference
Ziya, S., Medcalf, N., El, A., & Wright, K. (2017, June). Facilitating the operational readiness of the NHS for the in-house manufacture and delivery of autologous cell therapy. Poster presented at ISCT 2017 Annual Meeting, London, UK

Introduction: Cell-based therapies (CBTs) have been shown to confer regenerative capacity in various pathologies. The production of such treatments require
a range of business models. These business models either align with or disrupt
the current c... Read More about Facilitating the operational readiness of the NHS for the in-house manufacture and delivery of autologous cell therapy.

Poor clinical response to Autologous Chondrocyte Implantation is associated with a unique synovial fluid proteome profile (2017)
Journal Article
Hulme, C., Wilson, E., Peffers, M., Fuller, H., Roberts, S., Simpson, D., …Wright, K. (2017). Poor clinical response to Autologous Chondrocyte Implantation is associated with a unique synovial fluid proteome profile. Osteoarthritis and Cartilage, 25(S1), S92. https://doi.org/10.1016/j.joca.2017.02.146

Characterisation of joint macrophages: implications for osteoarthritis (2017)
Journal Article
Garcia, J., Wei, W., Wright, K., Mennan, C., Roberts, S., Richardson, J., …Bastiaansen-Jenniskens, Y. (2017). Characterisation of joint macrophages: implications for osteoarthritis. International Journal of Experimental Pathology, 97(6),

Introduction Inflammation in the synovium is a feature of osteoarthritis (OA) that contributes to the general degradation of the joint by the secretion of pro-inflammatory molecules and degradative enzymes. The infrapatellar fat pad (IPFP) is an intr... Read More about Characterisation of joint macrophages: implications for osteoarthritis.

The absence of detectable ADAMTS-4 (aggrecanase-1) activity in synovial fluid is a predictive indicator of autologous chondrocyte implantation success (2017)
Journal Article
Kuiper, J., Roberts, S., & Wright, K. (2017). The absence of detectable ADAMTS-4 (aggrecanase-1) activity in synovial fluid is a predictive indicator of autologous chondrocyte implantation success. American Journal of Sports Medicine, 1806-1814

Background:
Autologous chondrocyte implantation (ACI) is used worldwide in the treatment of cartilage defects in the knee. Several demographic and injury-specific risk factors have been identified that can affect the success of ACI treatment. Howeve... Read More about The absence of detectable ADAMTS-4 (aggrecanase-1) activity in synovial fluid is a predictive indicator of autologous chondrocyte implantation success.