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275 PATIENTS LIVING IN AREAS OF HIGHER SOCIOECONOMIC AREA DEPRIVATION HAVE SIGNIFICANTLY POORER PATIENT-REPORTED OUTCOMES FOLLOWING AUTOLOGOUS CHONDROCYTE IMPLANTATION IN THE UNITED KINGDOM (2024)
Presentation / Conference
Ismael, S., McCarthy, H. S., Williams, M., Barnett, A., Gallacher, P., Jermin, P., …Kuiper, J. H. (2024, April). 275 PATIENTS LIVING IN AREAS OF HIGHER SOCIOECONOMIC AREA DEPRIVATION HAVE SIGNIFICANTLY POORER PATIENT-REPORTED OUTCOMES FOLLOWING AUTOLOGOUS CHONDROCYTE IMPLANTATION IN THE UNITED KINGDOM. Poster presented at 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria

Using Nanopore sequencing to identify bacterial infection in joint replacements: A Preliminary study (2024)
Journal Article
Wilkinson, H., McDonald, J., McCarthy, H., Perry, J., Wright, K., Hulme, C., & Cool, P. (in press). Using Nanopore sequencing to identify bacterial infection in joint replacements: A Preliminary study. Briefings in Functional Genomics, Article elae008. https://doi.org/10.1093/bfgp/elae008

This project investigates if third-generation genomic sequencing can be used to identify the species of bacteria causing prosthetic joint infections (PJIs) at the time of revision surgery. Samples of prosthetic fluid were taken during revision surger... Read More about Using Nanopore sequencing to identify bacterial infection in joint replacements: A Preliminary study.

The clinical potential of meniscal progenitor cells (2024)
Journal Article
Yan, W., Wang, J., Fan, P., Roberts, S., Wright, K., & Zhang, Z. (2024). The clinical potential of meniscal progenitor cells. Journal of Cartilage & Joint Preservation (JCJP), 100166. https://doi.org/10.1016/j.jcjp.2024.100166

Introduction
The meniscus is an important cushioning structure of the knee joint, the maintenance of its normal structure and function plays a crucial role in protecting the joint from early degeneration. Stem/pro... Read More about The clinical potential of meniscal progenitor cells.

SYNOVIAL FLUID PROTEOMICS AND BIOINFORMATICS HIGHLIGHTS POTENTIAL MECHANISMS OF UMBILICAL CORD-MSC INDUCED RADIOLOGICAL IMPROVEMENT IN AN OVINE MODEL OF OSTEOARTHRITIS (2023)
Journal Article
Wright, K., McDonald, J., Mennan, C., Perry, J., Peffers, M., & Hulme, C. (2023). SYNOVIAL FLUID PROTEOMICS AND BIOINFORMATICS HIGHLIGHTS POTENTIAL MECHANISMS OF UMBILICAL CORD-MSC INDUCED RADIOLOGICAL IMPROVEMENT IN AN OVINE MODEL OF OSTEOARTHRITIS. Orthopaedic Proceedings, 105-B(SUPP_16), 53-53. https://doi.org/10.1302/1358-992x.2023.16.053

AbstractObjectivesA promising therapy for early osteoarthritis (OA) is the transplantation of human umbilical cord-derived mesenchymal stromal cells (hUC-MSCs). The synovial fluid (SF) from a pre-clinical ovine model treated with hUC-MSCs has been pr... Read More about SYNOVIAL FLUID PROTEOMICS AND BIOINFORMATICS HIGHLIGHTS POTENTIAL MECHANISMS OF UMBILICAL CORD-MSC INDUCED RADIOLOGICAL IMPROVEMENT IN AN OVINE MODEL OF OSTEOARTHRITIS.

CHARACTERIZING CELLULAR COMPONENTS OF BONE MARROW ASPIRATE CONCENTRATE: A ONE-STEP CELL THERAPY FOR ANKLE CARTILAGE DEFECTS (2023)
Journal Article
Lan, T., Wright, K., Makwana, N., Bing, A., McCarthy, H., & Hulme, C. (2023). CHARACTERIZING CELLULAR COMPONENTS OF BONE MARROW ASPIRATE CONCENTRATE: A ONE-STEP CELL THERAPY FOR ANKLE CARTILAGE DEFECTS. Orthopaedic Proceedings, 105-B(SUPP_16), 62-62. https://doi.org/10.1302/1358-992x.2023.16.062

AbstractObjectivesBone marrow aspirate concentrate (BMAC), together with fibrin glue (Tisseel, Baxter, UK) and Hyaluronic acid (HA) were used as a one-step cell therapy treating patients with ankle cartilage defects in our hospital. This therapy was... Read More about CHARACTERIZING CELLULAR COMPONENTS OF BONE MARROW ASPIRATE CONCENTRATE: A ONE-STEP CELL THERAPY FOR ANKLE CARTILAGE DEFECTS.

EVALUATING THE UTILITY OF SPECT/CT FOR THE IDENTIFICATION OF CARTILAGE LESIONS: A SYSTEMATIC REVIEW (2023)
Journal Article
Rix, L., Tushingham, S., Wright, K., & Snow, M. (2023). EVALUATING THE UTILITY OF SPECT/CT FOR THE IDENTIFICATION OF CARTILAGE LESIONS: A SYSTEMATIC REVIEW. Orthopaedic Proceedings, 105-B(SUPP_16), 45-45. https://doi.org/10.1302/1358-992x.2023.16.045

AbstractObjectiveA common orthopaedic pain found in a wide spectrum of individuals, from young and active to the elderly is anterior knee pain (AKP). It is a multifactorial disorder which is thought to occur through muscular imbalance, overuse, traum... Read More about EVALUATING THE UTILITY OF SPECT/CT FOR THE IDENTIFICATION OF CARTILAGE LESIONS: A SYSTEMATIC REVIEW.

A comprehensive review of quantum bioreactor cell manufacture: Research and clinical applications (2023)
Journal Article
Hulme, C. H., Mennan, C., McCarthy, H. S., Davies, R., Lan, T., Rix, L., …Wright, K. (2023). A comprehensive review of quantum bioreactor cell manufacture: Research and clinical applications. Cytotherapy, 25(10), 1017-1026. https://doi.org/10.1016/j.jcyt.2023.04.004

The Quantum cell expansion system manufactured by Terumo-BCT is perhaps the most widely reported Good Manufacturing Practice–compliant bioreactor used for the expansion of adherent cell populations, both for research purposes and cl... Read More about A comprehensive review of quantum bioreactor cell manufacture: Research and clinical applications.

Human vascularised synovium-on-a-chip: a mechanically stimulated, microfluidic model to investigate synovial inflammation and monocyte recruitment. (2023)
Journal Article
Thompson, C. L., Hopkins, T., Bevan, C., Screen, H. R., Wright, K. T., & Knight, M. M. (in press). Human vascularised synovium-on-a-chip: a mechanically stimulated, microfluidic model to investigate synovial inflammation and monocyte recruitment. Biomedical Materials, 18(6), https://doi.org/10.1088/1748-605X/acf976

Healthy synovium is critical for joint homeostasis. Synovial inflammation (synovitis) is implicated in the onset, progression and symptomatic presentation of arthritic joint diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). Thus, th... Read More about Human vascularised synovium-on-a-chip: a mechanically stimulated, microfluidic model to investigate synovial inflammation and monocyte recruitment..

Analysis of Synovial Fluid Proteomes After Treating an Ovine Osteoarthritic Model with Human Umbilical Cord Mesenchymal Stem Cells (2023)
Presentation / Conference
McDonald, J., Wright, K., Mennan, C., Peffers, M., Perry, J., Roberts, S., …Hulme, C. (2023, September). Analysis of Synovial Fluid Proteomes After Treating an Ovine Osteoarthritic Model with Human Umbilical Cord Mesenchymal Stem Cells. Presented at International Cartilage and Joint Preservation Society World Congress 2023, Melia Hotel Sitges, Sitges/ Barcelona