Outputs (85)

A comprehensive review of quantum bioreactor cell manufacture: Research and clinical applications (2023)
Journal Article
Hulme, C. H., Mennan, C., McCarthy, H. S., Davies, R., Lan, T., Rix, L., …Wright, K. (2023). A comprehensive review of quantum bioreactor cell manufacture: Research and clinical applications. Cytotherapy, 25(10), 1017-1026. https://doi.org/10.1016/j.jcyt.2023.04.004

The Quantum cell expansion system manufactured by Terumo-BCT is perhaps the most widely reported Good Manufacturing Practice–compliant bioreactor used for the expansion of adherent cell populations, both for research purposes and cl... Read More about A comprehensive review of quantum bioreactor cell manufacture: Research and clinical applications.

Genomic Sequencing to Diagnose Prosthetic Joint Infection in the Knee: A Case Report (2023)
Journal Article
Wilkinson, H., McCarthy, H. S., Perry, J., Smith, T., Wright, K., & Cool, P. (2023). Genomic Sequencing to Diagnose Prosthetic Joint Infection in the Knee: A Case Report. Cureus, 15(5), https://doi.org/10.7759/cureus.38788

There is currently no "gold-standard" method to diagnose prosthetic joint infections (PJI), and the current practice of using microbiological cultures has many limitations. The identification of the bacterial species causing the infection is crucial... Read More about Genomic Sequencing to Diagnose Prosthetic Joint Infection in the Knee: A Case Report.

PROTEOMIC IDENTIFICATION OF PREDICTIVE AUTOLOGOUS CHONDROCYTE IMPLANTATION BIOMARKERS IN PLASMA (2023)
Journal Article
Hulme, C., Roberts, S., Gallagher, P., Jermin, P., & Wright, K. (2023). PROTEOMIC IDENTIFICATION OF PREDICTIVE AUTOLOGOUS CHONDROCYTE IMPLANTATION BIOMARKERS IN PLASMA. Orthopaedic Proceedings, 105-B(SUPP_9), 76-76. https://doi.org/10.1302/1358-992x.2023.9.076

Stratification is required to ensure that only those patients likely to benefit, receive Autologous Chondrocyte Implantation (ACI); ideally by assessing a biomarker in the blood. This study aimed to assess differences in the plasma proteome of indivi... Read More about PROTEOMIC IDENTIFICATION OF PREDICTIVE AUTOLOGOUS CHONDROCYTE IMPLANTATION BIOMARKERS IN PLASMA.

AUTOLOGOUS CHONDROCYTE IMPLANTATION: MULTILEVEL MODELLING OF 20-YEAR LONGITUDINAL OUTCOME DATA (2023)
Conference Proceeding
Tierney, L., Kuiper, J., Williams, M., Roberts, S., Harrison, P., Gallacher, P., …Wright, K. (2023). AUTOLOGOUS CHONDROCYTE IMPLANTATION: MULTILEVEL MODELLING OF 20-YEAR LONGITUDINAL OUTCOME DATA. . https://doi.org/10.1302/1358-992x.2023.9.075

The objectives of the study were to investigate demographic, injury and surgery/treatment-associated factors that could influence clinical outcome, following Autologous Chondrocyte Implantation (ACI) in a large, “real-world”, 20 year longitudinally c... Read More about AUTOLOGOUS CHONDROCYTE IMPLANTATION: MULTILEVEL MODELLING OF 20-YEAR LONGITUDINAL OUTCOME DATA.

Proteomic Analyses of Autologous Chondrocyte Implantation Plasma Highlight Cartilage Acidic Protein 1 as a Candidate for Preclinical Screening. (2023)
Journal Article
Hulme, C., & Wright, K. (2023). Proteomic Analyses of Autologous Chondrocyte Implantation Plasma Highlight Cartilage Acidic Protein 1 as a Candidate for Preclinical Screening. American Journal of Sports Medicine, 51(6), 1422-1433. https://doi.org/10.1177/03635465231156616

BACKGROUND: Stratification is required to ensure that only patients likely to benefit receive autologous chondrocyte implantation (ACI). It would be advantageous to identify biomarkers to predict ACI outcome that are measurable in blood, avoiding the... Read More about Proteomic Analyses of Autologous Chondrocyte Implantation Plasma Highlight Cartilage Acidic Protein 1 as a Candidate for Preclinical Screening..

Umbilical Cord MSC Treated Osteoarthritic Sheep Display Reduced Radiographic Changes: Proteomic Biomarker Profiling of Synovial Fluids Implicate an Immunomodulatory Mechanism (2023)
Presentation / Conference
Perry, J., Mennan, C., Cool, P., Mccarthy, H., Newell, K., Hulme, C., …Roberts, S. (2023, March). Umbilical Cord MSC Treated Osteoarthritic Sheep Display Reduced Radiographic Changes: Proteomic Biomarker Profiling of Synovial Fluids Implicate an Immunomodulatory Mechanism. Presented at TERMIS 2023 – European Chapter, Manchester Central Conference Centre Manchester, UK

Comparative analysis of umbilical cord mesenchymal stromal cells versus their extracellular vesicles for the treatment of inflammatory arthritis (2023)
Presentation / Conference
Davies, R., Mennan, C., Platt, M., Wright, K., & Kehoe, O. (2023, March). Comparative analysis of umbilical cord mesenchymal stromal cells versus their extracellular vesicles for the treatment of inflammatory arthritis. Presented at TERMIS 2023 – European Chapter, Manchester Central Conference Centre Manchester, UK

Up-scale Manufacture of Chondrocytes from Adult and Juvenile Cartilage Donors for Allogeneic Chondrocyte Therapies (2023)
Journal Article
Hulme, C., Garcia, J., Perry, J., Baird, D., Freeman, R., Kiely, N., & Wright, K. (2023). Up-scale Manufacture of Chondrocytes from Adult and Juvenile Cartilage Donors for Allogeneic Chondrocyte Therapies. Osteoarthritis and Cartilage, 31(S1), https://doi.org/10.1016/j.joca.2023.01.210

Commonality Between The Proteome Signatures Of Clinical Response To Surgically Sustained And Acute Traumatic Cartilage Injuries In Two Human Knee Cohorts (2023)
Journal Article
Hulme, C., Williams, A., Vincent, T., Watt, F., & Wright, K. (2023). Commonality Between The Proteome Signatures Of Clinical Response To Surgically Sustained And Acute Traumatic Cartilage Injuries In Two Human Knee Cohorts. Osteoarthritis and Cartilage, 31(S1), S357. https://doi.org/10.1016/j.joca.2023.01.399

Chondrocyte Isolation and Expansion (2022)
Book Chapter
Harrison, P., Hopkins, T., Hulme, C., McCarthy, H., & Wright, K. Chondrocyte Isolation and Expansion. In Cartilage Tissue Engineering (9-19). Springer. https://doi.org/10.1007/978-1-0716-2839-3_2

Chondrocyte isolation requires a combination of enzymatic and mechanical digestion of cartilaginous tissues in order to release the chondrocytes. Extracted primary chondrocytes will then adhere to standard tissue culture plastics, typically in small... Read More about Chondrocyte Isolation and Expansion.