Outputs (117)

Iron stored in ferritin is chemically reduced in the presence of aggregating Aß(1-42). (2020)
Journal Article
Everett, J., Brooks, J., Lermyte, F., O’Connor, P. B., Sadler, P. J., Dobson, J., Collingwood, J. F., & Telling, N. D. (2020). Iron stored in ferritin is chemically reduced in the presence of aggregating Aß(1-42). Scientific reports, 20, Article 10332. https://doi.org/10.1038/s41598-020-67117-z

Atypical low-oxidation-state iron phases in Alzheimer's disease (AD) pathology are implicated in disease pathogenesis, as they may promote elevated redox activity and convey toxicity. However, the origin of low-oxidation-state iron and the pathways r... Read More about Iron stored in ferritin is chemically reduced in the presence of aggregating Aß(1-42)..

Analysis of neuronal iron deposits in Parkinson's disease brain tissue by synchrotron x-ray spectromicroscopy. (2020)
Journal Article
Brooks, J., Everett, J., Lermyte, F., Tjendana Tjhin, V., Sadler, P. J., Telling, N., & Collingwood, J. F. (2020). Analysis of neuronal iron deposits in Parkinson's disease brain tissue by synchrotron x-ray spectromicroscopy. Journal of Trace Elements in Medicine and Biology, 62, Article 126555. https://doi.org/10.1016/j.jtemb.2020.126555

BACKGROUND: Neuromelanin-pigmented neurons, which are highly susceptible to neurodegeneration in the Parkinson's disease substantia nigra, harbour elevated iron levels in the diseased state. Whilst it is widely believed that neuronal iron is stored i... Read More about Analysis of neuronal iron deposits in Parkinson's disease brain tissue by synchrotron x-ray spectromicroscopy..

Label-Free Nanoimaging of Neuromelanin in the Brain by Soft X-ray Spectromicroscopy. (2020)
Journal Article
Telling, & Everett. (2020). Label-Free Nanoimaging of Neuromelanin in the Brain by Soft X-ray Spectromicroscopy. Angewandte Chemie International Edition, https://doi.org/10.1002/anie.202000239

A hallmark of Parkinson's disease is the death of neuromelanin-pigmented neurons, but the role of neuromelanin is unclear. The in situ characterization of neuromelanin remains dependent on detectable pigmentation, rather than direct quantification of... Read More about Label-Free Nanoimaging of Neuromelanin in the Brain by Soft X-ray Spectromicroscopy..

Broadband optical measurement of AC magnetic susceptibility of magnetite nanoparticles (2020)
Journal Article
Soucaille, R., Sharifabad, M., Telling, N., & Hicken, R. (2020). Broadband optical measurement of AC magnetic susceptibility of magnetite nanoparticles. Applied Physics Letters, 116(6), 062404 - 062404. https://doi.org/10.1063/1.5140362

Characterization of magnetic nanoparticles in solution is challenging due to the interplay between magnetic relaxation and agglomeration. The AC magnetic susceptibility of magnetite nanoparticles in water has been studied using magneto-optical method... Read More about Broadband optical measurement of AC magnetic susceptibility of magnetite nanoparticles.

Emerging Approaches to Investigate the Influence of Transition Metals in the Proteinopathies (2019)
Journal Article
Telling, & Everett, J. (2019). Emerging Approaches to Investigate the Influence of Transition Metals in the Proteinopathies. Cells, https://doi.org/10.3390/cells8101231

Transition metals have essential roles in brain structure and function, and are associated with pathological processes in neurodegenerative disorders classed as proteinopathies. Synchrotron X-ray techniques, coupled with ultrahigh-resolution mass spe... Read More about Emerging Approaches to Investigate the Influence of Transition Metals in the Proteinopathies.

Magnetic Mechanoactivation of Wnt Signaling Augments Dopaminergic Differentiation of Neuronal Cells (2019)
Journal Article
Rotherham, M., Nahar, T., Goodman, T., Telling, N., Gates, M., & El Haj, A. (2019). Magnetic Mechanoactivation of Wnt Signaling Augments Dopaminergic Differentiation of Neuronal Cells. Advanced Biosystems, 3(9), 1900091 - 1900091. https://doi.org/10.1002/adbi.201900091

Wnt signaling is a key developmental pathway that regulates dopaminergic progenitor cell proliferation and differentiation during neuronal development. This makes Wnt signaling an important therapeutic target for neurodegenerative conditions such as... Read More about Magnetic Mechanoactivation of Wnt Signaling Augments Dopaminergic Differentiation of Neuronal Cells.

Metal Ion Binding to the Amyloid ß Monomer Studied by Native Top-Down FTICR Mass Spectrometry. (2019)
Journal Article
Lermyte, F., Everett, J., Lam, Y., Wootton, C., Brooks, J., Barrow, M., Telling, N., Sadler, P., O'Connor, P., & Collingwood, J. (2019). Metal Ion Binding to the Amyloid ß Monomer Studied by Native Top-Down FTICR Mass Spectrometry. Journal of The American Society for Mass Spectrometry, 30(10), 2123-2134. https://doi.org/10.1007/s13361-019-02283-7

Native top-down mass spectrometry is a fast, robust biophysical technique that can provide molecular-scale information on the interaction between proteins or peptides and ligands, including metal cations. Here we have analyzed complexes of the full-l... Read More about Metal Ion Binding to the Amyloid ß Monomer Studied by Native Top-Down FTICR Mass Spectrometry..

Correlative Spectromicroscopy and Tomography for Biomedical Applications involving Electron, Ion, and Soft X-ray Microscopies (2019)
Journal Article
Hitchcock, A. P., Wang, X., Grandfield, K., Everett, J., Collingwood, J. F., & Telling, N. D. (2019). Correlative Spectromicroscopy and Tomography for Biomedical Applications involving Electron, Ion, and Soft X-ray Microscopies. Microscopy Today, 27(2), https://doi.org/10.1017/S1551929518001256

Many important scientific and technical problems are best addressed using multiple, microscopy-based analytical techniques that combine the strengths of complementary methods. Here, we provide two examples from biomedical challenges: unravelling the... Read More about Correlative Spectromicroscopy and Tomography for Biomedical Applications involving Electron, Ion, and Soft X-ray Microscopies.

Nanoparticle-mediated magnetic hyperthermia is an effective method for killing the human-infective protozoan parasite Leishmania mexicana in vitro (2019)
Journal Article
Berry, S., Walker, K., Hoskins, C., Telling, N., & Price, H. (2019). Nanoparticle-mediated magnetic hyperthermia is an effective method for killing the human-infective protozoan parasite Leishmania mexicana in vitro. Scientific reports, 9, Article 1059. https://doi.org/10.1038/s41598-018-37670-9

Cutaneous leishmaniasis is a neglected tropical disease characterized by disfguring skin lesions. Current chemotherapeutic options depend on toxic, expensive drugs that are both difcult to administer and becoming less efective due to increasing level... Read More about Nanoparticle-mediated magnetic hyperthermia is an effective method for killing the human-infective protozoan parasite Leishmania mexicana in vitro.

The potential of magnetic hyperthermia for triggering the differentiation of cancer cells (2018)
Journal Article
Moise, S., Byrne, J. M., El Haj, A. J., & Telling, N. D. (2018). The potential of magnetic hyperthermia for triggering the differentiation of cancer cells. Nanoscale, 10(44), 20519-20525. https://doi.org/10.1039/c8nr05946b

Magnetic hyperthermia is a potential technique for cancer therapy that exploits heat generated by magnetic nanoparticles to kill cancerous cells. Many studies have shown that magnetic hyperthermia is effective at killing cancer cells both in vitro an... Read More about The potential of magnetic hyperthermia for triggering the differentiation of cancer cells.