Outputs (116)

Nanoscale synchrotron X-ray speciation of iron and calcium compounds in amyloid plaque cores from Alzheimer’s disease subjects (2018)
Journal Article
Everett, J., Collingwood, J. F., Tjendana-Tjhin, V., Brooks, J., Lermyte, F., Plascencia-Villa, G., …Telling, N. D. (2018). Nanoscale synchrotron X-ray speciation of iron and calcium compounds in amyloid plaque cores from Alzheimer’s disease subjects. Nanoscale, 10(25), 11782-11796. https://doi.org/10.1039/c7nr06794a

Altered metabolism of biometals in the brain is a key feature of Alzheimer's disease, and biometal interactions with amyloid-ß are linked to amyloid plaque formation. Iron-rich aggregates, including evidence for the mixed-valence iron oxide magnetite... Read More about Nanoscale synchrotron X-ray speciation of iron and calcium compounds in amyloid plaque cores from Alzheimer’s disease subjects.

Translation of remote control regenerative technologies for bone repair. (2018)
Journal Article
Markides, H., McLaren, J. S., Telling, N. D., Alom, N., Al-Mutheffer, E. A., Oreffo, R. O., …El Haj, A. J. (2018). Translation of remote control regenerative technologies for bone repair. npj Regenerative Medicine, 3, Article 9. https://doi.org/10.1038/s41536-018-0048-1

The role of biomechanical stimuli, or mechanotransduction, in normal bone homeostasis and repair is understood to facilitate effective osteogenesis of mesenchymal stem cells (MSCs) in vitro. Mechanotransduction has been integrated into a multitude of... Read More about Translation of remote control regenerative technologies for bone repair..

Dynamical Magnetic Response of Iron Oxide Nanoparticles Inside Live Cells (2018)
Journal Article
Cabrera, D., Coene, A., Leliaert, J., Artés-Ibáñez, E. J., Dupré, L., Telling, N. D., & Teran, F. J. (2018). Dynamical Magnetic Response of Iron Oxide Nanoparticles Inside Live Cells. ACS nano, 12(3), 2741-2752. https://doi.org/10.1021/acsnano.7b08995

Magnetic nanoparticles exposed to alternating magnetic fields have shown a great potential acting as magnetic hyperthermia mediators for cancer treatment. However, a dramatic and unexplained reduction of the nanoparticle magnetic heating efficiency h... Read More about Dynamical Magnetic Response of Iron Oxide Nanoparticles Inside Live Cells.

Nanoscale correlation of iron biochemistry with amyloid plaque morphology in Alzheimer’s disease transgenic mouse cortex (2017)
Journal Article
Telling, N., Everett, J., Collingwood, J. F., Dobson, J., van der Laan, G., Gallagher, J. J., …Hitchcock, A. P. (2017). Nanoscale correlation of iron biochemistry with amyloid plaque morphology in Alzheimer’s disease transgenic mouse cortex. Cell chemical biology, 24(10), 1205-1215. https://doi.org/10.1016/j.chembiol.2017.07.014

A signature characteristic of Alzheimer's disease (AD) is aggregation of amyloid-beta (Aß) fibrils in the brain. Nevertheless, the links between Aß and AD pathology remain incompletely understood. It has been proposed that neurotoxicity arising from... Read More about Nanoscale correlation of iron biochemistry with amyloid plaque morphology in Alzheimer’s disease transgenic mouse cortex.

Iron Biochemistry is Correlated with Amyloid Plaque Morphology in an Established Mouse Model of Alzheimer's Disease. (2017)
Journal Article
Telling, N., Everett, J., Collingwood, J. F., Dobson, J., van der Laan, G., Gallagher, J. J., …Hitchcock, A. P. (2017). Iron Biochemistry is Correlated with Amyloid Plaque Morphology in an Established Mouse Model of Alzheimer's Disease. Cell chemical biology, 24(10), 1205-1215. https://doi.org/10.1016/j.chembiol.2017.07.014

A signature characteristic of Alzheimer's disease (AD) is aggregation of amyloid-beta (Aß) fibrils in the brain. Nevertheless, the links between Aß and AD pathology remain incompletely understood. It has been proposed that neurotoxicity arising from... Read More about Iron Biochemistry is Correlated with Amyloid Plaque Morphology in an Established Mouse Model of Alzheimer's Disease..

ADVANCES IN X-RAY MICROSCOPY FOR THE ANALYSIS OF TRANSITION METALS IN THE BRAIN (2017)
Presentation / Conference
Collingwood, J., Everett, J., Telling, N., & Adams, F. (2017, May). ADVANCES IN X-RAY MICROSCOPY FOR THE ANALYSIS OF TRANSITION METALS IN THE BRAIN. Poster presented at Seventh Congress of the International BioIron Society (IBIS) Biennial World Meeting (BioIron 2017)

Introduction: X-rays have the advantage that they have a short wavelength and can penetrate through a thick biological sample. It was the need to ‘see inside’ opaque objects, especially biological tissues, and to resolve features too small for optica... Read More about ADVANCES IN X-RAY MICROSCOPY FOR THE ANALYSIS OF TRANSITION METALS IN THE BRAIN.

The cellular magnetic response and biocompatibility of biogenic zinc- and cobalt-doped magnetite nanoparticles. (2017)
Journal Article
Moise, S., Céspedes, E., Soukup, D., Byrne, J. M., El Haj, A. J., & Telling, N. D. (2017). The cellular magnetic response and biocompatibility of biogenic zinc- and cobalt-doped magnetite nanoparticles. Scientific reports, 7, Article 39922. https://doi.org/10.1038/srep39922

The magnetic moment and anisotropy of magnetite nanoparticles can be optimised by doping with transition metal cations, enabling their properties to be tuned for different biomedical applications. In this study, we assessed the suitability of bacteri... Read More about The cellular magnetic response and biocompatibility of biogenic zinc- and cobalt-doped magnetite nanoparticles..

Iron Oxides in the Human Brain (2016)
Book Chapter
Collingwood, J. F., & Telling, N. D. Iron Oxides in the Human Brain. In Iron Oxides: From Nature to Applications (143-176). Wiley. https://doi.org/10.1002/9783527691395.ch7

The presence and formation of iron oxide in the human brain are of interest to those engaged in understanding fundamental processes of biomineralization and of iron metabolism in neurobiology and neuropathology. There is evidence for the formation of... Read More about Iron Oxides in the Human Brain.

'Stealth' nanoparticles evade neural immune cells but also evade all major brain cell populations: Implications for PEG-based neurotherapeutics (2016)
Journal Article
Jenkins, S., Weinberg, D., Al-Shakli, A., Fernandes, A., Yiu, H., Telling, N., …Chari, D. (2016). 'Stealth' nanoparticles evade neural immune cells but also evade all major brain cell populations: Implications for PEG-based neurotherapeutics. Journal of Controlled Release, 224, 136-145. https://doi.org/10.1016/j.jconrel.2016.01.013

Surface engineering to control cell behavior is of high interest across the chemical engineering, drug delivery and biomaterial communities. Defined chemical strategies are necessary to tailor nanoscale protein interactions/adsorption, enabling contr... Read More about 'Stealth' nanoparticles evade neural immune cells but also evade all major brain cell populations: Implications for PEG-based neurotherapeutics.

Remote Cell Activation for Bone Regeneration - a Pre Clinical Animal Study (2015)
Journal Article
Markides, H., Telling, N., Henstock, J., & El Haj, A. (2015). Remote Cell Activation for Bone Regeneration - a Pre Clinical Animal Study. Tissue Engineering Part A, 21, S7-S8

We aim to develop a cell-based injectable solution for treatment of non-union bone fractures. Our approach is based on the use of functionalised magnetic particles (MNPs) targeted to the TREK-1 mecho-sensative receptor on the mesenchymal stem cell (M... Read More about Remote Cell Activation for Bone Regeneration - a Pre Clinical Animal Study.