Outputs (4)

Editorial (Current and Emerging Pharmacological Therapies of Ischaemic Stroke) (2013)
Journal Article
Chen, R. (2013). Editorial (Current and Emerging Pharmacological Therapies of Ischaemic Stroke). CNS and Neurological Disorders - Drug Targets, 12(2), 143-144. https://doi.org/10.2174/1871527311312020001

Stroke is a form of cardiovascular disease affecting blood supply to the brain. About 87% of strokes are ischemic, and the remainder are haemorrhagic. Ischaemic stroke is caused by the obstruction of blood flow in a brain artery leading to the lack o... Read More about Editorial (Current and Emerging Pharmacological Therapies of Ischaemic Stroke).

Stroke syndromes and clinical management (2013)
Journal Article
Balami, J. S., Chen, R. L., & Buchan, A. M. (2013). Stroke syndromes and clinical management. QJM: An International Journal of Medicine, 106(7), 607-615. https://doi.org/10.1093/qjmed/hct057

The knowledge of brain syndromes is essential for stroke physicians and neurologists, particularly those that can be extremely difficult and challenging to diagnose due to the great variability of symptom presentation and yet of clinical significance... Read More about Stroke syndromes and clinical management.

Stem cell therapy for ischaemic stroke: translation from preclinical studies to clinical treatment (2013)
Journal Article
Balami, J. S., Fricker, R. A., & Chen, R. (2013). Stem cell therapy for ischaemic stroke: translation from preclinical studies to clinical treatment. CNS & Neurological Disorders - Drug Targets, 12(2), 209 -219. https://doi.org/10.2174/1871527311312020007

No pharmacological intervention has been shown convincingly to improve neurological outcome in stroke patients after the brain tissue is infarcted. While conventional therapeutic strategies focus on preventing brain damage, stem cell treatment has th... Read More about Stem cell therapy for ischaemic stroke: translation from preclinical studies to clinical treatment.

Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy (2013)
Journal Article
Papadakis, M., Hadley, G., Xilouri, M., Hoyte, L. C., Nagel, S., McMenamin, M. M., …Buchan, A. M. (2013). Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy. Nature Medicine, 19(3), 351-357. https://doi.org/10.1038/nm.3097

Previous attempts to identify neuroprotective targets by studying the ischemic cascade and devising ways to suppress it have failed to translate to efficacious therapies for acute ischemic stroke1. We hypothesized that studying the molecular determin... Read More about Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy.