Outputs (6)

Development and evaluation of cationic nanostructured lipid carriers for ophthalmic drug delivery of besifloxacin (2019)
Journal Article
Yang. (2019). Development and evaluation of cationic nanostructured lipid carriers for ophthalmic drug delivery of besifloxacin. Journal of Drug Delivery Science and Technology, https://doi.org/10.1016/j.jddst.2019.101496

Besifloxacin hydrochloride (BSF) is a new ophthalmic antibiotic. However, its low water solubility limits its therapeutic efficacy. This article reported a novel lipid based drug delivery system to enhance ocular bioavailability of BSF. Cationic nano... Read More about Development and evaluation of cationic nanostructured lipid carriers for ophthalmic drug delivery of besifloxacin.

P1 Biomechanical Properties of the Aortic Dissection Flap in Chronic Aortic Dissection (2019)
Journal Article
Panpho, P., Davies, H., Field, M., Madine, J., Yang, Y., & Akhtar, R. (2019). P1 Biomechanical Properties of the Aortic Dissection Flap in Chronic Aortic Dissection. Artery Research, 25(Suppl 1), S43-S43. https://doi.org/10.2991/artres.k.191224.036

Background: Aortic dissection is a devastating condition, beginning with a tear through from intima to the medial layer, leading to splitting of aortic layers and creating the false and true lumen with a septum (or flap). Little is known about the pr... Read More about P1 Biomechanical Properties of the Aortic Dissection Flap in Chronic Aortic Dissection.

Cardiac Progenitor Cells from Stem Cells: Learning from Genetics and Biomaterials (2019)
Journal Article
Barreto, S., Hamel, L., Schiatti, T., Yang, Y., & George, V. (2019). Cardiac Progenitor Cells from Stem Cells: Learning from Genetics and Biomaterials. Cells, 8(12), https://doi.org/10.3390/cells8121536

Cardiac Progenitor Cells (CPCs) show great potential as a cell resource for restoring cardiac function in patients affected by heart disease or heart failure. CPCs are proliferative and committed to cardiac fate, capable of generating cells of all th... Read More about Cardiac Progenitor Cells from Stem Cells: Learning from Genetics and Biomaterials.

Regulation of endothelial cell arrangements within hMSC – HUVEC co-cultured aggregates (2019)
Journal Article
Yang. (2019). Regulation of endothelial cell arrangements within hMSC – HUVEC co-cultured aggregates. https://doi.org/10.1016/j.bj.2019.01.003

Background Micro-mass culturing or cellular aggregation is an effective method used to form mineralised bone tissue. Poor core cell viability, however, is often an impeding characteristic of large micro-mass cultures, and equally for large tissue-eng... Read More about Regulation of endothelial cell arrangements within hMSC – HUVEC co-cultured aggregates.

Dynamic Culture Substrates That Mimic the Topography of the Epidermal-Dermal Junction (2019)
Journal Article
Yang. (2019). Dynamic Culture Substrates That Mimic the Topography of the Epidermal-Dermal Junction. Tissue Engineering Part A, 214 - 223. https://doi.org/10.1089/ten.tea.2018.0125

The junction between the epidermal and dermal layers of human skin undulates, the width and depth of the undulations varying with age and disease. We previously showed that when primary human epidermal keratinocytes are seeded on collagen-coated undu... Read More about Dynamic Culture Substrates That Mimic the Topography of the Epidermal-Dermal Junction.

Investigation of Conjunctival Fibrosis Response Using a 3D Glaucoma Tenon’s Capsule + Conjunctival ModelFibrosis Response Within a 3D Tenon’s + Conjunctival Model (2019)
Journal Article
Gater, R., Ipek, T., Sadiq, S., Nguyen, D., Jones, L., El Haj, A., & Yang, Y. (2019). Investigation of Conjunctival Fibrosis Response Using a 3D Glaucoma Tenon’s Capsule + Conjunctival ModelFibrosis Response Within a 3D Tenon’s + Conjunctival Model. Investigative ophthalmology & visual science, 60(2), 605 -614. https://doi.org/10.1167/iovs.18-25335

Surgical techniques such as trabeculectomy aim to treat glaucoma by making an incision into the scleral tissue, to create an alternative drainage pathway for aqueous to flow into the sub-Tenon’s/subconjunctival space. However, tissue fibrosis and wou... Read More about Investigation of Conjunctival Fibrosis Response Using a 3D Glaucoma Tenon’s Capsule + Conjunctival ModelFibrosis Response Within a 3D Tenon’s + Conjunctival Model.