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Developing a Biomimetic 3D Neointimal Layer as a Prothrombotic Substrate for a Humanized In Vitro Model of Atherothrombosis (2024)
Journal Article
Echrish, J., Pasca, M.-I., Cabrera, D., Yang, Y., & Harper, A. G. S. (2024). Developing a Biomimetic 3D Neointimal Layer as a Prothrombotic Substrate for a Humanized In Vitro Model of Atherothrombosis. Biomimetics, 9(6), Article 372. https://doi.org/10.3390/biomimetics9060372

Acute cardiovascular events result from clots caused by the rupture and erosion of atherosclerotic plaques. This paper aimed to produce a functional biomimetic hydrogel of the neointimal layer of the atherosclerotic plaque that can support thrombogen... Read More about Developing a Biomimetic 3D Neointimal Layer as a Prothrombotic Substrate for a Humanized In Vitro Model of Atherothrombosis.

A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation (2024)
Journal Article
Campbell, K., Naire, S., & Kuiper, J.-H. (2024). A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation. Journal of Theoretical Biology, Article 111874. https://doi.org/10.1016/j.jtbi.2024.111874

Treating bone-cartilage defects is a fundamental clinical problem. The ability of damaged cartilage to self-repair is limited due to its avascularity. Left untreated, these defects can lead to osteoarthritis. Details of osteochondral defect repair ar... Read More about A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation.

Exploring practice and perspectives on shared decision-making about osteoporosis medicines in Fracture Liaison Services: the iFraP development qualitative study (2024)
Journal Article
Bullock, L., Manning, F., Hawarden, A., Fleming, J., Leyland, S., Clark, E. M., …Paskins, Z. (in press). Exploring practice and perspectives on shared decision-making about osteoporosis medicines in Fracture Liaison Services: the iFraP development qualitative study. Archives of Osteoporosis, 19(1), Article 50. https://doi.org/10.1007/s11657-024-01410-6

Summary: Interviews and focus groups with patients, FLS clinicians, and GPs identified challenges relating to clinical and shared decision-making about bone health and osteoporosis medicines. Findings will inform the development of the multicomponent... Read More about Exploring practice and perspectives on shared decision-making about osteoporosis medicines in Fracture Liaison Services: the iFraP development qualitative study.

Journal of Theoretical Biology A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation --Manuscript Draft-- Manuscript Number: JTB-D-23-00814R1 (2024)
Journal Article
Kuiper, J., Campbell, K., & Naire, S. (in press). Journal of Theoretical Biology A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation --Manuscript Draft-- Manuscript Number: JTB-D-23-00814R1. Journal of Theoretical Biology,

Treating bone-cartilage defects is a fundamental clinical problem. The ability of damaged cartilage to self-repair is limited due to its avascularity. Left untreated, these defects can lead to osteoarthritis. Details of osteochondral defect repair ar... Read More about Journal of Theoretical Biology A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation --Manuscript Draft-- Manuscript Number: JTB-D-23-00814R1.

Testosterone therapy over 60 months improves aging male symptoms scores in all men with adult-onset testosterone deficiency (2024)
Journal Article
Haider, K. S., Zitzmann, M., Ramachandran, P., König, C. S., Hackett, G., Haider, A., …Ramachandran, S. (2024). Testosterone therapy over 60 months improves aging male symptoms scores in all men with adult-onset testosterone deficiency. The aging male : the official journal of the International Society for the Study of the Aging Male, 27(1), Article 2357548. https://doi.org/10.1080/13685538.2024.2357548

Objective We evaluated change (Δ) in AMSS in men with adult-onset testosterone deficiency (TD) on/not on testosterone undecanoate (TU) by analysing a registry of men with adult-onset TD. Methods Analyses were performed using non-parametric stati... Read More about Testosterone therapy over 60 months improves aging male symptoms scores in all men with adult-onset testosterone deficiency.

Surgical approach on combined chronic patellar tendon and bicruciate knee ligament injury (2024)
Journal Article
Piedade, S. R., Górios, C., Spiezia, F., & Maffulli, N. (in press). Surgical approach on combined chronic patellar tendon and bicruciate knee ligament injury. Journal of Orthopaedic Surgery and Research, 19(1), 319. https://doi.org/10.1186/s13018-024-04724-w

A combined injury of the patellar tendon and both the anterior and posterior cruciate ligaments is disabling. It directly affects knee kinematics and biomechanics, presenting a considerable surgical challenge. In this complex and uncommon injury, dec... Read More about Surgical approach on combined chronic patellar tendon and bicruciate knee ligament injury.

Management of Medial Femorotibial Knee Osteoarthritis in Conjunction with Anterior Cruciate Ligament Deficiency: Technical Note and Literature Review (2024)
Journal Article
Legnani, C., Ventura, A., Mangiavini, L., Maffulli, N., & Peretti, G. M. (in press). Management of Medial Femorotibial Knee Osteoarthritis in Conjunction with Anterior Cruciate Ligament Deficiency: Technical Note and Literature Review. Journal of Clinical Medicine, 13(11), Article 3143. https://doi.org/10.3390/jcm13113143

In recent years, there has been increased interest in the management of medial femorotibial knee osteoarthritis (OA) in conjunction with anterior cruciate ligament (ACL) deficiency. Traditional treatment modalities included conservative therapy, high... Read More about Management of Medial Femorotibial Knee Osteoarthritis in Conjunction with Anterior Cruciate Ligament Deficiency: Technical Note and Literature Review.

Physiotherapeutic and non-conventional approaches in patients with chronic low-back pain: a level I Bayesian network meta-analysis (2024)
Journal Article
Baroncini, A., Maffulli, N., Schäfer, L., Manocchio, N., Bossa, M., Foti, C., …Migliorini, F. (in press). Physiotherapeutic and non-conventional approaches in patients with chronic low-back pain: a level I Bayesian network meta-analysis. Scientific Reports, 14(1), 11546. https://doi.org/10.1038/s41598-024-62276-9

Chronic low back pain (cLBP) is a major cause of disability and healthcare expenditure worldwide. Its prevalence is increasing globally from somatic and psychosocial factors. While non-pharmacological management, and in particular physiotherapy, has... Read More about Physiotherapeutic and non-conventional approaches in patients with chronic low-back pain: a level I Bayesian network meta-analysis.

Copper(II) Complexes with Isomeric Morpholine-Substituted 2-Formylpyridine Thiosemicarbazone Hybrids as Potential Anticancer Drugs Inhibiting Both Ribonucleotide Reductase and Tubulin Polymerization: The Morpholine Position Matters (2024)
Journal Article
Milunovic, M. N. M., Ohui, K., Besleaga, I., Petrasheuskaya, T. V., Dömötör, O., Enyedy, É. A., …Arion, V. B. (in press). Copper(II) Complexes with Isomeric Morpholine-Substituted 2-Formylpyridine Thiosemicarbazone Hybrids as Potential Anticancer Drugs Inhibiting Both Ribonucleotide Reductase and Tubulin Polymerization: The Morpholine Position Matters. Journal of Medicinal Chemistry, https://doi.org/10.1021/acs.jmedchem.4c00259

The development of copper(II) thiosemicarbazone complexes as potential anticancer agents, possessing dual functionality as inhibitors of R2 ribonucleotide reductase (RNR) and tubulin polymerization by binding at the colchicine site, presents a promis... Read More about Copper(II) Complexes with Isomeric Morpholine-Substituted 2-Formylpyridine Thiosemicarbazone Hybrids as Potential Anticancer Drugs Inhibiting Both Ribonucleotide Reductase and Tubulin Polymerization: The Morpholine Position Matters.