Outputs (1799)

Probiotics and gastrointestinal disorders: an umbrella meta-analysis of therapeutic efficacy (2025)
Journal Article
Zeng, Q., Li, P., Wu, H., Zhuang, Y., Zhang, Y., Asemani, S., Jamilian, P., Jamali, M., & Yu, H. (2025). Probiotics and gastrointestinal disorders: an umbrella meta-analysis of therapeutic efficacy. European Journal of Medical Research, 30(1), Article 515. https://doi.org/10.1186/s40001-025-02788-w

Background: Probiotic interventions are increasingly considered for alleviating gastrointestinal disorders such as diarrhea, nausea, bloating, and epigastric discomfort. This umbrella meta-analysis aims to resolve inconsistencies in existing research... Read More about Probiotics and gastrointestinal disorders: an umbrella meta-analysis of therapeutic efficacy.

Vein of Galen aneurysmal malformation treatment with direct open surgical access of the transverse sinus and transvenous selective endovascular embolization: a hybrid approach. (2025)
Journal Article
Gravino, G., Aamir, S., Dietvorst, S., Bhatt, K., Robertson, F., Parks, C., Craig, R., Mallucci, C., Chandran, A., & Puthuran, M. (2025). Vein of Galen aneurysmal malformation treatment with direct open surgical access of the transverse sinus and transvenous selective endovascular embolization: a hybrid approach. Journal of NeuroInterventional Surgery, https://doi.org/10.1136/jnis-2025-023490

Vein of Galen aneurysmal malformations (VOGMs) are rare congenital cerebrovascular malformations associated with an almost 100% morbidity and mortality rate if untreated. Open surgical case reports had reported intraoperative neonatal mortality rates... Read More about Vein of Galen aneurysmal malformation treatment with direct open surgical access of the transverse sinus and transvenous selective endovascular embolization: a hybrid approach..

Tenogenic Cues Are Biochemically and Environmentally Distinct for Tendon Stem Cells and Mesenchymal/Stromal Stem Cells (2025)
Journal Article
Citro, V., Clerici, M., Della Porta, G., Maffulli, N., Boccaccini, A. R., Dale, T. P., & Forsyth, N. R. (2025). Tenogenic Cues Are Biochemically and Environmentally Distinct for Tendon Stem Cells and Mesenchymal/Stromal Stem Cells. Stem Cells International, 2025, Article 9047956. https://doi.org/10.1155/sci/9047956

Tendon tissue engineering draws on regenerative medicine principles, offering innovative solutions to address the challenges posed by tendon injuries and degenerative conditions. Tendons’ inherent limited regenerative capacity often hinders complete... Read More about Tenogenic Cues Are Biochemically and Environmentally Distinct for Tendon Stem Cells and Mesenchymal/Stromal Stem Cells.

Growth Factor‐Loaded Mesoporous Silica Particles, Incorporated in Electrospun PCL Fibres, Provide Topographical and Chemical Cues for Tendon Tissue Engineering (2025)
Journal Article
Citro, V., Clerici, M., Shephard, M. T., Dale, T. P., Boccaccini, A. R., & Forsyth, N. R. (2025). Growth Factor‐Loaded Mesoporous Silica Particles, Incorporated in Electrospun PCL Fibres, Provide Topographical and Chemical Cues for Tendon Tissue Engineering. Advanced Materials Technologies, Article 2500246. https://doi.org/10.1002/admt.202500246

This study develops a biomaterial‐based strategy to address challenges in controlled growth factor delivery for tenogenic differentiation of mesenchymal stromal cells (MSCs) and tendon stem cells (TSCs). The 20% polycaprolactone (PCL) fibres, electro... Read More about Growth Factor‐Loaded Mesoporous Silica Particles, Incorporated in Electrospun PCL Fibres, Provide Topographical and Chemical Cues for Tendon Tissue Engineering.

Benign versus sinister aetiologies underlying basal cistern subarachnoid haemorrhage: a case series (2025)
Journal Article
Gravino, G., Abdelsalam, N., Patel, J., Aamir, S., Babatola, F., & Chandran, A. (in press). Benign versus sinister aetiologies underlying basal cistern subarachnoid haemorrhage: a case series. Journal of Medical Case Reports, 19(1), 1-15. https://doi.org/10.1186/s13256-024-04950-0

Background: Subarachnoid hemorrhage in the basal cisterns is usually identified on an unenhanced computed tomography scan of the head in patients presenting acutely with a characteristic sudden onset headache. Case presentation: Using imaging example... Read More about Benign versus sinister aetiologies underlying basal cistern subarachnoid haemorrhage: a case series.

A comprehensive proteomic and bioinformatics analysis of human spinal cord injury plasma identifies proteins associated with the complement cascade and liver function as potential prognostic indicators of neurological outcome (2025)
Journal Article
Harrington, G. M. B., Cool, P., Hulme, C., Stokes-Fisher, J., Peffers, M., El Masri, W., Osman, A., Chowdhury, J. R., Kumar, N., Budithi, S., & Wright, K. (2025). A comprehensive proteomic and bioinformatics analysis of human spinal cord injury plasma identifies proteins associated with the complement cascade and liver function as potential prognostic indicators of neurological outcome. Journal of Neurotrauma, 42(3-4), https://doi.org/10.1101/2022.07.12.499696

Spinal cord injury (SCI) is a major cause of disability, with complications postinjury often leading to lifelong health issues with the need for extensive treatment. Neurological outcome post-SCI can be variable and difficult to predict, particularly... Read More about A comprehensive proteomic and bioinformatics analysis of human spinal cord injury plasma identifies proteins associated with the complement cascade and liver function as potential prognostic indicators of neurological outcome.

Intra-Articular Injection of Human Umbilical Cord-Derived Mesenchymal Stromal Cells Reduces Radiographic Osteoarthritis in an Ovine Model (2024)
Journal Article
Perry, J., Mennan, C., Cool, P., McCarthy, H., Newell, K., Hopkins, T., Hulme, C., Wright, K., Henson, F., & Roberts, S. (2024). Intra-Articular Injection of Human Umbilical Cord-Derived Mesenchymal Stromal Cells Reduces Radiographic Osteoarthritis in an Ovine Model. Cartilage, https://doi.org/10.1177/19476035241287832

Objective
To determine if mesenchymal stromal cells (MSCs) derived from human umbilical cords (hUC) could reduce degeneration developing when injected into the knee of a large animal model of osteoarthritis (OA).
Design
Ten million culture-expande... Read More about Intra-Articular Injection of Human Umbilical Cord-Derived Mesenchymal Stromal Cells Reduces Radiographic Osteoarthritis in an Ovine Model.

ColMA ‐based bioprinted 3D scaffold allowed to study tenogenic events in human tendon stem cells (2024)
Journal Article
Cortella, G., Lamparelli, E. P., Ciardulli, M. C., Lovecchio, J., Giordano, E., Maffulli, N., & Della Porta, G. (in press). ColMA ‐based bioprinted 3D scaffold allowed to study tenogenic events in human tendon stem cells. Bioengineering and Translational Medicine, 1-15. https://doi.org/10.1002/btm2.10723

The advent of bioprinting has enabled the creation of precise three‐dimensional (3D) cell cultures suitable for biomimetic in vitro models. In this study, we developed a novel protocol for 3D printing methacrylated collagen (ColMa, or PhotoCol®) comb... Read More about ColMA ‐based bioprinted 3D scaffold allowed to study tenogenic events in human tendon stem cells.

Antidepressants for pain management in adults with chronic pain: a network meta-analysis (2024)
Journal Article
Birkinshaw, H., Friedrich, C., Cole, P., Eccleston, C., Serfaty, M., Stewart, G., White, S., Moore, A., Phillippo, D., & Pincus, T. (2024). Antidepressants for pain management in adults with chronic pain: a network meta-analysis. Health Technology Assessment, 28(62), 1-155. https://doi.org/10.3310/mkrt2948

Background
Chronic pain is common and costly. Antidepressants are prescribed to reduce pain. However, there has not been a network meta-analysis examining all antidepressants across all chronic pain conditions, so effectiveness and safety for most a... Read More about Antidepressants for pain management in adults with chronic pain: a network meta-analysis.

Inhibition of matrix metalloproteinases to reduce blood brain barrier disruption and haemorrhagic transformation in ischaemic stroke: Go broad or go narrow? (2024)
Journal Article
Kawa, H., Ahmed, Z., Majid, A., & Chen, R. (in press). Inhibition of matrix metalloproteinases to reduce blood brain barrier disruption and haemorrhagic transformation in ischaemic stroke: Go broad or go narrow?. Neuropharmacology, 262, Article 110192. https://doi.org/10.1016/j.neuropharm.2024.110192

Ischaemic stroke characterises impulsive cerebral-region hypoxia due to deep intracerebral arteriole blockage, often accompanied by permanent cerebral infarction and cognitive impairment. Thrombolysis with recombinant tissue plasminogen activator (rt... Read More about Inhibition of matrix metalloproteinases to reduce blood brain barrier disruption and haemorrhagic transformation in ischaemic stroke: Go broad or go narrow?.