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Outputs (158)

Using magnetic nanoparticles for gene transfer to neural stem cells: stem cell propagation method influences outcomes (2015)
Journal Article
Pickard, M., Adams, C., Barraud, P., & Chari, D. (2015). Using magnetic nanoparticles for gene transfer to neural stem cells: stem cell propagation method influences outcomes. Journal of Functional Biomaterials, 6, 259-279. https://doi.org/10.3390/jfb6020259

Genetically engineered neural stem cell (NSC) transplants offer a key strategy to augment neural repair by releasing therapeutic biomolecules into injury sites. Genetic modification of NSCs is heavily reliant on viral vectors but cytotoxic effects ha... Read More about Using magnetic nanoparticles for gene transfer to neural stem cells: stem cell propagation method influences outcomes.

SIFT-MS and FA-MS methods for ambient gas phase analysis: developments and applications in the UK (2015)
Journal Article
(2015). SIFT-MS and FA-MS methods for ambient gas phase analysis: developments and applications in the UK. Analyst, 2573 - 2591. https://doi.org/10.1039/c4an02049a

Selected ion flow tube mass spectrometry, SIFT-MS, a relatively new gas/vapour phase analytical method, is derived from the much earlier selected ion flow tube, SIFT, used for the study of gas phase ion-molecule reactions. Both the SIFT and SIFT-MS t... Read More about SIFT-MS and FA-MS methods for ambient gas phase analysis: developments and applications in the UK.

O51. DNA Methylation Profiling of Synovial Fluid-Derived Fibroblast-Like Synoviocytes from Patients with Rheumatoid Arthritis Reveals Common and Distinct Changes Relative to their Tissue-Derived Counterparts (2015)
Journal Article
Glossop, J. R., Haworth, K. E., Emes, R. D., Nixon, N. B., Packham, J. C., Dawes, P. T., …Farrell, W. E. (2015). O51. DNA Methylation Profiling of Synovial Fluid-Derived Fibroblast-Like Synoviocytes from Patients with Rheumatoid Arthritis Reveals Common and Distinct Changes Relative to their Tissue-Derived Counterparts. Rheumatology, 54(S1), i48. https://doi.org/10.1093/rheumatology/kev087.003

Background: Fibroblast-like synoviocytes (FLS) from patients with RA display an aggressive, invasive phenotype and play a key role in joint destruction. Increasing evidence indicates that alterations to the epigenome, including DNA methylation, contr... Read More about O51. DNA Methylation Profiling of Synovial Fluid-Derived Fibroblast-Like Synoviocytes from Patients with Rheumatoid Arthritis Reveals Common and Distinct Changes Relative to their Tissue-Derived Counterparts.

Simple Calix[n]arenes and Calix[4]resorcinarenes as Drug Solubilizing Agents (2015)
Journal Article
Hoskins, C., & Curtis, A. D. Simple Calix[n]arenes and Calix[4]resorcinarenes as Drug Solubilizing Agents. Journal of Nanomedicine Research, 2(3), https://doi.org/10.15406/jnmr.2015.02.00028

Many drug molecules have low solubility in aqueous media and, hence, poor bioavailability. The formation of a host-guest complex with some other compound which has a good solubility profile can facilitate solubilization of hydrophobic drugs. Complex... Read More about Simple Calix[n]arenes and Calix[4]resorcinarenes as Drug Solubilizing Agents.

Gait analysis to guide a selective dorsal rhizotomy program (2015)
Journal Article
Roberts, A., Stewart, C., & Freeman, R. (2015). Gait analysis to guide a selective dorsal rhizotomy program. Gait and Posture, 42(1), 16-22. https://doi.org/10.1016/j.gaitpost.2015.04.004

Selective dorsal rhizotomy is a valuable surgical option to manage spasticity in children with bilateral cerebral palsy with the objective of improving function. Choosing the correct patient for rhizotomy requires considerable effort and a comprehens... Read More about Gait analysis to guide a selective dorsal rhizotomy program.

Wnt-signalling in human articular chondrocytes (2015)
Journal Article
McCarthy, H., Owen, S., & Roberts, S. (2015). Wnt-signalling in human articular chondrocytes. International Journal of Experimental Pathology, 96(2), A27

Introduction Aberrant Wnt-signalling in cartilage results inchondrocyte dedifferentiation, hypertrophy, loss of type II collagen, aggrecan and glycosaminoglycans. Articular chondrocytes experience a pO2 gradient from~6% (surface) to~1% (within deeper... Read More about Wnt-signalling in human articular chondrocytes.

A pilot study to test the design, implementation and effectiveness of two types of clinical case study and the associated, evaluative research instruments (2015)
Presentation / Conference
Thompson, J., White, S., & Chapman, S. (2015, April). A pilot study to test the design, implementation and effectiveness of two types of clinical case study and the associated, evaluative research instruments. Poster presented at Health Services Research & Pharmacy Practice Conference, Riddel Hall, Queen's University Belfast

Applications of physiologically based pharmacokinetic modeling for the optimization of anti-infective therapies (2015)
Journal Article
(2015). Applications of physiologically based pharmacokinetic modeling for the optimization of anti-infective therapies. Expert Opinion on Drug Metabolism and Toxicology, 1203-1217. https://doi.org/10.1517/17425255.2015.1037278

Introduction: The pharmacokinetic properties of anti-infective drugs are a determinant part of treatment success. Pathogen replication is inhibited if adequate drug levels are achieved in target sites, whereas excessive drug concentrations linked to... Read More about Applications of physiologically based pharmacokinetic modeling for the optimization of anti-infective therapies.

Risk factors and birth outcomes of anaemia in early pregnancy in a nulliparous cohort (2015)
Journal Article
(2015). Risk factors and birth outcomes of anaemia in early pregnancy in a nulliparous cohort. PloS one, e0122729 -?. https://doi.org/10.1371/journal.pone.0122729

BACKGROUND: Anaemia in pregnancy is a major public health and economic problem worldwide, that contributes to both maternal and fetal morbidity and mortality. OBJECTIVE: The aim of the study was to calculate the prevalence of anaemia in early pregnan... Read More about Risk factors and birth outcomes of anaemia in early pregnancy in a nulliparous cohort.