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Defining Known Drug Space Using DFT (2015)
Journal Article
Matuszek, A. M., & Reynisson, J. (2016). Defining Known Drug Space Using DFT. Molecular Informatics, 35(2), 46-53. https://doi.org/10.1002/minf.201500105

A density functional theory (DFT) study was performed on a collection of clinically approved drugs, or Known Drug Space (KDS), to determine the statistical distribution of four properties: dipole moment (DM), polarisability (POL), ionisation potentia... Read More about Defining Known Drug Space Using DFT.

From molecules in space to molecules in breath. (2015)
Journal Article
(2015). From molecules in space to molecules in breath. Paediatric Respiratory Reviews, 50 - 52. https://doi.org/10.1016/j.prrv.2015.08.012

The evolution of the selected ion flow tube, SIFT, used to study ion-molecule reactions of interstellar significance, to the selected ion flow tube mass spectrometry, SIFT-MS, analytical technique is described briefly. Focus is placed on the applicat... Read More about From molecules in space to molecules in breath..

First results of LHCD experiments with 4.6 GHz system toward steady-state plasma in EAST (2015)
Journal Article
Liu, F., Ding, B., Li, J., Wan, B., Shan, J., Wang, M., …the EAST Team. (2015). First results of LHCD experiments with 4.6 GHz system toward steady-state plasma in EAST. Nuclear Fusion, 55(12), 123022. https://doi.org/10.1088/0029-5515/55/12/123022

A 4.6 GHz lower-hybrid current drive (LHCD) system has been firstly commissioned in EAST in the 2014 campaign. The first LHCD results with 4.6 GHz show that LHW can be coupled to plasma with a low reflection coefficient, drive plasma current and plas... Read More about First results of LHCD experiments with 4.6 GHz system toward steady-state plasma in EAST.

Cardiomyocytes from human pluripotent stem cells: From laboratory curiosity to industrial biomedical platform (2015)
Journal Article
Denning, C., Borgdorff, V., Crutchley, J., Firth, K. S., George, V., Kalra, S., …Young, L. E. (2015). Cardiomyocytes from human pluripotent stem cells: From laboratory curiosity to industrial biomedical platform. BBA - Molecular Cell Research, 1863(7 Part B), 1728 - 1748. https://doi.org/10.1016/j.bbamcr.2015.10.014

Cardiomyocytes from human pluripotent stem cells (hPSCs-CMs) could revolutionise biomedicine. Global burden of heart failure will soon reach USD $90bn, while unexpected cardiotoxicity underlies 28% of drug withdrawals. Advances in hPSC isolation, Cas... Read More about Cardiomyocytes from human pluripotent stem cells: From laboratory curiosity to industrial biomedical platform.

Research is the Future, the Future is……. (2015)
Journal Article
Gilchrist, F. J. (2015). Research is the Future, the Future is……. Paediatric Respiratory Reviews, 17, 32 - 33. https://doi.org/10.1016/j.prrv.2015.08.008

Over the past two decades, Professor Lenney has established the Paediatric Respiratory Department at the Royal Stoke University Hospital as a centre recognised for high quality research. A broad portfolio of clinical and laboratory based research is... Read More about Research is the Future, the Future is……..

Lifecourse transitions, gender and drinking in later life (2015)
Journal Article
Frisher, M., Holdsworth, C., MENDONÇA, M., DE OLIVEIRIA, C., PIKHART, H., & SHELTON, N. (2017). Lifecourse transitions, gender and drinking in later life. Ageing and society, 37(3), 462-494. https://doi.org/10.1017/S0144686X15001178

Older people consume less alcohol than any other adult age group. However, in recent years survey data on alcohol consumption in the United Kingdom have shown that while younger age groups have experienced a decline in alcohol consumption, drinking b... Read More about Lifecourse transitions, gender and drinking in later life.

A dedicated undergraduate gynaecology teaching clinic: the Keele experience (2015)
Journal Article
(2015). A dedicated undergraduate gynaecology teaching clinic: the Keele experience. Journal of Obstetrics and Gynaecology, 227-229. https://doi.org/10.3109/01443615.2015.1050651

Much discussion in the literature centres on how best to teach medical students the intricacies of gynaecological assessment and the subsequent formulation of a management plan. At Keele University skills are initially developed in a simulated settin... Read More about A dedicated undergraduate gynaecology teaching clinic: the Keele experience.

miRNA clusters as therapeutic targets for hormone-resistant breast cancer (2015)
Journal Article
Di Leva, G., Cheung, D. G., & Croce, C. M. (2015). miRNA clusters as therapeutic targets for hormone-resistant breast cancer. Expert Review of Endocrinology and Metabolism, 10(6), 607-617. https://doi.org/10.1586/17446651.2015.1099430

MicroRNAs are small non-coding RNAs that typically inhibit the translation and stability of messenger RNAs, controlling genes involved in cellular processes such as inflammation, cell cycle regulation, stress response, differentiation, apoptosis, and... Read More about miRNA clusters as therapeutic targets for hormone-resistant breast cancer.

Nicergoline inhibits human platelet Ca2+ signalling through triggering a microtubule-dependent reorganisation of the platelet ultrastructure (2015)
Journal Article
Harper. (2015). Nicergoline inhibits human platelet Ca2+ signalling through triggering a microtubule-dependent reorganisation of the platelet ultrastructure. British Journal of Pharmacology, 234-247. https://doi.org/10.1111/bph.13361

BACKGROUND AND PURPOSE:
Recently, we demonstrated that a pericellular Ca(2+) recycling system potentiates agonist-evoked Ca(2+) signalling and granule secretion in human platelets and hypothesized a role for the membrane complex (MC) in orchestratin... Read More about Nicergoline inhibits human platelet Ca2+ signalling through triggering a microtubule-dependent reorganisation of the platelet ultrastructure.