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Flourescent, online monitoring of PLGA degradation for regenerative medicine applications (2016)
Journal Article
Yang. (2016). Flourescent, online monitoring of PLGA degradation for regenerative medicine applications. RSC advances, 44364 - 44370. https://doi.org/10.1039/C6RA04690H

Degradable polymers such as poly(lactic-co-glycolic acid) (PLGA) are frequently chosen for tissue engineering, due to their ease of production, controllable degradation rates and Food and Drug Administration (FDA) approval. Within tissue engineering... Read More about Flourescent, online monitoring of PLGA degradation for regenerative medicine applications.

A Pilot Study of Ion - Molecule Reactions at Temperatures Relevant to the Atmosphere of Titan (2016)
Journal Article
(2016). A Pilot Study of Ion - Molecule Reactions at Temperatures Relevant to the Atmosphere of Titan. Origins of Life and Evolution of Biospheres, 533-538. https://doi.org/10.1007/s11084-016-9499-9

Reliable theoretical models of the chemical kinetics of the ionosphere of Saturn's moon, Titan, is highly dependent on the precision of the rates of the reactions of ambient ions with hydrocarbon molecules at relevant temperatures. A Variable Tempera... Read More about A Pilot Study of Ion - Molecule Reactions at Temperatures Relevant to the Atmosphere of Titan.

Does skeletal muscle have an 'epi'-memory? The role of epigenetics in nutritional programming, metabolic disease, aging and exercise (2016)
Journal Article
(2016). Does skeletal muscle have an 'epi'-memory? The role of epigenetics in nutritional programming, metabolic disease, aging and exercise. Aging cell, 603 - 616. https://doi.org/10.1111/acel.12486

Skeletal muscle mass, quality and adaptability are fundamental in promoting muscle performance, maintaining metabolic function and supporting longevity and healthspan. Skeletal muscle is programmable and can ‘remember’ early-life metabolic stimuli af... Read More about Does skeletal muscle have an 'epi'-memory? The role of epigenetics in nutritional programming, metabolic disease, aging and exercise.

Staying connected: structural integration at the intervertebral disc–vertebra interface of human lumbar spines (2016)
Journal Article
(2016). Staying connected: structural integration at the intervertebral disc–vertebra interface of human lumbar spines. European Spine Journal, 248 -258. https://doi.org/10.1007/s00586-016-4560-y

Purpose To investigate the microscopic fibrous integration between the intervertebral disc, cartilage endplates and vertebral endplates in human lumbar spines of varying degrees of degeneration using differential interference contrast (DIC) optics.... Read More about Staying connected: structural integration at the intervertebral disc–vertebra interface of human lumbar spines.

L-glutamine Improves Skeletal Muscle Cell Differentiation and Prevents Myotube Atrophy After Cytokine (TNF-alpha) Stress Via Reduced p38 MAPK Signal Transduction (2016)
Journal Article
(2016). L-glutamine Improves Skeletal Muscle Cell Differentiation and Prevents Myotube Atrophy After Cytokine (TNF-alpha) Stress Via Reduced p38 MAPK Signal Transduction. Journal of Cellular Physiology, 2720 - 2732. https://doi.org/10.1002/jcp.25380

Tumour Necrosis Factor-Alpha (TNF-a) is chronically elevated in conditions where skeletal muscle loss occurs. As l-glutamine can dampen the effects of inflamed environments, we investigated the role of l-glutamine in both differentiating C2C12 myobla... Read More about L-glutamine Improves Skeletal Muscle Cell Differentiation and Prevents Myotube Atrophy After Cytokine (TNF-alpha) Stress Via Reduced p38 MAPK Signal Transduction.

Antagonism of Bcl-XL is necessary for synergy between carboplatin and BH3 mimetics in ovarian cancer cells (2016)
Journal Article
Abed, M., Abdullah, M., & Richardson, A. (2016). Antagonism of Bcl-XL is necessary for synergy between carboplatin and BH3 mimetics in ovarian cancer cells. Journal of Ovarian Research, 25 - ?. https://doi.org/10.1186/s13048-016-0234-y

BACKGROUND: BH3 mimetics are a class of drugs that antagonize the Bcl-2 family of apoptosis inhibitors. We have previously shown that these compounds can potentiate the activity of carboplatin against several ovarian cancer cell lines. However, recen... Read More about Antagonism of Bcl-XL is necessary for synergy between carboplatin and BH3 mimetics in ovarian cancer cells.

Hydration Free Energy as a Molecular Descriptor in Drug Design: A Feasibility Study (2016)
Journal Article
Zafar, A., & Reynisson, J. (2016). Hydration Free Energy as a Molecular Descriptor in Drug Design: A Feasibility Study. Molecular Informatics, 35(5), 207-214. https://doi.org/10.1002/minf.201501035

In this work the idea was investigated whether calculated hydration energy (ΔGhyd) can be used as a molecular descriptor in defining promising regions of chemical space for drug design. Calculating ΔGhyd using the Density Solvation Model (SMD) in con... Read More about Hydration Free Energy as a Molecular Descriptor in Drug Design: A Feasibility Study.

Characterisation of synovial fluid and infrapatellar fat pad derived mesenchymal stromal cells: The influence of tissue source and inflammatory stimulus. (2016)
Journal Article
Garcia, J., Wright, K., Roberts, S., Herman Kuiper, J., Mangham, C., Richardson, J., & Mennan, C. (2016). Characterisation of synovial fluid and infrapatellar fat pad derived mesenchymal stromal cells: The influence of tissue source and inflammatory stimulus. Scientific reports, 6, 24295 -?. https://doi.org/10.1038/srep24295

The infrapatellar fat pad (FP) and synovial fluid (SF) in the knee serve as reservoirs of mesenchymal stromal cells (MSCs) with potential therapeutic benefit. We determined the influence of the donor on the phenotype of donor matched FP and SF derive... Read More about Characterisation of synovial fluid and infrapatellar fat pad derived mesenchymal stromal cells: The influence of tissue source and inflammatory stimulus..

MRSI-based molecular imaging of therapy response to temozolomide in preclinical glioblastoma using source analysis (2016)
Journal Article
(2016). MRSI-based molecular imaging of therapy response to temozolomide in preclinical glioblastoma using source analysis. NMR in Biomedicine, 732-743. https://doi.org/10.1002/nbm.3521

Characterization of glioblastoma (GB) response to treatment is a key factor for improving patients' survival and prognosis. MRI and magnetic resonance spectroscopic imaging (MRSI) provide morphologic and metabolic profiles of GB but usually fail to p... Read More about MRSI-based molecular imaging of therapy response to temozolomide in preclinical glioblastoma using source analysis.