Outputs (243)

Synthesis of 3-Amino-2-carboxamide Tetrahydropyrrolo[2,3-b]quinolines (2016)
Journal Article
Barker, D., Pilkington, L., Haverkate, N., van Rensburg, M., Reynisson, J., & Leung, E. (in press). Synthesis of 3-Amino-2-carboxamide Tetrahydropyrrolo[2,3-b]quinolines. SYNLETT, 27(20), 2811-2814. https://doi.org/10.1055/s-0036-1588619

This article communicates the first synthesis of 3-amino-2-carboxamide pyrrolo[2,3-b]quinolines and fused-ring pyrrolopyridines in an efficient synthesis via a Thorpe–Ziegler transformation. The reported synthetic route allows for a wide range of nit... Read More about Synthesis of 3-Amino-2-carboxamide Tetrahydropyrrolo[2,3-b]quinolines.

Repair of bone defects in vivo using tissue engineered hypertrophic cartilage grafts produced from nasal chondrocytes (2016)
Journal Article
(2016). Repair of bone defects in vivo using tissue engineered hypertrophic cartilage grafts produced from nasal chondrocytes. Biomaterials, 313-323. https://doi.org/10.1016/j.biomaterials.2016.10.014

The regeneration of large bone defects remains clinically challenging. The aim of our study was to use a rat model to use nasal chondrocytes to engineer a hypertrophic cartilage tissue which could be remodelled into bone in vivo by endochondral ossif... Read More about Repair of bone defects in vivo using tissue engineered hypertrophic cartilage grafts produced from nasal chondrocytes.

Prevalence and appropriateness of psychotropic medication prescribing in a nationally representative cross-sectional survey of male and female prisoners in England. (2016)
Journal Article
Hassan, L., Senior, J., Webb, R. T., Frisher, M., Tully, M. P., While, D., & Shaw, J. J. (2016). Prevalence and appropriateness of psychotropic medication prescribing in a nationally representative cross-sectional survey of male and female prisoners in England. BMC Psychiatry, 16, Article 346. https://doi.org/10.1186/s12888-016-1055-7

BACKGROUND: Mental illness is highly prevalent among prisoners. Although psychotropic medicines can ameliorate symptoms of mental illness, prescribers in prisons must balance clinical needs against risks to safety and security. Concerns have been rai... Read More about Prevalence and appropriateness of psychotropic medication prescribing in a nationally representative cross-sectional survey of male and female prisoners in England..

Pharmacological interventions other than botulinum toxin for spasticity after stroke. (2016)
Journal Article
(2016). Pharmacological interventions other than botulinum toxin for spasticity after stroke. Cochrane Database of Systematic Reviews, CD010362 - ?. https://doi.org/10.1002/14651858.CD010362.pub2

BACKGROUND: The long-term risk of stroke increases with age, and stroke is a common cause of disability in the community. Spasticity is considered a significantly disabling impairment that develops in people who have had a stroke. The burden of care... Read More about Pharmacological interventions other than botulinum toxin for spasticity after stroke..

Rheumatic mitral valve disease is associated with worse outcomes in stroke: a Thailand National Database Study (2016)
Journal Article
Mamas. (2016). Rheumatic mitral valve disease is associated with worse outcomes in stroke: a Thailand National Database Study. Stroke, 2695-2701. https://doi.org/10.1161/STROKEAHA.116.014512

Background and Purpose— Rheumatic valvular heart disease is associated with the increased risk of cerebrovascular events, although there are limited data on the prognosis of patients with rheumatic mitral valve disease (RMVD) after stroke. Method... Read More about Rheumatic mitral valve disease is associated with worse outcomes in stroke: a Thailand National Database Study.

Chondrogenic Potency Analyses of Donor-Matched Chondrocytes and Mesenchymal Stem Cells Derived from Bone Marrow, Infrapatellar Fat Pad, and Subcutaneous Fat. (2016)
Journal Article
Garcia, J., Mennan, C., McCarthy, H. S., Roberts, S., Richardson, J. B., & Wright, K. T. (2016). Chondrogenic Potency Analyses of Donor-Matched Chondrocytes and Mesenchymal Stem Cells Derived from Bone Marrow, Infrapatellar Fat Pad, and Subcutaneous Fat. Stem Cells International, 2016, Article 6969726. https://doi.org/10.1155/2016/6969726

Autologous chondrocyte implantation (ACI) is a cell-based therapy that has been used clinically for over 20 years to treat cartilage injuries more efficiently in order to negate or delay the need for joint replacement surgery. In this time, very litt... Read More about Chondrogenic Potency Analyses of Donor-Matched Chondrocytes and Mesenchymal Stem Cells Derived from Bone Marrow, Infrapatellar Fat Pad, and Subcutaneous Fat..

Development and Validation of a LC-MS/MS Assay for the Quantification Of Efavirenz In Different Biological Matrices (2016)
Journal Article
(2016). Development and Validation of a LC-MS/MS Assay for the Quantification Of Efavirenz In Different Biological Matrices. Bioanalysis, 2125-2134. https://doi.org/10.4155/bio-2016-0021

Aim: The non-nucleoside reverse transcriptase inhibitor efavirenz is one of the most prescribed antiretroviral therapeutics. Efavirenz-containing therapy has become associated with the occurrence of CNS side effects, including sleep disturbances, dep... Read More about Development and Validation of a LC-MS/MS Assay for the Quantification Of Efavirenz In Different Biological Matrices.

Biocompatibility of biodegradable medical polymers (2016)
Book Chapter
Ozdil, D., Wimpenny, I., Aydin, H., & Yang, Y. (2017). Biocompatibility of biodegradable medical polymers. . Elsevier. https://doi.org/10.1016/b978-0-08-100372-5.00013-1

Biomaterials have various applications in the medical field; whilst biodegradable biomaterials play an important role in regenerative medicine, tissue engineering and drug delivery. In addition to conversional biocompatibility, biodegradable material... Read More about Biocompatibility of biodegradable medical polymers.

Potential of hybrid iron oxide–gold nanoparticles as thermal triggers for pancreatic cancer therapy (2016)
Journal Article
Oluwasanmi, A., Malekigorji, M., Jones, S., Curtis, A., & Hoskins, C. (2016). Potential of hybrid iron oxide–gold nanoparticles as thermal triggers for pancreatic cancer therapy. RSC advances, https://doi.org/10.1039/c6ra20552f

Theranostics are emerging platforms for rapid cancer diagnosis and therapy. Hybrid iron oxide–gold nanoparticles (HNPs) have shown potential as theranostics due to their ability for imaging using MRI, heating using laser irradiation and carrier abili... Read More about Potential of hybrid iron oxide–gold nanoparticles as thermal triggers for pancreatic cancer therapy.

The oxoglutarate receptor 1 (OXGR1) modulates pressure overload-induced cardiac hypertrophy in mice (2016)
Journal Article
Mamas. (2016). The oxoglutarate receptor 1 (OXGR1) modulates pressure overload-induced cardiac hypertrophy in mice. Biochemical and Biophysical Research Communications, 708-714. https://doi.org/10.1016/j.bbrc.2016.09.147

The G-protein-coupled receptors (GPCRs) family of proteins play essential roles in the heart, including in the regulation of cardiac hypertrophy. One member of this family, the oxoglutarate receptor 1 (OXGR1), may have a crucial role in the heart bec... Read More about The oxoglutarate receptor 1 (OXGR1) modulates pressure overload-induced cardiac hypertrophy in mice.