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Rational Design, Synthesis, and Biological Evaluation of Heterocyclic Quinolones Targeting the Respiratory Chain of Mycobacterium tuberculosis (2017)
Journal Article
(2017). Rational Design, Synthesis, and Biological Evaluation of Heterocyclic Quinolones Targeting the Respiratory Chain of Mycobacterium tuberculosis. Journal of Medicinal Chemistry, https://doi.org/10.1021/acs.jmedchem.6b01718

A high-throughput screen (HTS) was undertaken against the respiratory chain dehydrogenase component, NADH:menaquinone oxidoreductase (Ndh) of Mycobacterium tuberculosis (Mtb). The 11000 compounds were selected for the HTS based on the known phenothia... Read More about Rational Design, Synthesis, and Biological Evaluation of Heterocyclic Quinolones Targeting the Respiratory Chain of Mycobacterium tuberculosis.

Advanced glycation products' levels and mechanical properties of vaginal tissue in pregnancy (2017)
Journal Article
Weli, H. K., Akhtar, R., Chang, Z., Li, W., Cooper, J., & Yang, Y. (2017). Advanced glycation products' levels and mechanical properties of vaginal tissue in pregnancy. European Journal of Obstetrics and Gynecology and Reproductive Biology, 78-85. https://doi.org/10.1016/j.ejogrb.2017.04.037

Objectives
Non-enzymatic glycation is closely associated with altered mechanical properties of connective tissue. Pregnancy, marked with high levels of female hormones, confers unique alteration to the mechanical properties of pelvic connective tiss... Read More about Advanced glycation products' levels and mechanical properties of vaginal tissue in pregnancy.

Association of psychological variables and outcome in tendinopathy: a systematic review. (2017)
Journal Article
(2017). Association of psychological variables and outcome in tendinopathy: a systematic review. British Journal of Sports Medicine, 743 - 748. https://doi.org/10.1136/bjsports-2016-096154

OBJECTIVE: Fear, anxiety, depression, distress and catastrophisation are all factors known to affect pain and disability levels. To date, the association of such psychological factors has yet to be established in tendinopathy. Therefore, the purpose... Read More about Association of psychological variables and outcome in tendinopathy: a systematic review..

Hypoxia augments LPS-induced inflammation and triggers high altitude cerebral edema in mice (2017)
Journal Article
Chen. (2017). Hypoxia augments LPS-induced inflammation and triggers high altitude cerebral edema in mice. Brain, Behavior, and Immunity, 226-275. https://doi.org/10.1016/j.bbi.2017.04.013

Abstract High altitude cerebral edema (HACE) is a life-threatening illness that develops during the rapid ascent to high altitudes, but its underlying mechanisms remain unclear. Growing evidence has implicated inflammation in the susceptibility to an... Read More about Hypoxia augments LPS-induced inflammation and triggers high altitude cerebral edema in mice.

Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface. (2017)
Journal Article
Tang, H., Leung, L., Saturno, G., Viros, A., Smith, D., Di Leva, G., …Marais, R. (2017). Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface. Nature communications, 8, Article 14909. https://doi.org/10.1038/ncomms14909

Lysyl oxidase (LOX) remodels the tumour microenvironment by cross-linking the extracellular matrix. LOX overexpression is associated with poor cancer outcomes. Here, we find that LOX regulates the epidermal growth factor receptor (EGFR) to drive tumo... Read More about Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface..

Cerebral Embolic Protection Devices During Transcatheter Aortic Valve Implantation: Systematic Review and Meta-analysis (2017)
Journal Article
Mamas. (2017). Cerebral Embolic Protection Devices During Transcatheter Aortic Valve Implantation: Systematic Review and Meta-analysis. Stroke, 1306-1315. https://doi.org/10.1161/strokeaha.116.015915

Background and Purpose—Silent ischemic embolic lesions are common after transcatheter aortic valve implantation (TAVI). The use of embolic protection devices (EPD) may reduce the occurrence of these embolic lesions. Thus, a quantitative overview and... Read More about Cerebral Embolic Protection Devices During Transcatheter Aortic Valve Implantation: Systematic Review and Meta-analysis.

Choice of Stent for Percutaneous Coronary Intervention of Saphenous Vein Grafts. (2017)
Journal Article
Mamas. (2017). Choice of Stent for Percutaneous Coronary Intervention of Saphenous Vein Grafts. Circulation: Cardiovascular Interventions, https://doi.org/10.1161/CIRCINTERVENTIONS.116.004457

BACKGROUND: There are limited data on comparison of contemporary drug-eluting stent (DES) platforms, previous generation DES, and bare-metal stents (BMS) for percutaneous coronary intervention in saphenous vein grafts (SVG). We aimed to assess clinic... Read More about Choice of Stent for Percutaneous Coronary Intervention of Saphenous Vein Grafts..

Aortic Stenosis and Non-Cardiac Surgery: A Systematic Review and Meta-Analysis (2017)
Journal Article
Rashid, & Mamas. (2017). Aortic Stenosis and Non-Cardiac Surgery: A Systematic Review and Meta-Analysis. International Journal of Cardiology, 145-153. https://doi.org/10.1016/j.ijcard.2017.04.037

Background
Aortic stenosis (AS) poses a perioperative management dilemma to physicians looking after patients who require non-cardiac surgery. The objective of this review is to investigate mortality and adverse cardiovascular events in patients wit... Read More about Aortic Stenosis and Non-Cardiac Surgery: A Systematic Review and Meta-Analysis.