Outputs (186)

Effect of weekend admission on process of care and clinical outcomes for the management of acute coronary syndromes: a retrospective analysis of three UK centres. (2017)
Journal Article
Mamas. (2017). Effect of weekend admission on process of care and clinical outcomes for the management of acute coronary syndromes: a retrospective analysis of three UK centres. BMJ Open, e016866 - ?. https://doi.org/10.1136/bmjopen-2017-016866

OBJECTIVES: The effect of weekend versus weekday admission following acute coronary syndrome (ACS) on process of care and mortality remains controversial. This study aimed to investigate the 'weekend-effect' on outcomes using a multicentre dataset of... Read More about Effect of weekend admission on process of care and clinical outcomes for the management of acute coronary syndromes: a retrospective analysis of three UK centres..

Proteomic mapping of differentially vulnerable pre-synaptic populations identifies regulators of neuronal stability in vivo (2017)
Journal Article
Llavero Hurtado, M., Fuller, H., Wong, A., Eaton, S., Gillingwater, T., Pennetta, G., …Wishart, T. (2017). Proteomic mapping of differentially vulnerable pre-synaptic populations identifies regulators of neuronal stability in vivo. Scientific reports, https://doi.org/10.1038/s41598-017-12603-0

Synapses are an early pathological target in many neurodegenerative diseases ranging from well-known adult onset conditions such as Alzheimer and Parkinson disease to neurodegenerative conditions of childhood such as spinal muscular atrophy (SMA) and... Read More about Proteomic mapping of differentially vulnerable pre-synaptic populations identifies regulators of neuronal stability in vivo.

Identification and evaluation of anticancer compounds from three Nigerian plants used in traditional medicines (2017)
Presentation / Conference
Rosa Johnson-Ajinwo, O., Richardson, A., & Li, W. (2017, September). Identification and evaluation of anticancer compounds from three Nigerian plants used in traditional medicines. Presented at IUPHAR, Aberdeen

Ovarian cancer is the second leading cause of death among women in the gynaecological category of cancers. The current post surgery treatment which involves the use of platinum-based therapy with its attendant adverse drug-resistance often results in... Read More about Identification and evaluation of anticancer compounds from three Nigerian plants used in traditional medicines.

Tailoring Clicker Technology to Problem-Based Learning: What’s the Best Approach? (2017)
Journal Article
Pearson, R. J. (2017). Tailoring Clicker Technology to Problem-Based Learning: What’s the Best Approach?. Journal of Chemical Education, 94(12), 1866-1872. https://doi.org/10.1021/acs.jchemed.7b00270

Different approaches to the use of “clickers” (also known as student response systems) were introduced to a cohort of 127 students over a two-year period with the aim of making students think more deeply in-class about their chemistry knowledge. Stud... Read More about Tailoring Clicker Technology to Problem-Based Learning: What’s the Best Approach?.

Effect of Routine Low-Dose Oxygen Supplementation on Death and Disability in Adults With Acute Stroke: The Stroke Oxygen Study Randomized Clinical Trial. (2017)
Journal Article
Sim, J., Bishop, J., Gray, R., and the Stroke Oxygen Study Collaborative Group, S. O. S. I., Roffe, C., Nevatte, T., …Ferdinand, P. (2017). Effect of Routine Low-Dose Oxygen Supplementation on Death and Disability in Adults With Acute Stroke: The Stroke Oxygen Study Randomized Clinical Trial. Journal of the American Medical Association, 318(12), 1125 - 1135. https://doi.org/10.1001/jama.2017.11463

Importance: Hypoxia is common in the first few days after acute stroke, is frequently intermittent, and is often undetected. Oxygen supplementation could prevent hypoxia and secondary neurological deterioration and thus has the potential to improve r... Read More about Effect of Routine Low-Dose Oxygen Supplementation on Death and Disability in Adults With Acute Stroke: The Stroke Oxygen Study Randomized Clinical Trial..

Nanotechnologies in Pancreatic Cancer Therapy. (2017)
Journal Article
Manzur, A., Hoskins, C., Oluwasanmi, A., Moss, D., & Curtis, A. (2017). Nanotechnologies in Pancreatic Cancer Therapy. Pharmaceutics, https://doi.org/10.3390/pharmaceutics9040039

Pancreatic cancer has been classified as a cancer of unmet need. After diagnosis the patient prognosis is dismal with few surviving over 5 years. Treatment regimes are highly patient variable and often the patients are too sick to undergo surgical re... Read More about Nanotechnologies in Pancreatic Cancer Therapy..

Metaphysis (2017)
Journal Article
Ogrodnik, P. (2017). Metaphysis

Diels Alder-mediated release of gemcitabine from hybrid nanoparticles for enhanced pancreatic cancer therapy (2017)
Journal Article
Oluwasanmi, A., Al-Shakarchi, W., Manzur, A., Aldebasi, M. H., Elsini, R. S., Albusair, M. K., …Hoskins, C. (2017). Diels Alder-mediated release of gemcitabine from hybrid nanoparticles for enhanced pancreatic cancer therapy. Journal of Controlled Release, 355-364. https://doi.org/10.1016/j.jconrel.2017.09.027

Hybrid nanoparticles (HNPs) have shown huge potential as drug delivery vehicles for pancreatic cancer. Currently, the first line treatment, gemcitabine, is only effective in 23.8% of patients. To improve this, a thermally activated system was develop... Read More about Diels Alder-mediated release of gemcitabine from hybrid nanoparticles for enhanced pancreatic cancer therapy.

Diels Alder-mediated release of gemcitabine from hybrid nanoparticles for enhanced pancreatic cancer therapy (2017)
Journal Article
(2017). Diels Alder-mediated release of gemcitabine from hybrid nanoparticles for enhanced pancreatic cancer therapy. Journal of Controlled Release, 355-364. https://doi.org/10.1016/j.jconrel.2017.09.027

Abstract Hybrid nanoparticles (HNPs) have shown huge potential as drug delivery vehicles for pancreatic cancer. Currently, the first line treatment, gemcitabine, is only effective in 23.8% of patients. To improve this, a thermally activated system wa... Read More about Diels Alder-mediated release of gemcitabine from hybrid nanoparticles for enhanced pancreatic cancer therapy.

Synthesis and in vitro Biological Evaluation of Ferrocenyl Side-Chain-Functionalized Paclitaxel Derivatives (2017)
Journal Article
Plażuk, D., Wieczorek, A., Ciszewski, W. M., Kowalczyk, K., Błauż, A., Pawlędzio, S., …Rychlik, B. (2017). Synthesis and in vitro Biological Evaluation of Ferrocenyl Side-Chain-Functionalized Paclitaxel Derivatives. ChemMedChem, 12(22), 1882-1892. https://doi.org/10.1002/cmdc.201700576

Taxanes, including paclitaxel, are widely used in cancer therapy. In an attempt to overcome some of the disadvantages entailed with taxane chemotherapy, we devised the synthesis of ferrocenyl-functionalized paclitaxel derivatives and studied their bi... Read More about Synthesis and in vitro Biological Evaluation of Ferrocenyl Side-Chain-Functionalized Paclitaxel Derivatives.