Outputs (203)

Long-term testosterone therapy in type 2 diabetes is associated with reduced mortality without improvement in conventional cardiovascular risk factors (2018)
Journal Article
Hackett, G., Cole, N., Mulay, A., Strange, R. C., & Ramachandran, S. (2019). Long-term testosterone therapy in type 2 diabetes is associated with reduced mortality without improvement in conventional cardiovascular risk factors. BJU International, 123(3), 519-529. https://doi.org/10.1111/bju.14536

Objective
To further characterise the beneficial impact of testosterone replacement therapy (TRT) on the association between mortality and hypogonadism (HG) in men with type 2 diabetes (T2DM). We aimed to determine firstly, if changes in cardiovascu... Read More about Long-term testosterone therapy in type 2 diabetes is associated with reduced mortality without improvement in conventional cardiovascular risk factors.

Long-term testosterone therapy in type 2 diabetes is associated with decreasing waist circumference and improving erectile function (2018)
Journal Article
(2018). Long-term testosterone therapy in type 2 diabetes is associated with decreasing waist circumference and improving erectile function. https://doi.org/10.5534/wjmh.180052M

Objective
To further characterise the beneficial impact of testosterone replacement therapy (TRT) on the association between mortality and hypogonadism (HG) in men with type 2 diabetes (T2DM). We aimed to determine firstly, if changes in cardiovascu... Read More about Long-term testosterone therapy in type 2 diabetes is associated with decreasing waist circumference and improving erectile function.

Early vs Standard Discharge After Transcatheter Aortic Valve Implantation: A Systematic Review and Meta-analysis (2018)
Journal Article
Mamas. (2018). Early vs Standard Discharge After Transcatheter Aortic Valve Implantation: A Systematic Review and Meta-analysis. JACC. Cardiovascular interventions, 1759-1771. https://doi.org/10.1016/j.jcin.2018.04.042

Objectives: We sought to assess the clinical outcomes of patients undergoing transcatheter aortic valve implantation (TAVI) with early discharge (ED) versus standard discharge (SD) pathways.

Background: Minimalist approaches for TAVI have been dev... Read More about Early vs Standard Discharge After Transcatheter Aortic Valve Implantation: A Systematic Review and Meta-analysis.

Persistent sex disparities in clinical outcomes with percutaneous coronary intervention: Insights from 6.6 million PCI precedures in the United States (2018)
Journal Article
Ensor, J., Burke, D., Kwok, C., Riley, R., Holmvang, L., Mamas, M., …Rashid, M. (2018). Persistent sex disparities in clinical outcomes with percutaneous coronary intervention: Insights from 6.6 million PCI precedures in the United States. PloS one, https://doi.org/10.1371/journal.pone.0203325

Background
Prior studies have reported inconsistencies in the baseline risk profile, comorbidity burden and their association with clinical outcomes in women compared to men. More importantly, there is limited data around the sex differences and how... Read More about Persistent sex disparities in clinical outcomes with percutaneous coronary intervention: Insights from 6.6 million PCI precedures in the United States.

Two cases of monkeypox imported to the United Kingdom, September 2018. (2018)
Journal Article
(2018). Two cases of monkeypox imported to the United Kingdom, September 2018. Eurosurveillance, https://doi.org/10.2807/1560-7917.ES.2018.23.38.1800509

In early September 2018, two cases of monkeypox were reported in the United Kingdom (UK), diagnosed on 7 September in Cornwall (South West England) and 11 September in Blackpool (North West England). The cases were epidemiologically unconnected and h... Read More about Two cases of monkeypox imported to the United Kingdom, September 2018..

The poor design of clinical trials of statins in oncology may explain their failure – lessons for drug repurposing (2018)
Journal Article
Abdullah, M., Jawad, M., Richardson, A., & Wolf, E. (2018). The poor design of clinical trials of statins in oncology may explain their failure – lessons for drug repurposing. Cancer Treatment Reviews, 84-89. https://doi.org/10.1016/j.ctrv.2018.06.010

Statins are widely used to treat hypercholesterolaemia. However, by inhibiting the production of mevalonate, they also reduce the production of several isoprenoids that are necessary for the function of small GTPase oncogenes such as Ras. As such, st... Read More about The poor design of clinical trials of statins in oncology may explain their failure – lessons for drug repurposing.

Multiple Sclerosis-Secondary Progressive Multi-Arm Randomisation Trial (MS-SMART): a multiarm phase IIb randomised, double-blind, placebo-controlled clinical trial comparing the efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis (2018)
Journal Article
(2018). Multiple Sclerosis-Secondary Progressive Multi-Arm Randomisation Trial (MS-SMART): a multiarm phase IIb randomised, double-blind, placebo-controlled clinical trial comparing the efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis. BMJ Open, https://doi.org/10.1136/bmjopen-2018-021944

Introduction
The major unmet need in multiple sclerosis (MS) is for neuroprotective therapies that can slow (or ideally stop) the rate of disease progression. The UK MS Society Clinical Trials Network (CTN) was initiated in 2007 with the purpose of... Read More about Multiple Sclerosis-Secondary Progressive Multi-Arm Randomisation Trial (MS-SMART): a multiarm phase IIb randomised, double-blind, placebo-controlled clinical trial comparing the efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis.

Modification of metal surfaces using TCM-derived cyclotides: an antibacterial and antibiofilm study (2018)
Presentation / Conference
Cao, P., Yang, Y., Uche, F. I., Hart, S., Yuan, C., & Li, W. (2018, August). Modification of metal surfaces using TCM-derived cyclotides: an antibacterial and antibiofilm study. Paper presented at 35th European Peptide Symposium, The Helix Conference Centre, Dublin City University, Ireland

Stimuli Responsive Polymeric Systems for Cancer Therapy. (2018)
Journal Article
Curtis, A., Lamprou, D., Hoskins, C., & Alsuraifi, A. (2018). Stimuli Responsive Polymeric Systems for Cancer Therapy. Pharmaceutics, https://doi.org/10.3390/pharmaceutics10030136

Nanoscale polymers systems have dominated the revolution of drug delivery advancement. Their potential in the fight against cancer is unrivalled with other technologies. Their functionality increase, targeting ability and stimuli responsive nature ha... Read More about Stimuli Responsive Polymeric Systems for Cancer Therapy..

Synthesis and Activity of a Novel Autotaxin Inhibitor-Icodextrin Conjugate (2018)
Journal Article
Allin, S., Wallis, J., Bulman Page, P., Mckenzie, M., Jones, S., Elsegood, M., …Hemming, R. (2018). Synthesis and Activity of a Novel Autotaxin Inhibitor-Icodextrin Conjugate. Journal of Medicinal Chemistry, 7942-7951. https://doi.org/10.1021/acs.jmedchem.8b00935

Autotaxin is an extracellular phospholipase D that catalyzes the hydrolysis of lysophosphatidyl choline (LPC) to generate the bioactive lipid lysophosphatidic acid (LPA). Autotaxin has been implicated in many pathological processes relevant to cancer... Read More about Synthesis and Activity of a Novel Autotaxin Inhibitor-Icodextrin Conjugate.