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Outputs (181)

Development and evaluation of cationic nanostructured lipid carriers for ophthalmic drug delivery of besifloxacin (2019)
Journal Article
Yang. (2019). Development and evaluation of cationic nanostructured lipid carriers for ophthalmic drug delivery of besifloxacin. Journal of Drug Delivery Science and Technology, https://doi.org/10.1016/j.jddst.2019.101496

Besifloxacin hydrochloride (BSF) is a new ophthalmic antibiotic. However, its low water solubility limits its therapeutic efficacy. This article reported a novel lipid based drug delivery system to enhance ocular bioavailability of BSF. Cationic nano... Read More about Development and evaluation of cationic nanostructured lipid carriers for ophthalmic drug delivery of besifloxacin.

The Oswestry-Bristol Classification. (2019)
Journal Article
Kuiper. (2019). The Oswestry-Bristol Classification. The Bone & Joint Journal, 102 - 107. https://doi.org/10.1302/0301-620X.102B1.BJJ-2019-0366.R3

AIMS: Trochlear dysplasia is a significant risk factor for patellofemoral instability. The Dejour classification is currently considered the standard for classifying trochlear dysplasia, but numerous studies have reported poor reliability on both pla... Read More about The Oswestry-Bristol Classification..

Investigating the possible mechanisms and gender effects of Omega-3 fatty acids on neuroblastoma, breast and prostate cancers (2019)
Thesis
Sutton, E. R. (2019). Investigating the possible mechanisms and gender effects of Omega-3 fatty acids on neuroblastoma, breast and prostate cancers. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/417795

Cancer is a worldwide disease characterised by uncontrollable cell division and tumour growth making it a leading cause of death worldwide. The use of dietary products such a poly-unsaturated fatty acids (PUFAs) to reduce cancer growth is a current a... Read More about Investigating the possible mechanisms and gender effects of Omega-3 fatty acids on neuroblastoma, breast and prostate cancers.

Developing an alveolar model to test the regenerative potential of placental membrane mesenchymal stem cells in bronchopulmonary dysplasia (2019)
Thesis
Bratt, J. A. (2019). Developing an alveolar model to test the regenerative potential of placental membrane mesenchymal stem cells in bronchopulmonary dysplasia. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/415216

Bronchopulmonary dysplasia (BPD) is a neonatal disease affecting the lungs of premature infants. Prematurely born infants have under-developed lungs and require invasive ventilation technologies to provide sufficient oxygen for survival. Artificial v... Read More about Developing an alveolar model to test the regenerative potential of placental membrane mesenchymal stem cells in bronchopulmonary dysplasia.

Antimicrobial nano-ninjas as chaperones of gemcitabine for pancreatic cancer (2019)
Thesis
Foulkes, R. L. (2019). Antimicrobial nano-ninjas as chaperones of gemcitabine for pancreatic cancer. (Thesis). Keele University

Pancreatic cancer is well known for its extremely high death rate, with the current treatments purely used to extend and better the quality of the patient's life instead of providing a “cure”. Because of this, novel drug delivery methods are being lo... Read More about Antimicrobial nano-ninjas as chaperones of gemcitabine for pancreatic cancer.

Development of conjunctival and retinal models for improved eye disease treatments (2019)
Thesis
Gater, R. V. A. (2019). Development of conjunctival and retinal models for improved eye disease treatments. (Thesis). Keele University

Eye diseases such as glaucoma, macular degeneration and retinitis pigmentosa can lead to significant sight problems and blindness if left untreated. Current treatments are invasive, have a low success rate and lack the ability to regenerate damaged o... Read More about Development of conjunctival and retinal models for improved eye disease treatments.

Assessment of fracture risk tools in care home residents (2019)
Thesis
Ihama, F. E. (2019). Assessment of fracture risk tools in care home residents. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/415215

Introduction Fragility fractures are common in care home residents. National guidelines recommend risk assessment to allow initiation of prophylactic measures. Currently available risk assessment tools have been tested in community dwelling adults b... Read More about Assessment of fracture risk tools in care home residents.

If it's 'only' asthma, why are children still dying? (2019)
Journal Article
(2019). If it's 'only' asthma, why are children still dying?. Archives of Disease in Childhood, 494 - 498. https://doi.org/10.1136/archdischild-2019-318215

Outcomes for children with asthma in the UK continue to lag behind other European countries. Mortality remains unacceptably high and in contrast to adults with asthma, most deaths occur in the 1 in 20 children with asthma who have severe asthma. Desp... Read More about If it's 'only' asthma, why are children still dying?.

Promising New Inhibitors of Tyrosyl-DNA Phosphodiesterase I (Tdp 1) Combining 4-Arylcoumarin and Monoterpenoid Moieties as Components of Complex Antitumor Therapy (2019)
Journal Article
Reynisson. (2019). Promising New Inhibitors of Tyrosyl-DNA Phosphodiesterase I (Tdp 1) Combining 4-Arylcoumarin and Monoterpenoid Moieties as Components of Complex Antitumor Therapy. International Journal of Molecular Sciences, https://doi.org/10.3390/ijms21010126

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is an important DNA repair enzyme in humans, and a current and promising inhibition target for the development of new chemosensitizing agents due to its ability to remove DNA damage caused by topoisomerase 1 (To... Read More about Promising New Inhibitors of Tyrosyl-DNA Phosphodiesterase I (Tdp 1) Combining 4-Arylcoumarin and Monoterpenoid Moieties as Components of Complex Antitumor Therapy.