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Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model (2020)
Journal Article
Chen. (2020). Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model. Scientific reports, https://doi.org/10.1038/s41598-020-58482-w

This study compared effects of five hypoxia-inducible factor (HIF) prolyl hydroxylases (PHD) inhibitors on PC12 cells and primary rat neurons following oxygen-glucose deprivation (OGD). At 100 µM, the PHD inhibitors did not cause cytotoxicity and apo... Read More about Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model.

First clinical evidence characterizing safety and efficacy of the new CoCr Biolimus-A9 eluting stent: The Biomatrix Alpha™ registry (2020)
Journal Article
Mamas. (2020). First clinical evidence characterizing safety and efficacy of the new CoCr Biolimus-A9 eluting stent: The Biomatrix Alpha™ registry. https://doi.org/10.1016/j.ijcha.2020.100472

Background The biolimus-eluting stent (BES) was the first to elute anti-proliferative drug from a biodegradable polymer. In the randomized LEADERS trial, a stainless steel BES showed non-inferior efficacy compared to a sirolimus-eluting stent and a l... Read More about First clinical evidence characterizing safety and efficacy of the new CoCr Biolimus-A9 eluting stent: The Biomatrix Alpha™ registry.

Model-based control of individual finger movements for prosthetic hand function (2020)
Journal Article
(2020). Model-based control of individual finger movements for prosthetic hand function. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 612-620. https://doi.org/10.1101/629246

Abstract Prosthetic devices for hand difference have advanced considerably in recent years, to the point where the mechanical dexterity of a state-of-the-art prosthetic hand approaches that of the natural hand. Control options for users, however, hav... Read More about Model-based control of individual finger movements for prosthetic hand function.

Scoliosis in paediatric onset spinal cord injuries. (2020)
Journal Article
Kuiper. (2020). Scoliosis in paediatric onset spinal cord injuries. Spinal Cord, https://doi.org/10.1038/s41393-020-0418-6

STUDY DESIGN: This is a retrospective longitudinal review. OBJECTIVE: The purpose of this review was to identify predictors of developing clinical scoliosis and compare between traumatic and neurological aetiologies of SCI. SETTING: This study was co... Read More about Scoliosis in paediatric onset spinal cord injuries..

Spacers and Valved Holding Chambers—The Risk of Switching to Different Chambers (2020)
Journal Article
(2020). Spacers and Valved Holding Chambers—The Risk of Switching to Different Chambers. Journal of allergy and clinical immunology in practice, 1569 - 1573. https://doi.org/10.1016/j.jaip.2019.12.035

Spacers are pressurized metered-dose inhaler (pMDI) accessory devices developed to reduce problems of poor inhaler technique with pMDIs. Spacers that feature a 1-way inspiratory valve are termed valved holding chambers (VHCs); they act as aerosol res... Read More about Spacers and Valved Holding Chambers—The Risk of Switching to Different Chambers.

Genetically engineered distal airway stem cell transplantation protects mice from pulmonary infection (2020)
Journal Article
Dale, T., & Forsyth, N. (2020). Genetically engineered distal airway stem cell transplantation protects mice from pulmonary infection. EMBO Molecular Medicine, https://doi.org/10.15252/emmm.201810233

Severe pulmonary infection is a major threat to human health accompanied by substantial, which increases medical costs, prolonged inpatient requirements, and high mortality rates. New anti-microbial therapeutic strategies are urgently required to add... Read More about Genetically engineered distal airway stem cell transplantation protects mice from pulmonary infection.

A scoping literature review of studies assessing effectiveness and cost-effectiveness of prosthetic and orthotic interventions (2020)
Journal Article
Healy, A., Farmer, S., Eddison, N., Allcock, J., Perry, T., Pandyan, A., & Chockalingam, N. (2020). A scoping literature review of studies assessing effectiveness and cost-effectiveness of prosthetic and orthotic interventions. Disability and Rehabilitation: Assistive Technology, 15(1), 60-66. https://doi.org/10.1080/17483107.2018.1523953

PURPOSE
Approximately 1.5% of the world's population (~100 million people) need a prosthesis/orthosis. The objective of the study was to establish an overview of the literature that has examined prosthetic and orthotic interventions with a view to i... Read More about A scoping literature review of studies assessing effectiveness and cost-effectiveness of prosthetic and orthotic interventions.

Noncontrast Computed Tomography Signs as Predictors of Hematoma Expansion, Clinical Outcome, and Response to Tranexamic Acid in Acute Intracerebral Hemorrhage (2020)
Journal Article
Roffe. (2020). Noncontrast Computed Tomography Signs as Predictors of Hematoma Expansion, Clinical Outcome, and Response to Tranexamic Acid in Acute Intracerebral Hemorrhage. Stroke, 121-128. https://doi.org/10.1161/STROKEAHA.119.026128

Background and Purpose— Blend, black hole, island signs, and hypodensities are reported to predict hematoma expansion in acute intracerebral hemorrhage. We explored the value of these noncontrast computed tomography signs in predicting hematoma expan... Read More about Noncontrast Computed Tomography Signs as Predictors of Hematoma Expansion, Clinical Outcome, and Response to Tranexamic Acid in Acute Intracerebral Hemorrhage.

Th17 cells increase in RRMS as well as in SPMS, whereas various other phenotypes of Th17 increase in RRMS only. (2020)
Journal Article
(2020). Th17 cells increase in RRMS as well as in SPMS, whereas various other phenotypes of Th17 increase in RRMS only. Multiple Sclerosis, 2055217319899695 - ?. https://doi.org/10.1177/2055217319899695

Background: The nature and extent of inflammation seen in multiple sclerosis (MS) varies throughout the course of the disease. Changes seen in CD4+ T-helper cells in relapsing-remitting (RR) MS and secondary progressive (SP) MS might differ qualitati... Read More about Th17 cells increase in RRMS as well as in SPMS, whereas various other phenotypes of Th17 increase in RRMS only..