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Outputs (101)

Computational study on the iodobenzene-catalyzed oxidative cyclization of a δ-alkynyl β-ketoester (2022)
Journal Article
Butt, S. E., Rodríguez, A., Sotiropoulos, J., & Moran, W. J. (in press). Computational study on the iodobenzene-catalyzed oxidative cyclization of a δ-alkynyl β-ketoester. Arkivoc, 2022(7), 19-26. https://doi.org/10.24820/ark.5550190.p011.745

The iodobenzene-catalyzed oxidative cyclization of a δ-alkynyl β-ketoester has been investigated by density functional theory (DFT) calculations at the CPCM(acetonitrile)/B3LYP/6-311++G(d,p)//B3LYP/SDD(I) levels. Three different mechanisms were consi... Read More about Computational study on the iodobenzene-catalyzed oxidative cyclization of a δ-alkynyl β-ketoester.

Professional Dilemmas Experienced by Pharmacy Graduates in the United Kingdom When Transitioning to Practice (2022)
Journal Article
Allinson, M., Black, P., & White, S. (2022). Professional Dilemmas Experienced by Pharmacy Graduates in the United Kingdom When Transitioning to Practice. American journal of pharmaceutical education, 86(5), Article 8643. https://doi.org/10.5688/ajpe8643

Objective. For many UK pharmacy students there are minimal opportunities to learn, or be exposed to, different ways of dealing with ethical and professional dilemmas in real life practice during undergraduate education. This study aimed to explore th... Read More about Professional Dilemmas Experienced by Pharmacy Graduates in the United Kingdom When Transitioning to Practice.

Sesquiterpene Lactones Modulated DNA Methylation through Inhibition of DNMTs in Ovarian Cancer Cells (2022)
Journal Article
Kitchen, Li, & Reynisson. (2022). Sesquiterpene Lactones Modulated DNA Methylation through Inhibition of DNMTs in Ovarian Cancer Cells. https://doi.org/10.1016/j.prmcm.2022.100074

Inappropriate DNA methylation of tumour suppressor genes can affect their expression and function, and as such, DNA methylation has been a promising target for anti-cancer therapy. In gynaecological malignancy, ovarian cancer has the highest associat... Read More about Sesquiterpene Lactones Modulated DNA Methylation through Inhibition of DNMTs in Ovarian Cancer Cells.

Adamantane-Monoterpenoid Conjugates Linked via Heterocyclic Linkers Enhance the Cytotoxic Effect of Topotecan. (2022)
Journal Article
Reynisson. (2022). Adamantane-Monoterpenoid Conjugates Linked via Heterocyclic Linkers Enhance the Cytotoxic Effect of Topotecan. Molecules, https://doi.org/10.3390/molecules27113374

Inhibiting tyrosyl-DNA phosphodiesterase 1 (TDP1) is a promising strategy for increasing the effectiveness of existing antitumor therapy since it can remove the DNA lesions caused by anticancer drugs, which form covalent complexes with topoisomerase... Read More about Adamantane-Monoterpenoid Conjugates Linked via Heterocyclic Linkers Enhance the Cytotoxic Effect of Topotecan..

Superparamagnetic-blocked state transition under alternating magnetic fields: towards determining the magnetic anisotropy in magnetic suspensions (2022)
Journal Article
Cabrera, D., Yoshida, T., Rincón-Domínguez, T., Cuñado, J., Salas, G., Bollero, A., …Teran, F. J. (2022). Superparamagnetic-blocked state transition under alternating magnetic fields: towards determining the magnetic anisotropy in magnetic suspensions. Nanoscale, 14(24), 8789-8796. https://doi.org/10.1039/D2NR00808D

The potential of magnetic nanoparticles for acting as efficient catalysts, imaging tracers or heating mediators relays on their superparamagnetic behaviour under alternating magnetic fields. In spite of the relevance of this magnetic phenomenon, the... Read More about Superparamagnetic-blocked state transition under alternating magnetic fields: towards determining the magnetic anisotropy in magnetic suspensions.

An international survey mapping practice and barriers for upper-limb assessments in movement analysis. (2022)
Journal Article
Philp, F., Freeman, R., & Stewart, C. (2022). An international survey mapping practice and barriers for upper-limb assessments in movement analysis. Gait and Posture, 96, 93 - 101. https://doi.org/10.1016/j.gaitpost.2022.05.018

BACKGROUND: Upper-limb movement analysis could improve our understanding of function, pathological mechanisms and inform rehabilitation and surgical decision-making. Despite the potential benefits, the use of clinical upper-limb motion analysis is no... Read More about An international survey mapping practice and barriers for upper-limb assessments in movement analysis..

Cost-Effectiveness Analysis of a Medial Meniscus Replacement Prosthesis for the Treatment of Patients with Medial Compartment Pain in the United Kingdom (2022)
Journal Article
Javanbakht, M., Mashayekhi, A., Carlson, A., Moloney, E., Snow, M., Murray, J., & Spalding, T. (2022). Cost-Effectiveness Analysis of a Medial Meniscus Replacement Prosthesis for the Treatment of Patients with Medial Compartment Pain in the United Kingdom. PharmacoEconomics, 6(5), 681-696. https://doi.org/10.1007/s41669-022-00336-4

Background The most common intra-articular knee injury is a meniscal tear, which commonly occurs secondary to trauma following twisting or hyperflexion. Treatment options for meniscal tears can either be surgical or non-surgical, and range from rest,... Read More about Cost-Effectiveness Analysis of a Medial Meniscus Replacement Prosthesis for the Treatment of Patients with Medial Compartment Pain in the United Kingdom.

Evaluating the Feasibility and Reliability of Remotely Delivering and Scoring the North Star Ambulatory Assessment in Ambulant Patients with Duchenne Muscular Dystrophy (2022)
Journal Article
Kuiper. (2022). Evaluating the Feasibility and Reliability of Remotely Delivering and Scoring the North Star Ambulatory Assessment in Ambulant Patients with Duchenne Muscular Dystrophy. Children, 728 - 728. https://doi.org/10.3390/children9050728

Objective: The North Star Ambulatory Assessment (NSAA) is a validated 17-item functional rating scale and widely used to assess motor function in boys with Duchenne muscular dystrophy (DMD). The SARS-CoV-2 pandemic and subsequent Government 'lockdown... Read More about Evaluating the Feasibility and Reliability of Remotely Delivering and Scoring the North Star Ambulatory Assessment in Ambulant Patients with Duchenne Muscular Dystrophy.

Osteoarthritis in Athletes Versus Nonathletes: A Systematic Review (2022)
Journal Article
Migliorini, F., Marsilio, E., Torsiello, E., Pintore, A., Oliva, F., & Maffulli, N. (2022). Osteoarthritis in Athletes Versus Nonathletes: A Systematic Review. Sports Medicine and Arthroscopy Review, 30(2), 78-86. https://doi.org/10.1097/jsa.0000000000000339

Introduction: Joint overload and sport-related injuries may accelerate the development of osteoarthritis (OA). A systematic review of the literature was performed to establish the risk of athletes to develop premature OA compared with nonathletes. Ma... Read More about Osteoarthritis in Athletes Versus Nonathletes: A Systematic Review.