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Outputs (163)

Isosorbide Mononitrate and Cilostazol Treatment in Patients With Symptomatic Cerebral Small Vessel Disease (2023)
Journal Article
Wardlaw, J. M., Woodhouse, L. J., Mhlanga, I. I., Oatey, K., Heye, A. K., Bamford, J., …Elyas, S. (2023). Isosorbide Mononitrate and Cilostazol Treatment in Patients With Symptomatic Cerebral Small Vessel Disease. JAMA Neurology, 80(7), 682. https://doi.org/10.1001/jamaneurol.2023.1526

ImportanceCerebral small vessel disease (cSVD) is a common cause of stroke (lacunar stroke), is the most common cause of vascular cognitive impairment, and impairs mobility and mood but has no specific treatment.ObjectiveTo test the feasibility, drug... Read More about Isosorbide Mononitrate and Cilostazol Treatment in Patients With Symptomatic Cerebral Small Vessel Disease.

Reperfusion by endovascular thrombectomy and early cerebral edema in anterior circulation stroke: Results from the SITS-International Stroke Thrombectomy Registry (2023)
Journal Article
Thorén, M., Escudero-Martínez, I., Andersson, T., Chen, S., Tsao, N., Khurana, D., …Ahmed, N. (2023). Reperfusion by endovascular thrombectomy and early cerebral edema in anterior circulation stroke: Results from the SITS-International Stroke Thrombectomy Registry. International Journal of Stroke, 18(10), 1193-1201. https://doi.org/10.1177/17474930231180451

Background: A large infarct and expanding cerebral edema (CED) due to a middle cerebral artery occlusion confers a 70% mortality unless treated surgically. There is still conflicting evidence whether reperfusion is associated with a lower risk for C... Read More about Reperfusion by endovascular thrombectomy and early cerebral edema in anterior circulation stroke: Results from the SITS-International Stroke Thrombectomy Registry.

New 5-Hydroxycoumarin-Based Tyrosyl-DNA Phosphodiesterase I Inhibitors Sensitize Tumor Cell Line to Topotecan (2023)
Journal Article
Khomenko, T. M., Zakharenko, A. L., Kornienko, T. E., Chepanova, A. A., Dyrkheeva, N. S., Artemova, A. O., …Lavrik, O. I. (in press). New 5-Hydroxycoumarin-Based Tyrosyl-DNA Phosphodiesterase I Inhibitors Sensitize Tumor Cell Line to Topotecan. International Journal of Molecular Sciences, 24(11), Article 9155. https://doi.org/10.3390/ijms24119155

Tyrosyl-DNA-phosphodiesterase 1 (TDP1) is an important enzyme in the DNA repair system. The ability of the enzyme to repair DNA damage induced by a topoisomerase 1 poison such as the anticancer drug topotecan makes TDP1 a promising target for complex... Read More about New 5-Hydroxycoumarin-Based Tyrosyl-DNA Phosphodiesterase I Inhibitors Sensitize Tumor Cell Line to Topotecan.

Debiased ambient vibrations optical coherence elastography to profile cell, organoid and tissue mechanical properties (2023)
Journal Article
Mason, J. H., Luo, L., Reinwald, Y., Taffetani, M., Hallas-Potts, A., Herrington, C. S., …Bagnaninchi, P. O. (2023). Debiased ambient vibrations optical coherence elastography to profile cell, organoid and tissue mechanical properties. Communications Biology, 6(1), Article 543. https://doi.org/10.1038/s42003-023-04788-0

The role of the mechanical environment in defining tissue function, development and growth has been shown to be fundamental. Assessment of the changes in stiffness of tissue matrices at multiple scales has relied mostly on invasive and often speciali... Read More about Debiased ambient vibrations optical coherence elastography to profile cell, organoid and tissue mechanical properties.

An Entropy-Based Method with a New Benchmark Dataset for Chinese Textual Affective Structure Analysis (2023)
Journal Article
Xiong, S., Fan, X., Batra, V., Zeng, Y., Zhang, G., Xi, L., …Shi, L. (2023). An Entropy-Based Method with a New Benchmark Dataset for Chinese Textual Affective Structure Analysis. Entropy, 25(5), Article 794. https://doi.org/10.3390/e25050794

Affective understanding of language is an important research focus in artificial intelligence. The large-scale annotated datasets of Chinese textual affective structure (CTAS) are the foundation for subsequent higher-level analysis of documents. Howe... Read More about An Entropy-Based Method with a New Benchmark Dataset for Chinese Textual Affective Structure Analysis.

A comprehensive review of quantum bioreactor cell manufacture: Research and clinical applications (2023)
Journal Article
Hulme, C. H., Mennan, C., McCarthy, H. S., Davies, R., Lan, T., Rix, L., …Wright, K. (2023). A comprehensive review of quantum bioreactor cell manufacture: Research and clinical applications. Cytotherapy, 25(10), 1017-1026. https://doi.org/10.1016/j.jcyt.2023.04.004

The Quantum cell expansion system manufactured by Terumo-BCT is perhaps the most widely reported Good Manufacturing Practice–compliant bioreactor used for the expansion of adherent cell populations, both for research purposes and cl... Read More about A comprehensive review of quantum bioreactor cell manufacture: Research and clinical applications.

Genomic Sequencing to Diagnose Prosthetic Joint Infection in the Knee: A Case Report (2023)
Journal Article
Wilkinson, H., McCarthy, H. S., Perry, J., Smith, T., Wright, K., & Cool, P. (2023). Genomic Sequencing to Diagnose Prosthetic Joint Infection in the Knee: A Case Report. Cureus, 15(5), https://doi.org/10.7759/cureus.38788

There is currently no "gold-standard" method to diagnose prosthetic joint infections (PJI), and the current practice of using microbiological cultures has many limitations. The identification of the bacterial species causing the infection is crucial... Read More about Genomic Sequencing to Diagnose Prosthetic Joint Infection in the Knee: A Case Report.

PROTEOMIC IDENTIFICATION OF PREDICTIVE AUTOLOGOUS CHONDROCYTE IMPLANTATION BIOMARKERS IN PLASMA (2023)
Journal Article
Hulme, C., Roberts, S., Gallagher, P., Jermin, P., & Wright, K. (2023). PROTEOMIC IDENTIFICATION OF PREDICTIVE AUTOLOGOUS CHONDROCYTE IMPLANTATION BIOMARKERS IN PLASMA. Orthopaedic Proceedings, 105-B(SUPP_9), 76-76. https://doi.org/10.1302/1358-992x.2023.9.076

Stratification is required to ensure that only those patients likely to benefit, receive Autologous Chondrocyte Implantation (ACI); ideally by assessing a biomarker in the blood. This study aimed to assess differences in the plasma proteome of indivi... Read More about PROTEOMIC IDENTIFICATION OF PREDICTIVE AUTOLOGOUS CHONDROCYTE IMPLANTATION BIOMARKERS IN PLASMA.

AUTOLOGOUS CHONDROCYTE IMPLANTATION: MULTILEVEL MODELLING OF 20-YEAR LONGITUDINAL OUTCOME DATA (2023)
Conference Proceeding
Tierney, L., Kuiper, J., Williams, M., Roberts, S., Harrison, P., Gallacher, P., …Wright, K. (2023). AUTOLOGOUS CHONDROCYTE IMPLANTATION: MULTILEVEL MODELLING OF 20-YEAR LONGITUDINAL OUTCOME DATA. . https://doi.org/10.1302/1358-992x.2023.9.075

The objectives of the study were to investigate demographic, injury and surgery/treatment-associated factors that could influence clinical outcome, following Autologous Chondrocyte Implantation (ACI) in a large, “real-world”, 20 year longitudinally c... Read More about AUTOLOGOUS CHONDROCYTE IMPLANTATION: MULTILEVEL MODELLING OF 20-YEAR LONGITUDINAL OUTCOME DATA.