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Outputs (161)

Small interfering RNAs in the management of human osteoporosis (2023)
Journal Article
Gargano, G., Asparago, G., Spiezia, F., Oliva, F., & Maffulli, N. (2023). Small interfering RNAs in the management of human osteoporosis. British Medical Bulletin, 148(1), 58-69. https://doi.org/10.1093/bmb/ldad023

Background Osteoporosis results in reduced bone mass and consequent bone fragility. Small interfering RNAs (siRNAs) can be used for therapeutic purposes, as molecular targets or as useful markers to test new therapies. Sources of data A systemat... Read More about Small interfering RNAs in the management of human osteoporosis.

Pharmacological agents for bone fracture healing: talking points from recent clinical trials (2023)
Journal Article
Migliorini, F., Cocconi, F., Vecchio, G., Schäefer, L., Koettnitz, J., & Maffulli, N. (2023). Pharmacological agents for bone fracture healing: talking points from recent clinical trials. Expert Opinion on Investigational Drugs, 32(9), 855-865. https://doi.org/10.1080/13543784.2023.2263352

Introduction Pharmacological strategies might influence bone healing in terms of time to union or quality of mature bone. This expert opinion discussed the current level I evidence on the experimental pharmacological agents used to favor bone fractu... Read More about Pharmacological agents for bone fracture healing: talking points from recent clinical trials.

Safety and Efficacy of Bone Marrow–Derived Mesenchymal Stem Cells for Chronic Patellar Tendinopathy (With Gap >3 mm) in Patients: 12-Month Follow-up Results of a Phase 1/2 Clinical Trial (2023)
Journal Article
Soler, R., Rodas, G., Rius-Tarruella, J., Alomar, X., Balius, R., Ruíz-Cotorro, Á., …Orozco, L. (2023). Safety and Efficacy of Bone Marrow–Derived Mesenchymal Stem Cells for Chronic Patellar Tendinopathy (With Gap >3 mm) in Patients: 12-Month Follow-up Results of a Phase 1/2 Clinical Trial. Orthopaedic Journal of Sports Medicine, 11(9), https://doi.org/10.1177/23259671231184400

Virtual screening, identification and in vitro validation of small molecule GDP-mannose dehydrogenase inhibitors † (2023)
Journal Article
Dolan, J., Ahmadipour, S., Wahart, A., Ni Cheallaigh, A., Sari, S., Eurtivong,, C., …Miller, G. (2023). Virtual screening, identification and in vitro validation of small molecule GDP-mannose dehydrogenase inhibitors †. RSC Chemical Biology, 4(11), 865-870. https://doi.org/10.1039/D3CB00126A

Upon undergoing mucoid conversion within the lungs of cystic fibrosis patients, the pathogenic bacterium Pseudomonas aeruginosa synthesises copious quantities of the virulence factor and exopolysaccharide alginate. The enzyme guanosine diphosphate ma... Read More about Virtual screening, identification and in vitro validation of small molecule GDP-mannose dehydrogenase inhibitors †.

Robotic-assisted total knee arthroplasty in clinical practice: protocol for a randomised controlled trial (2023)
Journal Article
Migliorini, F., Maffulli, N., Schäfer, L., Schneider, J., Nobili, A. M., Kämmer, D., …Bell, A. (in press). Robotic-assisted total knee arthroplasty in clinical practice: protocol for a randomised controlled trial. Journal of Orthopaedic Surgery and Research, 18(1), Article 623. https://doi.org/10.1186/s13018-023-04101-z

Between 2 and 20% of patients who undergo total knee arthroplasty (TKA) report restricted motion and anterior knee pain. Non-optimal alignment of the implant components is a common cause of such complaints. Robotic-assisted TKA has been advocated to... Read More about Robotic-assisted total knee arthroplasty in clinical practice: protocol for a randomised controlled trial.

Fourier Transform Infrared microspectroscopy identifies single cancer cells in blood. A feasibility study towards liquid biopsy (2023)
Journal Article
Dowling, L. M., Roach, P., Magnussen, E. A., Kohler, A., Pillai, S., van Pittius, D. G., …Sulé-Suso, J. (in press). Fourier Transform Infrared microspectroscopy identifies single cancer cells in blood. A feasibility study towards liquid biopsy. PLoS ONE, 18(8), Article e0289824. https://doi.org/10.1371/journal.pone.0289824

The management of cancer patients has markedly improved with the advent of personalised medicine where treatments are given based on tumour antigen expression amongst other. Within this remit, liquid biopsies will no doubt improve this personalised c... Read More about Fourier Transform Infrared microspectroscopy identifies single cancer cells in blood. A feasibility study towards liquid biopsy.

Survival analysis in nonagenarian patients with non-hip lower limb fractures. (2023)
Journal Article
Narayana Murthy, S., Cheruvu, M. S., Siddiqui, R. S., Sharma, N., Dass, D., & Ali, A. (in press). Survival analysis in nonagenarian patients with non-hip lower limb fractures. World Journal of Orthopedics, 14(8), 621-629. https://doi.org/10.5312/wjo.v14.i8.621

The United Kingdom has an aging population with nearly 1 in 5 being over the age of 65, and over 0.5 million over the age of 90. The treatment of acute fractures of the lower limb in the nonagenarian cohort of patients poses a technical challenge to... Read More about Survival analysis in nonagenarian patients with non-hip lower limb fractures..

Pharmacists' perspectives on the impact of postgraduate distance learning on their well-being: A qualitative study. (2023)
Journal Article
O'Byrne, R., White, S., & Chew-Graham, C. A. (in press). Pharmacists' perspectives on the impact of postgraduate distance learning on their well-being: A qualitative study. Currents in Pharmacy Teaching and Learning, 15(10), 861-867. https://doi.org/10.1016/j.cptl.2023.07.027

Introduction: Undertaking postgraduate education is becoming increasingly common among United Kingdom (UK) pharmacists to facilitate career progression. However, whilst there is evidence that postgraduate study can negatively affect well-being (defin... Read More about Pharmacists' perspectives on the impact of postgraduate distance learning on their well-being: A qualitative study..