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An investigation of magnetic nanoparticle mediated methods for neuro-regeneration (2024)
Thesis
Nahar, T. S. (2024). An investigation of magnetic nanoparticle mediated methods for neuro-regeneration. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/775525

Conditions such as Parkinsons disease, where specific cell types are affected such as the dopaminergic neurons in the substantia nigra pars compacta, cell transplantation and growth factor therapy could restore function and slow disease progression b... Read More about An investigation of magnetic nanoparticle mediated methods for neuro-regeneration.

Using Nanopore sequencing to identify bacterial infection in joint replacements: A Preliminary study (2024)
Journal Article
Wilkinson, H., McDonald, J., McCarthy, H., Perry, J., Wright, K., Hulme, C., & Cool, P. (in press). Using Nanopore sequencing to identify bacterial infection in joint replacements: A Preliminary study. Briefings in Functional Genomics, Article elae008. https://doi.org/10.1093/bfgp/elae008

This project investigates if third-generation genomic sequencing can be used to identify the species of bacteria causing prosthetic joint infections (PJIs) at the time of revision surgery. Samples of prosthetic fluid were taken during revision surger... Read More about Using Nanopore sequencing to identify bacterial infection in joint replacements: A Preliminary study.

Macroprolactin over time: Is there any point in rechecking it in people with a persistently elevated serum prolactin? (2024)
Journal Article
Livingston, M., Hashmi, S. F., Ramachandran, S., Laing, I., & Heald, A. (in press). Macroprolactin over time: Is there any point in rechecking it in people with a persistently elevated serum prolactin?. Clinical Endocrinology, 100(5), 450-458. https://doi.org/10.1111/cen.15051

Objective and Design Macroprolactinemia may influence the interpretation of serum prolactin levels—a recognised phenomenon since 1981. The degree of macroprolactinaemia over time is less well described. We determined how macroprolactin status (based... Read More about Macroprolactin over time: Is there any point in rechecking it in people with a persistently elevated serum prolactin?.

EFAS Score - Validation of Danish Version by the Score Committee of the European Foot and Ankle Society (EFAS). (2024)
Journal Article
Richter, M., Agren, P., Besse, J., Coester, M., Kofoed, H., Maffulli, N., …Johansen, J. K. (in press). EFAS Score - Validation of Danish Version by the Score Committee of the European Foot and Ankle Society (EFAS). Foot and Ankle Surgery, S1268-7731(24)00069-9. https://doi.org/10.1016/j.fas.2024.03.009

The Score Committee of the European Foot and Ankle Society (EFAS) developed, validated, and published the EFAS Score in 13 languages. Currently, the Danish version completed data acquisition and underwent further validation. The data were collected p... Read More about EFAS Score - Validation of Danish Version by the Score Committee of the European Foot and Ankle Society (EFAS)..

Label-Free In Situ Chemical Characterization of Amyloid Plaques in Human Brain Tissues (2024)
Journal Article
Everett, J., Brooks, J., Tjendana Tjhin, V., Lermyte, F., Hands-Portman, I., Plascencia-Villa, G., …Telling, N. D. (2024). Label-Free In Situ Chemical Characterization of Amyloid Plaques in Human Brain Tissues. ACS chemical neuroscience, 15(7), 1469–1483. https://doi.org/10.1021/acschemneuro.3c00756

The accumulation of amyloid plaques and increased brain redox burdens are neuropathological hallmarks of Alzheimer’s disease. Altered metabolism of essential biometals is another feature of Alzheimer’s, with amyloid plaques representing sites of dist... Read More about Label-Free In Situ Chemical Characterization of Amyloid Plaques in Human Brain Tissues.

Proteomic characterization of human LMNA-related congenital muscular dystrophy muscle cells (2024)
Journal Article
Storey, E., Holt, I., Brown, S., Synowsky, S., Shirran, S., & Fuller, H. (2024). Proteomic characterization of human LMNA-related congenital muscular dystrophy muscle cells. Neuromuscular Disorders, 38, 26-41. https://doi.org/10.1016/j.nmd.2024.03.006

LMNA-related congenital muscular dystrophy (L-CMD) is caused by mutations in the LMNA gene, encoding lamin A/C. To further understand the molecular mechanisms of L-CMD, proteomic profiling using DIA mass spectrometry was conducted on immortalized myo... Read More about Proteomic characterization of human LMNA-related congenital muscular dystrophy muscle cells.

Management of rotator cuff injuries using allogenic platelet-rich plasma (2024)
Journal Article
Gupta, A., Migliorini, F., & Maffulli, N. (in press). Management of rotator cuff injuries using allogenic platelet-rich plasma. Journal of Orthopaedic Surgery and Research, 19(1), Article 165. https://doi.org/10.1186/s13018-024-04657-4

Rotator cuff injuries are a major cause of shoulder pain, affecting the quality of life and producing a significant burden on healthcare systems. Conservative management modalities are prioritized, resorting to surgery only when required. The field o... Read More about Management of rotator cuff injuries using allogenic platelet-rich plasma.

Testosterone therapy reduces insulin resistance in men with adult‐onset testosterone deficiency and metabolic syndrome. Results from the Moscow Study, a randomized controlled trial with an open‐label phase (2024)
Journal Article
Tishova, Y., Kalinchenko, S., Mskhalaya, G., Hackett, G., Livingston, M., König, C., …Ramachandran, S. (2024). Testosterone therapy reduces insulin resistance in men with adult‐onset testosterone deficiency and metabolic syndrome. Results from the Moscow Study, a randomized controlled trial with an open‐label phase. Diabetes, Obesity and Metabolism, 26(6), 2147-2157. https://doi.org/10.1111/dom.15520

Aims To describe changes in homeostasis model assessment of insulin resistance index (HOMA-IR) following testosterone therapy in men with hypogonadism and metabolic syndrome (MetS). Materials and Methods A randomized, placebo-controlled, double-... Read More about Testosterone therapy reduces insulin resistance in men with adult‐onset testosterone deficiency and metabolic syndrome. Results from the Moscow Study, a randomized controlled trial with an open‐label phase.

Evaluating the utility of quantitative pupillometry in a neuro-critical care setting for the monitoring of intracranial pressure: A prospective cohort study. (2024)
Journal Article
Ali, A. M. S., Gul, W., Sen, J., Hewitt, S., Olubajo, F., & McMahon, C. (in press). Evaluating the utility of quantitative pupillometry in a neuro-critical care setting for the monitoring of intracranial pressure: A prospective cohort study. Clinical Neurology and Neurosurgery, 239, Article 108215. https://doi.org/10.1016/j.clineuro.2024.108215

Assessment of the pupillary light reflex (PLR) is key in intensive care monitoring of neurosurgical patients, particularly for monitoring intracranial pressure (ICP). Quantitative pupillometry using a handheld pupillometer is a reliable method for PL... Read More about Evaluating the utility of quantitative pupillometry in a neuro-critical care setting for the monitoring of intracranial pressure: A prospective cohort study..